Conserved Protein Domain Family
ECSCR

?
pfam15820: ECSCR 
Endothelial cell-specific chemotaxis regulator
ECSCR, endothelial cell-specific chemotaxis regulator, is a family of proteins found in eukaryotes. It is also known as ARIA for apoptosis regulator through modulating IAP expression. It is a cell surface protein that regulates endothelial chemotaxis and tube formation, and interacts with filamin A. Filamin A anchors transmembrane proteins to the actin cytoskeleton becoming a scaffold for various signalling proteins. ECSCR is also known to interact with and regulate the function of several endothelial transmembrane molecules. It has been shown to play a role in angiogenesis, a complex process involving the migration, proliferation, and lumen formation of blood vessels by endothelial cells. ECSCR appears also to regulate endothelial apoptosis, probably through modulating proteasomal degradation of cIAP-1 and cIAP-2 in endothelial cells.
Statistics
?
PSSM-Id: 292448
Aligned: 2 rows
Threshold Bit Score: 141.433
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
P0C8R9        71 SlrirEDSTILPSPTSETVLTVAAFGVISFIVILVVVVIILVSVVSLRFKCRKNKESEDPQKPGSSGLSEScSTANGEKD 150 dog
XP_007473770 138 A----TEKPILPTPTSETVLTVAAFGVITFIIILVVVVIILVSVVSLRFKCRKNKESEDPQKPEICGMFES-STAIGEKD 212
P0C8R9       151 -SITLISMKNINMNNSKGCPTAEK 173 dog
XP_007473770 213 tSITLISMKNINSNNNKGSYTEEK 236
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap