Conserved Protein Domain Family
DUF5427

?
pfam10310: DUF5427 
Family of unknown function (DUF5427)
This is a domain of unknown function. Family members found in Saccharomyces cerevisiae, are synthetic lethal with genes involved in maintenance of telomere capping. However, experimental evidence is yet to verify the exact function of family members and the domain.
Statistics
?
PSSM-Id: 431211
Aligned: 71 rows
Threshold Bit Score: 194.865
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
XP_007797603  19 EGIG-DDSAVKK--------------PTKAKSTAPKSrggdKHEkDPLAELEnEL-EevpsrphtprvrDAv-------s 75 
XP_004180572  17 DSLPqSGqngdk---------sdsmkDSKDLGSSKAGsntkKDE-DILDFLD-ELeK------------SNlsln-keks 72 
CCC67528      18 ESLPeTSsn---------------gnQDDKTKDATKKdpqkKDE-DIMDFLD-ELeK------------STadls-ekkd 67 
CCK73593      18 ESLPsENatd-------------ksiDDTNDNKGKTNeggaGDE-DIMDFLD-ELeK------------SNlsie-kpsk 69 
CAR24033      33 ESLPeSSk------------------TSGGSGAENSGkepkKDT-EILDFLD-ELeQ------------SNlslk-kdkk 79 
EDO18125      17 DSLPeAK---------------------KNDQNDQSKdngkKDE-DILDFLD-ELeK------------SNle------l 55 
XP_002496584  15 ESLPeAKggad------------skgDKKEKTEEKKSggkqGNE-DIMDFLD-ELeK------------SNlsvpkkeea 68 
P47018        17 DSLPeAKNGGKMvntdvkgsqegvkgGSNSVAGKTGNdgkkGDD-DIFEFLE-ELeK------------SNlslt-dkkg 81  Saccharomyces c...
Q6FL79        18 DSLPeDK--------------------KGAEGKSKAKgagkKDEeDVFEFLE-ELeK------------SKmdlg-akkg 63  [Candida] glabrata
XP_003958344  18 ESLPnDG--------------------ANEKVDDGNKkkgnKDE-DIFEFLD-ELeK------------SNlks----kg 59 
XP_007797603  76 SKRT--------------STATPppg----aprQSEDKstn-------------lpRKSveSTR--SFHA-SFTPSATSS 121
XP_004180572  73 EGSKvsktktenddkivkNDSSPavienssstsSTQMGk----------------kDQNedSLKkeELKQsDEEKEEEee 136
CCC67528      68 KKQTkkveervktedqpvQKEEKekeeskekitAE-------------------------------TAKTpEQEQEEEQV 116
CCK73593      70 KKKGltgnsadktgqqsaKEEGKektekvsptiTKEKEeevisg-----------------keeeeNQEQgHEEEEEEEV 132
CAR24033      80 AGqae-----------enAQEGEgdsvaqtstaSKEPAaaekpaaa--------ekpvaaeEPA--AVEDpASSKASQPK 138
EDO18125      56 NKNKtnsgdsannnknkkKASNNtkqeskpqsvGKEETkkapiknneqkpvkeeikEVPldEVT--NKEEsINENQEQDS 133
XP_002496584  69 QEKKkeeiskmkpskeepSKEEPpkeeppkeeaPKQELpkqepl-----------------keeapKQEPpKKEQPKEVP 131
P47018        82 VEKKapsesvnnkaqdekVEESKenknseqdahGKEKEp--------------------------qQQEKeEEEEEEEEE 135 Saccharomyces c...
Q6FL79        64 KKVAetkkldpqesndgkAKSETkqe--------------------------------------apAVKKdTEEKSEEAS 105 [Candida] glabrata
XP_003958344  60 KEAKvarkqeqplekegaKQEPEetkpkevepvSNE------------------------------TVSKgTVENPEEne 109
XP_007797603 122 -ELQDAEKKgp---------veQAAPAASGGAGGGWWGGifatasaTANAAMKQAEAaykeiQKNEEAK----KWAEQVR 187
XP_004180572 137 ea----------------deplG----DPISTFSNWWSS-------SGSATVSSFWN-----KTTEQAS----QLKNHLS 180
CCC67528     117 n--------------------------DPITSFSNWWSS-------SGSNTVSSLWN-----KTTEQASthlkKVTERIN 158
CCK73593     133 eqgrd-------------gtplN----DPITSISNWWSS-------SGQATVSTLWD-----KTTKQATsqikKIGDKIG 183
CAR24033     139 eTAASVSQAdaeiiqs-----epettsDPITSFSNWWSS-------SGSATVNSFFS-----KTAEQAT----HLKDRLA 197
EDO18125     134 vpke--------------gtplN----DPITSFSNWWSS-------SGSAAVTNIWN-----KTQKQAS----ELQKKIV 179
XP_002496584 132 pKESKGFHRegtpvesredtplN----DPITSFSNWWSS-------SGSATVSNFWS-----KTTEQAS----QIKTRLA 191
P47018       136 eeeee-------------etplH----DPIASISNWWSS-------SGSAKVSSIWN-----KTAEQAS----QIKNRLA 182 Saccharomyces c...
Q6FL79       106 nAKVeane----------etskQGTNPDPIASISSWWSS-------AGSATVSSLWS-----KTTEHAS----QIKNRIQ 159 [Candida] glabrata
XP_003958344 110 qd----------------geplN----DPITSISNWWTS-------SGSTAVSNLWS-----KTTEQAS----KVKDRIQ 153
XP_007797603 188 G-----NVGALKGL-GDDLRHR------------------ALPTIADIMHTLAPPI--SSHERLLIHITHDIVGYPSLDP 241
XP_004180572 181 Q-----EQQ---DFiAQSANRVkninmnkvvdmnvvnsvvNKSKITELAKNLQKIVvgETEEVLRIHLVHDLVNYPNLQY 252
CCC67528     159 Q-----EQQMEDSI-ASKLTKNl-----------------NPIKISELAKSLSKIVvgDTEEILRIHLVHDLINYSYLQY 215
CCK73593     184 Q-----DQL------LQQSRGA--------------------IKITELAKNLSKIVvgETDEILRIHLVHDLINYSYLQY 232
CAR24033     198 Q-----EQH---GI-ASKLQGTslg------------skiNTATLSTLAKNLSRIVvgDTDEVLRIHLVHDLVNYPLLSY 256
EDO18125     180 DeqsqiPIKELTSL-TSKLKTS---------------------TITDLANRLQEIVvgETEEVLRIHLVHDLVNYPLLQY 237
XP_002496584 192 Q-----EQL---DL-TSRLNTN---------------------TITDLARNLQKIVvgETEEVLRIHLVHDLVNFSFLQT 241
P47018       183 Q-----EQL---DL-TSKINTS---------------------TITEIARNLQKIVvgETEEVLRIHLVHDLVNYPSLQY 232 Saccharomyces c...
Q6FL79       160 Q-----EQL---DI-TSKLNTQ---------------------TITDLARNIQKIVvgETDEVLRIHLVHDLVKFPSLQY 209 [Candida] glabrata
XP_003958344 154 K-----EQQ---TL-TTTLPIKi-----------------NTNTISELAKNLSRIVvgETEEVLRIHLVHDLVNYSNLQY 207
XP_007797603 242 LIYEVFSRVM-SQVEGGDLLVIQRGQESTA---RRasdvtytkhsSSSSVAGWRDGPWWRqv--dAP-RNL--GAVRG-L 311
XP_004180572 253 IIHEKFNQILnEQVQGGIRIFVDEWGKPNSnsnLNll-------nlANKNINNQLNNIANnininSLpPNF--NVFHGkI 323
CCC67528     216 QIETKFDQVLsSQVQGGIRIFVDEWGNPNKkmdSSitnefn---------------------dakflkRKL--NLFNGkI 272
CCK73593     233 QIEDKFHQVLsSQVQGGVRIFVDEWGNPNKkdtGRrstitdf-------------------neakflkQKL--NLFRGkT 291
CAR24033     257 HVEQQFDNVLsSQVQSGVRIFVDEWDHPIEgndRVqd-----------------------------gkRHL--NMFTGkV 305
EDO18125     238 HVEQKFHDVLsSQVQGGIRIFVDEWTNPNErelYEke------vePTSKESKK---------------RQL--NMFNGkV 294
XP_002496584 242 IVDQKFDEVFsSQVQGGIRVFSDQWGHPHRtedEMnfhf-------------------------tsqqPKL--NIFTGkI 294
P47018       233 NIESKFDQVLsSQVEGGIRIFVDEWGHPNNngiTPve------kkPSVADGELGNSK-----------KKLqfNLFDGkV 295 Saccharomyces c...
Q6FL79       210 HIENRFDQVMsSQVEGGIRIFVDEWGRPNRsnsIStv------vdPEKREHEEKDAIEPK--------IKL--NLFSGkV 273 [Candida] glabrata
XP_003958344 208 YVESKFDQVLsSQVQGGIRIFVDEWGKPHQddtTTisfi-------------------------ndnrRSL--NLFVGkI 260
XP_007797603 312 PEGTKLCRVGAESYAHDYFAGRGGIA-----------------EAQRRALEPVSDENPVRTSDIFLAVQAITVDATPalf 374
XP_004180572 324 IDGEKLAFANLDNAIELFNKAQKEIQnqqnea-----kkeaneATATNDNDEDEDEQIANIIDIFISILPIAPSSSS--- 395
CCC67528     273 NDGEKLAFANLDNSIKLFNKAHEEIMkqk------------keNEKQEGKDGKDENDQNKISDIFIAILPIAIPNTG--- 337
CCK73593     292 TDGEKLALANLENSIKLFNKAHDELLkrkkel-----nekddeNSENDDDDEEEEEEQNKISDIFIAILPIAVEEKG--- 363
CAR24033     306 SDGEKLAFANLNNAIKLFTEAKDELAkqr-----------------feTVSAEEGEKELAISDVFISILPISVPEKH--- 365
EDO18125     295 VEGEKLAFANLDNAIKLFHKSRENIIkqqkeak----laetdqDQESKQSDTEAGDEEDNISDIFISILPVSVPGTN--- 367
XP_002496584 295 TDGEKLAFANLENSIKLFQKAHEEFMrqkeahstatnerqeqeQDGEDADDDEKDDQEDRISDIFISILPIAIPTKQ--- 371
P47018       296 TDGEKLAFANLENAVKLFNTAHEEYQkqq-----------keaDATPDDDRSSISSNSNKISDLFISILPIAIPQKQ--- 361 Saccharomyces c...
Q6FL79       274 SDGEKLAFANIDNSIKLFNKAHDEYIrqq------------keAEGESEEGSSAEKSENRISDIFVSILPVAIPDKN--- 338 [Candida] glabrata
XP_003958344 261 TDGEKLAFANLDNAIKLFNKAQEEISkqqk----------eaaDGDDENEKNTNEDTKDNISDIFISILPISIPISG--- 327
XP_007797603 375 agstAE-KAEKESSg----vADDDESsaadAHVCFAVYVLDPVHEIVYSTVSQALPARWIRWLDTPsattttattssgpT 449
XP_004180572 396 -----AkMDDDKSTi----iTDTTHS----GNFSFTIILKDISNDITSITRSQGFPLKWLKWIENS-------------K 449
CCC67528     338 ---------KDDDIi----tTDPSHP----GNFNFTIVLKDITNNITTITRSQGFPLKWVKWLENY-------------N 387
CCK73593     364 -----KtSSDDKDIi----tTDASYP----GNFNFTIVLKDITNNITTITRSQGFPLKWVKWLETE-------------K 417
CAR24033     366 -----Kn----PEIa----tTDSSHP----GNFAFTIVLKDISNDFTSITRSQGFPQRWADWLEGT-------------S 415
EDO18125     368 ----KD-----DPIk----tTDGNAP----GNFSFIIVLKDITNDITSITRSQGYPSKWAGWLEGS-------------Y 417
XP_002496584 372 --------EDENEIv----tTDPHQP----GNFSFTVVLKDITNDVSTITRSQSFPLKWVSWLEGD-------------S 422
P47018       362 -----------KDAdgdfqvTDSNTP----GNFNFTLVLKDITNDITTITRSQGFPVKWVNWLEGS-------------V 413 Saccharomyces c...
Q6FL79       339 -----------DSTkedmivTDPHHA----GNFSFTVVLKDISNDITAITRSQAFPTSWVEWLEGE-------------T 390 [Candida] glabrata
XP_003958344 328 -----SkDVETDDIl----tTDSSQS----GNFNFTIVLRDITNNITTITRSQGFPNKWAEWLEGT-------------K 381
XP_007797603 450 PKASG-----------SGDSeeeesseeeeeddddeegnerpppqrqtggarggggaaigvegdglSIPDEIRAIVEGGG 518
XP_004180572 450 DEEDNekdssksenatLTQKtten---------------------------------------ketKGNDETDDEDEDDG 490
CCC67528     388 DDEGEdadadadtnekTN------------------------------------------------RDKEEEEEEEEELG 419
CCK73593     418 DKGEEea----------------------------------------------------------kEEAADEEAKEEELG 439
CAR24033     416 ELKSKqdaiqd--------------------------------------------------reskrDAVERTDSADDAEG 445
EDO18125     418 ELTSKddaisqakekdEKKKqs------------------------------------------ssNEEDEEDEEDESNN 455
XP_002496584 423 EWKTKgkkeqegkeqeGKQQq---------------------------------------------QQQQQQQEDDEDED 457
P47018       414 EKTGStaseernksydQK------------------------------------------------KQKESEDEDEDDEI 445 Saccharomyces c...
Q6FL79       391 KKNKE-------------------------------------------------------------SKKGDDNEDEEDDI 409 [Candida] glabrata
XP_003958344 382 DEDNTkqeekskkeeeE-------------------------------------------------EEEEKEPANDEEGE 412
XP_007797603 519 VDPREWVAEWVEETLTLSIGVLAQRYVARRMGV 551
XP_004180572 491 VNPAEWVQNWVDDGINLAFGTAAQNYVLERMDf 523
CCC67528     420 VDPGDWVKEWIEDGLNLAFGIVAQNYVIQRMGF 452
CCK73593     440 VDPGDWVKDWIEDGLNLSFGIVAQNYVIQRMGF 472
CAR24033     446 IDPSDWVKEWVEDGLSLAFGVVAQNYVIDRMGF 478
EDO18125     456 IDPSEWVKEWIEDGLSLTFGIAAQNYVIERMGF 488
XP_002496584 458 VDPSDWVRDWVEDGLNVAFGVVAQNYVIKRMGF 490
P47018       446 IDPSEWVKEWIEDGLSLSFGVMAQNYVIDRMGL 478 Saccharomyces cerevisiae S288C
Q6FL79       410 VDPGEWVKDWIEDGLSLSLGILAQTYVIKRMGL 442 [Candida] glabrata
XP_003958344 413 IDPSDWVRDWIEDGLSLVFGVVAQNYVIDRMGL 445
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap