4AN8,4H3T


Conserved Protein Domain Family
Cas8e

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COG5942: Cas8e 
CRISPR-Cas system type I-E effector complex large subunit Cas8e [Defense mechanisms]
CRISPR-Cas system type I-E effector complex large subunit Cas8e is part of the Pathway/BioSystem: CRISPR-Cas system
Statistics
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PSSM-Id: 444640
Aligned: 68 rows
Threshold Bit Score: 224.49
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4AN8_A        11 FNLIDEPWIPVL-KG------GRVVEVGIGEALLrAHEF-ARIETPSPLEEAVLHRLLLAVLHRA--------LsGPRCP 74 
NP_417240      1 MNLLIDNWIPVRpRNg-----GKVQIINLQSLYC-SRDQ-WRLSLPRDDMELAALALLVCIGQII--------A-PAKDD 64 
WP_012182159   5 FDLTDQPWIPVVaK-------SELELVGLRELFVrAAEF-DDLAVPVPPAASGLWRILYAITARVtgl--dmlR-GP--- 70 
WP_012851312   7 FDLALEPWAEVRwKEag---pDRPSRLGLRDLLVhAHEI-EALAITPPPALSAMYRLLYALTARVtgl-----deNPDGD 77 
WP_004159620   1 MNLLTDDWIPVRpLGg-----GACQQITLQTLLC-NGQR-WLVALPRDDMEMATFQLLICLLQTL--------W-MPSDA 64 
WP_005223765   1 MDLLQSPWIPVRdHHg----tGDFRLLTYRELLC-EPGA-WRLSLPRDDLELAALQLLVCLTQAL--------F-TPEDD 65 
WP_020933001   1 MNLLTAAWVPIQdK-------GLYEKITVQQLLC-GEKE-RDICLPRDDMELACLQLLSAITQTL--------F-TPENK 62 
WP_045531465   1 MNLLDDPWIPVRaDHg----aGAFQLLTYRALLCeTSEN-WQISLPRDDLELACLQLLVCMTQVM--------F-LPDND 66 
WP_093942734   7 FDLRIEPWIPVRwLPtapaelQQRAALGLCDLLTyAHQI-VGPAITVPPAESALWRVLYALTARItgldrksgG-TASGA 84 
WP_114594513  23 YNLTVERWIPVIgPD------G-PDTVGLAGLLDrAHRLdLDDAGHGPLWRHSMERLLIGIGHLIa------qA-APg-- 86 
4AN8_A        75 EDVLDWWRk----gGFPqDPIRDYLNRFRDRFFLFHPEAPFLQVADLPE-----EN------PLPWSKLLPELasGNNPT 139
NP_417240     65 VEFRHRIMn-----PLTeDEFQQLIAPWIDMFYLNHAEHPFMQTKGVKA-----ND------VTPMEKLLAGVsgATNCA 128
WP_012182159  71 -QWRQRQErlldqgGFAaGDVDAYFAKYSDRFDLFGALRPWMQDPRLAVe---cPK------SSGVNKLVFDRpaGNSQV 140
WP_012851312  78 GDWLDRRAeif-gePLApDAVDAYFAEHEGRFDLFHPQRPFLQDPRLADpa-vcPK------SAGVNKLVLGRpaGNNSV 149
WP_004159620  65 QQLIQRIRq-----PLSaGEFADGVAGWQQAFDLNHPQQPFMQVKGVAA-----KE------VTGMDKLLVGLtgSTSGA 128
WP_005223765  66 EALFEQLDq-----PLDpAAFEHAIAEVLDWFQLDHPTQPFMQTRGVSA-----KE------VTPIQKLLIGLpeGNNHA 129
WP_020933001  63 KSLGKYVTq-----PLTpEVYLAAIQDKLNWFDLDHPDTPFMQFRGVKS-----TS------ATPMNKLMAGVadGTNKT 126
WP_045531465  67 AALRQRLSa-----PLTpAEFDAAIAPCLDWFDLDHPTQPFMQARGVKA-----AE------PTPIQKLLIGLpeGNNHT 130
WP_093942734  85 GKWSTRRLeilehgNFDvEAISSYFDTEASSFRLYDPERPFLQDPRLAEq---cPA------TVGVDKLVVTRpsGGNHA 155
WP_114594513  87 hDWAAVANsg---lPLPaDGATSVLARLADRLWLHHPTSPFLQRLDVLShmddkPDkpivevTDPFWALLPDVpsKSNSA 163
4AN8_A       140 LFDHTteENLPKATYAQAARALLVHQAFAPGg--LLRRYg---------vGsakDAP-VARPAlflpTGQNLLETLLLNL 207
NP_417240    129 FVNQP--GQGEALCGGCTAIALFNQANQAPGfggGFKSGl---------rG---GTP-VTTFV----RGIDLRSTVLLNV 189
WP_012182159 141 WFGHHtdADAVALAPGEAAWYLIAQLYYGAS---GRCSSrevagqkfansN---AGP-LRGVMsyhpLGENLFESLVVGV 213
WP_012851312 150 WFGHHwdASPIPVPTPDAFLSLLVWLYYGPS---GRCSTrthadvtaadvS---AGP-LRGSLsyhpEGDTLLETLLAGL 222
WP_004159620 129 FVNQP--GQGKALCGGCTAIALFNQACNAPGfggGFKSGl---------rG---GSP-VTTLV----QGDCLRTTIWFNV 189
WP_005223765 130 FFNAP--GEVRALSAPIAAIALFHQASNCPSfggGFQGSl---------rG---GAP-ITVLV----DAADLRLQVWSNV 190
WP_020933001 127 FVNPQ--GLIEGLCHGCVAIALFNAANNCPSmggGFKGSl---------rG---STP-ITLLI----KGKTVRETIWLNV 187
WP_045531465 131 FFNEA--GEVRHLSGPVAAIALFNQASNCPSfggGFKGSl---------rG---GAP-ITTLV----FDRDLCHMVWRNV 191
WP_093942734 156 WFSRVdsTRRTPVSSAEAVLHLLVWRYYGAS---GICSSrqveqtkehnsT---AGP-LRAALsyhpLAPTLFQSLLAGL 228
WP_114594513 164 WFNRA--DPDAKTGPADAANALLVRHTWAVP---GNETKngvgkarseggS---AGQgANDLThltiGGPTVAATIARNL 235
4AN8_A       208 VPYTP------------EDDAPIWEv----PPLRLGDlegartkWp-lTGRTRVYTWPARGVRLLD-EGd---------- 259
NP_417240    190 LTLPRlqkqf--pneshTENQPTWI-----KPIKSNEsi----pAs-sIGFVRGLFWQPAHIELCD-PIgigkcsccgqe 256
WP_012182159 214 PPGVssg-------qdeGLDLCPWErdelpDPLGAPWs------V---SWPCGALTGRARHAVLLVpDAag--------- 268
WP_012851312 223 TPPPEgl--------rrADDPCPWEladlpDPLAPPRt------PnpyPGPCTRLTGGWQHALLLVpDDtg--------- 279
WP_004159620 190 LSETTldqfcp-gwreqRAQPFTWQ-----QPIKKEEvi----aGs-sIGLARGLFWQPAHIKLSP-PDgagqcsacgrs 257
WP_005223765 191 LTRPRlqrllpswqpdhARDRPTWV-----EPITAQSti----qWn-qIGVVRGLLWQPAHVELVA-TEpgpcdllg-id 258
WP_020933001 188 LTEETinqmmp-wyeatKDQVPNYL-----TPINKGGti----qSs-aIGLLRGLLWQPAHFELLP-ATseqqicsccgc 255
WP_045531465 192 LTRPRveerqi-avpglAQDQPTWV-----SPIAEKSam----hWn-qIGLMRGLFWQPARVELVK-VDgarscdvlgge 259
WP_093942734 229 AEPASdv--------dpQRDLCAWErrellDPLGPRPa------V---TGPCSALTDQTSHAVLLLpDAtg--------- 282
WP_114594513 236 IGDWv------------DRGQRLWFe----NPAGAVGvl----aAd-dPDPLWLYTATTASTVLIPmfggyrv-----vr 289
4AN8_A       260 ----gVRFMGYGPGVEPlEATHRDPMVAQRLDAK----GNLLVLRLSEERSFWRDFSAMLP-----R----QGGKV--Aa 320
NP_417240    257 snlryTGFLKEKFTFTV-NGLWPHPHSPCLVTVKkg-eVEEKFLAFTTSAPSWTQISRVVVd---kIiqneNGNRV--Aa 329
WP_012182159 269 ---eaVSDAYVTWAWRLpGAASPDPYVVRRQNKe----GGWYQLPADDSRALWRDVDALLG-----GntevKTHRP--D- 333
WP_012851312 280 ---rhVTDAYITWGHRGkLPSTNDAYVIFQISKq----GNLYARPADAGRALWRDLDGLLDlp--tTatgtQPRRP--A- 347
WP_004159620 258 asqryCSFLKEKFNFTV-NGLWLHPHSPLIQQIKkg-qVEWRYMAFSTPAPSWTQIGRLLIeq--qVnkqqEGRRV--At 331
WP_005223765 259 agpryLGFRKEKFKFTV-DGLWPHPHGAVETRAKag-kLEQRFTSFTTTAPAWTRLSELAIa---rQsakgEGARP--Pl 331
WP_020933001 256 neqvyTGFNKEKFSYTI-EGVWPHPLSSRIFTIKag-nKKEKFPSFTTRAPTWTHMSRLVVd---qQte-kgGQQA--Ap 327
WP_045531465 260 atagySGFHKEKFNFTV-EGVWPHPHGAMTMSLKkg-eLEQRFASFTTTAPAWTHLSEFVIprslnDkdakEGSTP--Ag 335
WP_093942734 283 ---rcVADAYVTWAFRTaRPPTEDAYLIWQTSVa----GNRYPRPAKSDRALWRDLDALLLv---tSptagAPRRP--E- 349
WP_114594513 290 spmpePPEVAKQLGTTLk---aNNPHTVRFTSVDgkttPTLRLPVPSCGSDLLRRYHSRLA-----------GGRPltPs 355
4AN8_A       321 TLEH-AENLQGeledegleGRIT---LRVLGQVSD----QAKVL--DIRREVYPLPSGLLTp---kAEENLEKALKMAEE 387
NP_417240    330 VVNQ-FRNIAPq-------SPLE---LIMGGYRNN----QASIL--ERRHDVLMFNQGWQQ-----YGNVINEIVTVGLG 387
WP_012182159 334 IMAV-AADLGLdg------------rVRAYGFDQDg---QAKDR--QWFIALTPPVLGWLSerdpvTADGVALLTRAAES 395
WP_012851312 348 VFGTgLDDL----------GSFK---VRALGFEQDg---KTKDI--QFISAVTPPLLFRINdedlaTARRIGDMRTAGEL 409
WP_004159620 332 TVGQ-ARMLSGg-------RALR---LMIGGYRNN----QASII--ERRHEVLQINHGWQH-----AMPVINEIVTLGLE 389
WP_005223765 332 TVTQ-FGALEEd-------APLR---LLVGGYRNK----QASVL--ERRHELITLGAGWNA-----VDTRLHQLVELGLR 389
WP_020933001 328 VIQQ-ARQFIAs-------EKMQ---LIVGGYRNN----QATIL--ERRHDLFSLKQGWTE-----HGEVIHRLIETGLS 385
WP_045531465 336 PISQ-FHATTId-------EPLN---ILVGGYRTN----QASVL--ERRHELIGLAPGWGMe------KRLFTLVGIGKD 392
WP_093942734 350 VFAS-AADVDEae------vTLR---VRALGFDQDa---QAKDR--QFVTGTTPPVFGMFEetspkRAGDAGFLREKGES 414
WP_114594513 356 VLDLrglhv-----rparrPMVRaliVIGAGQAAGarvgDVAVAasELADLTLPAPAAVr------FAELARIIFGPSPS 424
4AN8_A       388 LGQGLKHLAQEVAKAV-VG-----ERDrghgrspyleeltkLANSLPLERLYWHALDGAFPRFFARVEEe-------ASL 454
NP_417240    388 YKTALRKALYTFAEGFkNK-----DFKga-----------gVSVHETAERHFYRQSELLIPDVLANVNFsq----adEVI 447
WP_012182159 396 IGRRVGAALRQAWREL-VSv----KDRe-------------GPWAHTGEAYYWTRAEAVFWEHVRdgr-----------f 446
WP_012851312 410 YGGRLEYAVKRAWAAV-VDd----KPKd-------------CAWAEHAAAAYWPKAEEIFWTRLRnqd-----------y 460
WP_004159620 390 YRKVLRTALWIFAEGAkES-----GIKga-----------gVALHEKVDAPYYRQSQARVLNLLAQIDFqs----plPQL 449
WP_005223765 390 AKGALQNALRFAAQGKqKKgshhrELPgl----------gnPALPSIAEQRFYSRTEPMILDILADPATftd---wrNAR 456
WP_020933001 386 YKQCLINSLIAFKNGRkKSkq-yeEIKga-----------gINLVQNAEENYYQQTENLMQQGLAQVHFea----peDDL 449
WP_045531465 393 AKKALRGKLYFAVQGNkDK-----GLKgl-----------gATVHETAEKLFYARTESLIHQTFSSDATfke---wgEAR 453
WP_093942734 415 IGHRLDRATKTAWLSY-TGgr-rqDSKd-------------IAWSRDAAARYWPAAEDEFWRRLTagd------ltpATA 473
WP_114594513 425 VRSRTATAISTVRGADg------eDDR--------------KQIRASVEHDLTVAADAVVFRLLSACRRnadgdlpdRIP 484
4AN8_A       455 DLWREALRGAALEAWKATRRFLGTGARHLKALAQGEQEFGRLL 497
NP_417240    448 ADLRDKLHQLCEMLFNQSVAPYAHHPKLISTLALARATLYKHL 490
WP_012182159 447 aEGGRAFARLGHEAIDHAADGDASSPRLVRATQTAHRLLTTPL 489
WP_012851312 461 dRHWQSFRRVAISVFDQITRDHARGARTARAIEEARLELYGGa 503
WP_004159620 450 AQFQTQQRQLCLQLFNDLSAPYAHHPKLICSLAQARRYLTSSL 492
WP_005223765 457 LRYIDRLAQDCHPLFAQLTDPYAHNPALIPIIAWSRRILERDL 499
WP_020933001 450 DALQQQLKSIVKDLFNQATAPYRQEPKMLKALAMARRSLHKYL 492
WP_045531465 454 RHYAQQIADHCRAIFEELTDPYALKPELIPVIAWSRRALNIDL 496
WP_093942734 474 AEAVKAFRDIAERAYNEVTRSATVTRSGARAVETARIELYRGr 516
WP_114594513 485 VPDSRLLIDTALGCFDRHVAPLTHRPATAATAVVQRRRLVRHL 527
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