Conserved Protein Domain Family
CmcI

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pfam04989: CmcI 
Cephalosporin hydroxylase
Members of this family are about 220 amino acids long. The CmcI protein is presumed to represent the cephalosporin-7--hydroxylase. However this has not been experimentally verified.
Statistics
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PSSM-Id: 428241
Aligned: 11 rows
Threshold Bit Score: 288.143
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_011941634  35 CQYSYNFHWLGRPIIQYPTDVIAMQELIWEVKPDLIVECGIAHGGSLIFSASMLALLdmceaieageplepaVSRRKVLG 114 Acidiphilium cr...
1_pfamImport   1 KKYSYHFRWAGRPIIQYPQDIVAMQEIIFDVKPDLIIETGIAHGGSIIFSAAMLAQLdlfeaiesgstidprHSKRKVIG 80 
P72897        38 NGYTYNYSWLGRPIIQYPQDIMAMQELIWSIQPDLIIETGIAHGGSLIFSASMLELNais----------ggPQDAEVLG 107 Synechocystis s...
WP_012175381  39 PGYSYNFDWLGRPIIQYPQDMAAMQELIWKVKPDLILETGIAHGGSLIFSASMLALLeycdaaekgelldpgNPIRRVLG 118 Desulfosudis ol...
WP_011812102  38 RRYVYNFDWLGRPIIQYPQDMVALQALVWRLRPDLIIETGIAHGGSLVLSASLLALLdlsdaieagdmldprASRRKVLG 117 Verminephrobact...
Q31S83        40 tKYAYHFSWINRPIVQLPQDIVAFQEIVSSVQPDIIIETGVAHGGSLALSASLLCLLdvmeg------lnprQSSRKVIG 113 Synechococcus e...
WP_012112281  42 QKYSYSFSWLGVPIIQLPEDMIRFQEAIFELKPDVIIETGVAHGGSAIFSASLCHLL----------------GHGRVVA 105 Parvibaculum la...
2_pfamImport   1 --WLYDTHWLGVPILKLPSDLFLYQEMIYELKPDLIIECGTCYGGSALYLASILDLI----------------GKGHVLT 62 
Q5P6Q3        26 NGVWETVRFLGVPCLKSVMDLWNYQEILFELKPSLIVEFGTRHGGSALYFSMIGQGI---------------NPLLRVLT 90  Aromatoleum aro...
Q9CD89        33 NFVWNTTTWMGIKCLKSVSDMWNYQEILIELEPSLVIEFGSRFGGSALFFANVMMHI---------------GQPFKVLS 97  Mycobacterium l...
P9WIM5        48 nlVWTKTTYMGINCWKSVSDMWNYQEILSELQPSLVIEFGTRYGGSAVYFANIMRQI---------------GQPFKVLT 112 Mycobacterium t...
WP_011941634 115 IDIDIRAHNRTAIDAHPMRSRIEMIEGSSISADVIAEVGRIASA-HRNVLVCLDSNHTHDHVYAELEAYASLVSVGSYCV 193 Acidiphilium cr...
1_pfamImport  81 IDIDIREHNRVQIESHPLSSRIQMLQGSSVDAEVIKKVYEIAAG-YEKVLLCLDSNHTHDHVLAELEAYAGLVSVGSYCV 159
P72897       108 IDIDIRQHNREAIEAHPMVKRISMIQGSSIAPEIIEQVKAKAEG-KQKILVCLDSNHTHDHVLAELEAYAPLTSVGSYCV 186 Synechocystis s...
WP_012175381 119 IDIDIREHNRAAIEAHPMAGRIQMIQGSSVDAEVIQKVHAVAKE-FSRILVCLDSMHTHDHVLAELEAYAPLVSPGSYCM 197 Desulfosudis ol...
WP_011812102 118 VDIDIRAHNRAAIEAHPMASRIAMIEGSSLAPEVVQQVRAFAQG-YRRVLLCLDSMHTHEHVLGELNAYAPLVTPGSYCV 196 Verminephrobact...
Q31S83       114 VDIEIRPHNRKALDEHPLRFKMELIEGSSIDPKIIQQVKSHVQS-SERVLVSLDSNHTHEHVMAELNAYASLVTAGSYCI 192 Synechococcus e...
WP_012112281 106 VDIEIRPKNRQRIEAHPFAHLITLIEGSSTAPEIVEQVRSHIKP-GDKVVVVLDSDHSYKHVTDELAAYAPMVSEGSWII 184 Parvibaculum la...
2_pfamImport  63 IDI-FPQPNR------PSHDRITYLTASSVSVTAVQTILSMRKP-DDVILVILDSDHSKEHVAKELLLYKSIVTKGSYII 134
Q5P6Q3        91 VDIEDHLLDPQVSRV----PAIEFMKCSSTDSAVAARITELRNSlPGPMFAILDSDHHQPHVLQEMLSLRSVMRSGDYLV 166 Aromatoleum aro...
Q9CD89        98 VDISHKDLDPAARQ-----PDILFIESPSTAPAIAEQIRRLKNEyPGKIFAILDSDHSMKQVLAEMKLLQPLLTAGDYLV 172 Mycobacterium l...
P9WIM5       113 VDNSHKALDPRARRE----PDVLFVESSSTDPAIAEQIQRLKNEyPGKIFAILDSDHSMNHVLAEMKLLRPLLSAGDYLV 188 Mycobacterium t...
WP_011941634 194 VFDTLIEDMEPDAYPDRPWGVGNNPKTAVHAYLKNHPE-FQIDK---LIPDKLM---ITVAHDGWLRRT 255 Acidiphilium cryptum
1_pfamImport 160 VFDTIVEDLPESLSSDRPWGPGNNPKTAVHSFLAKDTR-FVVDE---FIENKLM---ITVAPDGYLKRI 221
P72897       187 VFDTVVEDLPDEMFGDRPWGVGNNPKTAVWEYLKTHPE-FEIDK---SIQHKLL---ITVAPDGYLKRL 248 Synechocystis sp. PCC 6803
WP_012175381 198 VFDTIVEDLPEDFFSNRPWAKGNNPKTAVHEFLKTHRE-FEIDK---EIEHKLL---ITVAPDGYLKRV 259 Desulfosudis oleivorans
WP_011812102 197 VFDTFIEDLPPRFFPDRPWDRGNNPKTAVRQWLAGQTD-FEIDA---EMEQRLQ---LTAAPQGFLRRM 258 Verminephrobacter eiseniae
Q31S83       193 VFDTVIEDLPAGSFPDRAWDVGNNPKTAVHEWLKSHPE-FAIDK---DIDNKLL---ISVAPDGYLKRI 254 Synechococcus elongatus PC...
WP_012112281 185 ATDGVMQDLPDVPRGQPGWDK-DNPAAAARDFVAANPG-FVLETpawPFNESTLsdnITHWPDAWVRRA 251 Parvibaculum lavamentivorans
2_pfamImport 135 VEDTSINGNPVS----PDWGPG--PMEAVEEFLATNNN-FIIDE----SKHKFF---ISFNPKGFLKKI 189
Q5P6Q3       167 VEDSNINGHPVL----PGWGPG--PFEAIAEYVRQFPDdYVRDE---ARECKFG---FTFAPAGFLRRA 223 Aromatoleum aromaticum EbN1
Q9CD89       173 VEDSNLNGHPVL----PRFGAG--PYEAIEAYEREFPGdYEHDV---AREKKFG---FTFATNGFLIRK 229 Mycobacterium leprae TN
P9WIM5       189 VEDSNINGHPVL----PGFGPG--PYEAIEAYEDEFPNdYKHDA---ERENKFG---WTSAPNGFLIRn 245 Mycobacterium tuberculosis...
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