4QYW,4TMY,1U0S,3TMY,4IGA,6EKG,3HZH


Conserved Protein Domain Family
REC_CheY

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cd17542: REC_CheY 
Click on image for an interactive view with Cn3D
phosphoacceptor receiver (REC) domain of chemotaxis protein CheY
The chemotaxis response regulator CheY contains a stand-alone REC domain. Chemotaxis is a behavior known for motile bacteria that directs their movement in response to chemical gradients. CheY is involved in transmitting sensory signals from chemoreceptors to the flagellar motors. Phosphorylated CheY interacts with the flagella switch components FliM and FliY, which causes counterclockwise rotation of the flagella, resulting in smooth swimming. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.
Statistics
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PSSM-Id: 381097
Aligned: 24 rows
Threshold Bit Score: 162.833
Created: 8-Nov-2016
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1: metal binding site [ion binding site], 3 residue positions
Conserved feature residue pattern:[ED] [ED] [ED]Click to see conserved feature residue pattern help
Evidence:
  • Structure:4TMY: Thermotoga maritima CheY REC domain binds Mg2+
  • Structure:3TMY: Thermotoga maritima CheY REC domain binds Mn2+
  • Citation:PMID 9521117
  • Comment:signal transduction in two-component systems is mediated by metal ion dependent phosphorelay reactions between protein histidine kinases and phosphoaccepting receiver domains in response regulator proteins
  • Comment:for many receivers, Mg2+ is the preferred metal ion, but other divalent ions such as Mn2+ are also used
  • Comment:partly based on metal binding site of other family members

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                 ##                                              #                         
4QYW_A            2 KRVLIVDDAAFMRMMLKDIITKAGYe-vAGEATNGREAVEKYKELk--PDIVTMXITMPemnGIDAIKEIMKIdpNAKII 78   Thermotoga ...
4TMY_B            3 KRVLIVDDAAFMRMMLKDIITKAGYe-vAGEATNGREAVEKYKELk--PDIVTMDITMPemnGIDAIKEIMKIdpNAKII 79   Thermotoga ...
6EKG_Y            5 VKTMIVDDSAFMRNILKRILSTTNKyvvIGEAANGADAIKMAEELq--PDLISMDIVMPetdGITATKAIKEKtpEIKIV 82   Methanococc...
3HZH_A           37 FNVLIVDDSVFTVKQLTQIFTSEGFn-iIDTAADGEEAVIKYKNHypnIDIVTLXITMPkmdGITCLSNIMEFdkNARVI 115  Lyme diseas...
GAP62951          2 PTVLVVDDAQFVRKRLQKILSEAGFd--VLEAGDGQEAVDVYRQYh--PDVVLLDITMPkldGMEALRLIREYdpNARVV 77   Ardenticate...
OHC06765          2 RRILVVDDAKVIRMVIKQILTRHGFh-vAGEAGNGREAFERYKELk--PDAVTMDIIMPevdGIQGLKEILAFdkQAKVI 78   Planctomyce...
P45709            2 TRVLVVDDAKFMRVKIREILEEANYi-iAGEAADGEQAADLYKKLr--PDLVTMDITMPvknGIKALRDILTFdpKAKVI 78   Bacillus su...
B0R4K1            3 KQVLLVDDSEFMRNLLREILEEEFEi--ADEAENGVEAVEMYKEYd--PDLVMMDIVMPirdGIEATSEIKEFdaGAHII 78   Halobacteri...
YP_001087009      3 NKILIVDDAIFMRMIIKEALSKSGYn-nLIEANDGEEACNIFKYEk--PDLMLLDITMPkkdGLEVLREIKKLdsSAKVV 79   Clostridioi...
jgi:COB47_1692    1 MKILIVDDAVFIRKVLKGILQELGEe-vVGEASSGNEALRMVKEYr--PDVVTLDITLPdmsGLELLRKIKEIssSTQVV 77   Caldicellul...
Feature 1                                                   
4QYW_A           79 VASAMGQQAMVIEAIKAGAKDFIVKPfQPSRVVEALNKVS 118  Thermotoga maritima MSB8
4TMY_B           80 VCSAMGQQAMVIEAIKAGAKDFIVKPfQPSRVVEALNKVS 119  Thermotoga maritima
6EKG_Y           83 MCTSVDQEQKMIDAVNAGADGYIVKPfQAPKILEQFNKLF 122  Methanococcus maripaludis
3HZH_A          116 MISALGKEQLVKDCLIKGAKTFIVKPlDRAKVLQRVMSVF 155  Lyme disease spirochete
GAP62951         78 MLSALGQQAIILEALRRGARDFIVKPfKPEQVLHALELAT 117  Ardenticatena maritima
OHC06765         79 MISAIDQHDALTDAIRNGAADYVVKPfEDDRMVTALKNIF 118  Planctomycetes bacterium RIFOXYB12_FULL_42_10
P45709           79 MCTAMRQQRIVTEAIELGAKDFIVKPfEETKVLEAVSRVM 118  Bacillus subtilis subsp. subtilis str. 168
B0R4K1           79 MCTSIGQEEKMKKAVKAGADGYITKPfQKPSVMDAISDVL 118  Halobacterium salinarum R1
YP_001087009     80 MCSAIGQENMIVEAIKLGALDFIVKPfKTETLVKVVDNAL 119  Clostridioides difficile 630
jgi:COB47_1692   78 MITAISNHEVVKEAMKVGATNYITKPfSREKVEEVLKKVE 117  Caldicellulosiruptor obsidiansis OB47

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