Conserved Protein Domain Family
dcm
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TIGR00675: dcm 
DNA-methyltransferase (dcm)
All proteins in this family for which functions are known are DNA-cytosine methyltransferases. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Links
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Statistics
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PSSM-Id: 273211
Aligned: 15 rows
Threshold Bit Score: 335.45
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q59605     6 FIDLFSGMSGIRKGFEQAcrkq-----svaCECVFTSEIKPAALEVLKQNYPD--EVPYGDITKIETGD------IPDFD 72  Neisseria gonorrhoeae
BAA11167  74 MIDLFAGIGGTRLGFHQTn----------aVNVVFSSEWDKFAQKTYHANYG---DFPDGDITKIDEKD------IPDHE 134 Salmonella enterica...
P43420     4 IASLFAGVGGIDLGFEQTg----------yFETVWANEYDKNAAITYQSNFKN--KLIIDDIRNIKVED------VPDFD 65  Bacillus sp. RFL6
CAA73243   4 IASFFAGVGGIDLGFENAg-----------FKTIYANEFDNYAADTFEMNFDV--KVDRRDINDVQADE------IPDFD 64  Lactococcus lactis ...
P00476     6 VMSLFSGIGAFEAALRNIgv---------gYELVGFSEIDKYAVKSFCAIHNVdeQLNFGDVSKIDKKK------LPEFD 70  Bacillus phage SPR
P50192    47 YIDLFSGAGGFSLGFDRAg-----------FHQLLSVEIEPHYCDTYRANFPDh-QVLQQDLTTLSDDNllrhinHRKVD 114 Haemophilus parahae...
P11408   107 FIDLFSGIGGIRQSFEVNg-----------GKCVFSSEIDPFAKFTYYTNFG---VVPFGDITKVEATT------IPQHD 166 Moraxella sp.
AAB84141  12 VASLFCGCGGMDVGIQGDfkflkkhydtlpFKVVYAVDNDAYATKIYNDNFAH--KCETKDVRDIVPSE------VPDHD 83  Flavobacterium aqua...
P29567     5 IASFFSGAGGLDLGFTKAg-----------FNIVFANDNWKGCWKTFEKNHGi--KINKKPIEWLKPSE------IPDVV 65  Methanothermobacter...
CAA68841  79 LVELFAGAGGLALGLEQAg-----------FKSVLLNEKDKYACATLRANRPNw-NVIEDDIENVDFTHl-----NGKVD 141 Psychrobacter sp.

Q59605    73 ILLAGFPCQAFSFAGKRL---GFE--DTRGTLFFDVARILKAKKPKGFILENVEGLVTHDRkdstqkiGRTLTVILETLE 147 Neisseria gonorrhoeae
BAA11167 135 ILVGGFPCVAFSQAGLKK---GFN--DTRGTLFFDIARIIKEKKPHAFLLENVKNLLGHDK-------GRTFSIIKNTLE 202 Salmonella enterica...
P43420    66 VLLSGFPCTSFSVAGYRK---GFEdeKS-GDLFFETLRLIVAKKPQVIFLENVKNLVGHDN-------GNTFKVIYEALE 134 Bacillus sp. RFL6
CAA73243  65 IMLAGFPCQAFSIAGYRQ---GFNdeQGRGNLFFELVRILETKKPRVAFFENVKNLVSHDS-------GNTFRVICSELE 134 Lactococcus lactis ...
P00476    71 LLVGGSPCQSFSVAGHRK---GFE--DTRGTLFFQYVETLKEKQPKFFVFENVKGLINHDK-------GNTLNVMAEAFS 138 Bacillus phage SPR
P50192   115 VVIGGPPCQGFSMAGKIGr--TFAd-DPRNHLFKEFVRVVKLTQPKFFVMENVARLFTHNS-------GKTRAEITEQFE 184 Haemophilus parahae...
P11408   167 ILCAGFPCQPFSHIGKRE---GFEh-PTQGTMFHEIVRIIETKKTPVLFLENVPGLINHDD-------GNTLKVIIETLE 235 Moraxella sp.
AAB84141  84 ILLGGFPCQSFSISAQNPprlGYK--DDRGKLFFEMIKVLKEKKPRFFIGENVKGLLSANK-------GQAFPMIIKEFE 154 Flavobacterium aqua...
P29567    66 GFIGGPPCQSWSLAGSMC---GAD--DPRGKTFYAYVDLVKEKDPLFFLAENVPGIVSRTH-------LPEFKRLVNSFI 133 Methanothermobacter...
CAA68841 142 LLTGGFPCQPFSYAGKQL---GFE--DLRGTLVFEMARAIKEIKPKVFLAENVKGLAENDG-------GRTLSIIIKVLE 209 Psychrobacter sp.

Q59605   148 ALGYYVSWK-VLNAKEFg-IPQNRKRIYLTGSLkskpdlsfetspspklknilesglptessPFIKKLLKKF-PPSElyg 224 Neisseria gonorrhoeae
BAA11167 203 ELNYTVYYN-IFAAKDFg-VPQNRERIYIVGFNk---------------------------eKVRNHEHFTFpTP----- 248 Salmonella enterica...
P43420   135 SNGYHIKYQ-VLNAKDFgnIPQNRERIYIVGFR-----------------------------NIEHYKNFNFpMP----- 179 Bacillus sp. RFL6
CAA73243 135 RLGYKYLFQ-VFNASEYgnIPQNRERIYIVAFK-----------------------------NKKDYANFELpKS----- 179 Lactococcus lactis ...
P00476   139 EVGYRIDLE-LLNSKFFn-VPQNRERLYIIGIRedlikneewsldf---krkdilqkgkqrlVELDIKSFNFrWTAQ--- 210 Bacillus phage SPR
P50192   185 RLGYKVKCK-VLNAADFg-VPQLRSRIVFIGRK------------------------------DGGEITFPEpSHTEy-- 230 Haemophilus parahae...
P11408   236 DMGYKVHHT-VLDASHFg-IPQKRKRFYLVAF-------------------------------LNQNIHFEFpKP----- 277 Moraxella sp.
AAB84141 155 KAGYHINYK-LLNSSEFg-VPQKRERVFIVGFR-----------------------------DFDDYLNFKFpQPITl-- 201 Flavobacterium aqua...
P29567   134 DIGYNVEYK-VLNAKDYg-VPQDRKRVFIVGYR------------------------------EDLNLKFEFpKPLN--- 178 Methanothermobacter...
CAA68841 210 DLGYKILEKeVYKAIFYk-VPQKRERLIIIGVRt----------------------------DLYDKLAYEKpSPYYkvl 260 Psychrobacter sp.

Q59605   225 kSVKDKRGGKNNIHSWdiELKGAVTEEEKQLLNILLKERRKKnglqkigidwmdgmpLTKAQISt-----------FYKH 293 Neisseria gonorrhoeae
BAA11167 249 -LKTKTRVGDILEKSV--DNKYTLSDALWNGHQRRKLVNAAA---------------GKGFGYG------------LFNE 298 Salmonella enterica...
P43420   180 -QPLTLTIKDMINLSDklDDRFYYTEDKCSFYSPLQEQMTSD---------------ETIYQWRr-----------KYVR 232 Bacillus sp. RFL6
CAA73243 180 -IPLKTTIHDVIDFSKkqDDKFYYTSEKNKFFDELKENMTNH---------------DTTYQWRr-----------VYVR 232 Lactococcus lactis ...
P00476   211 -SAATKRLKDLLEEYV--DEKYYLNEDKTNSLIKELSTSRln-------------enLTVEQVGninpsgngmngnVYNS 274 Bacillus phage SPR
P50192   231 -NTVGDAIGHFPKLNAg-eNSLILNHEAMNHSTQMLEKMSFVk-------------nGGDRNDIp----------eSLRP 285 Haemophilus parahae...
P11408   278 -PMISKDIGEVLESDV---TGYSISEHLQKSYLFKKDDGKPS---------------LIDKNTTg----------aVKTL 328 Moraxella sp.
AAB84141 202 -EGSKIVLKEVIDKKAdtEEKWFFSQKAVDGMLRVREKMNK----------------GRVQDLN-------------QPC 251 Flavobacterium aqua...
P29567   179 ---KKVTLRDAIGDLP--EPKPALEKNRSNGENLEVPNHEYMt-------------gTFSSRYMs-----------RNRV 229 Methanothermobacter...
CAA68841 261 tVADALKAGELYDVDVpeSTGQLYPERKAEIMSYVPEGGYWRdlp---------iriAKEYMMKs-----------FYLG 320 Psychrobacter sp.

Q59605   294 PDLQNILDSLTD---KGYlvlehpkqkiggqr--ikdeslpkgynivSGKKSFEINkildpndv---------------- 352 Neisseria gonorrhoeae
BAA11167 299 NSP--YTNTISA---RYY-----------------------------KDGSEILIEq----------------------- 321 Salmonella enterica...
P43420   233 ENKSNVCPTLTA---NMG-----------------------------TGGHNVPLVk----------------------- 257 Bacillus sp. RFL6
CAA73243 233 ENKSNLVPTLTA---NMG-----------------------------TGGHNVPIIl----------------------- 257 Lactococcus lactis ...
P00476   275 SGLSPTITTNKGeglKIAveysrksglgrelavshtlsasdwrglnrNQ-KQNAVVevrpvltpergekrqngrrfkddg 353 Bacillus phage SPR
P50192   286 ISGDVRKYIRYHs---------------------------------dKPSVCVTGD------------------------ 308 Haemophilus parahae...
P11408   329 VSTYHKIQRLTGtf--------------------------------vKDGET---------------------------- 348 Moraxella sp.
AAB84141 252 NTISSHLAKVSL-----------------------------------NGTDPVLMV------------------------ 272 Flavobacterium aqua...
P29567   230 RSWDEVSFTIQAg--GRHapc------------------------hpQANKMIKVG------------------------ 259 Methanothermobacter...
CAA68841 321 GGKTGMARRLSWd----------------------------------EPSLTLVCT------------------------ 342 Psychrobacter sp.

Q59605   353 --aptlfamdMEHLFV--VDNGGLRTLTGKEGLRLFGYPDD-YPFD----IPKKDRCDLLGNTVAVPVIKAVSERL 419 Neisseria gonorrhoeae
BAA11167 322 -------------------KGSNPRKITPREASRLQGFPSD-FIIP----VSDTQAYKQFGNSVAVPVINAIAEKI 373 Salmonella enterica sub...
P43420   258 ------------------tKHG-IRKLTPRECFNFQGYPED-FILPe---LAPTHLYKQAGNSVVVPVIRRIAENI 310 Bacillus sp. RFL6
CAA73243 258 ------------------tYSGDIRKLTPRECFNVQGFPKE-YKLPn---QSNGRLYKQAGNSVVVPVIERIAKNL 311 Lactococcus lactis subs...
P00476   354 epaftvntidRHGVAVgeYPKYRIRRLTPLECFRLQAFDDEdFEKAfaagISNSQLYKQTGNSITVTVLESIFKEL 429 Bacillus phage SPR
P50192   309 --------------MRkvFHYEQNRALTVRELAALQSFPDD-FVFLg----KKIAQQQQVGNAVPPLLAQAIAEAV 365 Haemophilus parahaemoly...
P11408   349 ----------------------GIRLLTTNECKAIMGFPKD-FVIP----VSRTQMYRQMGNSVVVPVVTKIAEQI 397 Moraxella sp.
AAB84141 273 --------------------NERYRRLTPREAANIQSFPQS-FKLDs---VSENRQYKAIGNAVPPVLMWNVANAL 324 Flavobacterium aquatile
P29567   260 ----------PDKFIFdpESPKPYRRLSVRECARIQGFPDD-FIFYy---KNVADGYTMVGNAVPVKLAEELAKKI 321 Methanothermobacter the...
CAA68841 343 ----------PAQKQTerCHPSESRPLTTREYARIQTFPDD-WEFKg----SVGQIYKQIGNAVPVNLALAIGKAI 403 Psychrobacter sp.
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