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Bacterial HORMA domain family 1 Family of bacterial HORMA domains found in conserved genome contexts with Pch2/TRIP13 P-loop NTPases. Acts as a 'third component' in broad class of conflict systems reliant on the production of second messenger nucleotide or nucleotide derivatives. Together with Pch2/TRIP13, could act as co-effectors or in regulation of other effectors of the systems. It is found in proteins from the CBASS (cyclic oligonucleotide-based antiphage signaling system), a system that provides immunity against bacteriophage. This domain is found in CD-NTase-associated protein 7 (Cap7) from E.coli, that acts as a sensor protein of CBSS and binds to a closure peptide allowing it to activate the CD-NTase CdnC for second messenger synthesis and, therefore, it activates a diverse range of effectors. |
Jiyao W et al.(2023). "The conserved domain database in 2023.",