Conserved Protein Domain Family
hsFATP4_like

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cd05939: hsFATP4_like 
Fatty acid transport proteins (FATP), including FATP4 and FATP1, and similar proteins
Fatty acid transport protein (FATP) transports long-chain or very-long-chain fatty acids across the plasma membrane. At least five copies of FATPs are identified in mammalian cells. This family includes FATP4, FATP1, and homologous proteins. Each FATP has unique patterns of tissue distribution. FATP4 is mainly expressed in the brain, testis, colon and kidney. FATPs also have fatty acid CoA synthetase activity, thus playing dual roles as fatty acid transporters and its activation enzymes. FATPs are the key players in the trafficking of exogenous fatty acids into the cell and in intracellular fatty acid homeostasis.
Statistics
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PSSM-Id: 341262
Aligned: 7 rows
Threshold Bit Score: 871.362
Created: 14-Nov-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:putative active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
NP_001017737  99 DEKWSFKELDEYSNRVANFLlqqGFREGDVVALFMENRHQYVGLWLGMAKIGVEAALINFNLRLEALVHCVNISSAKAVV 178 zebrafish
NP_509509    105 GRQLTYQELNALANQYANLYvseGYKMGDVVALFMENSIDFFAIWLGLSKIGVVSAFINSNLKLEPLAHSINVSKCKSCI 184 nematode
Q6P1M0        99 DTHWTFRQLDEYSSSVANFLqarGLASGDVAAIFMENRNEFVGLWLGMAKLGVEAALINTNLRRDALLHCLTTSRARALV 178 human
NP_001034691 101 GEKWTFRWLDKYSNAVANFFyqqGFRLGDVIAIFMESRPEFVGLWLGMAKVSIEAALINFNLRLDSLVYCITTSGAKAVI 180 chicken
NP_524723     79 TQRWTFRQVNEHANKVANVLqaqGYKKGDVVALLLENRAEYVATWLGLSKIGVITPLINTNLRGPSLLHSITVAHCSALI 158 fruit fly
NP_611906    110 DRHLSFAEALEFSQKIAGYFsdrGLERGDCVALLMETRLEYPCIWLGLSQLGVITALINSNLRGESLLHSIKVANAKALI 189 fruit fly
NP_502367    134 NTTETYAEFNAHCNRYANYFqglGYRSGDVVALYMENSVEFVAAWMGLAKIGVVTAWINSNLKREQLVHCITASKTKAII 213 Caenorhabditis ...
Feature 1                                                                                   #    
NP_001017737 179 Fgselteamcevhssmgkt-------vklfvsgewdpkrvpvgtEHLDPLLETTSTIQPkqpd-rsfTDRLFYIYTSGTT 250 zebrafish
NP_509509    185 Tninllpmfkaareknlis--------deihvflagtqvdgrhrSLQQDLHLFSEDEPPvidg-lnfRSVLCYIYTSGTT 255 nematode
Q6P1M0       179 Fgsemasaicevhasldps-------lslfcsgswepgavppstEHLDPLLKDAPKHLPscpd-kgfTDKLFYIYTSGTT 250 human
NP_001034691 181 Fggelssaitevngmlgkn-------makfcsgdynpevvpaetRHLDPLLSTTSKSPPtqipakglDDRLFYIYTSGTT 253 chicken
NP_524723    159 Ygedfleavtdvakdlpanltl--fqfnnennnseteknipqakNLNALLTTASYEKPNktq--vnhHDKLVYIYTSGTT 234 fruit fly
NP_611906    190 VgselldvlvslrekeqldevpiyqytddevrgvaghdllpgavDLVTALKTQKKLELPsavcpgeaRSKLLYVYTSGTT 269 fruit fly
NP_502367    214 Tsvtlqnimldaidqklfdv------egievysvgepkknsgfkNLKKKLDAQITTEPKtldi-vdfKSILCFIYTSGTT 286 Caenorhabditis ...
Feature 1                                           ##                                           
NP_001017737 251 GMPKAAIVVHSRYYRMAALVYYGFRmkpEDVLYDCLPLYHSAGNIVGIGQGLIHGMTVVIRKKFSASKFWDDCIKYNCTI 330 zebrafish
NP_509509    256 GNPKPAVIKHFRYFWIAMGAGKAFGinkSDVVYITMPMYHSAAGIMGIGSLIAFGSTAVIRKKFSASNFWKDCVKYNVTA 335 nematode
Q6P1M0       251 GLPKAAIVVHSRYYRMAALVYYGFRmrpNDIVYDCLPLYHSAGNIVGIGQCLLHGMTVVIRKKFSASRFWDDCIKYNCTI 330 human
NP_001034691 254 GMPKAAIVVHSRYYRIAAFGYYAYRmhpEDILYNCLPLYRSAGNIMGVGQCLIHGLTVVIRKKFSASRFWDDCAKYRCTI 333 chicken
NP_524723    235 GLPKAAVISHSRYLFIAAGIHYTMGfqeEDIFYTPLPLYHTAGGIMCMGQSVLFGSTVSIRKKFSASNYFADCAKYNATI 314 fruit fly
NP_611906    270 GLPKAAVITNLRFLFMSAGSYYMLKmssDDVVYDPLPLYHTAGGIVGVGNAILNGSTVVLRKKFSARNFWLDCDRHNCTV 349 fruit fly
NP_502367    287 GMPKAAVMKHFRYYSIAVGAAKSFGirpSDRMYVSMPIYHTAAGILGVGQALLGGSSCVIRKKFSASNFWRDCVKYDCTV 366 Caenorhabditis ...
Feature 1                    # ##  #           ##                   ######                       
NP_001017737 331 VQYIGEICRYLLNQPRKDTERKHKVRMALGNGLRqSIWEEFTNRFNVpQIAEFYGATECNCSLGNFDNKTGACGFNSRil 410 zebrafish
NP_509509    336 TQYIGEICRYLLAANPCPEEKQHNVRLMWGNGLRgQIWKEFVGRFGIkKIGELYGSTEGNSNIVNVDNHVGACGFMPIyp 415 nematode
Q6P1M0       331 VQYIGELCRYLLNQPPREAENQHQVRMALGNGLRqSIWTNFSSRFHIpQVAEFYGATECNCSLGNFDSQVGACGFNSRil 410 human
NP_001034691 334 IQYIGEICRYLLNQPVRESETQHCVRLAVGNGLRpTIWEDFTKRFRIkQIGEFYGATECNCSIANLDGKVGACGFNSRil 413 chicken
NP_524723    315 GQYIGEMARYILATKPSEYDQKHRVRLVFGNGLRpQIWPQFVQRFNIaKVGEFYGATEGNANIMNHDNTVGAIGFVSRil 394 fruit fly
NP_611906    350 AQYIGELCRYLLATSYSPDQQKHNLRLMYGNGLRpQIWSQFVRRFGIpHIGEIYGATEGNSNLINITNRVGAIGFVPVyg 429 fruit fly
NP_502367    367 SQYIGEICRYLLAQPVVEEESRHRMRLLVGNGLRaEIWQPFVDRFRV-RIGELYGSTEGTSSLVNIDGHVGACGFLPIsp 445 Caenorhabditis ...
Feature 1                                                                                        
NP_001017737 411 p--yvYPIRLVKVDEETMELIRGPDGVCIPCGPGEPGQLVGRIiqndpLRRFDGYVNQTATNKKIAQDVFKKGDSAYLSG 488 zebrafish
NP_509509    416 higslYPVRLIKVDRATGELERDKNGLCVPCVPGETGEMVGVIkekdiLLKFEGYVSEGDTAKKIYRDVFKHGDKVFASG 495 nematode
Q6P1M0       411 s--fvYPIRLVRVNEDTMELIRGPDGVCIPCQPGEPGQLVGRIiqkdpLRRFDGYLNQGANNKKIAKDVFKKGDQAYLTG 488 human
NP_001034691 414 p--nvYPIRLVKVNEDTMELIRDSRGLCVPCRPGEPGLLVGQInqqdpLRRFDGYVNESATHKKIAYNVLQKGDQAYLSG 491 chicken
NP_524723    395 p--kiYPISIIRADPDTGEPIRDRNGLCQLCAPNEPGVFIGKIvkgnpSREFLGYVDEKASAKKIVKDVFKHGDMAFISG 472 fruit fly
NP_611906    430 s--slYPVQVLRCDEYTGELLKDSKGHCIRCQPGQAGLLVGKVdarraVSAFHGYADKGASEQKLLRNVFTSGDVFFNSG 507 fruit fly
NP_502367    446 ltkkmHPVRLIKVDDVTGEAIRTSDGLCIACNPGESGAMVSTIrknnpLLQFEGYLNKKETNKKIIRDVFAKGDSCFLTG 525 Caenorhabditis ...
Feature 1        #           #  #       ####                                                     
NP_001017737 489 DVLVMDDFGYMYFRDRTGDTFRWKGENVSTTEVEGTLSRLLDMKDVVVYGVEVPGaEGKAGMAAIADPe-----NNTDLA 563 zebrafish
NP_509509    496 DILHWDDLGYLYFVDRCGDTFRWKGENVSTTEVEGILQPVMDVEDATVYGVTVGKmEGRAGMAGIVVK------DGTDVE 569 nematode
Q6P1M0       489 DVLVMDELGYLYFRDRTGDTFRWKGENVSTTEVEGTLSRLLDMADVAVYGVEVPGtEGRAGMAAVASPt-----GNCDLE 563 human
NP_001034691 492 DVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEGMLSHILNQTDVAVYGVEVPGvEGKAGMAAIADPk-----TKVNPN 566 chicken
NP_524723    473 DLLVADEKGYLYFKDRTGDTFRWKGENVSTSEVEAQVSNVAGYKDTVVYGVTIPHtEGRAGMAAIYDPe-----RELDLD 547 fruit fly
NP_611906    508 DMVVRDILGYFYFKDRTGDTFRWRGENVATQEVEAIITNCVGLEDCVVYGVQIPHvEGKAGMAAIVDPe-----RKVDMD 582 fruit fly
NP_502367    526 DLLHWDRLGYVYFKDRTGDTFRWKGENVSTTEVEAILHPITGLSDATVYGVEVPQrEGRVGMASVVRVvsheedETQFVH 605 Caenorhabditis ...
Feature 1                        #                                
NP_001017737 564 KFSRDLEKALPp----YARPVFLRFlpEVDKTGTFKFQKTDMRRDGFDP 608 zebrafish
NP_509509    570 KFIADITSRLTenlasYAIPVFIRLckEVDRTGTFKLKKTDLQKQGYDL 618 nematode
Q6P1M0       564 RFAQVLEKELPl----YARPIFLRLlpELHKTGTYKFQKTELRKEGFDP 608 human
NP_001034691 567 ILYQELQKVLPs----YARPIFLRLspQVDTTGTFKIQKTRLQREGFDP 611 chicken
NP_524723    548 VFAASLAKVLPa----YARPQIIRLltKVDLTGTFKLRKVDLQKEGYDP 592 fruit fly
NP_611906    583 YLSVVLRGSLPp----YARPLFIRLldEIPRTATFKLKKRELAKEAYDI 627 fruit fly
NP_502367    606 RVGARLASSLTs----YAIPQFIRIcqDVEKTGTFKLVKTNLQRLGIMD 650 Caenorhabditis elegans

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