2CC3,4NHF


Conserved Protein Domain Family
VirB8_like
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cd16384: VirB8_like 
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virulence protein VirB8
This family contains bacterial virulence protein VirB8 and similar proteins which consist of cytoplasmic, transmembrane, and periplasmic regions. VirB8 is an essential assembly factor of type IV secretion system (T4SS) channel proteins that are highly diverse in function relative to other bacterial secretion systems. T4SS proteins are important virulence factors for many Gram-negative pathogens, such as Agrobacterium, Brucella, Legionella, and Helicobacter. This family also includes the conjugal transfer protein family TrbF, a family of proteins known to be involved in conjugal transfer. The TrbF protein is thought to compose part of the pilus required for transfer. This domain has a similar fold to the nuclear transport factor-2 (NTF2) protein.
Links
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Statistics
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PSSM-Id: 319760
Aligned: 3 rows
Threshold Bit Score: 186.768
Created: 29-Mar-2013
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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dimerization
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1: dimerization motif [polypeptide binding site], 4 residue positions
Conserved feature residue pattern:N P X GClick to see conserved feature residue pattern help
Evidence:
  • Comment:NPXG motif of each monomer in the dimer is important for dimerization
  • Structure:2CC3: Agrobacterium tumefaciens VirB8 structure protein-protein interaction sites; contacts 4.0A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                     
2CC3_A      8 EAVVNASLWEYVRLRE-SYDa----dTAQYAYDLVSNfs-aPMVRQNYQQffnypnptspqvilgkhgRLEVEHiASNDv 81  Agrobacterium tume...
4NHF_A     42 EVVDRYWLNQYVLNRE-NYDy----dTIQLNYDTTALls-aASVQQEYYKiydgenar--dkvlsnkaRITVKVrSIQLn 113 Bartonella grahami...
ADZ27982  118 RVVHASVAAFINDLRMvTPDialqrrAIFRAYAMLSNndpaTAKANEWFNsseassp----fkraetqTVNVEIiSVIPq 193 Nitrosomonas sp. A...

Feature 1                                                      ####          
2CC3_A     82 tpgvQQIRYKRTLivdg--kmpMASTWTATVRYEkvtslp---grlrltNPGGLVVTSYQTSE 139 Agrobacterium tumefaciens
4NHF_A    114 glgqATVRFTTQQldssgattgPKQHQIATIGYTyvgapmk--ssdrllNPLGFQITSYRSDP 174 Bartonella grahamii as4aup
ADZ27982  194 spetWQVDWLEKVydrqghltePPFKMRALLRVYnkpttqstteeqirnNPLGIYIQDFSWSK 256 Nitrosomonas sp. AL212

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