2QCQ


Conserved Protein Domain Family
TGF_beta_BMP3
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cd19393: TGF_beta_BMP3 
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 3 (BMP-3) and similar proteins
BMP-3, also termed BMP-3A, or osteogenin, negatively regulates bone density. It antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification.
Links
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Statistics
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PSSM-Id: 381663
Aligned: 7 rows
Threshold Bit Score: 228.765
Created: 19-Jul-2018
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
homodimer
Conserved site includes 29 residues -Click on image for an interactive view with Cn3D
Feature 1:homodimer interface [polypeptide binding site]
Evidence:
  • Structure:2QCQ; Homo sapiens BMP-3 forms a homodimer, contacts at 4A.
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                    # #   ## #         # ###                ##  ## ##  #  # ###  # ##  #
2QCQ_A         1 QWIEPRNCARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQSIVRAVGVVPGIPEPCCVPEKM 80  human
Q7T2X7       349 QWNEPRNCARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQSIVRAVGVVPGIPEPCCVPEKM 428 African clawed ...
NP_001029991 353 QWNEPRYCARRYLKVDFADIGWSEWIISPKSFDAYYCSGECQFPIPKALKPSNHATIQSIVRAVGVVPGIPEPCCVPDKM 432 chicken
P12645       363 QWIEPRNCARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQSIVRAVGVVPGIPEPCCVPEKM 442 human
XP_005999823 348 QWNEPRNCARRYLKVDFADIGWSEWIISPKSFDAYYCSGSCQFPMPKSLKPSNHATIQSIVRAVGVVPGIPEPCCVPEKM 427 coelacanth
NP_001071233 343 QWNEPRNCARRYLKVDFADIGWSEWIISPKSFDAYYCSGSCQFPMPKSLKPSNHATIQSIVRAVGVVPGIPEPCCVPEKM 422 zebrafish
XP_007895156 351 QWIEPRNCTRRDLIVDFADIGWNEWIISPKSFDAYYCAGACQFPMPQSLRPSNHATIQSIVRAVGVVPGIPEPCCVPEEM 430 elephant shark

Feature 1                           ### #     #
2QCQ_A        81 SSLSILFFDENKNVVLKVYPNMTVESCACR 110 human
Q7T2X7       429 SSLSILFLDENKNVVLKVYPNMTVESCACR 458 African clawed frog
NP_001029991 433 SSLSILFFDENKNVVLKVYPNMTVESCACR 462 chicken
P12645       443 SSLSILFFDENKNVVLKVYPNMTVESCACR 472 human
XP_005999823 428 SSLSILFFDEDKNVVLKVYPNMTVQSCACR 457 coelacanth
NP_001071233 423 SSLSILFFDEDKNVVLKVYPNMTVDSCACR 452 zebrafish
XP_007895156 431 SPIVILFMDENEDVILKSYPNMKVESCACR 460 elephant shark

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