Conserved Protein Domain Family
SMP_PDZD8

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cd21674: SMP_PDZD8 
synaptotagmin-like mitochondrial-lipid-binding protein (SMP) domain found in PDZ domain-containing protein 8 (PDZD8) and similar proteins
PDZ domain-containing protein 8 (PDZD8), also called Sarcoma antigen NY-SAR-84/NY-SAR-104, is a molecular tethering protein that connects endoplasmic reticulum (ER) and mitochondria membranes. PDZD8-dependent endoplasmic reticulum-mitochondria membrane tethering is essential for ER-mitochondria Ca(2+) transfer. In neurons, PDZD8 is involved in the regulation of dendritic Ca(2+) dynamics by regulating mitochondrial Ca(2+) uptake in neurons. It plays an indirect role in the regulation of cell morphology and cytoskeletal organization. PDZD8 is also a novel Gag-interacting factor that promotes retroviral infection. It may act as a novel moesin-interacting cytoskeletal regulatory protein that suppresses infection by herpes simplex virus type 1 (HSV1). This model corresponds to the SMP domain of PDZD8, which may be implicated in lipid transport.
Statistics
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PSSM-Id: 439230
Aligned: 39 rows
Threshold Bit Score: 195.076
Created: 14-Apr-2020
Updated: 17-Oct-2022
Structure
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Aligned Rows:
 
putative lipid
Feature 1:putative lipid binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                   #  ##   #   #                    #    #               
Q8NEN9         93 ETCYFLNATILFLFRELRDTaltRRWVTKKIKVEFEELLQtk--taGRLLEGLSLRDVFLGetVPFIKTIRLVRpvvpsa 170  human
XP_004365966  220 NNCRWFNLLAAFMFRHLRDAknlRQYFLRQMRRQMAAFLRsd---aRKVVEGIRLRDYAFGssLPCFSNAQVTTlvt--- 293  Capsaspora ow...
XP_013077004  128 EDCIWLNFFFQFLFHELKDSlnvRRLITKKIQVEFEELLKsk---sGVFMDELFLRDFHLGdkFPVIMAMTVENvdvq-- 202  Biomphalaria ...
XP_011403319   62 ESCDWFNIITDFLYQELRDTetaRRLIMKQIKKEFKELLLtk--teGKMFDELKVREYNMGesLPIFSNIELVDvirdse 139  Amphimedon qu...
OXA44086       79 ESCWAINFVLYFLFRELRNSegiRRWVLRKLSLEFEELLAtt--vlGKFFSSISIQNVDVGqnFPILSWLKTSKvelhp- 155  Folsomia candida
KPI95476       64 TPEGVLNAMLQFIFQQSTAD---TRWLRRRMASELAELLAkt--ssGKIFESLTLRSLEVGteFPSIANMQLISgelee- 137  Asian swallow...
EFX86420      267 ETLLAVNLLLQFFFREAQNNglvRRFLIHRINKEMQEGVAkggatvNKIIKGLKIYDIEMGtkAPSIGGFEVNSlvlde- 345  common water ...
XP_004994058   74 ESVECLNVLFDFLFFQLRDTirvRRHVLKLIDRNLAFLMNks--slGNICKRMKVIDVKLGseMPHLSDVKIVRpavg-- 149  Salpingoeca r...
XP_004345414  219 ESCIWLNALASRLWIELHQTk-iKPLFTKLVQDELDDLFKlp---aGGFLISATVVECNGPpsAPSFSNMSIIHpq---- 290  Capsaspora ow...
XP_002430619   68 ESCVSLNLMLQFLFHELRDTekiRLWFRKKLCIEFEELLSks--tiGKMVGNIKIVEIDLGseFPVLNNISIQDvkvnk- 144  human body louse
Feature 1                                  #     # # #                 # #   # #         # # #    
Q8NEN9        171 tgepdgpegealpaacPEELAFEAEVEYnGGFHLAIDVDLVFGK-SAYLFVKLSRVVGRLRLVFTRvPFTHWFFSFVE-- 247  human
XP_004365966  294 -------------dpgAERLDLCFDLDYvGGFRFTVDMDLKLGF-TAAVSIAVQRLAGPIRVSVGDaPRAHWSVAFVE-- 357  Capsaspora ow...
XP_013077004  203 -------------ddiIRTLDLKAHLVYdGGLKIAIDAALPLAT-TAYISIKVIKIRGVARLQFTNvPYTHWSVSFYE-- 266  Biomphalaria ...
XP_011403319  140 -----------lpnkrIELIEFNCSVDYtGSFEIGIDAVMMFGR-SAYVSIQLRQLKGRGRFQMSRsPFNHWSFAFLE-- 205  Amphimedon qu...
OXA44086      156 ------------vfknISTLDILVDLEYaGGFQFSIQAETHLRH-SAYLSVQFNGVKGQARLQFATePYAHWSFSFAE-- 220  Folsomia candida
KPI95476      138 ------------dgarLRSLDIRFDLAYdGNFRIDVDAVMLLGK-IANISITVESISGSVRLMFRRnPYTHWALAFES-- 202  Asian swallow...
EFX86420      346 ------------dqklIESVDLIIHLEYsGGFAMGIDVALPYGK-TAFLAAKLCLLKGDLRLKFSRlPYSHWTIAFSP-- 410  common water ...
XP_004994058  150 ------------aigsSDVLDLDATLLYkGKFNVRIEADVIFQR-KATLSITIVELRGRARFSFRSePHPHWTFGFLEqg 216  Salpingoeca r...
XP_004345414  291 --------------geVPSVMLAADISAlSGFQFAVKLAVRYLEaPIYVALQCEKFEAQLLIEIFKrPESMISYGFSR-- 354  Capsaspora ow...
XP_002430619  145 ------------dyshIDVLDLKLDVNYsGGFRLVVEANMLLGK-AALISIQINELYGEGRLEFTRlPYSHWSFTFFN-- 209  human body louse
Feature 1                 #                    #  ##                  # ####     
Q8NEN9        248 -DPLIDFEVRSQFEGRp-mPQLTSIIVNQLKKIIKRKH------------TLPNYKIRFKPFF 296  human
XP_004365966  358 -DPVIELDIASTVEGReipQLVRDRIVNQFRRVIRRKH------------LLPNFKMRKFHVY 407  Capsaspora owczarzaki ATCC 30864
XP_013077004  267 -EPEIELEVTAQLDGRs-mPKLKNIIANQIKRIVRKKH------------TLPMYKMRFKPFF 315  Biomphalaria glabrata
XP_011403319  206 -EPQVEVIVTSRFEGRs-lPRLSAFLESQFKRWIRRTH------------TLPNYKVRFKPFF 254  Amphimedon queenslandica
OXA44086      221 -NPDIDISVVSQLYGKs-fSHITSIIASQLKRSVRKKH------------TLPMYKIRYKPFF 269  Folsomia candida
KPI95476      203 -QPKLELRVRGRFQGRqlkPRLASLVAAHIRRAVAQRH------------TLPNYKIRYKPFF 252  Asian swallowtail
EFX86420      411 -PPILDMPISSRIQGQs-yDAVTDLLASLITSWIQKQH------------CLPNSKMLTHPLF 459  common water flea
XP_004994058  217 dEPHIDLEVEALIDNHl-fRQLGSMVIYQIRAALRKVHtipapsdddddhGPPKQKMRYDPFF 278  Salpingoeca rosetta
XP_004345414  355 -MPHLDLKINSFVLHQh-tDSLRRLIFSLVKKMLTKKF------------VLPNLKTRWMNPQ 403  Capsaspora owczarzaki ATCC 30864
XP_002430619  210 -EPKIELHVESYFQGRp-fQQITNFISSQIKKTLKKKH------------TLPNYKIRYKPFF 258  human body louse

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