Conserved Protein Domain Family
cyanamide_fam

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TIGR03401: cyanamide_fam 
HD domain protein, cyanamide hydratase family
Members of this protein family are known, so far, in the Ascomycota, a branch of the Fungi, and contain an HD domain (pfam01966), found typically in various metal-dependent phosphohydrolases. The only characterized member of this family, from the soil fungus Myrothecium verrucaria, is cyanamide hydratase (EC 4.2.1.69), a zinc-containing homohexamer that adds water to the fertilizer cyanamide (NCNH2), a nitrile compound, to produce urea (NH2-CO-NH2). Homologs are likely to be nitrile hydratases.
Statistics
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Structure
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PubMed ReferencesClick to see Conserved Features Help

TIGR03401 is a member of the superfamily cl21469.
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
P22143      7 KANGWTAVPVSAKAIVDSL--GKLGDVSSYSVEDIAFPaADKLVAEAQAFVKARLSPETYNHSMRVFYWGTVIARRLLPE 84  Myrothecium verruc...
XP_391308   7 KTNGWTAVPLNAKNILDTV--GKLAEVPTYKAEDIQFPsDDKLVAEAQAFAKARLSPEAYNHSMRVFYWGNILAKRLLPE 84  Fusarium graminear...
XP_663015   7 AANGWTAVPVDAGAIFTKQ--PLVEDAKAVSLEELRFPaEDLVVSKTVEYAKAVLDPETFNHSMRVYYFGMAIAKQQFPS 84  Aspergillus nidula...
BAE61376   10 EEYGWTAVSCDPQQRAATN--PPTKPSVPQLVKDTTLP-DTPLVKDAIEYVKAELPAHTFNHSMRVYYYGLAIARQHFPE 86  Aspergillus oryzae...
BAE65603    7 IEYGFTPVISSARALLSAA--KPSTPAPFISVADNPIP-KTALAQRIDLYARSQLPEPTYNHSLRVYHYGLAIKRHVFPS 83  Aspergillus oryzae...
XP_664025   6 AKHGFASVPANTNTLFSEVdlKAKSYPIAVPVSETPIP-DTPLCRRIQECARTRLPQPTYHHSLRVYHYGLAIKRYAFPD 84  Aspergillus nidula...
P43543      2 SQYGFVRVPREVEKAI-----PVVNAPRPRAV--VPPP-NSETARLVREYAAKELTAPVLNHSLRVFQYSVAIIRDQFPA 73  baker's yeast
XP_456412   2 SKYGFVKIARDIKTAV-----GKINEPTAQSV--VELP-DSPLGKFMLDYATKELPEKVLFHSLRVYQYSIAIINDHFDK 73  Debaryomyces hanse...
XP_722360   2 SKYGFIKISRDVQQAI-----PNPKKPSIQLN--TELPlDSPLTKFVYDYSKKRLPNETFNHSLRVYFYSVAIIKDQFAD 74  Candida albicans S...
P22143     85 QakDLSPSTWALTCLLHDVGTAEAYFTSTRMSFDIYGGIKAMEVLKVL----G---SSTDQAEAVAEAIIRHEDVGVDGN 157 Myrothecium verruc...
XP_391308  85 HfgALSTSTWALTCLLHDIGTADVFFTSTHMSFDLYGGIKAMEVLKVL----G---GTTDQAEAVAEAIIRHQDVGVDGT 157 Fusarium graminear...
XP_663015  85 QsaDLNPATWALTCLLHDIGTAKENLTATRMSFDLYGGIKALQVLKDH----G---AAIDQAEAAAEAIIRHQDMGVDGT 157 Aspergillus nidula...
BAE61376   87 W--KFSDETWLLTCLFHDIGTIDKYTQDVFMSFDIYGGIVALNVLTEK----G---APAPQAESVAEAIIRHQDPVKVGT 157 Aspergillus oryzae...
BAE65603   84 W--SFTDETYFLCCLLHDIGSTEENLNKTKLSFEFYGGLLALGVLQDGtgpfGnavAPRDQAESVAEAIIRHQDLCEEGK 161 Aspergillus oryzae...
XP_664025  85 W--SFSDETYFLACMLHDIGTTRENLHATKLSFEFYGGYLALDVLQTQyd-aGdaiASKDQAESIAEAIIRHQDLRDVGS 161 Aspergillus nidula...
P43543     74 W--DLDQEVLYVTCLLHDIATTDKNMRATKMSFEYYGGILSRELVFNAt---G---GNQDYADAVTEAIIRHQDLTGTGY 145 baker's yeast
XP_456412  74 W--ALDSEVLFVTCLLHDIGTTEKNMKATKMSFEFYGGMITRDLILEHt---N---GNQDYAEAVSEAVIRHQDLGDTGF 145 Debaryomyces hanse...
XP_722360  75 W--TLDPEIVFVTSLLHDIGTSHENMHATKMSFETWGGILSRDLVLEQt---K---GNKDYADAVCEAIVRHQDLGESGY 146 Candida albicans S...
P22143    158 ITFLGQLIQLATLYDNVGAYDgiddfgSWVDDTTRNSINTAFPRHGWCSWFACTVRKEESNKPWCHTTHIPQ--FDKQME 235 Myrothecium verruc...
XP_391308 158 ITFLGQLIQLATLYDNVGVYEgiqdygSWVDEATRDNINRAFPRHKWTSCFASVIRQEESNKPWCHSTHIVD--FPEKLE 235 Fusarium graminear...
XP_663015 158 ITFLGQLIQLATLYDNVGAHPrvkgyeKLIHPTFRREVNEAHPRIGWCGFFSGIIRKEEEIKPWCHSTHIVD--FDKQIE 235 Aspergillus nidula...
BAE61376  158 IHSIGLLIQLATQFDNLGAHK------EYVHPDTVEDVNQHYPRRQWSKCFSSKLREEIGLKPWCHTTAEGEg-FPIGIE 230 Aspergillus oryzae...
BAE65603  162 ITAVGQLLQLATIFDNTGAYA------DLVHPSTIDEVSRRYPRKQWSTCFAATIRRENELKPWAHATTLGEeaFPSKVL 235 Aspergillus oryzae...
XP_664025 162 ITALGQLVQLATIFDNVGGHA------SLVHDDTVKDVVEHYPRLKWSSCFAATVAEEVELKPWAHTTALGD--FKGHIL 233 Aspergillus nidula...
P43543    146 ITTLGLILQIATTLDNVGSNT------DLIHIDTVSAINEQFPRLHWLSCFATVVDTENSRKPWGHTSSLGDd-FSKKVI 218 baker's yeast
XP_456412 146 ITTLGLILQISTILDNVGLNT------DLIHPDTLAAVNKEYPRHGWLNCFADHIDNENTKKPWGHTSSLGVpdFRNNVL 219 Debaryomyces hanse...
XP_722360 147 ITTLGLILQISTILDNVGLNS------HLIHEDTLDAVNKKYSRKGWLNCFAGAIDKENELKPWGHTSALGVdkFKDDVL 220 Candida albicans S...
P22143    236 ANTLMK 241 Myrothecium verrucaria
XP_391308 236 ANTLMK 241 Fusarium graminearum PH-1
XP_663015 236 GNALMK 241 Aspergillus nidulans FGSC A4
BAE61376  231 NNTLME 236 Aspergillus oryzae RIB40
BAE65603  236 GNSLME 241 Aspergillus oryzae RIB40
XP_664025 234 ANPYNS 239 Aspergillus nidulans FGSC A4
P43543    219 CNTFGY 224 baker's yeast
XP_456412 220 ANKVKY 225 Debaryomyces hansenii CBS767
XP_722360 221 ANKLRY 226 Candida albicans SC5314
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