Conserved Protein Domain Family
FIN1

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pfam17300: FIN1 
Filaments in between nuclei protein-1
Fin1 is a kinetochore protein, predicted to contain two putative coiled-coil regions at its C terminus. It is present in a filamentous structure associated with the spindle and spindle pole in dividing cells during anaphase. Fin1 is a substrate of S-phase cyclin-dependent kinase (CDK). It binds to PP1 creating the Fin1- PPI complex which is recruited onto kinetochores promoting spindle assembly checkpoint (SAC) dis-assembly during anaphase. This is an important step in cell division since the kinetochore is the docking site for the spindle assembly checkpoint that monitors the defects in chromosome attachment and blocks anaphase onset. Fin1 has two RXXS/T sequences: S377 (RVTS), S526 (RKVS) that can be phosphorylated. Upon phosphorylation, interactions with other proteins such as Bmh1 and Bmh2 is promoted. However, de-phosphorylation during anaphase promotes the kinetochore recruitment of Fin1-PP1.
Statistics
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PSSM-Id: 407411
Aligned: 10 rows
Threshold Bit Score: 176.128
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_001645579  10 NKVGNekdgsfpshrDN-NVFKR--LTLSPPKKYLSK---PSSNSPSRLPVSTSGNVkgKYGIqvTPKRIASPDCLKDFN 83 
XP_003674824   1 MKEYS----------TKkDVFRR--LSNSPTKNKVAKl--SVSSSKVQNFPITSRTSpiRNIK--THARLTSPKCLKDYQ 64 
CCE62254      10 NSSTSkrseslnhagKGiTDFKKnsLQKDPVRSILKSs--RLFKSPEKLNNCKVSK---KSTLhiTPKKLASPECLRDYI 84 
Q6FXC3         6 SDIGNvvq-----grDTrNVFDR--LSISPQKRSSNKrdsVVWKPASRISPKKSNNAplTTAIheTPKRLQSPSFLKDR- 77  [Candida] glabrata
Q6CJB4        24 QELSSnasp---pssASgEIFKR--LSVSPNRNRk-----LLEKPAARLSPQQ---------RvqTPKRLPSPDIL---- 80  Kluyveromyces l...
Q750A6         6 NDISNrea-----atRGsDVFKR--LAGSPMRRDGAA----MDKPAMRLSPG-------KHAYqtSPKRLLAPEHLR--- 64  Eremothecium go...
XP_003646152  17 NDISNkdt-----snRGsNVFKR--LSTSPMRKPGLS---VIDKPAVRLSPT-------KSSYqtSPKRLIPPEHLS--- 76 
XP_003682446  12 DINNLmeppsterlhQS-NVFKR--LSTSPSKAYAND----LSKPPVRMSPVKRSPS--KSGNqlTPKRLASPDCLKNDV 82 
XP_002496708  15 NTRTSshs-----psTQgNVFKR--LGTSPSMRYPNG----LSKPPARVSPARKSPV--KPLLqlTPKRIQSPECLREYN 81 
AQZ13461      15 NVRTTshs-----psNYnHGLKR--FATSPASRHLND----LSKPPARISPSRKTPM--KHSIqlTPKRLPSPECLKEYK 81 
XP_001645579  84 V-K----I---DQPLMmtdsgsk---------krsvlvdTDSVTKVTFPTSPIKi---kFAET-KPLGGDGSLNRIRAKF 142
XP_003674824  65 PtMlvqsV---DRHHF-----------------------NEGRGDLNFLTSPTK-----FNLE-KTVGGDGSRTRIRSRF 112
CCE62254      85 P-KvtrsV---DYSDFrkmhe-------------piietNGTVTNVLFPTSPLKi---rFSDSiKPIGGDGSLNRIRAKF 144
Q6FXC3        78 --SftqsL---DRPQFdpkdivsatpvnkvkpgiprsvgNPTTSTFMIPISPTKi---tFSNE-KRTGGDGSSSRILSRM 148 [Candida] glabrata
Q6CJB4        81 --GpnlsLdryERQKSs----------------------VVKINEIVFPNSPTKas-gaLRNV-PVLGGDGSLSRIRNRF 134 Kluyveromyces l...
Q750A6        65 --SltqsV---DRHFFntar----------------atgRPGSRDAAFTASPTKgd-ggFSNM-TVAGGDGSLSRIRNRF 121 Eremothecium go...
XP_003646152  77 --NvtrsV---DRHHFikrpeht----------ssliqsLHGGADIVIPISPIKmesekFGSV-TTVGGDGSLSRIKNRF 140
XP_003682446  83 S-KitqsM---DRPYFekhggn------------pkiedSGSVTNLVFPASPTRv---tFSNE-RKIGGDGSLSKLRSRF 142
XP_002496708  82 P-KfmhsG---GSPSIddnlt-------------skvenRGSTTSILFPTSPTRt---iFANE-RKIGGDGSLGRIRSRF 140
AQZ13461      82 T-KrlknT---ESPLMhpevt--------------dveqRGSSTTVVFQTSPTRa---iFSNE-RKIGGDGSLGRIRSRF 139
XP_001645579 143 KNGLMSPERHNAGStsilh------sepinEIRPSLRAGRNLFKELQREDSigseEDYNSVTKRNTSYNASMk---KSGS 213
XP_003674824 113 KNGLLSPERLQNERe--------------qLSPSKHIQGSNLFTKLKREDEe---WDMDKLTEINTSHNKKS----EDSP 171
CCE62254     145 KNGLMSPEKLIQRKgts---------------iiTSKARRNLFEEIQRESTst-tIDTNKIKTIQKSLNNGIl---KKEI 205
Q6FXC3       149 RNIRASPVRSVPSTa-------------------TTIKKRNLTERLRQEEEg---ENKNNEKRVRFQVPSQP----RPGS 202 [Candida] glabrata
Q6CJB4       135 KINNASPV------------------------------KANLLDKLNKEET----ETDTAKRKRKTDTPNAMkg-sRVEK 179 Kluyveromyces l...
Q750A6       122 -----SPVKERKPIla-------------sEQEDGAATRQNLLAKLQREED------VTQVTRRNTRQNSEAsr-yKVGK 176 Eremothecium go...
XP_003646152 141 -----SPSKDRKSImt-------------vNEETLSPTRQNLLNKLQRDED------LSKVTKKNTKLNSELisnfKVGK 196
XP_003682446 143 TNGLLSPQRGA-------------------NMPKTELQGKNLFSKLENDEQ------INDFTTSPKRRLENLe---EEAI 194
XP_002496708 141 TNGLLSPQKRLAPTpmknrlehamesdntsDNSNNELQAKNLFEKLKEAEK------MEQET--------------NQER 200
AQZ13461     140 GNGLLSPQRRIVPAprq----------kalNPEEKELEAKNLFEKLEEAEK---------LERTHSDLTSDDdr-aKDAK 199
XP_001645579 214 I-TKSSPMKKSVKFAVPSDDqeySELKSELSDIKNLLLSLVNKQTSIESRLSQLEEQ 269
XP_003674824 172 TyIPLSPNKKNVKFELPITTr-dQEINDSLKDIKSMLINVIKKQDEMNSRISQLEDT 227
CCE62254     206 Q--KGESPHKSVKFHIPDNE---SDIRQQLNDINNLLNAILTRQDVLEKEISEIKRN 257
Q6FXC3       203 SqSSSRTPSRDSNESMTNAN---KHISRERKAPMPVKTSPDARIDQLENTVRLLEER 256 [Candida] glabrata
Q6CJB4       180 N--ERRTRSKSVMFKLPED----RIISIELNEMRKLNEALIARIEELEQRMARLEDR 230 Kluyveromyces lactis
Q750A6       177 S--QIVTRSRNVKFELPED----RMIAIELQNLKQLIHTLIERQDQLEDRLTRLEEQ 227 Eremothecium gossypii
XP_003646152 197 S--QITTRSKNVKFELPED----RMIAIELQNLKQLLQMLLERQDRLELKIAELESK 247
XP_003682446 195 SsNKRKQIKKTVKFELPASDe-nENLRKQVQDLKHTLSKVIEHQNEMEVRLKLVESQ 250
XP_002496708 201 S--KTQPHKKSVKFELPRKDs-kEALKKELQALKELLKEATRRQSELEVRLSKLEEG 254
AQZ13461     200 ApKSVQCSKKSVKFELPLEDt-rEKILEELHEVGKLLEEAFKRHRELELRLAKFEHQ 255
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