3ZIK


Conserved Protein Domain Family
Wap1

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pfam16997: Wap1 
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Wap1 domain
The Wap1 domain is found at the C-terminus of fungal Wpl1 proteins (also known as Rad61). These proteins are members of the cohesin complex. The Wap1 domain binds to the ATPase domain of Smc3.
Statistics
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PSSM-Id: 435701
Aligned: 13 rows
Threshold Bit Score: 305.393
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3ZIK_B         5 SRHFNELRTMGETLKYSEDLDFILSDNSMTTPEh-----rRNNMLRLCLDMMNNEDLCQYIVKYRHREVWEWCFQGTD-P 78  Eremothecium go...
XP_001644127 237 THHYNELKNMGNMLRFQDDLEFITEESPQEISKes----fISKLLNLSLTMNSDEAFLAYINKHSNKDIYQWCFQRDE-F 311
CCE65657     268 TQHFLELKHIGGTLRFEDDLEFLTSGSPEKLTKdk----fISKLLNFSLAIQTDKDLISYINKHCKNEVYEWCFTKAT-V 342
XP_003681184 223 THHYNELKNMGESLKYQDDLGFLTEKSPSKLDTds----fTSRLLNLALTLKQDEDFLLYVDKHCAIDVCSWSLAKKA-L 297
CCK71557     202 ANSFHELRNLGHSLKYRQDLEFLLTDCISH----------AERLLNVNLSIRRDNLFKEYLSKHHANDIWGLCFNEDA-- 269
XP_003957398 245 TYHYNELKNMGSSIKYQEDLEFLTFNGSTDMKIss----fASKLLNFIYAIDNDQSFLEYIQKNHESKLLDWCFTKNV-L 319
EJT43065     255 TNHYNELKNMGDTIKYQDDIDFFLSNSKNSVNDsgsindyFKKLLNLSLMIINDDGFFQYARRYFKKEIISLSFFRVE-L 333
Q99359       254 TNHYNELKNMGDTIKYQDDIEFLLSNSKSNDNTtvpineyFKKLLNLSLMIINDEEFFQYAKRYFKKEIIKLSFAQFR-S 332 Saccharomyces c...
XP_002494534 207 TYHINELKNMGDMLQYQDDLELLLEGTPSRMSRsq----fVSHLLNIALAMNGDQEFCRYVNKRQARDMWRRTFHQMD-F 281
XP_002552583 195 THHFNHLKTMGESLKYQDDLEFMMQKEAQMTLAa-----kTSNLLIFVLNLINNAGFFEYVMKYSRKEIWQWCLHLGN-C 268
Q6CW44       226 VIHVNQLKTLGEGLKFEDDLDFLPFTTSDek-------lfVVKLISCCLLLLNNTELTSYTQKYKSNEVWNWFLQQIN-P 297 Kluyveromyces l...
CCH62231     267 TFHYSELKNMGDTLKYQDELEFLSLDTNDMSLKen---fvINKFVNLALLLNSEVDFFAYVQKYKATDIWEWCFPKNRiF 343
XP_003647251 192 SQHFNQLRNMGEWVKYQDDLDIVINYEYNSVGDk------RAALLSLCLDMINNEKLSQYIVRYRHHEFWKWCFEFTD-P 264
3ZIK_B        79 KQKVTSLLQCFIADKIpLLRHDkrWAMlSLEN---FILPLATDE-VF--PKKI---AGSRLVKLNYQDLLRKLK-FTNTC 148 Eremothecium go...
XP_001644127 312 DNPLVLLLLGFITSKLpISQDL--LPA-NFDK---FIRRLSLQE-KL--PPVTi--AGKKMVQLNYKDFLTKTN-NNTCL 379
CCE65657     343 RDPIIILLLGVICHEIeIPINEh-----NIDShltMLSELSKQH-DI--PEDTt--LTQKLVKLNYKDFVNIIC-PNTGV 411
XP_003681184 298 DHPVTTMLQAFLLAKIdLPQESlpFLS---EK---LIVALLSAD-KV--PPKSa--LHSKMTRLNFIDFLKRTD-HTTGQ 365
CCK71557     270 PSPELDFLKGTLLSELkLRPTEirSWP-TFSQ---LITRLSNNYsKPngPAKNkkkKTSKMVLMNYNEFYSKSH-FDTSL 344
XP_003957398 320 DIPELLVLQGALMYKLnIKLADnnIHK--IANlgaFLIALSKIE-GI--PNSSkifKSNKLLNLSYQDYLEKRNiGEDGL 394
EJT43065     334 DFPELMLLQGYLLGKVsESQCD--FPP-SFES---FSIELSRNEgSI--CRKNr--RINKLSHLNFEDFLQETQ-FKTGL 402
Q99359       333 DFPELILLQGYLLHKVsESQSD--FPP-SFDN---FSIELSKDDgKIr-TKKNk--HIKKLSHLNFEDFLRKTQ-FKTGL 402 Saccharomyces c...
XP_002494534 282 HDDVLLLIQGFLATKFqLPPNE--LPK-FFNE---FIQALYKRN-RL--PINGl--SGNKIAQLNYNDFLHNTQ-DRTGQ 349
XP_002552583 269 EDPVLRHLCAFIYSKLpLDADDpmWGElNLYE---FVLPLTSQK------SGTlkiKGSKFTEMSYLEFLNATE-SKPGL 338
Q6CW44       298 ENNVMSYLQLWIANLVpLPRSApqWQQ--------LSPLLMTCS-SL--TENPkliEGSKITKLNYTDFVQRAE--TNPQ 364 Kluyveromyces l...
CCH62231     344 SDPVLILLQGFFASTL-FNENFgaTPS-YFSN---FLIKLQKQV-RI--PKLQs--DLSKMACLNFQDFLNFTN-NKLGI 412
XP_003647251 265 NQKVLSFLQCFIVDTIpLKNDDsfWRMiSLEE---FILPLVTEE-SL--PKQI---AGSRLVKLNYKDFMKVFP-HRSLG 334
3ZIK_B       149 EYALYIWATYL------LYTEAVYGAVPALARLISRGQLKDWDTACSLLENNIVAAP------SGSdieeyaqaFQTLAG 216 Eremothecium go...
XP_001644127 380 TYSTLLWKNYGkn--lfKSSNVIVDICKVLNRYNNCENEDIIVAILALIETIASTGCldlettRES--------LDILIP 449
CCE65657     412 TYTIKLLEKNTsv---lMNQSSCQKITCTLLKNYNELQTQDQDLLMKHLQDILSNYKfelnflQn--------vVNSLES 480
XP_003681184 366 VYALELCLKYRni---lKSEDISRRVIRLIEEN---KNPQLRVLLHPLADCILTQDTtilqdfTQGss-----lLSNLVA 434
CCK71557     345 DLALDLLQYYHke--vsLGSELQRNILVFVSEHP--EREDTLVKTYSTLSNILLDCTi-----NDSstf--nflLEVFTK 413
XP_003957398 395 FYSIKLWERYNta--fkGSHPTIKRLLEII------KKGDINIAFLIVLETVLSLVNf----rNERvsinlsktVGPLVT 462
EJT43065     403 YYSLSLWEMYGk-----fSASMIKR-ISIIASNRDLFNQHVIK-LIPLLEKMMSDSKfglifiKQPdif--dgvISNLNN 473
Q99359       403 YYSLSLWEMHGn-----lSLDIIKR-ISILASNKDLFSRHVKT-FIPLLEKLITASEfchmyiEQPemf--dslISNLNN 473 Saccharomyces c...
XP_002494534 350 EYVLELCVQYPgv--ilSCAPLVNRIVQTL-----VASEALPRGIFPVVEKLASSGNt----aEDAnll--svvSNKLID 416
XP_002552583 339 YYALLLWPPFLg-----HQKEIDQNVVDAFTALLQ-NSCEYVDTILPIVEKLVSKET------VEGhstsyknmMQALVP 406
Q6CW44       365 DLTFTLWEFHLd-----PNSNEFSKLIESLNNPTPR--------LFVLVEQHLDKFIt-----EEMmtnlypkmLYYLS- 425 Kluyveromyces l...
CCH62231     413 DYSFEIFSKYKrdilidNSQAVLSSCIDYISRIVDIEELSNLEAIFQVLNILLENDIk----nMEItnveklkiIDFLMK 488
XP_003647251 335 NLVLKIWNRHTds---iGTSEIS---IPVFSALLPTTDIEDTTTILCLIEKNIPASHs----pDTRykkqyqslFNLLMS 404
3ZIK_B       217 LSR-EKLTNEGVLKCLIKLTN----HTTVLe-LSADLLPSLVRSLAMSVQLHqnniVSSISEI--------------KTN 276 Eremothecium go...
XP_001644127 450 LLD-ERINNETYIKVLILLSN----SSESLtsITNNNKSKVVNKTLPFIARN----ILPLSKD--------------KVD 506
CCE65657     481 IFM-SANGNTEVLKSLILITN----DQEMVkhIKYQTKQNMYNTCSTHIVNH----FFSRKGS--------------IIE 537
XP_003681184 435 ALP-QECNDEFLIKSLILLSN----EHKIItqASKDDKTKIMNCSLDFVLDN----VRAEKSD--------------NLD 491
CCK71557     414 NLP-TGYANPYYSQGFILLTNrlleEFKMTpqLADQIALPTFSLIVADLLDG----ESTIEQQ--------------KTN 474
XP_003957398 463 NFN-GFKENDKYVKNLILLTN----EDTILvkIPQGEKNSIFLNSFNFVLSN----INEAE----------------NLD 517
EJT43065     474 QFK-NMIDNDYFIRTLILLTNmeghNHKLWesMD-----MIFQDSMNTILKG----IHPLIDA--------------KVD 529
Q99359       474 QFK-DMLDDDSLIKILILLTNmevhNYTLWkeAD-----MIFQSSMNTILES----IHPLTDA--------------KVD 529 Saccharomyces c...
XP_002494534 417 LLP-NNCQDDHLIKSLILFTN----EETL------ERNSEVFHTCMKFVLDH----LPPLGS----------------TD 465
XP_002552583 407 LFE-PHARNDSLIKALVKMTN----ESTLVaeLKDGQKTVLLTNSLEFLLAYdrflFDEQESE--------------LLD 467
Q6CW44       426 ----SYIEDICTIKIMVKLTN----HAFFLslLSPLEKVKIVRACLSYIIKVre-kIESEQDT--------------D-D 481 Kluyveromyces l...
CCH62231     489 LMNtEYINTMDFNKCLILLTN----DEELI--IENSTRNEIVNHCFKYFIAS----IDIINDAtrntsedykllpllDIN 558
XP_003647251 405 LRN-NVLDKEAILKCFIKLTN----HCHLLe-MKKDSLTILFQDSVTLLHKLkksfLSTDEDP--------------MIN 464
3ZIK_B       277 LLILQLGLLLNIVS--EATTAASTEe---LTNFGAVFRSVFVKKPTEM-------SFVLQLFLLVYAYS--AGAAGVQLP 342 Eremothecium go...
XP_001644127 507 LVILNLALSLNFIS--EGDSRLSLDes-iVSRYKEIFNRVTSLVRTREqe---nhTFLFNMFFLNFTYI--SKIANISLT 578
CCE65657     538 LLLLYNGLLLNIIS--QTNNDLQLSre-tLDNFTKIYNKLNDETPNESn------QFLHDMIYLNFAYLlrQFQDSNLIN 608
XP_003681184 492 MVILHLGLILNLVD--ACDWQID------ASRLELARDMLYKNMNTGNt------EFMVFMLSLALTHL--LHRSGVLLP 555
CCK71557     475 --VCQLALCLNVLD--YCDIGIKIEq---WSKVPQILSGLQKQGAD---------KFLVGLFALTVSLVsiKSLSVHPTT 538
XP_003957398 518 ILLLHLGLCLNVIN--ECDGSIRN-----LDQLCSTAGEIIMSNHVRIt-----nKLMRGLICLNLTFLi-KLEPSNKID 584
EJT43065     530 NVLLHLGLCLNLCG--GKNCDLEVDde-lWHNMRATFLKMIR---DDSev---enRLMQGLFYLNFAFVvnQRKEGDYLD 600
Q99359       530 NILLHLGLCLNICS--RENSRLKLDgk-lWYDMKTIFVKMIR---DGSdt---enRLVQGLFYLNFSFLikQRKENSNLD 600 Saccharomyces c...
XP_002494534 466 ILILHLGLCLNVIS--GESGISHLEna-lWLQAQTFFHKLESNDDD---------SFLLNMFYLNFAYM--TVLLNKRLP 531
XP_002552583 468 IFVLYLGLALNLVKalKQDDAVFEDknplMERLKRTFQDLQAASDESNq-----hNFNQNIFILIYCYI--AMHYKVRLQ 540
Q6CW44       482 IVILQLGLVLNIVA--KDTIKIE----------NSITQQIQDMIGQSKs-----eSFLKQLLALVFVLH--TNTTEWNHD 542 Kluyveromyces l...
CCH62231     559 VLILKLGLCLNVVS--SSQISLDIHcessWSDLTILMHSISTTNPSKSdnlepqvEFIYNMILLNVAYLyiKQNNDEHLK 636
XP_003647251 465 MLILHLGLCLNVIT--EVPLTIGTTq---LDSLTKIFNTIYKNENIKQe-----lSFIHDLFLLVFAYS--IHEYKMVIG 532
3ZIK_B       343 PAEADFLKSELEAFATDVSSYNHNIHTRIT 372 Eremothecium gossypii
XP_001644127 579 QEERDVLIQKLHEFHNVTIKYNENLLKKID 608
CCE65657     609 DTTTSELHSKLKQFNLSVKEYNINLSRKIE 638
XP_003681184 556 RDEKNLLTKILKPFDSEAKNCNESIRIKVT 585
CCK71557     539 PSLQELLRQELHSL-KIIAKDNKSVSSKVE 567
XP_003957398 585 DEMKTQLTHELNIFEEQTGIFNKSINEKVK 614
EJT43065     601 SWELNTLTVALEAFESETSQFNEGISSKIE 630
Q99359       601 PGELNLLLVELEAFKSETSQFNEGISNKIE 630 Saccharomyces cerevisiae S288C
XP_002494534 532 TKVKTGLISHLELFAQESQHYNGSISDKIK 561
XP_002552583 541 EAERAFVIPRLEAFSQEIKRYNESIYTAIA 570
Q6CW44       543 LSTTASITKLLKNLSNDMKDTNETIYNNVQ 572 Kluyveromyces lactis
CCH62231     637 KKDLNLIVVSLKKFYEDTNDYNESIHLKIK 666
XP_003647251 533 GCELAYLKTQLSVFASDVESYNNSIYERTA 562
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