Conserved Protein Domain Family
PRK12466

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PRK12466: PRK12466 
3-isopropylmalate dehydratase large subunit
Statistics
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PSSM-Id: 183543
Aligned: 50 rows
Threshold Bit Score: 660.06
Created: 9-Dec-2010
Updated: 25-Oct-2021
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
220923003   1 MSPRTLYDKLIDSHTITRLDDRdgpgaEVLLYIDRTVLNEYTSPQAFSGLREAGRQVWRPGAALAVVDHVNPTAPHRGAA 80 
33601793   12 APPRTLFDRLWDSHHVADLPDG-----RSLIHIDRHLLHDLSSPQAFSALRAQGRTVHSPARNVAIADHIVSTAP-GRRG 85 
91779630    2 NAPRTLFDKLWDSHTIANLPGG-----ADLLQVDRNLMHELTGVEAVRVLEARHLPVSNPELTFATLDHVISTRPGRE-A 75 
27375527   46 TRGRTLLAKIWDQHVIAHVSDD-----TDLLHVDRHLLHDLGGSRGLIDLKSRNLPVHNPELTFATPDHAISTAS-GR-A 118
113867560   5 SQGRTLFDKIWQAHAIAELDGA------SLLHIDRVFLHERTGSIALSSLRAAGRRVRAPALAFCTMDHIVDTRPGRNDS 78 
33600004    1 MAARTLFDKIWDNHVIASTEEG------DVLHVDRHYLHDLGGAPALKALAARGLAVRAPDLTVAIPDHTVATGP-GRVS 73 
109899075   1 -MDRTLFEKIWQHHLVEELDDG-----AALIYIDRVFLHERTGSIALKSLEADNRQVVSPEHVFCTMDHIVDTMVGRDDN 74 
148557223   1 -MGRTFFEKVWDDHVVADLGDG-----AFLIHIDRHFLHEVSGAVSLKEIDARHRTVRNPELTFGTVDHVLETVPGRGMT 74 
167644476  16 QRPRTMQDKLWDAHVVRDLGGG-----WSLLHIDRHIIHDLSGPVALAQLEARGLPVRNRELTFATPDHAVSSLP-GRTG 89 
158423730   4 KTARTLFDKVWDAHVVVQREDG-----QSLLWIDRHFLHE-GSFHAFDKVAGRGASLARPDLTFGVEDHYVPTRV-RQLD 76 
220923003  81 MPDEGGARQVRYFGENCRDFGIELFDV-LHPLQGIEHVVAPELGFILPGMVVGAGDSHTTTYGALGALGFGIGTSDIEHY 159
33601793   86 EHVDGSQAMIDALAANAARTGIRHYGP-DDPDQGIVHVIAPELGLVLPGMTVACGDSHTSTLGALGAWAWGIGTSEAEHV 164
91779630   76 GDADWSTTMVDTLREQAAQHAIPLFDIgTEGRQGIVHVIGPELGLSLPGTLIVCADSHTCTHGALGALAFGIGSTELVHV 155
27375527  119 GTITTGQELLAALRTETSASGIRLFDI-DQPGQGIVHVIGPELGLSLPGCLIVCGDSHTCTHGGLGALAFGIGSSELTHV 197
113867560  79 TLMPGGEAFITSTRDSARREAIRLFDI-GDPGQGIVHVVSPEQGIALPGTTVVCPDSHTCTQGGLGALAWGIGSSEAEHA 157
33600004   74 PIPHIVLRLVDDLQARCQAAGIRYIAA-DDDAHGIVHVIAPEQGLTLPDMIVVCCDSHTCTHGALGAIGFGIGSSEVEHV 152
109899075  75 TKVPSGKNFILATREACIDANIKLFDV-NDPQQGIVHVVSPELGIVQPGATLVCPDSHTCSQGALGALAWGIGSSEAEHA 153
148557223  75 TRMPGGDDFLREFTERIGPHGIRFFDL-HDRRQGIVHVIAPELGVALPGMTFICGDSHTCTVGGVGAFAWGVGSSDSEHA 153
167644476  90 ATYPPGERLWAKLKAGSEREGIRFFDT-GTEGQGIVHVMGPELGLALPGMTLICGDSHTCTNGGIGALAFGVGQSESMHA 168
158423730  77 LIDPAIRRMMEQLRANTLRHKVRLFDV-DDPAQGIVHVVGPEQGLTLPGLSIVCGDSHTATHGAFGALAFGIGASEVAHV 155
220923003 160 LATQTLRYRRTRTMRVTLEGALPPSVTPKDVVMALIRRIGASGATGYAVEFAGDGLTALPVEGRMTICNMAVEGGARGVI 239
33601793  165 LATQTLAMRRPRAMRLTLQGALPAGLSAKDLTLHVLRQLGVRGAAVGFLELAGEPVAALSMEERLTLCNMAIEAGARAAL 244
91779630  156 LATQTVRQKKPKTMRIRFKGSVAEGVTAKDMILYVIGALGAGAGTGYAVEFAGEAVEALSMEARLTLCNLTIELGAKFGL 235
27375527  198 LATQTIIQRRPKTMRVTFDGRMPFGVTAKDLILALIGHVGAAGGTGYAVEYAGSAIRGMPIEGRLTICNLSVELGAKMGL 277
113867560 158 LATQTLRVTRPRTMRVSFDGALPAGVGAKDLMLWLIARYSAAGAGGHMLEFGGSAVRSLPVEARLTLCNLAVEFSAFSGI 237
33600004  153 LATQAIVQRKPRQLRVRLHGRRRPGVTAKDVALHLVSVIGAAGGSGHAVEYAGEAVAAMDIEERMTLCNLSIEFGAKIGL 232
109899075 154 LATKTLRVSKPKTMRVNFHGEMGFGVSAKDMILHLIGTYGAAGGAGYVIEFAGSAVEALEIEGRLTLCNMAVEFSAFSGL 233
148557223 154 LATQTVIMTRPKTLRVNFTGQLRPGVHAKDMILALIAKYTADGGTGYAIEFAGEAVRSLPMDGRLTLCNMAVEFGGRTGT 233
167644476 169 LATQCLRLRRPLTMRINIDGVLGLGVTAKDVALHLLRRLGTSGGLEHTIEYAGSTVRAMGVEARLTLCNLTVELGARSGF 248
158423730 156 LMTQTLWQNRPKRLRIRVEGRLAPGIVAKDVALSIIAAIGADGAAGHAIEYAGSVVRGLSMEGRLTLCNLSIEAGGRCGM 235
220923003 240 MAPDAAVFDYLADKPRAPKGAAWEAAVRHWSTLRSDPDAVFDREMRLKASEIEPLVTWGISPDQAMPIGGRVPDPASEPD 319
33601793  245 IAPDDVTLDYLRRHAPAVRGD--EAALAAFRALRSDAGARYESERAITLGLQAPQMTWGVNPAQVVDVHEPLPDPAA-AD 321
91779630  236 VAPDETTFAYLRGRPYAPQGASFEAALEDWRRLPTDDGAHFEREVEIDAAAIAVQVTWGTSPEHVIAIDAAVPDPGNESD 315
27375527  278 IAPDQTTFDYVRGRPYAPQGEMWERAVTAWRTLRSDSDAMFDREVTIDVGTIIPQITWGTSPEHVLGVDGRVPDPRDIAD 357
113867560 238 VAPDDTVFEYLAGRPYAPAGAQWEPALWHWRSLYSDADAVFDRELSVDCRQLAPMVTWGTSPQHGVAVDGAVPNPAMAID 317
33600004  233 IAPDDTTFAWLAGRRHAPRGARLQQALAAWRALRSDADAVFDRELDLDLGALAPQITWGTSPQDAMDVAGVAPDPRGYAD 312
109899075 234 VAPDEKAITYLKGREYAPKGELWQQAVTYWQSLFSDEQAQFDKTIEIDCADISPTITWGNSPQHACSVNSRVPSAQADAT 313
148557223 234 VAPDEITFAYLRDREFSPRGADWDRAVAYWRTLPSDADAAYDMEYELDCSTLEPQVTWGTSPEHSVAIGGVMPDPAASAD 313
167644476 249 VAADDTTFAYVDGRPFAPKGAAFDRAVALWRGFASDDEARFDREISIDAADIAPTLTWGVTPEQVISVDGRVPDPSAVSD 328
158423730 236 IAPDATTLDYVRGRPYAPEGALFDAAAEAWLALGSDADAEFDREVVLDGDAIAPIVTWGTSPEDALPITATVPDPERVDD 315
220923003 320 ANRRRDMAHALAYMDLAPGTALEAVPIQRAFIGSCTNARLSDLREAAGVLRGRRIAEGVRGMVVPGSSSVRRAAEAEGLD 399
33601793  322 AGERAAMQQAYDYMGLRAGRPLAGVPVQWAFIGSCTNGRLSDLQAAAAVARGRRVAAGVRALVVPGSQRVKRAAEALGLD 401
91779630  316 PARREALQRALDYMGVHAGQHLDELAVDRVFIGSCTNSRIEDLQAAARIVAGHHVAEGVTAWVVPGSLSVAREAEAQGLA 395
27375527  358 PARRGAIEIALDYMGLKPGAPIAGTKVDWVFIGSCTNSRLSDLRAAAEVARGRKVAPGVRAWVVPGSETVKRDAVAEGLD 437
113867560 318 ADTRQAMERALSYMDLRPGQRMADIAIDAAFIGSCTNSRLSDLRSAAGVLAGRKVAPGVTAICVPVSSAVKRAAEAEGLD 397
33600004  313 PARQRAAAAGQAYLGVTPGAPLAGLAVDRVFIGSCANGRLDDLRAAAAQVRGRRVADHVTAWVVPGSQAVKRQAEAEGLA 392
109899075 314 QNQLKALKRAYEYMDVQPGSALKGLPIGAAFIGSCTNSRISDLRLAAKVLKGRKVADNVNAICVPGSTTVKRQAEAEGLD 393
148557223 314 PIARTSRQRAADYAEIEPGASVMGLPITGAFIGSCTNSRIDDLRAAAAILKGRKVAEGVTAICSPGSTATKLLAEAEGID 393
167644476 329 ETQREAMVQALDYMGLTPGQALTDAVVDWVFIGSCANSRLSDLRAAAQIAKGRRVAAGVTAWVVPGSEIVKRAAEAEGLD 408
158423730 316 AAKAAHIRDAVSYMDLRPGQRLSDIAVDRVFIGSCTNSRIEDLRAAAAVLAGRSAKVP--GLVSPGSALVKRQAEEEGLD 393
220923003 400 RVFIEAGFEWRQSGCSLCL--AMNDDVLAPGERCASSTNRNFEGRQGAGGRTHLMSPAMVAAAAVTGHLTDVRRLTREN 476
33601793  402 RVFLDAGFEWREPGCSMCV--GMNADKVPAGQRCVSTSNRNFEGRQGPGARTHLASPASAAAAAIAGAIVDHRDLV--- 475
91779630  396 QIFRTAGFEWREPGCSMCV--GANGDVVGRGERCVSTSNRNFVGRQGPGARTHLASPAVAAASALAGHIAAPVSYAGAA 472
27375527  438 KIFIDAGFEWREPGCSMCL--AANGETVPPGQRSVSTSNRNFIGRQGPRARTHLASPAMAAAAAVSGAIADVRTMER-- 512
113867560 398 RVFREAGFEWRESGCSMCF--YAGGESFGHRQRVISSTNRNFESRQGPQTRTHLAGPATVAASAVLGRIADPRRPPGA- 473
33600004  393 RVFTDAGFDWREPGCSMCL--AANGELAEPGQRVVATSNRNFVGRQGRDVRTHLASPATAAACAIAGVIAAPLP----- 464
109899075 394 KIFIAAGFEWREAGCSMCF--FAGGESFGYRQRVVTSTNRNFESRQGPETRSHLASPATVAASAIAGCIADVREYL--- 467
148557223 394 RIFIEAGFEWRESGCSLCMsgATGGESFPRDARVIASTNRNFEDRQGPHVRSHLASPVTVAASAIAGRIADARAFASKE 472
167644476 409 KIFLDAGFAWREPGCSMCV--AANGETVPPGARAVSTSNRNFVGRQGPRARTHLASPATAVASAIRGKIADVRAL---- 481
158423730 394 AIFRAAGLEWVEAGCSMCV--GMNGDLVPAGERCASTTNRNFKGRQGPGARTHLMSPAMVAAAAVTGHLTDMRPLLEGR 470
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