Conserved Protein Domain Family
HsdR

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COG4096: HsdR 
Type I site-specific restriction endonuclease, part of a restriction-modification system [Defense mechanisms]
Statistics
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PSSM-Id: 443272
Aligned: 233 rows
Threshold Bit Score: 589.119
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_025411318   1 MPLEAAAR-EEIDRALVASGWLVQDlaAM----Nlyag----pgvAVRevplAPGHGVADYLLYADCQAVGVVEAKRVGE 71  
WP_013148478   1 -MNEAETRaEHIDPALKAAGWGVVDgsYVkrehit-----lgrlqGGGk---RSKQEIADYVLVYKNHKLAVIEAKAWDK 71  
WP_015026043   1 -MNEAQTKhDLIEPALRAAGWGSVEgsRLrlefPitkg----rliGLNr---RATPLFADYILEYKNRRIGVVEAKKKHS 72  
WP_013459758   2 ALSESDTRsKLIDPRIKESEWNES---HIvreyFftdg----rklIGNk---RGKQYFVDYLLTYKNTNLAIIEAKAENK 71  
WP_014801741   1 -MNEAQTRaEIIDPQLVAAGWGVIPdsRIlreyHineg----kiqLGGg---RGKKLTADYVLVYRNLKMAVVEAKSDDL 72  
WP_015180109   1 -MNEAETRaELIDPALKAAGWGVIEgsRIrrevia-----pgrlvGNGk---RAKSDIADYVLVYHGEKLAVIEAKKRGL 71  
WP_062403150   1 -MNEAETRaEHIDPALAAAGWGQVDgsRIlrehNitag----rlqGAGk---RARADIADYVLVYRNTKLAVVEAKAWAK 72  
WP_063463505   5 GLNEAETRaELIDPALKEAGWGVMEasRVrrevit-----lgrlqGGGk---RARQDIADYVLIYRGQKLAVIEAKKRDL 76  
WP_096366524   1 -MNEAETRaELIDPALKEAGWGVVDgsRPrrevIiapg----rliGGGr---RGQRDIADYVLTYRGQNLAVIEAKKCGL 72  
WP_102995165   1 -MNEAQTRlDLIDPALKAAGWNVVPesKIkvevitigriigktarGENr---RKQPLACDYVLEYKGRRLAVIEAKARDK 76  
WP_025411318  72 TLTGVEIQSEKYGAGLPagipapvrpLPFLYQSTGVETRFTNRLDpvPrSREVFAFHRPETLAAWAT--------AEplw 143 
WP_013148478  72 HYTEGVAQAKTYAQKLN---------SRFAYATNGQRIYGIDMHT--GkEADVTHYPSPDELWNLTF--------AE--- 129 
WP_015026043  73 YYTDGVGQAKDYAERLD---------IRFTYATNGLQIYGIDLDE--GtEGDVSKYPTPDELWEMTYptpkedykVE--- 138 
WP_013459758  72 DPLDGLQQSINYAEKLR---------IDFVYTTNGHKIYEHSLKE--GnGRWIENYPTPTELFERKY--------GQ--- 129 
WP_014801741  73 EVGEGVAQAKLYAEKLA---------LDVAYAANGREIYGINMQS--GgEGLLTKFPSPDELWNKTF--------EE--- 130 
WP_015180109  72 PDTEGLGQAKKYAEKLQ---------TRFAYSTNGDRIYQVDMHT--GaEGYINQYPTPDQLWNTTF--------SQ--- 129 
WP_062403150  73 PLTEGVGQAKSYAAKLA---------IRRAFATNGQGIYSIDMHT--GaEGEVACYPTPDELWELAFge----seAQ--- 134 
WP_063463505  77 PVTEGLAQAKRYAERLQ---------TRFAYATNGDGIYRVDMGT--GtEGPVDAWPSPDALWVETF--------GEaa- 136 
WP_096366524  73 PVTEGLGQAKRYAERLQ---------ARYAFATNGEDIYRVDMHT--GtEGPVEAWPAPDDLWNATF--------AE--- 130 
WP_102995165  77 YYTSGLGQAKDYAEKLN---------TRFAYCTNGLLIYGVDTHE--GtEGDVAKFPTPAELWEMTYpkpkeaykIE--- 142 
WP_025411318 144 lplaggapdprserPAtlRARLTAMPg---vEPGGLWPAQLDTVRHLEASLAAGRPRALVQMATGSGKTIAAVASIYRLL 220 
WP_013148478 130 --------------QNawRDRFSEVPfedkgGTWGARYYQHNAVEAVLEAIANNQLRILLTLATGTGKTFIAFQLAWKLF 195 
WP_015026043 139 --------------IAdwKERLFAIPfedrgGTWQPRYYQQNAIAKVLEAISEKKDRLLLTLATGTGKTAIAFQIAWKLF 204 
WP_013459758 130 --------------PQtkQEAIITYPfh-ieGSMKPRFYQQIAVQKTIEAIADGKDRILLTLATGTGKTYISFQIVYRLF 194 
WP_014801741 131 --------------QNewRDRFNSVPfefvgGKKGARFYQEIAVNRTLEAIAQKKERILLTLATGTGKTFIAFQIAWKLF 196 
WP_015180109 130 --------------ANqwRDNFAAIPfedrsGTWEARYYQHNAIKHVLSAICQGQDRILLTMATGTGKTFIAFQLAWKLF 195 
WP_062403150 135 --------------AAawRKHFAAVPledkgGTWTGRYYQEAAINRVLESVAQGNDRVLLTLATGTGKTFIAFQLAWKLF 200 
WP_063463505 137 ------------gvQGtwRERFGAVPfedkgGFWQARYYQHNAINQALEAVAAGRDRILLTLATGTGKTAIAFQIAWKLF 204 
WP_096366524 131 --------------RKvwRERFGAVPfeargGAWEARYYQHNAINSALEAIADGRDRILLTLATGTGKTAIAFQIAWKLF 196 
WP_102995165 143 --------------IAnwKERFANVPyalfkGQYLPRYYQRNAVEKSLAAIAEKKDRILLTMATGTGKTATAFQLCWKLF 208 
WP_025411318 221 KFG-------------GAKRVLFLVDRANLGRQALKEFQSYRTpdDGrLFTELYNvqr-ltANrVDPVANVVIGTVQRLY 286 
WP_013148478 196 YSRwnlsre-ldqskqRRPRILFLADRNGLADQAYNAFSAF----AEdALVRIAPdei-skKGrVPKNGNIFFTIFQTFM 269 
WP_015026043 205 HAKwnlr-----rdgsRSPRILFLADRNILADQAFNSFNAF----DEdALVRISPkei-kkKGkVPKNGSVFFTIFQTFM 274 
WP_013459758 195 QSKwnrd------gsdRRPKVLFLADRNVLADQSMNTFNPL----Ek-DCVRINGkeikkrGGkVPTNANVFFAIYQSIA 263 
WP_014801741 197 KTRwnlk-----rdssRQPRILFLADRNILADQAFNDFSAF----PEdALVRINPkei-nkAGkVLTNGSVFFTIFQTFM 266 
WP_015180109 196 QSRwnls-----rqptRRPRILFLADRNILANQAYNSFSAF----PDdALVRIDPeai-kkRGrVPKNGSIFFTIFQTFM 265 
WP_062403150 201 HSRwnlkdwkdgtepsRRPRILFLADRNILADQAFTAFSPF----PEdAVVRIDPgdi-kkKGrVPKNGSVFFTIFQTFM 275 
WP_063463505 205 HARwsltar-asgtpgRQPRILFLADRNILANQAFNDFSAF----PEdALVRIDPeii-rkKGrVPKNGNVFFTIFQTFM 278 
WP_096366524 197 HARwslvar-esgetgRLPRILFLADRNILADQAFNAFSAF----PDdALVRIDPesi-rkKGrVPKNGSLFFTIFQTFM 270 
WP_102995165 209 HAKwnlk-----rdgsRSPRILFLADRNILADQAFNAFNDFDVi-DEnIKKRISPgei-rkTGrMPKNGSIFFTIFQTFM 281 
WP_025411318 287 SmlrgeptmaeeaDELdadtaldavaltgdagtggglaalrrdpipvAYNp---DLPVELFDVVFVDECHRSIY---TLW 360 
WP_013148478 270 Sg-----------TDAegn-------------------------papNFG----EYPPDFFDFIIIDECHRGGAndeGNW 309 
WP_015026043 275 Tn-----------ANQeedekdeeneeenys--iaaepaakyntddfNFG----QYPKDFFDLIIIDECHRGGSrdeSSW 337 
WP_013459758 264 En-----------KNRvievseed----------------geddvkgYYQ----QYPSNFFDLIIIDECHRGSAndeSSW 312 
WP_014801741 267 Tg-----------RGEdgk-------------------------papYFG----SYPPDFFDFIIIDECHRGGAqdeSNW 306 
WP_015180109 266 Tg-----------RDEagn-------------------------ptpKFS----DYPPDFFDFIIIDECHRGGAsdeSTW 305 
WP_062403150 276 Sg-----------PGdt-----------------------------pYFG----EYPPDFFDFIIIDECHRGGAndeGSW 311 
WP_063463505 279 Tg-----------RDAagh-------------------------papNFGanyeRFPADFFDFIIIDECHRGGAndeSHW 322 
WP_096366524 271 Sg-----------RDAegn-------------------------pqpSFG----DYPPDFFDFIVIDECHRGGAndeSTW 310 
WP_102995165 282 Tt-----------SLDeetiedteealsm-----aaeppqvyespsfNFG----QYPKDFFDFIIIDECHRGGAndeSSW 341 
WP_025411318 361 RQVVEYWD-AFLVGLTATPSK----LTYGFFdANVVQEYGHEHAVADGVNVDFDVYRIRTEITERGSA-VEagqivdrrd 434 
WP_013148478 310 RSILEYFSpAVQLGLTATPKRkdnvDTYAYF-GEPVYVYSLKEGINDGFLTPFKVKQIATTMDEYIYAlGDgv------v 382 
WP_015026043 338 RAIMEHFSpAVQLGLTATPKRdingDTYDYF-GEPVYTYKLKDGINDGFLTPFKVKEISTTIDEYVHT-SGd-------e 408 
WP_013459758 313 REILNHFKsAVHLGLTATPKRddngDTYKYF-GDPIYEYSLKDGINDGFLTPYKVKRIQTNIDEYRFD-PNdi------- 383 
WP_014801741 307 RGILEYFApAVQLGLTATPKRnnnvDTYKYF-GEPIYTYSLKEGINDGYLTPFKVKRIKTTLDDYFYT-SDde------v 378 
WP_015180109 306 RGILEYFSpAVQLGLTATPRRannaDTYTYF-GEPVYTYALKDGINDGFLTPFKVRQIETNLDEYIYS-SEde------l 377 
WP_062403150 312 RAILEYFSpAVQLGLTATPKRtinaDTYGYF-GDPVYTYSLKDGINDGFLTPFRVKQIVTTLDDYVYT-ADdm------v 383 
WP_063463505 323 RGILEYFQpAVQLGLTATPKRthnaDTYAYF-GEPVYIYSLKEGINDGFLTPFKVRQIATTLDDYVYA-PDdq------v 394 
WP_096366524 311 RGILEYFSpAVQLGLTATPRRdanaDTYDYF-GEPVYIYSLKDGINDGFLTPFKVRQIATTLDEYVYT-SDdq------v 382 
WP_102995165 342 RAILEYFSpAVQLGLTATPKRdvngDTYDYF-GEPIYTYALKEGINDGFLTPFRVKQVRTNYDEYTVT-SDdt------i 413 
WP_025411318 435 RETRRRrweqldEPLVYDAAALDRDVVAPDQIRTVVRAFrdrFLPevfpErTHVPKTLVFAKDDSHADDLVKILRDELSl 514 
WP_013148478 383 VQGEAE------PGRLYKESDFNRTIKIPAREQYRVKLF---MDL----I-NQREKTLVFCASQEHALEVRDYINQIKTs 448 
WP_015026043 409 VDGEIE------EGKTYSESDFNRIIAIKAREEYRVKLF---MDS----I-NQNQKTLVFCATQIHAATVRDLINQYATs 474 
WP_013459758 384 iTGEL-------ESQIVTLEQFEKQIVIPKRTELIAKTV---LEN----M-NPMDKTIVFCVNQQHASDMKIAIDKFKTi 448 
WP_014801741 379 LEGEVE------QGRLYTEPDFNRIIEIKAREEKRVQIF---LAD----A-NPKEKAIIFCATQDHAAAVRDIVNQLKKn 444 
WP_015180109 378 IEGAID------EGRTYTEGDFNRIIEISDRERYRVQLF---MEE----I-NQNQKTLVFCANQDHALAVRDLINQIKIs 443 
WP_062403150 384 LDGEVQ------QGKRYEEKDFNRSIEIKEREAYRVKLF---MDS----I-DQREKTIVFCATQQHALLVRDLINQIKTs 449 
WP_063463505 395 IEGEVE------SGRRYREDDFNRVIEIAERERYRVKLF---MDQ----I-DPREKTLVFCATQEHALAVRDLINQLKTr 460 
WP_096366524 383 VEGEIE------EGKRYIEDDFNRVIEIEAREKYRVKLF---LES----I-DPREKTLVFCATQEHALAVRDLVNQMKSn 448 
WP_102995165 414 ISGEAE------VGDTFTYKDYGRKIIIDEIERFRVKKF---LSE----I-NQNHKTLVFCATQIHAAAIRDIINQESDs 479 
WP_025411318 515 -GNDAVQKITYKTgtarivervpgpdgaevervtykssgVR-PEDLLQSFRn--SYHPRIAVTVDMIATGTDVKPLEVLW 590 
WP_013148478 449 kDPDYCVRVTAAD--------------------------GAlGDQYLKAFQdndNAIPTILTTSQKLSTGVDARNVRNIV 502 
WP_015026043 475 kSINYCHRVTADD--------------------------GQiGEQHLRDFQdneKSIPTILTTSQKLSTGVDAPEIRNIV 528 
WP_013459758 449 kDNNYCVRVTSDE--------------------------GDiGRNFLEMFQnndRDIPTILTSSKMLTTGVDAKNVRNVV 502 
WP_014801741 445 pDPLYCVRVTAND--------------------------GSiGDQYLKDFRdneKTIPTILTTSQKLSTGVDARNIRNIV 498 
WP_015180109 444 sNPNYCVRVTADD--------------------------GKlGEQHLSTFQdneKNIPTILTTSQKLSTGVDARNVRNIV 497 
WP_062403150 450 pAPDYCVRVTADD--------------------------GKlGEQHLSQFQdneKTLPTILTTSQKLSTGVDARNVRNIV 503 
WP_063463505 461 tDPHYCERVTAND--------------------------GKeGERFLKQFQdneKTIPTILTTSQKLSTGVDARNVRHIV 514 
WP_096366524 449 pDPHYCERVTAND--------------------------GAeGERWLRAFQdneKTIPTVLTTSQKLSTGVDARNVRHIV 502 
WP_102995165 480 rNIDYCQRVTAED--------------------------GSmGEQALKYFQdneRIIPTILTTSQKLSTGVDAPEIRNIV 533 
WP_025411318 591 FMRTVRSRTLFEQMKGRGVRVVSpddlravtpdaaAKTRYVIVDCVGVCEEPMADTr---PMDV---Qptvslerllqav 664 
WP_013148478 503 LMREVNSMIEFKQIIGRGTRLYD------------GKDYFTIYDFVKAHHHFADPEwdgePEPIeptEpggnvakpntv- 569 
WP_015026043 529 LMRPVNSMVEFKQIVGRGTRLFD------------GKDYFTVFDFVDAHHHFQDPEwdgdPLEPkrpTeggapgdcnics 596 
WP_013459758 503 LTAPIKSMTEFKQIIGRGTRVYE------------GKDFFTIIDFVGATNLFYDDRwdgiPEEVsggKgetsp------- 563 
WP_014801741 499 LLRPVRNMIEFKQIVGRGTRLFD------------GKDFFTIYDFVNASLNFLDPEwdgdPLEPeetEpkpapeate--- 563 
WP_015180109 498 LMRPINTMIEFKQIIGRGTRLFD------------GKDYFTIYDFVRAYEHFNDPEwdgePQEPvivTnrrerqsssttn 565 
WP_062403150 504 LMRPVNSMIEFKQIIGRGTRLYD------------GKDYFTIYDFVKAHHLFSDPEwdgePVEPeppTekplppswqpqd 571 
WP_063463505 515 LMRPVNSMIEFKQIIGRGTRLFD------------GKDYFTIHDFVKAYEHFSDPEwdgePLPPepcEqcghspcsctrp 582 
WP_096366524 503 LMRPVNSMIEFKQIIGRGTRLFE------------GKDYFTIHDFVKAYEHFEDEEwdgePLPPepcGrcgnspctcvvd 570 
WP_102995165 534 LLRPVNSMVEFKQIVGRGTRLFD------------GKDYFTVYDFVEAHQHFQDPSwdgeAEPPeppTgdggsrtckvcg 601 
WP_025411318 665 amgnvdpevastlasrlvrldarlgrDERASVaat--------tgGPTLRDLAHGIVdaldpdrqraaareaaaaapgar 736 
WP_013148478 570 ------------------------------------eqpkqpytpePKPEKILIKLSd---------------------- 591 
WP_015026043 597 etpcvcqk--------------------ppeeacpkcenipcvcetppRAMISVRLSd---------------------- 634 
WP_013459758 564 ---------------------tprppKEEDEDsntgggdntiivdPPIREKVTIDIr----------------------- 599 
WP_014801741 564 -----------------apqeappsdEEGek--------------rtRPRKIKIRLRd---------------------- 590 
WP_015180109 566 tnr-------------------------------ntdtnsnentetsrpQTIKIKLAd---------------------- 592 
WP_062403150 572 ----------------------------------ptdppkvsmpgeERPAKLVVKLAd---------------------- 595 
WP_063463505 583 ppqac-----gvcgerpcvcektppePCQvcger--------pclcEKRRKVKIRLAd---------------------- 627 
WP_096366524 571 pprpc-----pvcgqrpcvcekpppeACPvcgey--------pcvcDNRRKVKVKLAd---------------------- 615 
WP_102995165 602 vrpcqctv--------------------dppepcaecdnipciceqppQQIIKIKLSd---------------------- 639 
WP_025411318 737 vaepgwepgeaavaRARAALLRAALAPLAgdPQlrerlldlkrakeqtidtasadtllgaglspEARDRALGLTTSFEAF 816 
WP_013148478 592 -------------gKTRQIQHMMATSFWG--AD-------------------------------GKPMSSAQFLESLFGV 625 
WP_015026043 635 -------------nQVREIDSMVKTSFWS--PS-------------------------------GKPISSQEFITQLFGD 668 
WP_013459758 600 --------------gKKLKVINIETTYVG--ED-------------------------------GIPLKTEDYLELLIGV 632 
WP_014801741 591 -------------gKEREIQHMVSTSFWS--AD-------------------------------GKPLSVEEFLQNLYGK 624 
WP_015180109 593 -------------gKERTFQHRISTSFWS--PD-------------------------------GKPMSAAEFVERLFGE 626 
WP_062403150 596 -------------gKTRTIQHITSTSYWG--PD-------------------------------GKPLSPAQFLESLFGA 629 
WP_063463505 628 -------------gKERAIQHMTATSFWG--PD-------------------------------GKPISAAEFIQRLFGD 661 
WP_096366524 616 -------------gKERTIQHMAATSFWS--PD-------------------------------GKPISAAEFVQRLFGE 649 
WP_102995165 640 -------------gKAREIDATIRTTFWG--SD-------------------------------GKQIGMEEFMNQLFGD 673 
WP_025411318 817 LTEhrdELSALRLLYGSrgpgqarlTRAAVEELRRALldrqPPLAL--DAVWRAYETLdrsrvrggparlLTDVVALVRF 894 
WP_013148478 626 LPE---FFKDEDQLREIw------sNPETRIKLLEGL----SEKGFnkEVLAEMQRIVda---------eNSDLFDVLAH 683 
WP_015026043 669 LPS---FFNNEEQLRTLw------sVPSTRKKLLTEL----SEKGYtnSQLEDLRHLIhg---------eDSDLFDVLSY 726 
WP_013459758 633 LGK---FYNNEDGLREIw------sNPKNRKDLLNKL----KEMNIdeSQLDDLKQIFea---------qDSDIYDVLAH 690 
WP_014801741 625 LPE---LFKNEAELRSIw------sSPTTRRALLERL----ADAGYgkSELASLQALVqa---------eKSDLFDVLEY 682 
WP_015180109 627 IPQ---LFTNENELRAIw------sRPDTRKALLEGL----AEKGYaeEQLTEISRLIda---------eKSDLYDVLAY 684 
WP_062403150 630 LPE---FFKNEDELRTLw------aDPTTRKALLGGL----ADKGFgrDPLREMQRIIea---------eKSDLFDVLAY 687 
WP_063463505 662 LPE---LFKDEDELRRLw------gRPDTRKKLLEGL----EEKGYgrQELADMGKLIea---------eHSDLYDVLAY 719 
WP_096366524 650 LPE---LFRNEDELRELw------sDPETRRRLLAGL----EEKGYgiEQLREIGKLIea---------eNSDLYDVLAY 707 
WP_102995165 674 LPS---LFKNEDELREIw------sLPSTRKKLLEEL----SEKGYtsSQLDELRKLVhg---------eDSDLYDVLSF 731 
WP_025411318 895 ATHrDdaLAPLPSVARARLDT-WLarmeaggrR-FTDEQRVWLAMMVDHVAADVEIEAED---FDDPPFTqRGGLAGAHR 969 
WP_013148478 684 VAF-AlhPLSRADRAEVAKGK-VHe-------Y-FNDKQQAFLDFVLTQYVKQGVDELNQeklRGLLELKy-QSIHDATE 752 
WP_015026043 727 VAY-HkeLVPRLERASRAKIQ-Mn--------S-YNVKQQEFLNFVLDQYVREGVDELDDsklPDLLELKy-KAIADAKK 794 
WP_013459758 691 LSF-NmdIKSRNERVIAVENSdFVe-------KyHNEKAKQFIEFILDRYRKDGVKELDDdklGKLVDLSgLGTIREVAV 762 
WP_014801741 683 IAF-AikPITREARVNQARVK-MLq-------S-IDERQREFLDFVLAKYIESGVEELDDeklPNLLELKy-ESLSDATA 751 
WP_015180109 685 IAY-AspPISRRERVLAHKSL-IFs-------R-YIGKQQEFLDFVLEQYIKAGVGELDRtklPQLLELKy-HTVRDAVG 753 
WP_062403150 688 VAF-AlpTETRATRAERAKAH-NAv-------T-YGQKQQAFLAFVLDQYVTQGVDQLDAdklTPLLKLRy-NALNDAMA 756 
WP_063463505 720 IAF-NmaPVSRAERVDAHKAR-IFh-------G-HDYRQQEFLRFVLDHYVAQGVSELDTaklPQLIELKy-HSVGDAVR 788 
WP_096366524 708 IAF-AlpPVTRAERVALHRED-IFr-------P-YDFHQREFLDFVLNHYIERGVTELDTeklPQLITLKy-NTVDDAVY 776 
WP_102995165 732 VAY-SkdLMPRLDRAERAKIH-Fq--------D-YNPAQQEFLNFVLDQYVKVGVEELDDdklGDLLILKy-KGIADAKT 799 
WP_025411318 970 VFG--TELPRVLEEIGEVIA 987 
WP_013148478 753 TLGkaAEIRHIFMGFQKHLY 772 
WP_015026043 795 ELGdtKSIRDTFIGFQQHLY 814 
WP_013459758 763 NFGgiPQMGHEYLELQKEIY 782 
WP_014801741 752 ALGdvKAIRSTFIESQKYLY 771 
WP_015180109 754 ELGsvANISEVFVGFQQYLY 773 
WP_062403150 757 ELGdaVQVRQAFVGMQRYLY 776 
WP_063463505 789 ELGpvGNIRDVFVDFQQYLY 808 
WP_096366524 777 ELGevKNIREVFVGFQRNLY 796 
WP_102995165 800 HLGdiSTIRNTFIGFQEHLY 819 
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