Conserved Protein Domain Family
PDDEXK_nuclease
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cd22346: PDDEXK_nuclease 
uncharacterized PDDEXK nuclease may function as a restriction endonuclease
This family belongs to a superfamily of PDDEXK nucleases including very short patch repair (Vsr) endonucleases, archaeal Holliday junction resolvases, MutH methyl-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and FokI.
Links
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Statistics
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PSSM-Id: 411750
Aligned: 46 rows
Threshold Bit Score: 292.911
Created: 2-Jul-2020
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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Conserved Features/SitesClick to see Conserved Features Help
 
putative active
Feature 1: putative active site [active site], 3 residue positions
Conserved feature residue pattern:[D] [EDQNH] [KH]Click to see conserved feature residue pattern help
Evidence:
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
EFU69778       7 ILKNAKLWFKESIAKQHIKNt----kKLSNIDNFQINPFLITYLsnfLEGNHEPISIAKALILPKVLGTSINTSFGTQIQ 82  Arcobacter butz...
KFI44767      11 VLQKASAFFRNEVIKKHVKNtkklsnEKRFEHNFEFNPFTLAYIakfSFGDTSPESLAKALVYPRVMGTSIATSFGSAIQ 90  Bifidobacterium...
WP_117892749   9 ILANAKKFFKERIIDKHIVNt----kKCEDLSNFNVNPFLHKYLaqyAFGDSSPQSMAKALIYPRILGTSINTSFGTNMQ 84  Ruminococcus sp...
TVQ41969       6 LIKEIVDYFEENIFNNHVENsl---kKNSKLKTYNINPIVVKYLskvLEGAYTPEGVAKALYYPRVLGTSINTSFGTRIQ 82  Saprospirales b...
WP_114983426   7 LIEKVVDFVEQSIFQPHIKAsl---eKHTKLRSYKINPIIVKYLskvLEDEYTPIGVAKALYFPRVLGTSINTSFGTQVQ 83  Candidatus Cycl...
KAB8290967    11 ILNSAISFFQQRIIANHIKNv----qKCARLDTFNINPFITAYLakfAFSDVNAETLAKALIYPRVLGTSITTSFGNQLQ 86  Bifidobacterium...
WP_119526981  10 ILMQISQFFEKQIIENHVKNt----eKLVDIRALRFNPFLVSYLarfAFGNAQPESVAKVILYPRVLGTSITTSFGTSIQ 85  Bifidobacteriac...
WP_119195019   4 RVRAVAEKCFEDIMEGQVKKi-----KSWKMKNFKINPFTIKMLsqiGFGGCDPRSMARALVYPRILGTSLATSFGTRTQ 78  Butyricicoccus ...
RNC84733       6 LIDEIVQYFDENIAQVHQENli---nKHAKLSSYQINPILVKYLsqlIESGITEEGIAKALFYPRALGTSITGSFGSKFQ 82  Balneola sp.
WP_094517161   9 ILANAYDFFLKLFNDKSKAY------KKRNVKNFKVNPFTVHAAakaVSDDVNAESIAKAIVYPFALGTSMATSFGTKAQ 82  Lactobacillus t...

Feature 1                           #              # #                                           
EFU69778      83 KFTSNVLs--sFASTTSGIDIEFIDqIDGEKKYCQLKSGPNTINKDDVETIAGHFKNIINLGKTnn--lKLGFHNLIVGV 158 Arcobacter butz...
KFI44767      91 RFSSKVLs--aYASTTAGMDIEYKDsQNQRHIYCQLKAGPQTINKDDVKTICDHFSAVGRLKRTngstdFNPSTDCVVGV 168 Bifidobacterium...
WP_117892749  85 YFCNEVLs--sYASTTSGIDIEFVDcIDGRKKYAQIKSGPNCINKDDIKTITGHFKSIHNLARAnk--lQLNTTDCIVCV 160 Ruminococcus sp...
TVQ41969      83 NMFVELNl--aSGSLIKGMDIEFVDkIDDRKKWCQLKSGPNTINSEDVKPLIQKFTKTITLARTnnafkGISNTDFIVGV 160 Saprospirales b...
WP_114983426  84 NMFVELGi--aQGSMIKGMDIEFIDrHDNRKKWCQLKAGPNTINSEDVKPILSKFEGTIRLAKTnnamrGIRNSDFIVGV 161 Candidatus Cycl...
KAB8290967    87 KFSTEVLs--aYASTTAGMDIEYVDsRTNRHVYCQLKAGPQTINKDDVETICNHFKGIRNLLRVngsndFNPSTDCIVGI 164 Bifidobacterium...
WP_119526981  86 KLSSEILs--gFASTTSGIDIEYEDyETGRHIYCQLKSGPETINKDDVKTICDHFKDLGRLAKTngstqVNPLTDCIVGV 163 Bifidobacteriac...
WP_119195019  79 FFCVEAGf--aKASGVAGMDIEFTDkINGRDIYAQLKAGPTTINKDDVKPMCDKFDDARRLFKTng--vKYDEDNFIVGV 154 Butyricicoccus ...
RNC84733      83 KMLVDLGl--vKGSLIPGMDIEYQDkLDGRDKYCQLKSGPNTINSKDVDPMLSEFDKVANLARAns-skDFSNNDLVVGI 159 Balneola sp.
WP_094517161  83 EFIVTALgdqiSGSVVAGMDIEYDDaIDGRHKYCQIKSGPTTINHDDIKTIEDHFQSLVSLGRTnh--lNIGIDDRVVGV 160 Lactobacillus t...

Feature 1                                                                                  
EFU69778     159 IYGEKEELSSHYKRIskdynYEVIVGEDFWHRLTGDKDFYSDLIKSia---evAVEANFKNELNEIIIELSKSD 229 Arcobacter butzleri JV22
KFI44767     169 LYGTPKQLSANYKRIkd-enYRVLIGKEFWTSLTGDDDFYEDLITAmvnsdstGITGVIGSTLDQVTQFLAQNP 241 Bifidobacterium bohem...
WP_117892749 161 IYGKKDELNDHYKKIne--yYPVYVGQDFWFRLTGDKEFYNDIINAfv---eaGNDADSTKLINEVIDKLARKI 229 Ruminococcus sp. AF19-15
TVQ41969     161 LYGEPSELSMHYKTIdk--tHPVIIGKEFWHRVTGFPNFYNKLVKElh---ksINNVDTKNLINKGCDDLAKEI 229 Saprospirales bacterium
WP_114983426 162 LYGTSNELSQHYRKInd--vYPVYIGNEFWSRITGYENIYSKLEDEmq---amIESLNTHDFINQGCNTLAEEI 230 Candidatus Cyclonatro...
KAB8290967   165 FYGNRASLSTNYKNIek-egYTVLIGDEFWTSLTGDPTFYEELIGAmv----nGGADASNEVLQQTIRELSNDI 233 Bifidobacterium apri
WP_119526981 164 LYGSREDLSANYKRIen-egYTVKIGEEFWESFTGDKQFYQDLVNTit----kVKSEKIYGVLDKTIVKLADSI 232 Bifidobacteriaceae ba...
WP_119195019 155 LYGKHDDLSANYKKIek-kgWQVIVGKKFWTHLTGDEHFYQDLIGVag---dvAERFDASKHVEELIERIAKEL 224 Butyricicoccus sp. OF...
RNC84733     160 MYGDKDQLSAHYLRIde--rYPVIIGQEFWERITGYPSFYGELISSid---dlIDSMPFSDSFQSAYHKLVSEI 228 Balneola sp.
WP_094517161 161 LYGTQDDLSQMYKKLld-dgIVVLTGADFWYHLTGYKDIYSKLVQTae---kaAEKSSIKDNVDILTNKVKDKI 230 Lactobacillus taiwane...

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