Conserved Protein Domain Family
GT29_ST8SIA1
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cd23989: GT29_ST8SIA1 
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1
Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).
Links
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Statistics
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PSSM-Id: 467717
Aligned: 6 rows
Threshold Bit Score: 495.505
Created: 28-Nov-2018
Updated: 27-Apr-2023
Structure
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Aligned Rows:
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putative active
Feature 1:putative active site [active site]
Evidence:
  • Comment:based on homology to other members of the family
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                             ###        
Q92185        73 TAARAFRKQMEDCCDPAHLFamtkmnspMGKSMWYDGEflySFTIDNstySLFPQATPFqlplKKCAVVGNGGILkkSGC 152 Homo sapiens
NP_001279115  72 TATTAFRRLLENCCETKRMFavtqhnspMGKNLWFDGEflhSLSVNNemfAMFPQDTPFqiplKKCSVVGNGGILkrSAC 151 elephant shark
NP_001314770  54 TAVELYRKLLTDCCNPKRMFavtkenspLGKVLWYDGEfyhYHTVTNetyPIFVQDTPLqlplKRCSVVGNGGVLkhSGC 133 zebrafish
Q6ZXA0        75 SSGDSFRKLLQDCCDPPRLFsmtkantaLGENLWYDGEffqSLTIDNttrSLFPQDTPIklplKRCSVVGNGGILknSRC 154 African clawed ...
NP_990339     59 TAVAVFRKLLEDCCDPGQLFamtkqnspMGKNLWFDGEflySFTIDNttySLFPQATPLqlplKKCSVVGNGGILkkSGC 138 chicken
XP_031420624  61 TNSEALRRNLKECCDAERLFavtqhnapLGSVLQFDLDsstSHTVDAhtySLFVKEPPLprrlSSCAVVGNGGILknSGC 140 Atlantic herring

Feature 1                    ##                     #                                            
Q92185       153 GRQIDEaNFVMRCNlPPLSSeytkDVGsKSQLVTANPSIIrqrfqnllwSRKTFVDNMKiynhSYIYMPAFsmkTGTEPS 232 Homo sapiens
NP_001279115 152 GDKIDKaDFVMRCNlPPLSNeyarDVGhRTQLVTANPSIIkkryqnlmwSRKAFVESMKvygrSYIYMPGFsmkAGTEPS 231 elephant shark
NP_001314770 134 GNEIDRaDFIMRCNlPPLSKdytdDVGtKTHLVSANPSIIeksfqnllwSRKSFVESMKaygsSYIYIPAFsmkPGTDPS 213 zebrafish
Q6ZXA0       155 GEQIDEaDFVMRCNlPPLSReytdDVGtKTQLVTVNPSIIdkrfqnllwSRKSFVESVSvykqSYVYMPAFstkRGTDPS 234 African clawed ...
NP_990339    139 GKQIDQaDFVMRCNlPPLSReyskDVGlKTQLVTANPSIIqkrfqnllwSRKAFVDSVKvynhSYIYMPAFsmkTGTGPS 218 chicken
XP_031420624 141 GQEIDRaQFIIRCNlPPLTT----DSGkRTHIVTANPSIIdkrf--kdlKGSKLLECLSvydrSFIYMPAFsssIGIKPS 214 Atlantic herring

Feature 1                                                 ###                 ##            ###  
Q92185       233 LRVYYTLSdvganQTVLFAnpNFLRSIGKFWksrgihakrlSTGLFLVSAALGlCEEVAIYGFWPFsvnmheqpISHHYY 312 Homo sapiens
NP_001279115 232 FRTYYTLSdvnanQTIIFAnpDFLRNVQKFWkgkgvhakrlSTGLFLVSVALGlCEEVTLYGFWPFstdleertISHHYY 311 elephant shark
NP_001314770 214 LRAYHALAdsssnQTVLFAnpDFLKNVGIFWknhgvhgkrlSTGLFLVSLALGlCEEVTAYGFWPFsvglderpVSHHYY 293 zebrafish
Q6ZXA0       235 LRVYYTLEdfgtnQTVLFAnpNFLRNVGKFWkskgvhskrlSTGLFMVSAALSlCEEVTIYGFWPFqmdlggrhISHHYY 314 African clawed ...
NP_990339    219 LRVYYTLKdfgakQAVLFAnpNFLRDIGKFWknkgihakrlSTGLFLVSAALGlCEEVTIYGFWPFsvdlhgkfISHHYY 298 chicken
XP_031420624 215 FWAAQTVAdasanQTVLFAhpEFLRRVSAFWaardvsaqrlSTGLFMVTLALSlCDQVDVYGFWPFshgpdnktLSHHYY 294 Atlantic herring

Feature 1                 #                      
Q92185       313 DNVlpfsgfHAMPEEFLQLWYLHkiGALRMQL 344 Homo sapiens
NP_001279115 312 DNVmpdtsyHAMPEEFLQLWLLHksGILKIHV 343 elephant shark
NP_001314770 294 DNIlpssrfHAMPEEFLQLWHLHksGTLRMRV 325 zebrafish
Q6ZXA0       315 DNMlplsgvHAMPEEFLQLWHLHksGVLQMQL 346 African clawed frog
NP_990339    299 DNVlpdsgfHAMPEEFLQLWFLHksGVLRMQL 330 chicken
XP_031420624 295 DNEppn-syHAMPQEFKQLTQLHdsGVIRLQL 325 Atlantic herring

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