Conserved Protein Domain Family
thrA

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PRK09436: thrA 
bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional
Links
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Statistics
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PSSM-Id: 181856
Aligned: 205 rows
Threshold Bit Score: 1116.77
Created: 9-Dec-2010
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
300721715   1 MRVLKFGGTSVANHQRVLSVADIAENELSLgQVALVLSAPAKITNHLVAMIEKTVAGQDIVSNISDATQIFTdllSGLKK 80 
84623764   20 TVVHKFGGTSVADADRYRHVAQLLLARDET-VQVTVVSAMKGVTDALIELAELAAKDRPEWRDRWHETRARH---RGAAV 95 
188576576  20 TVVHKFGGTSVADADRYRHVAQLLLARDET-VQVTVVSAMKGVTDALIELAELAAKDRPEWRDRWHETRARH---RGAAV 95 
21242564   20 TVVHKFGGTSVADAERYRHVAQLLLARDET-VQVTVVSAMKGVTDALIELAELAAKNRPEWRERWHETRARH---RGAAV 95 
78047422   20 TVVHKFGGTSVADAERYRHVAQLLLARDET-VQVTVVSAMKGVTDALIELAELAAKNRPEWRERWHETRARH---RGAAV 95 
15838816   13 TVVHKFGGTSVADADCYRHVARLLLAREET-VQVTIVSAMKGVTDTLIALAEQAANHSPDWQALWQQTRTRH---CDAAQ 88 
28199159   13 TVVHKFGGTSVADADCYRHVTRLLLAREET-VQVTIVSAMKGVTDTLIALAEQAANHSPDWQVLWQQTRTRH---CDAAQ 88 
182681890  20 TVVHKFGGTSVADADCYRHVTRLLLAREET-VQVTIVSAMKGVTDTLIALAEQAANHSPDWQVLWQQTRTRH---CDAAQ 95 
194365526  20 TVVHKFGGTSVADAERYRHVAGLLLARPES-LQVAVVSAMKGVTDALIELAQMAAKGDEGWREAWHALRARH---RGAAV 95 
190574111  20 IVVHKFGGTSVADAERYRHVAGLLLARPES-LQVTVVSAMKGVTDALIELAQLAAKGDEGWREAWHALRARH---RGAAV 95 
300721715  81 HQAGFDYVRLKGIVEREFANLKQILHGISLLQQCPDSINAALICCGEKLSIAIMEAVLQARGHQVTVIDPVKNLLAHGHY 160
84623764   96 ALLGEHSGPTVEWLDERFEHLSQILGALAVIGELPREVLDRVQGLGEVYSAQLLGDHFRAIGEDCAVLDARDVLVVNRGE 175
188576576  96 ALLGEHSGPTVEWLDERFEHLSQILGALAVIGELPREVLDRVQGLGEVYSAQLLGDHFRAIGEDCAVLDARDVLVVNRGE 175
21242564   96 ALLGEHSGPTVEWLDERFAHLSQILGALAVIGELPREVLDRVQGLGEVYSAQLLGDHFRAIGEDCAVLDARDVLVVNRGE 175
78047422   96 ALLGEHSGPTVEWLDERFEHLSQILGALAVIGELPREVLDRVQGLGEVYSAQLLGDHFRAIGEDCAVLDARDVLVVNRGE 175
15838816   89 ALLGEHAGTLQNWLNTRFNELHEMLVALSVIRMLPSEVLDRLQGLGEVYSAQLLGQYLQAQGEDCVVLDARQVLVVSPGE 168
28199159   89 ALLGEHAATLQDWLNTRFNELHEMLVALSVIGMLPSEVLDRLQGLGEVYSAQLLGHYLQSQGEDCVVLDARQVLVVSPGE 168
182681890  96 ALLGEHAATLQDWLNTRFNELHEMLVALSVIGMLPSEVLDRLQGLGEVYSAQLLGHYLQSQGEDCVVLDARQVLVVSPGE 175
194365526  96 ALLGEQVGETVEWIDVRFDQLADVLAALAVIGELPREVLDRVQGLGEVFSAQLLGTHLRALGEDCAVLDARDVLVVAHGE 175
190574111  96 ALLGEQVGETVEWIDARFEQLAEVLAALAVIGELPREVLDRVQGLGEVFSAQLLGTHLRALGEDCAVLDARDVLVVGHGE 175
300721715 161 LESTVDIHESSKRIAERNIPA-DHIILMAGFTAGNENGELVVLGRNGSDYSAAVLAACLRADCCEIWTDVDGVYTCDPRA 239
84623764  176 LGVDVDWEVSAQQLATWRQAHpQTRVVVTGFVARDRADRITTLGRNGSDYSGAIFAALFDADELHIWTDVDGVLSADPRV 255
188576576 176 LGVDVDWEVSAQQLATWRQAHpQTRVVVTGFVARDRADRITTLGRNGSDYSGAIFAALFDADELHIWTDVDGVLSADPRV 255
21242564  176 LGVDVDWEASAQRLATWRQAHpQTRVVVTGFVARDRADRVTTLGRNGSDYSGAIFAALFDADELHIWTDVDGVLSADPRV 255
78047422  176 LGVDVDWEASAQRLATWRQAHpQTRVVVTGFVARDRADRITTLGRNGSDYSGAIFAALFDADELHIWTDVDGVLSADPRV 255
15838816  169 FGAEVDWATSAQHLAHWRMQHpQRRVVVTGFVASDRTGRAITLGRNGSDYSGAIFAALFEADELHIWTDVDGVMSADPRV 248
28199159  169 FGAEVDWATSAQHLAHWRMQHpQRRVVVTGFVASDRTGRAITLGRNGSDYSGAIFAALFEADELHIWTDVDGVMSADPRV 248
182681890 176 FGAEVDWATSAQHLAHWRMQHpQRRVVVTGFVASDRTGRAITLGRNGSDYSGAIFAALFEADELHIWTDVDGVMSADPRV 255
194365526 176 LGVDVDWEVSADRLARWRLQHpQSRLVATGFVARDRHDRITTLGRNGSDYSGAIFAALFNADQLHIWTDVDGVLSADPRL 255
190574111 176 LGVDVDWESSADRLAKWRLRHpQMRLVATGFVARDRHDRITTLGRNGSDYSGAILAALFNADELHIWTDVDGVLSADPRL 255
300721715 240 VADARLLKSMSYQEAMELSYFGAKVLHPRTIAPIAQFQIPCLIKNTANPDAPGTLIsnglmGHGQKD--NEMPIKGITNL 317
84623764  256 VPEAVQLETLSYDEACELAYFGAKVVHPQTMSPAIERGLPIIIRNTFQPEHPGTRI-----TASSAV---RGPIKGLTLS 327
188576576 256 VPEAVQLETLSYDEACELAYFGAKVVHPQTMSPAIERGLPIIIRNTFQPEHPGTRI-----TASSAV---RGPIKGLTLS 327
21242564  256 VPEAVQLETLSYDEACELAYFGAKVVHPQTMSPAIERGLPIIIRNTFQPEHPGTRI-----TASSAV---SGPIKGLTLS 327
78047422  256 VPEAVQLETLSYDEACELAYFGAKVVHPQTMSPAIERGLPIIIRNTFQPEHPGTRI--------TASsaVSGPIKGLTLS 327
15838816  249 VPDAVQLDALSYDEACELAYFGAKVVHPQTMSPVMKRGVPIIIRNTFQPGHPGTRI-----TADSVV---SGSVKGLTLS 320
28199159  249 VPDAVQLDALSYDEACELAYFGAKVVHPQTMSPVMKRGVPIIIRNTFQPGHPGTRI--------TADsvVSGSVKGLTLS 320
182681890 256 VPDAVQLDALSYDEACELAYFGAKVVHPQTMSPVMKRGVPIIIRNTFQPGHPGTRI--------TADsvVSGSVKGLTLS 327
194365526 256 VPEAVQLESLSYDEACELAYFGAKVVHPQTMSPAIRLGLPIFIRNTFQPAHPGTRI--------SAErsPRGPVKGLTLS 327
190574111 256 VPEAVQLESLSYDEACELAYFGAKVVHPQTMSPAIRLGLPIFIRNTFQPAHPGTRI-----SAERSP---RGPVKGLTLS 327
300721715 318 DHMAMINVSGPGMKGMVGMAARVFSVMSSKGISVVLITQSSSEYSISFCVPQKELAKAQKALTEEFYLELKDGVLDPIDV 397
84623764  328 PDLAVLNLEGTGLIGVPGTAERVFASLRTAQVSVVMISQGSSEHSICCVVKQHESERARNALLQAFAHELTVGQVQRVQL 407
188576576 328 PDLAVLNLEGTGLIGVPGTAERVFASLRTAQVSVVMISQGSSEHSICCVVKQHESERARNALLQAFAHELTVGQVQRVQL 407
21242564  328 PDLAVLNLEGTGLIGVPGTAERVFAALRTAQVSVVMISQGSSEHSICCVVKQHESERARNALLQAFAHELTVGQVQRVQL 407
78047422  328 PDLAVLNLEGTGLIGVPGTAERVFAALRTAQVSVVMISQGSSEHSICCVVKQHESERARNALLQAFAHELTVGQVQRVQL 407
15838816  321 PGLAVLNLEGTGLIGVPGTAERVFAALRNARLSVVMISQGSSEHSICCVVHQTEAERARDALLYAFAHELAIGHVQRVQL 400
28199159  321 PGLAVLNLEGTGLIGVPGTAERVFAALRNARLSVVMISQGSSEHSICCLVHQTEAERARDALLYAFAHELAIGHVQRVQL 400
182681890 328 PGLAVLNLEGTGLIGVPGTAERVFAALRNARLSVVMISQGSSEHSICCLVHQTEAERARDALLYAFAHELAIGHVQRVQL 407
194365526 328 PGLALLNLEGTGLIGVPGTAERVFAALRQAQVSVVMISQGSSEHSICCVVRAAEAARGREALLQAFAHELSVGHVQRVQV 407
190574111 328 PGLSLLNLEGTGLIGVPGTAERVFAALRQAQVSVVMISQGSSEHSICCVVRAAEAARGREALLHAFAHELSVGQVQRVQV 407
300721715 398 INNLAIISVVGDGMRTQRGISARFFSALTRANINIIAIAQGSSERSISAVIENSAATTAVRLCHQMLFNTAQIVEVFVVG 477
84623764  408 TTGISVLAAVGDGMAGQPGVAARLFESLGRAHVNILAIAQGSSERNISVAIDAAHATKALRAAHAGFWLSPQTFSVGVIG 487
188576576 408 TTGISVLAAVGDGMAGQPGVAARLFESLGRAHVNILAIAQGSSERNISVAIDAAHATKALRAAHAGFWLSPQTFSVGVIG 487
21242564  408 TTGISVLAAVGDGMAGQPGVAARLFESLGRAQVNILAIAQGSSERNISVAIDAAHATKALRAAHAGFWLSPQTFSVGVIG 487
78047422  408 TTGISVLAAVGDGMAGQPGVAARLFESLGRAQVNILAIAQGSSERNISVAIDAAHATKALRAAHAGFWLSPQTFSVGVIG 487
15838816  401 TNNISVLAAVGDGMAGHLGVAARLFESLRRAHVNILAIAQGSSERNISVAIDSQQATKALRAAHAAFWLSPQTFSIGVIG 480
28199159  401 TNNISVLAAVGDGMAGHLGVAARLFESLRRAHVNILAIAQGSSERNISVAIDSQQATKALRAAHAAFWLSPQTFSIGVIG 480
182681890 408 TNNISVLAAVGDGMAGHLGVAARLFESLRRAHVNILAIAQGSSERNISVAIDSQQATKALRAAHAAFWLSPQTFSIGVIG 487
194365526 408 SDGVSVLAAVGDGMAGQPGVAARLFEALGRAQVNILAIAQGSSERNISVAVDSADATRALRAAHAGFWLSPQTFAVGVIG 487
190574111 408 SEGVSVLAAVGDGMAGQPGVAARLFEALGRAQVNILAIAQGSSERNISVAVDSADATRALRAAHAGFWLSPQTFAVGVIG 487
300721715 478 VGGVGSALIEQIRRQQAWLKQK-HIELRVCGIANSRALLTDMQGICLDnWQQVLSEATEPFSLSRLIRLEKEYHLLNPVI 556
84623764  488 PGNVGAALLDQLRVAQPQLLGKaNLDLRLRAVVSRGRMLLDERGLVGD-WRDAFASAATPTDLERFTTHLLSAHLPHTVI 566
188576576 488 PGNVGAALLDQLRVAQPQLLGKaNLDLRLRAVVSRGRMLLDERGLVGD-WRDAFASAATPTDLERFTTHLLSAHLPHTVI 566
21242564  488 PGNVGAALLDQLRNAQPQLLGKaNLDLRLRAVVSRGRMLLDERGLVGD-WRDAFASSATPTDLERFTTHLLSAHLPHTVI 566
78047422  488 PGNVGAALLDQLRTAQPQLLGKaNLDLRLRAVVSRGRMLLDERGLVGD-WRDAFASAATPTDLERFTTHLLSAHLPHAVI 566
15838816  481 PGHVGEALLDQLCAAQQQLLSKaNLDLRLRAIVSRRRMLLDERGLGSD-WRHAFAAVPEAVDLDAFTAHLQAAHLPHAVI 559
28199159  481 PGHVGEALLDQLCAAQQQLLSKaNLDLRLRAIVSRRRMLLDERGLGSD-WRHAFAAAPEAVDLDAFTAHLQAAHLPHAVI 559
182681890 488 PGHVGEALLDQLCAAQQQLLSKaNLDLRLRAIVSRRRMLLDERGLGSD-WRHAFAAAPEAVDLDAFTAHLQAAHLPHAVI 566
194365526 488 PGNVGAALLDQLLSARPQLLAKaNVDLRLRALASRSRMRLEADGLHAD-WRQALQQAGEASDLDRFTEHLLAAHLPHAVV 566
190574111 488 PGNVGAALLDQLLAARLQLLAKaNVDLRLRALASRSRMRLEVDGLHAD-WREALQDAGEPSDLDRFTEHLLAAHLPHAVV 566
300721715 557 VDCTSNQAIAEQYASFLSDGFNVVTPNKKANTLSMGYYRQIRQAAEKSKRKFLYDTNVGAGLPVIENLQNLLNAGDELVQ 636
84623764  567 IDCSGSAEVADRYAGWLAAGIHVVTPNKQAGSGPLARYEAIRAAADASGARFRYEATVGAGLPVITTLRDLVDTGDTVTS 646
188576576 567 IDCSGSAEVADRYAGWLAAGIHVVTPNKQAGSGPLARYEAIRAAADASGARFRYEATVGAGLPVITTLRDLVDTGDTVTS 646
21242564  567 IDCSGSAEVADRYAGWLAAGIHVVTPNKQAGSGPLARYEAIRAAADASGARFRYEATVGAGLPVITTLRDLVDTGDAVTS 646
78047422  567 IDCSGSAEVADRYAGWLAAGIHVVTPNKQAGSGPLARYEAIRTAADASGARFRYEATVGAGLPVITTLRDLVDTGDAVTS 646
15838816  560 IDCSGSAEVADRYADWLAAGIHVVTPNKQAGSGPLHRYHAIRAAADASGARFRYEATVGAGLPVITTLRDLMDTGDSVTS 639
28199159  560 IDCSGSAEVADRYADWLAAGIHVVTPNKQAGSGPLHRYHAIRAAADASGARFRYEATVGAGLPVITTLRDLMDTGDSVTS 639
182681890 567 IDCSGSAEVADRYADWLAAGIHVVTPNKQAGSGPLHRYHAIRAAADASGARFRYEATVGAGLPVITTLRDLMDTGDSVTS 646
194365526 567 IDCSGSAEVAERYEGWLAAGIHVVTPNKQAGAGPLARYQRIRAAAAASGARFRYEATVGAGLPVITTLRDLVDTGDEVLA 646
190574111 567 IDCSGSADVAERYEGWLAAGIHVVTPNKQAGAGPLPRYQRIRAAAAASGARFRYEATVGAGLPVITTLRDLVDTGDEVLA 646
300721715 637 FSGILSGSLSYIFGMLDEGMTLSQATLLAKEKGFTEPDPRDDLSGMDVARKLLILAREAGYELELEDIHVEPVLPASFDA 716
84623764  647 IEGIFSGTLAWLFNKYDGSVPFAELVTQARSMGYTEPDPRDDLSGVDVARKLVILAREAGRAISLEDVQVESLVPAALRQ 726
188576576 647 IEGIFSGTLAWLFNKYDGSVPFAELVTQARSMGYTEPDPRDDLSGVDVARKLVILAREAGRAISLEDVQVESLVPAALRQ 726
21242564  647 IEGIFSGTLAWLFNKYEGSVPFAELVTQARGMGYTEPDPRDDLSGVDVARKLVILAREAGRSISLEDVQVESLVPEALRQ 726
78047422  647 IEGIFSGTLAWLFNKYDGSVPFAELVTQARGMGYTEPDPRDDLSGVDVARKLVILAREAGRSISLEDVQVESLVPEGLRQ 726
15838816  640 IEGIFSGTLAWLFNKYDGSVPFSQLITQARAMGYTEPDPRDDLSGVDVARKLVILARDAGRDISLEDVAVESLVPETLCQ 719
28199159  640 IEGIFSGTLAWLFNKYDGSVPFSQLIAQARAMGYTEPDPRDDLSGVDVARKLVILARDAGRDISLEDVAVESLVPETLCQ 719
182681890 647 IEGIFSGTLAWLFNKYDGSVPFSQLIAQARAMGYTEPDPRDDLSGVDVARKLVILARDAGRDISLEDVAVESLVPETLCQ 726
194365526 647 IEGIFSGTLAWLFNRYDGSQPFSALVAQARSMGYTEPDPRDDLSGIDVARKLVILAREAGHPLSLEQVEVESLVPALLRE 726
190574111 647 IEGIFSGTLAWLFNRFDGSQPFSQLVAQARSMGYTEPDPRDDLSGVDVARKLVILAREAGHALSLEQVQVESLVPALLRD 726
300721715 717 NGDVDNFLQRLPQLDQEFSQRAADAAEQGKVLRYVGLI-EQGCCTVRMVAVDGNDPLYKVKNGENALAFYTRYYQPIPLV 795
84623764  727 S-SVEDFMARLPEVDAAFAQRLANARVRGNVLRYVAQLpPDRAPSVGLVELPADHAFANLRLTDNVVQFTTRRYCQNPLV 805
188576576 727 S-SVEDFMARLPEVDAAFAQRLANARVRGNVLRYVAQLpPDRAPSVGLVELPADHAFANLRLTDNVVQFTTRRYCQNPLV 805
21242564  727 A-SVDDFMARLPEVDASFAQRLAQAHARGNVLRYVAQLpPDRAPSVGLVELPADHAFANLRLTDNVVQFTTRRYCENPLV 805
78047422  727 A-SVDDFMARLSEVDAVFAQRLRDARARGNVLRYVAQLpPDRAPSVGLVELPADHAFANLRLTDNVVQFTTRRYCENPLV 805
15838816  720 L-SVADFMARLNEVDATFAERLAAAKQRGCVLRYVAQLsPGHVPSVSLIELPSDHAFVNLRLTDNVVQFTTRRYSENPLV 798
28199159  720 L-SVADFMERLNEIDATFAERLAAAKQRGCVLRYVAQLsPGHVPSVSLIELPSDHAFVNLRLTDNVVQFTTRRYSENPLI 798
182681890 727 L-SVADFMERLNEIDATFAERLAAAKQRGCVLRYVAQLsPGHVPSVSLIELPSDHAFVNLRLTDNVVQFTTRRYSENPLI 805
194365526 727 GG-VDDFMARLGESDASLLQRLQDARQRGAVLRYVARLgADGA-SVGLQELPIEHAFANLRLTDNVVQFRTRRYCDNPLV 804
190574111 727 G-SVDDFMARLGESDASLLQRLQDARARGAVLRYVAQLgADGA-SVGLQELPADHAFANLRLTDNVVQFRTRRYCDNPLV 804
300721715 796 LRGYGAGNDVTAAGVFADILRTLSWKLGV 824
84623764  806 VQGPGAGPEVTAAGVFADLLRVAAGEGAR 834
188576576 806 VQGPGAGPEVTAAGVFADLLRVAAGEGAR 834
21242564  806 VQGPGAGPEVTAAGVFADLLRVAAGEGAR 834
78047422  806 VQGPGAGPEVTAAGVFADLLRVAAGEGAR 834
15838816  799 VQGPGAGPEVTAAGVFADLLRVAAGEGAR 827
28199159  799 VQGPGAGPEVTAAGVFADLLRVAAGEGAR 827
182681890 806 VQGPGAGPEVTAAGVFADLLRVAAGEGAR 834
194365526 805 VQGPGAGPEVTAAGVFADLLRVAAGEGAR 833
190574111 805 VQGPGAGPEVTAAGVFADLLRVAAGEGAR 833
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