7KPX


Conserved Protein Domain Family
Med12
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pfam09497: Med12 
Transcription mediator complex subunit Med12
Med12 is a negative regulator of the Gli3-dependent sonic hedgehog signalling pathway via its interaction with Gli3 within the RNA polymerase II transcriptional Mediator. A complex is formed between Med12, Med13, CDK8 and CycC which is responsible for suppression of transcription. This subunit forms part of the Kinase section of Mediator.
Links
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Statistics
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PSSM-Id: 462818
Aligned: 73 rows
Threshold Bit Score: 69.0903
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
7KPX_C        113 FQLPNRITLTDHRKETWLHELSSSHTSLVKIGKFIPHGLKRRQVIEQCYLKFIPLKRAIWLIK 175  Saccharomyces cerevisiae S288C
XP_002953707  222 VQLPELRTASDVGRRLWLSALAG-SASLGYLAQTAPTMPDRRLFLGLMWQTGVPIPRATWFVR 283 
EFA81264      168 RAVPEQNAWMQSARDSWVARLAG-NEPLCKLAQSVPHGHKGDSLIKMLLENQIPLIRATWYTK 229 
EGG20242      206 RHVPEQSAYSISLREAWVNKLKETNEPLQKLAAAVPHGYKSDQLIKMFLEFHIPVLRATWYTK 268 
Q54U49        448 RPVPEQKAWSANHRESWVLKLAG-NEPLQKLASSVPHGYKGETLLKMFLDNQVPLIRATWYTK 509  Dictyostelium discoideum
XP_001754008   26 GVFPDHRTCGDDFRKKWIEDLSQ-RKRLRALAEHVPHGYQRRTIFEALIKHDVPLLRATWFIK 87  
EFJ05540      164 GQFPERHTYGEDYRKKWIEDLSQ-RKRLSLLAEHVPHGFHRRTLFEALVKQNVPFLRATWFIK 225 
XP_002274479  157 CVFPEQRPCGEDFRKKWIEGLSQHHKRLRSLADHVPHGFRKKNLFEVLIRNNVPLLRATWFIK 219 
XP_015697431  162 GMYPEQMHSNEDTRRKWIEALSQPNRRLLSLAEHIPRGFRRKSLFNYLIRYNVPLLRASWLVK 224 
RQL82691      146 G-FPEQKSCGEETKKKWIESLSQQHKRLRSLADNIP-GYRRKTLFEVLIRNNVPLLRATWFIK 206
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