Conserved Protein Domain Family
YrbL-PhoP_reg
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pfam10707: YrbL-PhoP_reg 
PhoP regulatory network protein YrbL
This is a family of proteins that are activated by PhoP. PhoP protein controls the expression of a large number of genes that mediate adaptation to low Mg2+ environments and/or virulence in several bacterial species. YbrL is proposed to be acting in a loop activity with PhoP and PrmA analogous to the multicomponent loop in Salmonella where the PhoP-dependent PmrD protein activates the regulatory protein PmrA, and the activated PmrA then represses transcription from the PmrD promoter which harbours binding sites for both the PhoP and PmrA proteins. Expression of YrbL is induced in low Mg2+ in a PhoP-dependent fashion and repressed by Fe3+ in a PmrA-dependent manner.
Links
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Statistics
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PSSM-Id: 402374
Aligned: 9 rows
Threshold Bit Score: 233.36
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q2KYP8        24 IDLNDASLLAHGGDRYVFEHPNDSCLLIKVMDMQArgvylasrpfkrwykqfqRESAYRVYLNEFNEYVTSTT-RPSGIW 102 Bordetella aviu...
Q16BG7         8 IKLSDDHSIANGTVRIVYAFPGQPDLLIKVFHAFEerssrrpl--krlawrlfPMLKFRTILNELKCELLASLkLGADIE 85  Roseobacter den...
WP_012132942   4 LTLTENDLLARGNDRYVFQHPHNHQLLIKVVIPSI--------------------PKYKSKLREVYRDVKECK-PRDETD 62  Citrobacter
Q7VT79        49 VDLLGATLLATGSERDVYQHPGNAALLIKIVNRARinepgrrr---pwhkkfhREDAHRVFITELIEYISTTVqLRQADG 125 Bordetella pert...
Q7VWB8        13 LDLSQARLLAQGGDRYVFQHPHEPALLVKVMDMEAravylearpfkrwykqfqRESAYRVYLNEITEYVTTST-SASGVW 91  Bordetella pert...
WP_012135340   2 ILLSEQNPLGTGRHRKCYAHPGDAQRCIKIIYNAD-------------------RSGKKEIRRELKYYAHLS---RYLQD 59  Citrobacter
Q7CPN6         2 ILLSKQTPLGAGRHRKCYTHPDNARRCIKVIYNRD-------------------HGGDKEIRRELSYYAHLS---RYLTD 59  Salmonella ente...
WP_012147768   2 IELREELLLGDGGERLVFIHPNDSKKVIKVLQPQI-------------------KKHNFQNELEFKYYNFLT---KKNVD 59  Aliarcobacter b...
WP_012147761   2 IILKDEDFVGKGNERACYIHPEDKNKAIKITYENN------------------NRKESKQTKLEVNYYKELEK--RRMIN 61  Aliarcobacter b...

Q2KYP8       103 QVPLARVMGVAQTNLGLGLLVEKIRDKNGNMAPSLKDLI---KQGLYTQ-DIARQMDQLFEDLADAHVVAH-DISAGNVV 177 Bordetella aviu...
Q16BG7        86 NMPISRMLGIVQTDRGVGVVVERIDGLDGDLAQRLNRLC---RRGRMDE-PVLEALNVFVGRMFDLHIVAR-DINFSNIV 160 Roseobacter den...
WP_012132942  63 SLFIQKIEGLVETDKGIGQVIVKEHDQQGNIARTLYDLA---KHNELDA-EKFSKLNAFLAWFIHTDVIIN-SLHCKNIV 137 Citrobacter
Q7VT79       126 NTLLARIAGLALTSAGLGLVVEKIVDAEGKAAPTLAQVV---STQGFGP-QLREQLRAFFLALIEAHVIFN-DVSARNIV 200 Bordetella pert...
Q7VWB8        92 QVPLARIVGLAQTSLGLGLLAEKITDAAGNMAPTVSDLV---KRGEFDT-ALAQRLDRFFEDLADAHIVIH-DISASNIA 166 Bordetella pert...
WP_012135340  60 WSGIPRYHGTVETDCGTGYVYDVITDFDGKPSVTLTEFVaqcRNDEDAA-VLRQLLKTLKRYIYDNRIVTM-TLKPQNIL 137 Citrobacter
Q7CPN6        60 WSAIPRYYGTVETDCGTGYVYDMITDFNGAPSITLTEFAaqcRYEEDVA-VLRRLLKKLKRYLLDNHIVTM-SLKPQNIL 137 Salmonella ente...
WP_012147768  60 FSHITKCFGYVDTNFGKGLVFERVVDFDGEDSKFLRNCL---QENIFTKdQEKRLLDDLKKYLEDNEILFI-DCSSHNVF 135 Aliarcobacter b...
WP_012147761  62 FKHLPKYFGEVKTDKGAGFVVELIRDFDGEVSKTFEYYL---KKDGVLK--YKKELEEYKQYFLDNCIIFNyGMMPKNIL 136 Aliarcobacter b...

Q2KYP8       178 MGYNAEGRh-GLFLVDGFGVQPL---IPAYAWSRRLNRRRLLKKYRNMRAKLP 226 Bordetella avium 197N
Q16BG7       161 YGTRGAGA--ACFLIDGYGERNL---IPFRSMSRRMNDRSLDRQFATIARKTG 208 Roseobacter denitrificans OCh 114
WP_012132942 138 YAWDDARQeyRFKVIDGFGDKTL---FQLSKFWSVIRDKNKLKCLRRMLRDLQ 187 Citrobacter
Q7VT79       201 VGRNATGQd-GLFLVDGFGPKQL---LPLYAWSKTLNRRRLLRKYEDMVRKLa 249 Bordetella pertussis
Q7VWB8       167 CGRNAEGRe-GLYLIDGFGVLPL---IPTYAWSRRLNRKRIMRKYAELRARMp 215 Bordetella pertussis
WP_012135340 138 CHRISESEa-IPVICDNIGESTL---IPLASWSAWFCHRKQERQWERLIAQPG 186 Citrobacter
Q7CPN6       138 CQRISESEv-VPVVCDNLGESTF---IPLATWSTWCCERKLERVWQRFIAQPa 186 Salmonella enterica subsp. enterica serova...
WP_012147768 136 CKKVSADKy-TLIIYDGLGARRDnikLTLYMKSRFYTRYKIKKQWKLFMKNCE 187 Aliarcobacter butzleri
WP_012147761 137 LRKNSETDf-DLVLIDGLGDVSY---FTLPNKIPYFARKRINRRWDKFIKKYL 185 Aliarcobacter butzleri
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