Conserved Protein Domain Family
MATE_like_8

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cd13134: MATE_like_8 
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins
The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Statistics
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PSSM-Id: 240539
Aligned: 82 rows
Threshold Bit Score: 279.772
Created: 23-May-2012
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
ABN51537   9 KKMSVFALTWPIFIETLLRTMLGNVDTFMLSTYSDDAVGAVGVVSQISYILIMLYNVVSSGTLVLISQYLGAKKkKEASV 88  Clostridium thermoc...
EFH84434  34 FYRTLFALVLPIALQNLLTAVGSSANVIMLGSVSQTDLSAVSLASQILFILNLFFAGLTIGATMLVAQYWGKGDtGAIET 113 Ktedonobacter racem...
AEX21943  11 FFPRLFSIALPFALQLLLYAVLGLVDIMMVGQLGETEVAAVGLSNRIFYFNLVLILGITGGVNVLAAQYYGSGDeAGIRR 90  Vibrio sp. EJY3
ABS60385   4 LLKNILKIAIPVSLENIIANTGTFILTILLSQLGEVEVAINGVANQGSFLVILFLFGLNTGGAIFLAQYWGKKDtENIKK 83  Fervidobacterium no...
EFW25207   7 FYQHLAAMMIPLVIQEIINFCVQMLDTVMVGSLGDAAVSAVTLAGQPYFIFNVFAFGLTSAGAVIISQYWGQKNiEKIKH 86  Solobacterium moore...
EDY82986  14 FVRRLLATAIPVCLQTLMFSSRSLADIMMTSHLGVSEVAAIGFSGRIIFVMNLALFGIASGGGVIIAQNWGAKKkEGARQ 93  Verrucomicrobiae ba...
EDN82017  14 FLGHVFKLALPIAFQQLMLSLSSCADTLMLSGVGQNELAAVSLATQFQFLFSLFTAALTLGMSILVAQYWGAGNrDAVER 93  Bifidobacterium ado...
ACT03128  15 FNRQLISLVIPIAMQNLISALAVTVDVVMLGFINQSAMSAVSLAGQITFVLTLFYMGLATGAGILTAQYWGKQDlATIER 94  Paenibacillus sp. J...
ACM31158   5 FLLPLLAIAVPAALQNFVFSAQQVLDTIMVARLNDEYVAALAFCGAAFLVITSSLFGIALATSALVAQHWGAIDyARMRS 84  Agrobacterium radio...
ABX81384  13 FYKMALAIIIPVVIQQLILNLAGLIDTFMINGFSQTAYTGVSTANRFMFIINFFWIGLAAGISVFVSQYFGAKNkKGIIG 92  Acholeplasma laidla...
ABN51537  89 VAVTSIAGSLIFGLFVGLAvFLFRSQi-----LTFLNLPPELMGYAMTFLGIVGGFSFTQALIATLSAIIRSYGNTRITM 163 Clostridium thermoc...
EFH84434 114 LYGITLRLSLLIAVIFCAG-ACLCPQl----lMLLFTSDKDLIATGASYLRFAGPSYLFMSISLIYLCFIRSMERVHIST 188 Ktedonobacter racem...
AEX21943  91 CVVQAVMAATLISLPFIAL-YSIHPRl----fLHLASEDAPLVLLSAEYMQITGVSLFFTCLVVPIEAALRATGDSKTPT 165 Vibrio sp. EJY3
ABS60385  84 IMSLMIYFSLLISLAFFVLtFFFPKVf-----IKMFSNDTRVIDRGILYLRLISISYFGLALEISFRTLLRSIERATIPM 158 Fervidobacterium no...
EFW25207  87 IMSVMLWSVIVVSILYMGAcWLFPREi-----IHIFARDEKLVELGISYLQVVVISYLLNGLSMWYFSSLSAKENVKISA 161 Solobacterium moore...
EDY82986  94 STAIAMLMGIPFALLFVVLcSLIPERm-----VGLASSDASVIELGATYLQIAGLMAFPLTIGTVLSVALRSIGLAKICM 168 Verrucomicrobiae ba...
EDN82017  94 VLGFVMLYAGMLSTAFFLAaLLVPEQl-----MSIMTNDGTLIMLGARYLRISSLSYLFIGLSQMYLCLMKNTGSAVMGM 168 Bifidobacterium ado...
ACT03128  95 VFWIGCLFCTIISFIFFGI-SLFMPEw----lMSFFTNDGDLIDYGSSFLQVISFSYVVSGISQMYFSVIRSMENARFSA 169 Paenibacillus sp. J...
ACM31158  85 YLFLGIALSMLVAVPAVVLfVGFPELl-----MSLGPDSIQVRNAGVEYLQIAGWSILLWPISVGLSMALNMIGQARLSL 159 Agrobacterium radio...
ABX81384  93 TFQLGILLAIVFGIFSTFLiNVLGPEmikmflPTTDPEQVESVMFGIEYIKIIGYGAIVFLSSFMIATFFRSVGRAKAPL 172 Acholeplasma laidla...
ABN51537 164 YISVGMNILNIIGNSIFLYGllg--apkMGVTGVAIATVISQAVGVVAMLIVMLTglnqkfsfr--dlvplpweiLRDIL 239 Clostridium thermoc...
EFH84434 189 LITSISLVLNVGLNALFIFGlfg--apkLGVVGVALATTIAQAFGLAWCLIDSRRastaqlrlr--alfvrspllFRDYL 264 Ktedonobacter racem...
AEX21943 166 IISLISVALNIALNWLLIFGnlg--fpeLGVAGSAWGTTIARFLQTVCIVGLIWRkkqwliptqndvenalsrknIRLFA 243 Vibrio sp. EJY3
ABS60385 159 MSYVYGTIIQIFLAYGFVKGlfg--lpkLGLVGIAISLIVSRFVIPLYQILRASTlklpytfs----lsgisrnmLSKFL 232 Fervidobacterium no...
EFW25207 162 AVYTGSFFVNLICNYLLIYGnfg--fpkLGVVGAAIGTIVARAFQLVCASIYARYhekdirfglr-difdfdktmIPTYF 238 Solobacterium moore...
EDY82986 169 RLSVVGVGSNLVLNYALIFGawg--fpaLGIAGAAYATLISSALETACVLAYVFLrksalafsiadlkegldnglWKKIG 246 Verrucomicrobiae ba...
EDN82017 169 TVSTVGVIVHVVLNAALIYGigslgipaLGIFGAAISTVISRAIELAWSVVATRRgpylrlgh----vlhpdgplQKDFW 244 Bifidobacterium ado...
ACT03128 170 WTSSMCLIINILFNALSIFVlfpd-hpqKAIAAVALSTVVARFIELGCCIVHSVKgkikfkfpv---ydamqqnlQKDFF 245 Paenibacillus sp. J...
ACM31158 160 LISVAFAVITIVSNYVLIFGwgp--ipkLEIRGAAFGTLGTSVLFAGVYLLFVLRpnnalrfssrelsstitlplIRKLI 237 Agrobacterium radio...
ABX81384 173 FAGVIGIVVNMVLNMILIYGflg--fpaMGAIGAAWATVISKIVELVVLLVIAFFysnenyareifkkflitkrlVIMYI 250 Acholeplasma laidla...
ABN51537 240 KIGLPSAGEgIAYEASQLTITRIITVLGKVALTTRVYTlNIMYFVMVFSVAVGQGTQIVVGHLVGAGDnEKAYKTCIKSL 319 Clostridium thermoc...
EFH84434 265 RYASPVLGNeCVWGGAIAMYAVILGHLGADVVAANSLAtVVGDLATVVSLGIASGGAILLGKEIGEKQlERARGDASRLC 344 Ktedonobacter racem...
AEX21943 244 AIAIPVMLHdGGWALGTLVYAFIYGQMGVEALAIMSLLsPLENCLYAFFLGFALACSTMLGHELGANRyHQAWSQSKVFL 323 Vibrio sp. EJY3
ABS60385 233 EFATPTTLNeIAWSLGMTVYGIIFGRMGTQAYAARNILsSFENYVWTFTFGIVIAASVIIGKYIGQMEyEKAQQFAKKIL 312 Fervidobacterium no...
EFW25207 239 HLSLPVIGDdLIWSLAVSTQLAIIGRMNSDYVAAASIAsVAQQFVMILVYSMTKSATITTGKAVGQGNyERVKQIGRTFL 318 Solobacterium moore...
EDY82986 247 KVAYPLAINgVVWSGGVLIYNIMVGRMGTSELAVLAMItPIESIIVALYVGIATAASVITGHRLGAEDyEVAWSEGKAFL 326 Verrucomicrobiae ba...
EDN82017 245 KYSLPVLGNeLVWGCGFTMYTVIMGHLGADAVAANSIAnIVKDLLVCLSLGLGNAGGILVGNLLGRGDfRQAKAMGDRMC 324 Bifidobacterium ado...
ACT03128 246 RYTLPVLGNyIVWGGALTVTAAIFGHVNADMVAANSVAsVVKNLAIVLCGGIASGGSVLIGKYLGNGDmDTARRAGSKIN 325 Paenibacillus sp. J...
ACM31158 238 AQSTPLFINgTLWAGGLFTYNVIFSQLGTAGMTVIALLaPIITVSLVIFNGLATGANSVIGNALGRKDfDYAWNCAKSAI 317 Agrobacterium radio...
ABX81384 251 SKGGPIIINeILWSIAMVLYAMFITSGIYEWVTAYGYSqNATDIFFVYYSGMATATGVILGQALGEGDfENAKDYLIKLR 330 Acholeplasma laidla...
ABN51537 320 RYAVVVAIILAGIVSFFSEQLLGIFt-DDRAIIEMGSKLLLIAVIL-EPGRVFNIVII-NSLRAAG-DARFPVIMGIISM 395 Clostridium thermoc...
EFH84434 345 KLALLCGAAGGILILLTRPLLLQIVp-LTRAASGYLAVMLFINAYY-VIGKSINATAIvGVFCAGG-DSRFGLVNDALVM 421 Ktedonobacter racem...
AEX21943 324 WLGTGVAVLVGIVLYLLREEIVPLFakLNEQTLTNAIYVLAVLASA-LCIKVFNTVAViGVLRSGG-DIKFAALFNLFCM 401 Vibrio sp. EJY3
ABS60385 313 MWSFVIGLLSAVIVMVVYYILYPTFk-IEENTKKILTYAMWVMLIG-APVKAFNGAAIvGVLRAGG-DAKFAFLLETFTL 389 Fervidobacterium no...
EFW25207 319 VLSAFVGILACGVVLFIRTPVLSLYpnVTVETKNLAYQFMTVIAGLmLFTGIENAAIV-GILRGAG-DMHYAFRIDAGCM 396 Solobacterium moore...
EDY82986 327 VWSVLCAVFSSILIWSCKGLIISFYpaIEGDTLTNASQVLTALALV-SGFRSVNVTVIvGMLRSGG-DTRFCLGLDLFCQ 404 Verrucomicrobiae ba...
EDN82017 325 VLVAVVGTATGLLIVAARPLALQWAn-LTPEATRYLSVMLFVCAYYaACGCMTNLTIA-GIFPAGG-DAKFGLMCDAIVM 401 Bifidobacterium ado...
ACT03128 326 AYAVLFGILAGLSVLFIKPLVLQVVs-LNDQAQSYLNGMLFICAYY-CIPKSINSSTIgGIFVAGG-DSKFGFWCDVAVM 402 Paenibacillus sp. J...
ACM31158 318 SLTLVTGACTSLCMLLLQGVLPTLYsgVSQGVFTEFESVYTIAAAF-IWVRGLNIFLV-NGLLRTGaDNDYILKLDTISS 395 Agrobacterium radio...
ABX81384 331 AVMMVTNIGIMLLIVLLSPIILLMFt-PVNSLYWLAYQLILINVIF-IAIYGYNVMSY-YALRAGG-DSIRTFLLDQLPT 406 Acholeplasma laidla...
ABN51537 396 WGIGVLLSYFLGVa---cGLGLIGVWIAFASDEWFRGIAMLLRWRSRVWYKMAL 446 Clostridium thermocellum ATCC 27405
EFH84434 422 WGFSVPLGLLCAFv---fRFPAMVVYFVLCLDEFVKMPFIYRHYRRFTWLKNIT 472 Ktedonobacter racemifer DSM 44963
AEX21943 402 WCIGIPLVYLSALq---wLWPLYLVYLISMTEEVVKAGLAIYRVLQRKWLNNLI 452 Vibrio sp. EJY3
ABS60385 390 WCLGVPLAFIGAFi---wKQPLPVVYALTLSDEVVKSVIAYIRIKSKKWIKNVT 440 Fervidobacterium nodosum Rt17-B1
EFW25207 397 WFIGLPMGLLAAFv---wKLPVTYVYFFLRFDIIFKIILCIRRILKGEYIKDFT 447 Solobacterium moorei F0204
EDY82986 405 WAVGIVLTYLTAFv---wHMPLYVVFLAINSEEFVKLFLCVYRFASKKWIRNLI 455 Verrucomicrobiae bacterium DG1235
EDN82017 402 WLIVVPVGLLAAFv---fKLPVLVVYALLNTDECIKMVPALLHYRKYRWLRNVT 452 Bifidobacterium adolescentis L2-32
ACT03128 403 WGIILPLGYLSAFv---wRLPPITLFAIICLDEVIKSPVAFMRYRRFKWLNNIT 453 Paenibacillus sp. JDR-2
ACM31158 396 WGISIPLTCAAVYa---fDLSLIFVYLASLTGDFVKMIFYVARVRKRLWLRSLV 446 Agrobacterium radiobacter K84
ABX81384 407 YLVGLPIVMLLSHyrvelGVNILIIFLASKSTDVVKLIFARHIIKKGTWLNNLT 460 Acholeplasma laidlawii PG-8A
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