Conserved Protein Domain Family
Condensin2nSMC
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pfam12422: Condensin2nSMC 
Condensin II non structural maintenance of chromosomes subunit
This domain family is found in eukaryotes, and is approximately 150 amino acids in length. This family is part of a non-SMC subunit of condensin II which is involved in maintenance of the structural integrity of chromosomes. Condensin II is made up of SMC (structural maintenance of chromosomes) and non-SMC subunits. The non-SMC subunits bind to the catalytic ends of the SMC subunit dimer. The condensin holocomplex is able to introduce superhelical tension into DNA in an ATP hydrolysis- dependent manner, resulting in the formation of positive supercoils in the presence of topoisomerase I and of positive knots in the presence of topoisomerase II.
Links
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Statistics
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PSSM-Id: 463573
Aligned: 40 rows
Threshold Bit Score: 147.705
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_002431793   74 KVVESTAFVESEHGQKFIAWSLL-LSSKLMLDIHKTIMLEL--SLCNKKKAGWYGKIYVIAWHNAVDd----VKSAL--- 143 
Q20818         58 CIFFAPALLICPEGIKLSAEILPkIG---VGNGLILLEKLIlkFNLTDTECQRYGEVFVTAWRNAYQeanfdLTEEL--- 131  Caenorhabditi...
EFP05554       66 MMFFSPALTICPEGVKLVAEVFVkIG---ISNGLTLLEKNItkFDITDAECQRYGEVFKTAWLDAYQdasfdLTEEI--- 139 
CAP39597       58 MMFFSTALTACPEGVKLVAAILFkIG---VANGMTLVEKNMtkYDMTDAECQRYGQVFTTAWLDAFQegefdLAEEM--- 131 
EGT38869       58 MMYCSPALMACKEGIKLLALILDkIG---VRNGLTLLEKQIlkSDLTDTDCQRYGDVFATTWLNAHSdanfdLTEEL--- 131 
Q5CVQ5         42 SCLYSSTIVKNVEGQNFISRVISkLSIDIHNELVNIIKSFV--PKLSSSLLICYGNILFILWLDYSNq---sNEERMqnl 116  Cryptosporidi...
XP_002139716   56 NCLNSITIIKNSDGQDLISYMIVqLGSKMIDKLFACIDEIL--PKSNNSVISGLSNILYSIWKNSNMn---sTKEYT--- 127 
EAY14929       58 DTIHCPNYYKTEKAKKFVASIVH-VVFFKLPEICERFKSIL--RNEKTEQAEQFGELCVTVWSKCDVt----ERSTF--- 127 
XP_016659232   88 KC---PLFLETETGKLAIADIFT-CSQQLFLKFHQTVRQNI--PKANRSEAEAYGEIYFMAWINSNSt----IREVI--- 154 
2_pfamImport    1 ECVTSLTYLNTREGRLHIASVLS-KDVTLVKPIQEIIRQYL--PELTKNQAAYYGEVYFNAWNMAKPn----VQKEI--- 70  

XP_002431793  144 EKSCLQHLMEAFFKEHrtslelSKCGKNILTVLDVLHSErkKKNPEFVTMITEAYQPILWKYLQSGFNMHRCNAADIFYK 223 
Q20818        132 ETDVISVMCQHALYAH------RPTCTKFQNVIAAFAHAk-KLDKSVDEMVTRLLNGCLYRALDAPNYIVQSSAAEVFFN 204  Caenorhabditi...
EFP05554      140 ETDVIRIICQYALYGQ------KPFAAKFRKVLSAFVSGk-KKDVNFAEMITRILNGCLYRAMDATNYIVSSSAVELFFM 212 
CAP39597      132 ENDIIRVICQNALYAQ------KPLGSKFRKMLVPFATSk-KQEVSVDEMISRILEGCLWRALESSNYIVQSAASEVFFM 204 
EGT38869      132 ETDVYHVFFQHALFGQ------KPLCAKFQKVLSAFAAQr-KENPDFAIMISGMLNGCIYRALDSKNSAVQTSGMEVFFM 204 
Q5CVQ5        117 EEAIQRTFCIGSIKLN------PLIALRMRLILHGFHSN--RDDFRVNKLLLRLYDPLIWRYISVANWKVRLNTTALLAI 188  Cryptosporidi...
XP_002139716  128 EELIQKKLCNGCIRLN------PFMASKIRLLLSSFHEN--RYESDVNDLLVRLYDPILWRYLSVANWKVRLNSTALFAI 199 
EAY14929      128 QVQLLKPIAECAILAEt-----PQFSKNCRAFLEKFGVKr-SRRKELWTALTHIYEPIVFRYLHAANPLVRDNSLSLFTS 201 
XP_016659232  155 EEQMF-DFISKTLTLRrtg-lafYAYRNALILLQSMQNH--RKHLMFSKVITKLYAPVIWRQLTSEFSVVRCNATDILAR 230 
2_pfamImport   71 EECCIQDLMERVFTLNrhglemGKIGVRVLMILSSLHSS--RRLHKFSDKITELYAPLIWRYLRSDHPLVRCNAAQVFLD 148 

XP_002431793  224 -AFPLQR 229 
Q20818        205 -FYPLIG 210  Caenorhabditis elegans
EFP05554      213 -FFPLIS 218 
CAP39597      205 -FFPLTG 210 
EGT38869      205 -FFPFVE 210 
Q5CVQ5        189 -LFPLID 194  Cryptosporidium parvum
XP_002139716  200 -LFPLID 205 
EAY14929      202 cAFPIES 208 
XP_016659232  231 -AYPLEK 236 
2_pfamImport  149 -VFPLEK 154
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