4ES6,3RE1,3D8N


Conserved Protein Domain Family
HemD

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COG1587: HemD 
Uroporphyrinogen-III synthase [Coenzyme transport and metabolism]
Uroporphyrinogen-III synthase is part of the Pathway/BioSystem: Heme biosynthesis
Statistics
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PSSM-Id: 441195
Aligned: 924 rows
Threshold Bit Score: 41.8115
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4ES6_A         4 MSG--W-RLLLTRPDEECAALAASLGEAGVHSSSLPLLAIDPLE-ETPEQRTLMLD-L---DRYCAVVVVSKPAARLGLE 75 
WP_069125415   1 --M--A-RIIVTRMPHQAATLCQLINETGHEAVLFPVLKIEPLN-QAE-ITKKLRA-L---TAADFVVFTSQNTVHRVLE 69 
WP_013505754  61 lgktdgpIVINTRPVSQSFTFTRRLLEEGFRVLVAPASRTAPLS-AEHQLPAALQc-L---GNYSHILLTSREGVEHLAR 135
WP_009887202   1 MDTs-K-YIITTRPGIKFKP----VKTQCIDILNIPLTSIQARNfDEN-IGK---E-Li-qAKPGVIVLTSSFGAMEFFK 68 
WP_011177051   1 MTMdtR-FIVTTRPAEKYNE----IKGSCFDVINIPVTRIV----D-------LEPpVid-yKPDVIILTSEHGADLFFK 63 
WP_010900998   1 --Mk-I-FVLSIRPEEKAQR----TGGACFDILNVPVTRLEPIPvD-------YTD-Li-rSGVDCVAFTSSYGVRLFFK 63 
WP_021790110   1 -----M-VIISFRPEEKFKD----VEIRGKDVLNIPLVRILK-------LD-NVKSpDl--EMFDGIAFTSSTGVRYFFS 60 
WP_083817357 287 aplagR-RLLCARARPGRSAIAAELRALGAEVLEIPEVVAEPLy-GEPTMDAALAR-V---HEFHGMIFGCAAGVDAVIP 360
WP_013336114   1 -----MiRVLILRASGKIRP----IHLNGADIIQVPVIDVVPNE-D--AIDR-VS--L---NGVNYVIIMSTTVVKYVSE 62 
WP_010916891   1 MTLr-K-FIISLRPAEKFVK----FDSPCFDLINIPVTRLMPLDiN-------IEK-IlkeSAADCIVFTSTFGVDLFFS 66 
4ES6_A        76 RLDRYWPQP-PQQTWCSVGAATAAILEAYGLDVTY-PEQGdDSEALLAL--PAfqdslR--V-HDPKVLIMRGEGGREFL 148
WP_069125415  70 NGPNRQf------KAISIGPATSQALESYGLKPVI-EAADfISSGLFEV--IAqq-----lK-DTDrIWLPQSARATNEL 134
WP_013505754 136 MLAMANMDaaSAPPVLAIGQGTRQACEARNLRVEY-VADTsEAAAFARE--LC-----QhyKpSNSRFLLARGAGGREIL 207
WP_009887202  69 NYYK----FtVNPDFVAIGEKTAGIIRKYAGNVK--VPTvkDSYGVLDL--LS-----G--Y-ENTDIALFRSNESNNII 132
WP_011177051  64 YYN-----L-KGI-FMAIGRKTGDEIKRHGINP-L-IPKDeSSYGLINL--LD-----K--Y-KDKRIAMFRSMKSNNII 124
WP_010900998  64 NAP-----V-KNFRYFGIGKSTCEEVRKYGYDCEY--PEKmDSEGLADM--II-----Sh-C-SGRKVALIRSANANEIV 126
WP_021790110  61 IYS--GidE-KIM-IFSIGDSTARELRKYVNKPLV--CSDsYSGGFASF--I------Ad-Y-KPKRVLIPRGMTHSSVL 124
WP_083817357 361 RIP-----Vf-TVPVIAVGVEAAQALSRHGIEPVArV-RGaCEEALREHarL---------L-KDQGFLLVTSEAGRPNL 423
WP_013336114  63 KLRQ----LsNDVKVIGVGPQTCSEVEKLNVTC-I-MPREfSSYGIIDM--MR-----D--L-PRGKVVVLRSLRGNDYI 126
WP_010916891  67 RVN-----M-KGFTILGIGKATCERVQAYGHKCLY--PENmDSEGLANL--II-----Sk-C-KDKKILILRSKKANEVL 129
4ES6_A       149 AERLRGQGVQVDYLPLYRRRAPDYPAGE-LLA-RVR---AER-LNGLVVSSGQGLQNLYQLA---AADWPEIGRLPLFVP 219
WP_069125415 135 AEKL-ATVCEVEHTSAYTVV------EA-KRE-PFQ---FKA-DDTVVFTSPSAVIAFINLLt--AEEHQLLSQLTLLSI 199
WP_013505754 208 PDTLRHHGFAVEELHLYHSEGIAH-PGE-FLQrTV----DRK-PDFVVFTSSFAAGYFLDRVr--DSG--ILwQVPIITI 276
WP_009887202 133 RESLTRRGVKYHEYHVYDVIQLEN--TG-LKD-SFL---SSS-CNGILVTSSMEARIFRETIg--T----YTGGKKIYSI 198
WP_011177051 125 RDYLIKNHFDFKEYFLYDIVPVN---SD-ICN-YIN---DDK-CMGVVITSSMEAEIIVSMCh--G-----IKN--AFAI 186
WP_010900998 127 NEKIMGH-VDFIDLRNYRAVNTN---VD-LTP-YMA---KEEcM-GIIVTSSMEAKIAMPAIk--A------TGKPVYSI 188
WP_021790110 125 NEDLRKAGIYSENFYLYKY---EN--ID-QRD-NIAravKNK-QIALIFTSPLEVKLFNQYTggrY------LDNPAYPI 190
WP_083817357 424 RAELARIGATIEALAAYRYS-------H-RMP-LMPl---PP-IDLVVLPSSSAARAVLSg----Dv-GQAIRTVPMIAI 485
WP_013336114 127 INELKKLNYDVIEYRLYDVRPNPAGV-EiACR-LI-----NY-VDYVVFMSSMTYEAVRDCAr--D----ALRGKSVIAI 192
WP_010916891 130 TEKLKEEGIDFLEFRIYDAVPDT---KD-FEK-HYK---DQNcL-GVIITSSMEAEIVIPFLk--E------DKKMVFSI 192
4ES6_A       220 SPRVAEMARelg-aqRVI 236
WP_069125415 200 GPVTTAVIVekg-lnAAY 216
WP_013505754 277 GPPTTATVKqrg-yqILA 293
WP_009887202 199 GKITTSTLEslg-ykVSL 215
WP_011177051 187 GRVTEEKLRsmn-inV-I 202
WP_010900998 189 GSVTTKTLEeag-ihPAi 205
WP_021790110 191 GKTTFSTLKeagfvnIRf 208
WP_083817357 486 GPRTEAEARhyg-aqQVV 502
WP_013336114 193 GKVTESRIRddg-vnP-L 208
WP_010916891 193 GVTTTNTLMshg-imPDi 209
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