1F3U


Conserved Protein Domain Family
TFIIF_beta
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cd07980: TFIIF_beta 
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Transcription initiation factor IIF, beta subunit
The TFIIF-beta subunit, also called RNA Polymerase II-associating Protein 30 (RAP30), forms a heteromeric complex of RAP30/74 (TFIIF, beta/gamma) that is involved in both initiation and elongation of RNA chains by RNA polymerase II. Accurate transcription in vivo requires at least six general transcription initiation factors, in addition to RNA polymerase II. TFIIF-beta binds directly to RNA polymerase II and helps bring polymerase into a pre-initiation complex.
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Statistics
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PSSM-Id: 259828
Aligned: 79 rows
Threshold Bit Score: 69.278
Created: 1-Oct-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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heterodimer
Conserved site includes 40 residues -Click on image for an interactive view with Cn3D
Feature 1:heterodimer interface [polypeptide binding site]
Evidence:
  • Structure:IF3U: Human TFIIF RAP30/74 heterodimeric interactions; contacts at 4.0 A
  • Comment:TFIIF consists of a heterodimer of RAP30 and RAP74
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1        ##     # #  ########  #  #  #                          #########                
1F3U_C         5 ELDLTGAKQNTGVWLVKVPKYLSQQWAKASGr----------------------gEVGKLRIAKtq-------------- 48  human
XP_002115507   5 KESVDVSSADQSVWLLKVPKFVSQAWQKSESg-----------------------KVGSVKIQKkg-------------- 47  Trichoplax adha...
EFA84517      10 VGEINTDNVETQAWLIKVPKHLADHWMTAGGg----------------------tEIGKLFFKSs--------------- 52  Polysphondylium...
EGG22940      10 VDELNTDNAENQAWLVKVPKFLVDHWMSRGAd----------------------aEIGKLYFKS---------------- 51  Dictyostelium f...
ACO66782     127 PGCLDTQRGEHLAWLVKVPAFVTRAWRAASDaldevse----------ldggvgtEIDGGKVDDke-------------- 182 Micromonas sp. ...
CBI31490      51 NANVDTSRSERAVWLMKCPPVVSRSLSSSSAsds-------------------lrPVAKVIVSLdpllan---------- 101 wine grape
ADE77647       9 GSAFDTLKADRSVWLMKCPLVIGQAWKEISDsg---------------------qPLAKITVSVdpckaddqpieakved 67  Sitka spruce
EFJ21220       8 SVPLDVAQAEGQVWLLKLPAIVATAWNAQDSsgk-------------------svAAGAGPADPt--------------- 53  Selaginella moe...
EFH65288       4 SHELDMEKTDRRIWLMKCPVVVAKTWEKLAPssssys------------ssdslpNLAKVVLDVdplr------------ 59  Arabidopsis lyr...
CCO18876     103 PSALDTQRANHRAWLVKVPNFVDRAWKSFSDrrskadnendedgmdidaelndndELGKVRVVIdpfd------------ 170 Bathycoccus pra...

Feature 1                                       #                                                
1F3U_C        49 ----------------------------grTEVSFTLNEdlanihdi-------ggkpasvsAPREHPFVLQSVg----- 88  human
XP_002115507  48 ----------------------------pnEEMLFLLENslttat-----------ssgeanIPTEYKLVSNEC------ 82  Trichoplax adha...
EFA84517      53 ------------------------------NNLSLSINFkdken--------------nngyVPSEELQLVTTPlp---d 85  Polysphondylium...
EGG22940      52 ------------------------------SNLSLTISGtt--------------------nENEEFQLATTPVi----e 77  Dictyostelium f...
ACO66782     183 ----------------------------llGRMRMTVDPfappekrqrhfltlednvsaanrIPKEYDMVMTPD------ 228 Micromonas sp. ...
CBI31490     102 ------------------------ddddspPQFTMELAGtes------------------gnAPKCYSMDMSQD------ 133 wine grape
ADE77647      68 ptapsatrrkverqqmsssrsqtqsthrikSEFMMEVAAngs------------------vtAPKSYSLNMSTE------ 123 Sitka spruce
EFJ21220      54 -----------------------------lAKVTCTFDPlnp-----------------dpeAALEFTMELSGPd----- 82  Selaginella moe...
EFH65288      60 --------------------------pdysPEFTMQMVAaey------------------gnMPKCYALNMFKD------ 89  Arabidopsis lyr...
CCO18876     171 --------------------------kenkEAFAVTLNAav--------------------nEDEEHEIPVKYImtenie 204 Bathycoccus pra...

Feature 1        ###########                                    # ##     #     
1F3U_C        89 GQTLTVFTESS---------------------------------SDKLSLEGIVVQRAECRP 117 human
XP_002115507  83 GQYQVALKRSLsidn-------------------------aadsSTEPEIVGKVVRKIDLRA 119 Trichoplax adhaerens
EFA84517      86 SNPIKIFSEDT---------------------------------ENALSFEGSIGLRCDVRM 114 Polysphondylium pallidum PN500
EGG22940      78 SNPLKIFSEDK---------------------------------ENALALEGSVGLKCDIRM 106 Dictyostelium fasciculatum
ACO66782     229 DQPIHVFSDVRentaaaaaraaarlaaeralagrgsgenqlslpHDEFVLEGAVSEKFDVRP 290 Micromonas sp. RCC299
CBI31490     134 FIPMAVFSESS---------------------------------QGETAVEGKILNKFDMKP 162 wine grape
ADE77647     124 IIPMYIFSETS---------------------------------EGKVAVDGKVEHKFDMKP 152 Sitka spruce
EFJ21220      83 DIKAYSLNLQKdvvpth----------------------ifsdtQGRLAVEGKVERKFDIKP 122 Selaginella moellendorffii
EFH65288      90 FVPMEAFSETN---------------------------------LVNTAVEGNVDHKFDMKP 118 Arabidopsis lyrata subsp. lyrata
CCO18876     205 APEIHVFSETRegtaaa----------------------tsamdVNEFIVEAKVHKKLDMRP 244 Bathycoccus prasinos

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