3QXY,2H21,3SMT


Conserved Protein Domain Family
SET_LSMT
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cd10527: SET_LSMT 
SET domain found in Rubisco large subunit methyltransferase (LSMT) and similar proteins
Rubisco LSMT is a non-histone protein methyl transferase responsible for the trimethylation of lysine14 in the large subunit of Rubisco (ribulose-1,5-bisphosphate carboxylase/oxygenase). The family also includes SET domain-containing proteins, SETD3, SETD4 and SETD6, which belong to methyltransferase class VII that represents classical non-histone SET domain methyltransferases. Members in this family contain a SET domain and a C-terminal RubisCO LSMT substrate-binding (Rubis-subs-bind) domain.
Links
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Statistics
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PSSM-Id: 380925
Aligned: 254 rows
Threshold Bit Score: 69.7855
Created: 28-Apr-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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putative activeSAM bindingcatalytic
Conserved site includes 19 residues -Click on image for an interactive view with Cn3D
Feature 1:putative active site [active site]
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens SETD2 binds H3K36M peptide and SAM.
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                       ##                  #                                          
3QXY_A      39 KVAVSRQgt------vaGYGMVARe--sVQAGELLFVVPRAALlsqhtcsiggller----------------------- 87   human
CBH16089    22 GIFLHPDvaflvptktmGAGVFARr--qLPKETVIVSCPFSSSispyagpstveapcv---------------------- 77   Trypanosoma bruc...
CCC52210   133 TLSCSTIgdl-----srGTSFVATq--rILPGVFLLSLPTAAVffaqppsandt-------------------------- 179  Trypanosoma viva...
EGR32441    40 EIELKSIndplk-ninkGLGLVSQq--eIQAGSEVFLVSTEKSitglelvgsdrikayeinds----------------- 99   Ichthyophthirius...
EJK57852    53 SVDLAIRpps-----ngGTGIVAKd--vLAEGSVALSLSLHEIgmidarsildgfdagedddavlsmlsdmwknevkhak 125  Thalassiosira oc...
EWM25747   149 PLPFQTRv--------hGLGLKAPdr-gYSAGDVVFSLPLEVWgpasapfaledsqasnsgffq---------------a 204  Nannochloropsis ...
CUG88197    22 DIFLNPDvaflvptkrmGLGVYALk--pLKKGSTIISCPLASAispyeknvetstspsasaiaaaipq--------skss 91   Bodo saltans
GAQ86851    70 SLGACSQdgi-----scYRGVVATq--dISAGATVVSIPLNLGvydfdgaaglp-------------------------- 116  Klebsormidium ni...
OLP75125    69 KIAYIDGt---------GKGAMLQtsapVYAGESLMKIPHKLHisdanirrghagsrlpa-------------------- 119  Symbiodinium mic...
OLP92528   733 QLDVQRIpg-------rGHGVVVSh--aVPCGRTLAEIPWTLIishklaqedadvqa----------------------- 780  Symbiodinium mic...

Feature 1                                                                                      
3QXY_A      88 -------ervalqsqsgwvpLLLALLHELQa-------------PASRWRPYFALWPelgrl------ehpmFWPEEERR 141  human
CBH16089    78 ------kalndtqvkdnvlyVTLRFMAEVLr-------------PSSPWVPWLKTCPrml----------dhLFGNVIDD 128  Trypanosoma bruc...
CCC52210   180 ----------lisffmhvedLVGQLVAADAsve--------cegPVPSHSGYISYLKksvtp------cnnlPFLELEEV 235  Trypanosoma viva...
EGR32441   100 vtkiaskyyeknpyqfyyiqNVLKIITQLNvhs---------kfETMQLYPYADYLLkyfldna-neipknpLYWDTNTI 169  Ichthyophthirius...
EJK57852   126 dkevsedgkrlavlagclahLQLTRFKDKTawtsnevneghalrESRRLGPFLDAMPllptpdgtnpmpthyLYWSDDEI 205  Thalassiosira oc...
EWM25747   205 lcdvdrdlgggrqkllgpvaLAAHLSMALMd-------------RDNIIHPFARFLKdidmq-----ntthpLLLNAQEL 266  Nannochloropsis ...
CUG88197    92 sgggssgtlhnsvlvdntlrVCLRLMSELSr-------------PKSTMRPWLECCPrmp---------thlFGLSQEVL 149  Bodo saltans
GAQ86851   117 ---------epyaesipetrLAAWLCRQRSl------------gSTSRFAPYLDMLPkai---------pmpLFYQNKEA 166  Klebsormidium ni...
OLP75125   120 ---hvdsivdlslgrsgvaaMAAWLTSQHGsyls-------kpaSTGFWQPWWDMFTppy---------smpFYRQETEL 180  Symbiodinium mic...
OLP92528   781 -------llqdlawtdgshaVRLWLLRHAEd-------------AMSPWWPWLSQLPeedsag----agclpVVLAQQSH 836  Symbiodinium mic...

Feature 1                                                                                 #####
3QXY_A     142 CLLqgt------gvpEAVEKDLANIRSEYQSIVLPFmeahpdl---------------fslrvrsLELYHQLVALVMAYS 200  human
CBH16089   129 KAFc-----------SATCTSLGTVSTRWTCLSQQLlemnvsqrwglaeeimkrypehwpedratFPLFCECLALVLSRN 197  Trypanosoma bruc...
CCC52210   236 TQLlandstvkggndASRDSPAFQLWEYFHRDMEGLpltafl------------------rerlsKEEYAWWVSLVLSRR 297  Trypanosoma viva...
EGR32441   170 KGIy----------sSYLASLISSTHSQFQSITEDLynnrl--------------------fgfvFQDFCNYMSIVRSRN 219  Ichthyophthirius...
EJK57852   206 QMLlagt-----fglTRARENRAGIGLVLRQWSPSFlkehst-----------------lgqtaiLNSVFSSFASVMSRS 263  Thalassiosira oc...
EWM25747   267 QYLq----------aSPARGAVRKRQEVYGRIHHRLfaspsspgtas--------enkrssihipKTTFFWAISRVLSRA 328  Nannochloropsis ...
CUG88197   150 ERIdl--------hsAAQCTQWSNVGQQFTEINADAlweraqriiae-------ypdiwpadictAELFAECLTQILSRN 214  Bodo saltans
GAQ86851   167 EAAall------pchAGMQELLNWTRDEFDKSNPDAlgg------------------------asFVTFKWAFAIVLSRT 216  Klebsormidium ni...
OLP75125   181 LLLfgs------yefQELGRMLFWYQHDFEKLQQQPcsskaagc-------------irelqlmdFDMYQAMNQFILSHG 241  Symbiodinium mic...
OLP92528   837 DALlgt------pvqRQAELLLQSLREEWQALEALRanhgw--------------------ipfsWHRWLWCQAIVSTRS 890  Symbiodinium mic...

Feature 1      #                        #####         #                                        
3QXY_A     201 Fqepleee--edekepnSPVMVPAADILNHLAn--HNANLEYsan------------------------clRMVATQPIP 252  human
CBH16089   198 Fhrenv-------egreGPYLLPGLDMVNHSFe--ANAILEIrgggrk------------------hsltfCLVASKELR 250  Trypanosoma bruc...
CCC52210   298 Vg---------------SATLIPVVDKLNHSPe--PNCYYTMatdksfcgldvfdnllagvdygllyepyvHLFSIREIS 360  Trypanosoma viva...
EGR32441   220 Lnflpeqp--khfdinsVVIMTPVVDWINHSFq--PNCRVTGtyfehe------------------nesyvCVKAIKDIL 277  Ichthyophthirius...
EJK57852   264 Fgddvgr-----dldgkGRMLVPVVDMLNHDTe-dPNVHWTWhvkddede-------------isqgkgdiLVTALRDIK 324  Thalassiosira oc...
EWM25747   329 Vsgp-----------rqPLSFLPFFDLMNHRRq--SNCLYGLdekt----------------------gtlVVRSSRPIR 373  Nannochloropsis ...
CUG88197   215 Fhreev-------pgqeGPYLLPGVDFVNHSFt-qTNAEFTMhgggra------------------hnlsfDVMALRDIA 268  Bodo saltans
GAQ86851   217 FetrvllggsedgalsaMIMMLPFADMINHSPh--NQLVWQLddgg----------------------qrfEMTATRDIA 272  Klebsormidium ni...
OLP75125   242 Ckgp-----------gdKPHIIPVFEFLNHSPelaSDLNYQLdqe-----------------------gnlVLWAKWDIP 287  Symbiodinium mic...
OLP92528   891 Gtlpve------cseeeVQCIIPMFDFLNHSTe--PNACIVGttt------------------------svKLVSVQDIE 938  Symbiodinium mic...

Feature 1            ####                 
3QXY_A     253 kGHEIFNTYGqm---anWQLIHMYGFV 276  human
CBH16089   251 rGEQVLLSYGki---gaARFAVEFQFV 274  Trypanosoma brucei gambiense DAL972
CCC52210   361 pGEELTLCYAsppttgrQKPEVTGGFS 387  Trypanosoma vivax Y486
EGR32441   278 pGEELTLNYGnm---pnYDFLMKYGFV 301  Ichthyophthirius multifiliis
EJK57852   325 aGEELLKCYGwr---psWDIASSYGFV 348  Thalassiosira oceanica
EWM25747   374 pGEELSLCYSdrk--dnHQMLVTYGFV 398  Nannochloropsis gaditana
CUG88197   269 kGEQVYYNYGpi---seARFFLEFQFL 292  Bodo saltans
GAQ86851   273 kGEEVFTTYGsk---tnEQWLLYYGYV 296  Klebsormidium nitens
OLP75125   288 aGTEITNSYGrr---snPELLQSYGFA 311  Symbiodinium microadriaticum
OLP92528   939 gGQEVMISYGsh---saEQFLFAFGFL 962  Symbiodinium microadriaticum

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