Conserved Protein Domain Family
AAA_21

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pfam13304: AAA_21 
AAA domain, putative AbiEii toxin, Type IV TA system
Several members are annotated as being of the abortive phage resistance system, in which case the family would be acting as the toxin for a type IV toxin-antitoxin resistance system.
Statistics
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PSSM-Id: 433102
Aligned: 71 rows
Threshold Bit Score: 73.5778
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
jgi:Bind_0896    23 LTILVGLNGSGKSHLLQAIEIGAAEtdlfpsLPGFHAGHPATIPPGSIVRIENSFITADIFSGAVLSSI-AGGHNPNHQL 101
tgen:AM1_4802    26 FNILIGPNGTGKTNLLRIIDGLQF----------------------NYRKIAKSIDLYQPEIPFNLADN-LGSQDTNISG 82 
jgi:Taci_0026    21 LTVLVGPQGAGKSVLLQLFKLA------------------IDRAYVEDTMASFGQDWQRGNPRALLDAYlGLGMGRSWNE 82 
jgi:Ppha_1135    24 LNVITGDNGLGKSFLLDIAWWA------------------------MTRKWPAELNPKLTSGKVALPTDkKHEAEIDFSF 79 
ACL06559         25 FSVIVGDNNAGKSSVLEAAALLLRP------FDLSQWFNVARQRDSDLAVVDGVWSMFPSKEPLDVEEGpVQTQHIELKA 98 
jgi:RoseRS_2592  24 FNVLIGPNNSGKSALLELLYLGSLSr----rTCQLITKTIDPPVHAATMLVTRDFLSYAPTERLRWRHGyALRETDSFLI 99 
jgi:Galf_1538    23 LTLLTGVNGGGKSSVMQALVLLSQTf----rQQEWGRSLLLEGPELALGNAADVLNQDSARRDLALGVT-TDEQKVKWSF 97 
jgi:Plav_2287    52 VTFVVGDNSSGKTSLIYLLSVIASRd-----FGNQFDIFSDSSPLSTIDDVRSPFVTGDKTVVGFSLVRrHFDDSGEERA 126
WP_012595089     41 LTILAGANSSGKSSIMQPLLLMKQTl----eSPYDPGALLINGSHVKFTTSQQLLSSIPGKPEVNDLELkIEIDKSNYIK 116 Rippkaea ori...
wustl:BV3560     24 LTVFIGKSAGGKSIIMKVIVLMRYIy----kMVNIRSYLKNA----KITRSPFKLRFNSLLHDGLKGMI-TAQTEIYYTV 94 
jgi:Bind_0896   102 NHRLLNFDIlrk---tvlADSLSNLENALGCPISSYLSSEEDPWQFGYDAILTKAGITVGSRKALEIKEAFDDAQSKLTI 178
tgen:AM1_4802    83 ILRIGYSQV------------------DELDGPTLDKEILFEYDVKNPVWRYIHGDVQGFSLKTHLVNIPNDLQFMKDLT 144
jgi:Taci_0026    83 SSQMLLQGEpv------dLASEPKGHPTQEALFYIPAQRAISMPAGWPQPYRAYRSTDPFVLKNFSEALRTHMDNISSRD 156
jgi:Ppha_1135    80 SAVSKTKGF------------ISTFEPRGQSWTVQKGRPANPGLVFYAMADGSFAVWDPARNYWKSKNPDENKERPAAYV 147
ACL06559         99 TIGDEDRNF---------------SARGHASTDLDDEDLPIIALNVECKVDNMRETLAFRKSAFATIHRSEGVVSYRCFT 163
jgi:RoseRS_2592 100 DLDKEQNLI-------------LELPDLPATYPLHRFRLAAEAPDWLRKTDVQRTILFSLVQPDHAPPEFIPPLLATHRP 166
jgi:Galf_1538    98 RAEDRRALS-------------IELEHVELDGIPVPLGVSTRWLMPPACAETSQAVTALRNLSWITAERTGPRELLPLRV 164
jgi:Plav_2287   127 SVEARFAEYthsgkhecvATKIGALRDKQARFVLRKNRTFYRKNVTIEEGAVEKKIESFFEGWSDESLSYNRYISFPPTL 206
WP_012595089    117 NTFTKKSTGgf------eITKVSSKRKEIKVTYYPNMRKQDIIDFLGSNNKDLEDVLKNPNHPISEHLNYSTAYNKCFLD 190 Rippkaea ori...
wustl:BV3560     95 EINGNKYTL-------------KYTNRGLQSDINIPDKDLIFFKEAYVSGMRSLIPIWASKAVSVKGENLGFFFHETFND 161
jgi:Bind_0896   179 HLTQPGHPLDADLHALRllvkdvaeilRISPLEVTKMQVLSRNCWGGFSIFEPQISLVIARYRDAMAQNDLYTCADRRNG 258
tgen:AM1_4802   145 DITHRAESALPLL--------------NFGLFFIFGAHFTFYKNGRFTQGRMHPSGPDEIEPSAL--------------- 195
jgi:Taci_0026   157 NIFPTKWKLKGPMRKQI----------DWGVFHGAKVSMGDLSMQRQVVLKVGGGRDNYGVSYTAW-------------- 212
jgi:Ppha_1135   148 FSPKDVWDGLQNQDG------------TWLCNGLIRDWAGWQKEKGRAFESLISVLDVLSPSSTEKIVTGSLTRISLDDV 215
ACL06559        164 ITSATHRSIKT----------------LVEHLSKAVDSGKKGMAVELLQYFDDSVTDLDVSVSNGR-------------- 213
jgi:RoseRS_2592 167 DLPYQRWHYVWDQRWVY----------RWNDTHPLDRLAIWAEAGDGRAEHVLFFDFHTAHAHFEGAFAQRCYRTVSKWE 236
jgi:Galf_1538   165 ADGHARVGHHGEMAAGLl---------YWRGEDEVNPALCLPDTPPTLFHQVRGYMQRFFPGCDLRVSPIEGVSAI---- 231
jgi:Plav_2287   207 EISGEHWSVVLVDVDKEknsi---smpYMRTTPLVNFIQYGPMRISPEHVYSGHAIPQDHRGAHTPAMLKKIYDSRKTSK 283
WP_012595089    191 LLIKSKMEVPPNSNSLLnyai---fdsKPRTQAIIQEIYQIIHLPGLRGTPERSYPITAIGDTFQGTFDNYVASVIHEWQ 267 Rippkaea ori...
wustl:BV3560    162 FNDATDVIKEQKLEYLNlk-------mKVRKSGNRPKLFTIESLQNDAVPIELRYASSGIQTSAPLVAIVHYFAQEFSFK 234
jgi:Bind_0896   259 TSnglsdnafrehyghppwelvsefiqsfglayrvtapalelsqpYTFSLERTDTGATVQFGAlSSGEKVL-L--RFALS 335
tgen:AM1_4802   196 ----------------------------------------------------------------PSGVREC-A--KLITS 208
jgi:Taci_0026   213 ----------------------------------------------------------------STGQREF-F--PFLMS 225
jgi:Ppha_1135   216 R--------------------------------------------DMPTLKMPYDQEVAVVHA-SSGMRRIiSlaYFLVW 250
ACL06559        214 ---------------------------------------------SSVKVSHKERGIVDLSSF-GDGMRRS----AALAL 243
jgi:RoseRS_2592 237 ERiaqsmarvfpdmag---------------mrvnvkptptgttwGGYLELPDRTLPLEIDQF-GDGARHA-F--KVLAA 297
jgi:Galf_1538   232 ---------------------------------------------SLRLRSDSRSDFQRPQNV-GFGLTQL-F--PIIVS 262
jgi:Plav_2287   284 SSriiekinkfgvqsgmf------------dqvivnsynkrdskaPFGIHIEKRGHIFSIDEV-GYGVSQV-L--PIIID 347
WP_012595089    268 HNndsrinqlsnyltnlglt--------sqvaatrtndvqveiqvGKLTNNIDNRHLINIADV-GLGVSQV-L--PVIVA 335 Rippkaea ori...
wustl:BV3560    235 DA-------------------------------------------FQRSVLNYLYKQDLLTKF-TPGINRN----KLGKY 266
jgi:Bind_0896   336 LFPFDPLrisi-----irpRLLLLDEMDASLHPemayRWL----KGISd----GLVq------------KLG-------- 382
tgen:AM1_4802   209 ILRRNGK------------PVLLFDEPELHLEP----RVI----RRLF-----TFIfwlmvrgkqdrttKEEeafcqvqs 263
jgi:Taci_0026   226 CYRLLPSskktk---ddniQWVVIEEPEMGLHP-----------RAIFssvlpLVF-------------DMLhr------ 272
jgi:Ppha_1135   251 CWEEHVKakellgeepetnTVFLIDEVESHLHP----KWQrtviPSLM-----KVI-------------KQLtkspdill 308
ACL06559        244 ALTRANE------------GVLLIDELEAGIHP----AIM----PSIL-----GWM-------------LNAart----- 280
jgi:RoseRS_2592 298 LIALVDRaeq------qepGLFLWEDPELFMHP----ATL----GRLL-----DEV-------------ARLvag----- 340
jgi:Galf_1538   263 LLAARVG------------DVLLIENPEVHLHP----RAQ----QNIG-----ILL-------------AETaa------ 298
jgi:Plav_2287   348 AIRSIGSs----------dTMISIQQPELHLHP----KAQ----AAFG-----ELV-------------YELag------ 385
WP_012595089    336 LLVAKPG------------QLVYIEQPEIHLHP----RAQ----ANLA-----PIL-------------VDAan------ 371 Rippkaea ori...
wustl:BV3560    267 VH-------------------IHIEEVELSLAPedqrAFM----SNLVe----EVFh------------KNKkd------ 301
jgi:Bind_0896   383 --------------------------IKCILTTHSPTTVA 396
tgen:AM1_4802   264 ildtkwpsegdkfrivpptqqhiswlSQIFVASHSPVLIN 303
jgi:Taci_0026   273 -------------------------gYRVVISTHSPSVLE 287
jgi:Ppha_1135   309 iddtd---------pvhphhtlmisdVQLIAVTHSPLIMA 339
ACL06559        281 ------------------------anVQIIATTHSLEAID 296
jgi:RoseRS_2592 341 ------------------------kpVQVFMSTQSLEVIA 356
jgi:Galf_1538   299 ------------------------tgIQVVLETHSDHVLN 314
jgi:Plav_2287   386 ------------------------egIAFFIETHSDYIID 401
WP_012595089    372 ------------------------rgVKVVVETHSDLLLT 387 Rippkaea orientalis
wustl:BV3560    302 ------------------------rkLGLMVSTHSPYIVN 317
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