Conserved Protein Domain Family
EFh_HEF_CBN

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cd16179: EFh_HEF_CBN 
EF-hand, calcium binding motif, found in Drosophila melanogaster calbindin-32 (CBN) and similar proteins
CBN, the product of the cbn gene, is a Drosophila homolog to vertebrate neuronal six EF-hand calcium binding proteins. It is expressed through most of ontogenesis with a selective distribution in the nervous system and in a few small adult thoracic muscles. Its precise biological role remains unclear. CBN contains six EF-hand motifs, but some of them may not bind calcium ions due to the lack of key residues.
Statistics
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PSSM-Id: 320079
Aligned: 8 rows
Threshold Bit Score: 409.877
Created: 11-Feb-2015
Updated: 2-Oct-2020
Structure
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Aligned Rows:
  next features
Feature 1:putative Ca binding site [ion binding site]
Evidence:
  • Comment:Drosophila melanogaster calbindin-32 contains six EF-hand motifs, but some of them may not bind calcium ions due to the lack of key residues.
  • Citation:PMID 8478695

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                # # #      #                                       # # #      #         
P41044        40 FMDVWAHYDKDGNGYIEGTELDGFLREFVssanatdisp-eavtdtmleeLKSCFMEAYDDNQDGKIDIRELAQLLPMEE 118 fruit fly
XP_009027798 223 FMEVWNHYDTDGNGYIEDHELDGFLREFVlssvsendnrpeilsdaamslFKETFMDAFDENQDGMIDISELAEILPTDE 302 Helobdella robusta
KGB36789      19 FVEVWNHYDTDGNGYIEGSELDNFLREFIysvfseelgn-etipsdelelMKKEFMEAFDENSDNRIELTEMAKILPTEE 97  Schistosoma hae...
XP_009067059  32 FNDVWTHYDQDGNGYIEGTELDNFLYELVtsvntldvgp-evvsqtaledAKALVMNAFDENQDGRIDIAELAQLLPMEE 110 owl limpet
EFX89968      49 FMDVWSHYDKDANGYIEGTELDGFLAEFVssvnimdvgp-evvsdamlaeLKQCFMEAYDDNQDGKIDIRELAQLLPMEE 127 common water flea
XP_003745759  41 FMEVWSHYDHDGNGYIEGRELDDFLREFVssvsltdvgp-evvsesmleeLRECFMEAYDDNKDGKIEIRELAQLLPLEE 119 western predato...
CCD82926      33 FLKCWQHYDTDGNGYLEGEELNGFLREFItsvipdeigs-eiisetamqqLMTEVMDAYDENNDGRIDINELCQILPTEE 111 Schistosoma man...
CCD80099      52 FGDVWNHFDQDGNGFIDGEELEMFMGKLVeciipkharn--qlseddtreLVNELLKVIDTNNDNRIDIRELAQLLPTDE 129 Schistosoma man...
Feature 1                                 # # #      #                                   # # #   
P41044       119 nflllfrfdnplessvEFMKIWREYDTDNSGYIEADELKNFLRDLLkeakkind-vsedklieYTDTMLQVFDANKDGRL 197 fruit fly
XP_009027798 303 nflllfhlknplqssvEFMKIWRLYDKDCLGFIESKQLKSFLKHILdnqkttv---sedklneYTETILNLFDSNRDGKL 379 Helobdella robusta
KGB36789      98 nfillfhrdnpldssvEFMRVWKRFDKDRSGYIEADELKSFLLHLLkeakpetn-ieegklieYTSSILQLFDQNKDGKL 176 Schistosoma hae...
XP_009067059 111 nflllfrrdnpldssvEFMKVWRQYDKDNSGYIEADELKLFLKDLLknckkdid-vseeklieYADTMLQLFDRNKDAKL 189 owl limpet
EFX89968     128 nflllfrfdnpldssvEFMKIWREYDSDGSGFIEADELKNFLRDLLteaqrdke-vtedklieYTDTMLQVFDANRDGKL 206 common water flea
XP_003745759 120 gflllfrfdnpldssvEFMKIWRDYDTDGSGYIEADELKNFLKDLLreakrdni--eedklieYTDTLLQIFDSNKDGKL 197 western predato...
CCD82926     112 tflalfqidtplsssvEFMRVWKQFDTDLSGSIDSNELKQFLKHLIviskvel---sdeklneYAETLIRLFDRNGDGKL 188 Schistosoma man...
CCD80099     130 eflilfqrenklnssvDFMKVWREFDKDHSGFIEADELKDFLTELLsfgvrkddekfdekiieYTDTILKLFDHNRDGKL 209 Schistosoma man...
Feature 1           #                                    # # #      #                            
P41044       198 QLSEMAKLLPVKEnflcrqvfk-gatkltkeDIEKVFSLYDRDNSGTIENEELKGFLKDLLelvkkddydaqdlaaFEET 276 fruit fly
XP_009027798 380 QLSEMARLMPVKQnflskpilk-gagcltrrDIDKLFRIYDQNRNGTIEDEELTGLLKDIMdlgqkdy-tlddinkMKKI 457 Helobdella robusta
KGB36789     177 QLSEMARLLPVKEnylcrpifk-naskitsaDIDRAFSLYDLDANGTIEDEELSGFLKDLLelaqedy-deadlefFKKV 254 Schistosoma hae...
XP_009067059 190 QLSEMAKLLPVKEnflcrpvfk-sgkqltyeDINRVFKLYDRDNNNMIENEELTGFLKDLMelvqedy-daedmeeFKEI 267 owl limpet
EFX89968     207 QLSEMSKLLPVREnflcrqvfk-gptvlskdDIERVFALYDRDNNGTIENEELRGFLKDLLelvkkdy-daqdlldFEET 284 common water flea
XP_003745759 198 QLSEMAKLLPVKEnflcrsafk-gaskltreDIERVFALYDRDKNGTIENEELKGFLKDLLelvkkdy-daqdleeFQES 275 western predato...
CCD82926     189 QLSEMARLLKVKEnylikplfnnnnhclddrTIDRIFRKYDTDNNGVLENEELMGFLKDLLeangeev-neeglkiMKEG 267 Schistosoma man...
CCD80099     210 QLSEMSRLIPVEEnflcrpifk-hagkitaaDVDRVFALYDTDKNGAIEDLELYGFLKDLLelveedf-desdldyTRSM 287 Schistosoma man...
Feature 1                                 
P41044       277 IMRGVGTDKHGKISRKELTMILLTL 301 fruit fly
XP_009027798 458 IMDHWDQDHDGTISKSELRMFLIQQ 482 Helobdella robusta
KGB36789     255 ILNQWDVNNDGKINRDELKMMLMQQ 279 Schistosoma haematobium
XP_009067059 268 LLKKCDLNHDGKIDRDELSMVLMSF 292 owl limpet
EFX89968     285 ILRGCDFNRDGKISKKELTMILLAL 309 common water flea
XP_003745759 276 ILRGCDFNKDGKISKKELTMVLLAL 300 western predatory mite
CCD82926     268 ILKQWDINNDGKIGRQEINDLILQT 292 Schistosoma mansoni
CCD80099     288 ILQNWDFNNDGKISLEEMRMLLLAY 312 Schistosoma mansoni

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