3CUZ


Conserved Protein Domain Family
AceB

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COG2225: AceB 
Malate synthase [Energy production and conversion]
Malate synthase is part of the Pathway/BioSystem: TCA cycle, glyoxylate bypass
Statistics
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PSSM-Id: 441827
Aligned: 288 rows
Threshold Bit Score: 529.292
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3CUZ_A         3 Qa-------TT---TDE--LAFTRPYGEQEKQILTAEAVEFLTELvTHFTPQRNKLLAARIQQQQDIDNGT----LPDFI 66 
BAJ50995       1 ----------MichQSS-----SRKLTKKYLTVLSKDAVDFVRHLvEKHGPELRRLLAKREETAEALRRGA----RLDFP 61 
WP_011643563   1 ------mtlIA---PSG--VEVLGHLEPGYRDILSHEALGFLAGLhRRFEKRRQSLLRYRKERQAELDQGA----LLMFP 65 
WP_053335784   1 ----------M---VRGatPVFRRAALEGYPDIFTAQTRKVLAAL-SGFEPRRRELMNLRMERRLKRHRLGgaesSPAFR 66 
WP_052761194   8 Ta-------ST---GQR--IRVNAPLAEGQERILTPEALRFVADLeQRFGQRRQQLLGLRADRQRRFNEGE----LPAFR 71 
WP_082169541   6 QqhpgdslaTT---PCR--PEFKAPIPEQARALFPTALLNLLGELgQRYGDRRAQLLAERQARQLEWNAGA----SPGFD 76 
WP_083965254   7 Gh-------PG---PSP---TITGAIKPGHERVLTPAALDLLQDLhRRFDGRRRALLDARDQRQARFDAGE----LPDFL 69 
WP_096296861  39 Ta-------PS---ADAprFTL---PADTATDLLDAPALAFLAELhQRFEPRRRALLTARGERQAAYDAGA----LPDFR 101
WP_106889669   8 Ps-------SI---QAA--LTI-QGEAAAVANVLDAATTELLVQLhRRFNARRLELLDARRVRQARFDAGE----LPDFL 70 
WP_127567570   5 Ai-------ST---PAG--VTIKGAMRPGYETILTGEALSLLADIhRRFDARRKALMAARAERQKRLDSGAe---TLGFR 69 
3CUZ_A        67 -SET---------ASIRDADWKIRGIPADLEDRRVEITGPVER---------KMVINALNANVKVFMADFEDSLAPDWNK 127
BAJ50995      62 -AET---------AEIRASGWKVSDIPADLSVRHVEITGPVDR---------KMMINALNSGADAYMADFEDSFSPVWSQ 122
WP_011643563  66 -HET---------VDIRSGEWKVRPAPADLQDRRVEITGPVDR---------KMVVNALNSGAKCFMADFEDATSPLWSN 126
WP_053335784  67 dPEEqigssglrvGDAREGNFAGSEIPHDLRRQWIQGTGPAARpredelqglRNVAYALLSGADGWMFDGEDALGQRGFM 146
WP_052761194  72 -PET---------AELRRTAWRVKQTPADLRGRRVEIVGPVDQ---------QSVMSAFQSGASCFVMDFEDSHAPTWNG 132
WP_082169541  77 -PDT---------RSIREGSWKVARIPEDLRDRRVEITGPVDR---------KMIINALNSGARVFMADFEDSSTPTWSN 137
WP_083965254  70 -PQT---------RALREADWTVAPIPAALADRRTEITGPVDR---------KMIINALNSGAKVFMADFEDSTAPTWDN 130
WP_096296861 102 -VAS---------RAIRETEWRVAPLPAALRDRRVEITGPVDP---------KMVINALNSGANCYMADFEDSTAPTWHN 162
WP_106889669  71 -PET---------RRIREGDWKVAPLPPKLLDRRIEITGPVDA---------KMIINALNSGANVFMADFEDSSSPTFAN 131
WP_127567570  70 -ADT---------AAIRAGEWTVPAAPADLADRRVEITGPVDR---------KMIINALNCGAKCFMADFEDASTPSWTN 130
3CUZ_A       128 VIDGQINLRDAVNGTISYTN-EA--------------G----KIYQLKp--NPAVLICRVRGLHLPEKHVTW-RG----- 180
BAJ50995     123 TLDGQINLMDAVRKTIEYRS-PD--------------G----KLYTLAd--KTATLLVRPRGLHLVEKNMRI-NG----- 175
WP_011643563 127 LIEGQINLRDANTREIDFTDpKN--------------N----KRYQVKd--DAAVLIVRPRGLHLDERHVHV-NG----- 180
WP_053335784 147 SLDNQRNLKLAIQRDPRFLEtAEqvslemnrwsrdffGrdiiQNWHTAm--NFTTRIFRVRGLHLADRHVGTqEG----- 219
WP_052761194 133 TLEGQLNLYDAVRGDFDRPDaGN--------------G----QDRGSDs--SRIALSMRPRGWHLSETHLQV-NG----- 186
WP_082169541 138 MIDGQVNLYDAVRRTIEFTA-DN--------------G----KHYALGp--NPATLIVRPRGWHLDEKHVEV-DG----- 190
WP_083965254 131 LIEGQANLADAVAGTISLVT-AE--------------G----KAYALKp--QTAVLMVRPRGWHLDEKHVQV-DG----- 183
WP_096296861 163 LLTGQRALRDAVAGTLEFNA-PG--------------G----KRYTLRpedQRAVLLVRPRGWHLDEKHVCIgDGpgags 223
WP_106889669 132 VIQGQANLQAAVRGELSFTS-PE--------------G----KHYALKa-sGLATLMVRPRGWHLSEKHVLV-DG----- 185
WP_127567570 131 MMEGQVNLRDAVHKKIDYTDpDS--------------G----KSYALNk--DHAVLIVRARGLHLDEAHIEI-DG----- 184
3CUZ_A       181 -EAIPGSLFDFALYFFHNYQALLAKGSGPYFYLPKTQSWQEAAWWSEVFSYAEDRFNLPRGTIKATLLIETLPAVFQMDE 259
BAJ50995     176 -SPVPAPLFDFGLYLFHNAAELRRRGTGPYFYIPKLEHYLEARWWANVFADAEKTLNLPRGTIKCSVLIETVTAAFQMDE 254
WP_011643563 181 -QAISGSLFDFGLYVFHNHAALKERGTAPYFYLPKLESRLEARLWSLVFQHAEDELGLERGTLRATVLIETLPAAFELDE 259
WP_053335784 220 -E-LSAGICDAVLYLVNNHRTLLRENRSLVLYLPKIQTAEEALLWNDILDALEDELELPRGTVKVYVLVEQLEAAFQLME 297
WP_052761194 187 -NPVSASLFDFGLFMFHNGLQLLEQGATPSFHLPKLESYIEAQLWSDLFAYTEESLGLNHGDICCTVAIETLPAAFEMDE 265
WP_082169541 191 -RPIPGGIFDAAVYVFNNANSLMAQGSGPYLYLPKLEHWREAELWESVLTDIEKALQLQPGTIKVTVLIETLPAVFQMDE 269
WP_083965254 184 -QAMSGSLFDFGLFAFHNAAALHARDRGPYFYLPKLQSHHEAALWEEVLAHTEHALGLPPGTMKVTVLIETLPAVFEMDE 262
WP_096296861 224 qAPMSAALFDAGLFAFHNAHALAAKDRGPYFYIPKLESADEARLWDDVLAYIERRLGLPGGQIRVTVLIETLPAVFEMDE 303
WP_106889669 186 -ERMSGGIFDLAVFAIHNAKRLASEDRGPYFYLPKMQSHLEAQLWDEVMSYIETRLVLPIGTMKATVLIETLPAVFEMDE 264
WP_127567570 185 -APMSGGFADFALYLLHNHAQLKKNGTGPYFYLPKLETMEEAQLWSLVIRHCESVLGLPAGTVRVTILIETITATFELDE 263
3CUZ_A       260 ILHALRDHIVGLNCGRWDYIFSYIKTLKNYPDRVLPDRQAVTMDKPFLNAYSRLL---IKTCHKRGAFAM--GGMAAFIP 334
BAJ50995     255 ILYELRDYVTALNLGRWDYIFSFIKRLGHDPRYLMPDRSHLTMDKHFLKSAALLM---VKTCHRRGAYAI--GGMAAQVP 329
WP_011643563 260 ILYELKDHIVGLNCGRWDYIFSYIKRLKSRPEHVLPDRSAVTMSSPFMAAYSRRV---VAVCHRRGAHAM--GGMSAFIP 334
WP_053335784 298 IRAVLGSHFVGFNTGRWDYINSVSDALAGNRDFLNPDIESVTMTYPYMAAYEDRVrraVNTSDRNGNFALwqGGMEPNIP 377
WP_052761194 266 MLYALRDYALGLDFGRRNYIFSFIKRFQADPARVLPEHKQITVDSGFVQACSRLL---LETCYQRGAHAT--CAIAAAMP 340
WP_082169541 270 ILYALRSRIVGLNCGRWDYIFSYIKCFQAHPDKVLPDRAQVTMTVPFLRAYSQLL---IRTCHHRGAFAM--GGMAAQIP 344
WP_083965254 263 ILHALKSRITGLNCGRWDYIFSYIKTFRAHRDRILPERGQVGMTVPFLKAYSELL---VRTCHRRGAFAM--GGMAAQIP 337
WP_096296861 304 ILHALKDRVAGLNCGRWDYIFSYIKTFRRHRDRVLPERAQVTMAQPFLKAYSELL---IQTCHRRGAHAM--GGMAAQIP 378
WP_106889669 265 ILHALKSRIAGLNCGRWDYVFSYIKTFRKHPNRCLPERGQVTMTTPFLKRYSELL---IQTCHRRGALAM--GGMAAQIP 339
WP_127567570 264 ILYVLRENITALNAGRWDYIFSYIKRQKTNPAAILPDRGQVTMTVPFMAAYAKRL---IAVCHRRGAHAM--GGMSAFIP 338
3CUZ_A       335 SK-DEEHNNQVLNKVKADKSLEANNGHDGTWIAHPGLADTAMAVFNDILgsRKNQLEvMREq-DAPITA---DQLLAPCD 409
BAJ50995     330 IRgNPEAQERAFAKVREDKLREISQGFDGAWVAHPDLVPLVKSLFAENLk-APNQLHvKHE--NLVITA---DDLLKVPE 403
WP_011643563 335 VKnDPAANAAATEKVREDKLREVKNGHDGTWVAHPDLVPVAMEVFNERMk-GPNQLDrPADphERPVTT---QQLLEAPA 410
WP_053335784 378 VG-NPQAVTRGMEKALAGARREQQAGASGKWVAHWKMVHVIRPVWQEAG--EDNQLGrQFP--PLSYDDasaEELLRLEE 452
WP_052761194 341 A----EADSDAVKRLEADLAQPLTEGYDAVRVTHPGLVSLANRQLER----CPSRADrRPT--ESAVSE---ADLLQPAQ 407
WP_082169541 345 IRdDAEANAQALDRVRADKEREAGDGHDGTWVAHPGLIGLAMEIFDRHIe-GRNQLDrLRE--DVEVGA---AELTAPCQ 418
WP_083965254 338 IAdDPEANEAAMARVRADKKREAGAGHDGTWVAHPGLLAVAVAEFDAAMp-GPNQLDvRRE--DVRVTR---DDLITAPA 411
WP_096296861 379 IAdDATANEIAMSRVRADKLREVTAGHDGTWVAHPALIPLARQVFDERMr-GPHQHAmTRD--DVLVDR---DDLIAPPI 452
WP_106889669 340 INhDPEANAAAMAKVRADKLREVTAGHDGTWVAHPGLIPIAREIFDAHMp-TANQLHvEKP--PVAAER---DVLIDPPT 413
WP_127567570 339 VKgDDAANEAAIAKVKADKTREASIGHDGAWVAHPALVPVAMEAFDAVMt-GPNQLSkIp---DVTEDA---AALLTAPE 411
3CUZ_A       410 GERTEEGMRANIRVAVQYIEAWISGNGCVPIY-----------GLMEDAATAEISRTSIWQWIHH------QK------- 465
BAJ50995     404 GERTAEGMRANMEVGLRYLESWLRGNGCVAIN-----------FLMEDAATFEIARALIWQWIRH------GA------- 459
WP_011643563 411 GDITDAGVNDNIDVAIRYIAAWLGGRGAVPIR-----------NLMEDAATAEIARAQLWQWRTF------GQ------- 466
WP_053335784 453 APRTLRGVRNLVSVAMQYGNAFAQGFQAAALKpgedfqdqsvlYLMEDAATGEIRMSILWEWIHK------NArfthdde 526
WP_052761194 408 GTITASGFGDNISLALHYLAGWLGGQGTVMIN-----------HCLEDAASAEIARAQIWQWIQHp-----RG------- 464
WP_082169541 419 GTITEAGLRGNLEVAIRYMAAWLSGQGCVPIH-----------NLMEDAATAEIARAQVWQWIRHp-----AG------- 475
WP_083965254 412 GTITRAGFQANVDVCVRYLAAWLDGLGCVPIH-----------HLMEDAATAEISRAQLWQWLHHs-----GL------- 468
WP_096296861 453 GTISRAGFDGNVEVCVRYIAAWLDGNGCVPIH-----------HMMEDAATAEIARAQLWQWIHYaddghaPL------- 514
WP_106889669 414 GTITRTGFLNNIDVCVRYIAAWLDGLGCVPIH-----------YLMEDAATAEISRAQLWQWLHVg-----GQ------- 470
WP_127567570 412 GTITHAGVLGNADVAIRYIASWLQGRGAAPIH-----------NLMEDAATAEISRAQLWQWRTH------GA------- 467
3CUZ_A       466 --TLSNGKPVTKALFRQMLGEEMKVIASELGEERFSQGR---FDDAARLMEQITTSDE----LIDFLTL--------PGY 528
BAJ50995     460 --RLADGRTVTPQVFEEELGKVLQKLRGEMGPA-YQGTK---FEQAAEILRKTVLSNE----FIEFTPP--------IAY 521
WP_011643563 467 --STKEGTALTGPMLENKIEDICSTIQDEVPDQTELCDR---IRAAADILTGLVLSED----FAEFLTL--------PAY 529
WP_053335784 527 qgGVKSGDLIDARLVNRIIQTEFERLQKADPRNVHEKSKhttLPVVRRIIRRYLESERkipwYIDLLNLclhvtepeAAE 606
WP_052761194 465 --ILEDGQEITIELFQQKLSQELERVRQEIGEPALTTDH---YSTAAELLGELVDTNH----FIEFLTL--------PAY 527
WP_082169541 476 --KLEDGRDIDEALVAGFQAETLASIREELGDAVFQAGA---YEQANQLLAEVTADDH----FVEFLTL--------PAY 538
WP_083965254 469 --SLEDSTPIDFALFQAVLTGTEDRLPK-A--GLPGQDR---VREAIAMLDALTRART----LADFLTV--------PAY 528
WP_096296861 515 --HLDDGTAIDAALLDRVLLGLPSKLA---GLDIPGAAR---VPEAIAMLEALTLRET----LEDFLTV--------PAY 574
WP_106889669 471 --TLDDGTALDFALFDAAIDTIDQRIDRS---GLPGEHR---IDEAAKLLKLWTHAPE----LIEFLTL--------PCY 530
WP_127567570 468 --KTAEGRVVDAAYVKEVIAGAAKAIRAEIGDNAWGEGR---FGEAEDILTSLALDEA----FEEFLTL--------PAY 530
3CUZ_A       529 RLLA 532
BAJ50995     522 EHLQ 525
WP_011643563 530 DRLT 533
WP_053335784 607 KRLD 610
WP_052761194 528 HKLA 531
WP_082169541 539 RMID 542
WP_083965254 529 ERLP 532
WP_096296861 575 ARLP 578
WP_106889669 531 ERLA 534
WP_127567570 531 EKIR 534
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