Conserved Protein Domain Family
JMY

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pfam15871: JMY 
Junction-mediating and -regulatory protein
JMY, Junction-mediating and -regulatory protein is also a WASP homolog-associated protein with actin, membranes and microtubules. This middle region is the coiled-coil region that putatively binds microtubules to the scaffold. This ability to interact with microtubules plays a role in membrane tubulation.
Statistics
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PSSM-Id: 464915
Aligned: 13 rows
Threshold Bit Score: 447.596
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EDM08696      67 WAGALSAAGFRGAHRQLAALWPALERCFPPLPPeld----aasGAGWGLgrglwalvWALV-WPAPA---NPGDAALQDL 138
XP_413835     59 WAGLFSAPALRGVHRQLAAVCPRLEPALPALPPal-------pGASGGL--------WAVL-FPSGP---APSEAEVAEL 119
XP_014344877 204 WAGLYSFQDLRAVHQQLCSVNSELEPCLPAFPE-----------EPTGM--------WTVL-F-GAP---EMTDREVDGL 259
XP_022532395 169 WAGLFSFQDVRAAHLQLCAVNSDLDPCLPAFPE-----------EPSAV--------WSVI-F-GHP---QLTQREMEAL 224
Q6NVC9       123 WAGLFSFQDLRAAHLQLCAVNADLEPCLPALPE-----------EQTGV--------WSVL-F-GVP---EMSARDTDAL 178 zebrafish
EKC42626      93 RTGIFSFHELEAIHNLLCHVHPALGPHLPVLPE-----------EPRSL--------WTYLgY-------EECNTDYSHV 146
XP_015795311  64 MACCISVQSLRAIHNQLKIVHPILDAHFPANLD-----------VSEGF-------------FPNLLatfRAQEDVDPET 119
XP_015198438  73 WAGLFSVSDLRNVHRQLTGVSDVLGAFFPDLSA----------FEVGNL--------WDLL-FLGRPsglEEPDMDLDWP 133
XP_005989684  66 WAALFSVQDLRNIHRQLVAVDTNLELCFPQLPTf---------DVAESL--------WNLL-FPGRSp-fEGAEREAESF 126
XP_001365503  90 WAGLFSATELQGVHRQLAAVSPQLEACFPALPP----------EVGPSL--------WTLL-FPARP---APDEAVLQER 147
2_pfamImport   1 WTGLLSAAGLRGAHRQLAALWPPLERCFPLLPPga------grERRWGLgsgfcgvgWSAN-LSGGG---RTAGGSLQEL 70 
XP_001927350  80 WAGLLSASGLRGAHRQLAALWPPLEPCFPQLPPeldaggggawGLGRGL--------WTLV-WPARA---GPGEAALQEL 147
XP_003228536  70 WAALFTPQALRGLHGQLSALAPALEAAFPELPQalt----tshCSSAAP--------WALLfFPSRP---ALGEAELEAL 134 green anole
EDM08696     139 CRQL--EHYLGLAADGCGGATVRDVLFPAPGDSaD--CEGLSEFRERMLRARLDQTVARLRQLLQDHRKANTMVTLMKVY 214
XP_413835    120 CRQL--ERYLGWALELCGGRVLLDVLFAADRRD-DeyFESLHEFRGKALHGHLARAKEALRRVLQQHKNADTMVALMKVY 196
XP_014344877 260 CCQL--QVYLGHALDTCGWKILSQVLFT-ESDDpEeyYESLSELRQKGYEEVLQRARRHLQELLEKHKNTESMVELLELY 336
XP_022532395 225 CYQL--QVYLGHALDTCGWKILSQVLFA-DGDDsEeyYESLSELRQKGYEDALQRAKKRLQELLEKQRGMESMVELLQLY 301
Q6NVC9       179 CFQL--QVYLGHALDTCGWRILSQVLFP-DSEDaEeyYESLSELRQKGYEDALQRAKRRLQQLLEQQRAVERMVELLQLY 255 zebrafish
EKC42626     147 CYQI--EEYLCYSLEICKEKLLMSTLFEYEEHSaEeyFENISELRRQGYDEEINKVEEELKNVIFLRTNASHMTDMKDVY 224
XP_015795311 120 CNAI--ENYLESALSIVGKGLLMALLFDDDNDPlSdfEEDIQELRLKGYENVVQSSLRDLEDVLRYRDRARNMKELVAVY 197
XP_015198438 134 CRQL--ERYFSTAVDICGRTIVLDCLFAQDCRDvEeyFENLHEFKKKSMEDQVVRAREQLRKILQQHKAADKMVLLLKIY 211
XP_005989684 127 CRQL--EQYFSYAIDVCGRKIVLDFLFSQDDENvDeyFENLHEFRKKSLDQQVLRAKENLRLILHQHKIADTMVILMRTY 204
XP_001365503 148 CGQL--ELYLSAAADRCGARMLLDSLFSADTEPgDeyFENLHEFRKKSLQGHVARAKERLQRIIHEHKNAEKMMDLMKVY 225
2_pfamImport  71 CMRL--PEGLNCWAEGCGDHNLGNEVIPEVYPSaK---DGTGPWNKTRLKGSTSPGAVTGRQVLQGHEKANTMVTLMKVY 145
XP_001927350 148 CGQL--ERYLGQAADGCGGSAVRDALFPADGCAaD--CESLREFRERALRARRDEAGSRLRQLLRGHKKANTMVALMEVY 223
XP_003228536 135 CRGPxeR-YLGWAAELCGRRALLDALFARDTEEeAryFEGLAELRRKALKAGLGRAKEALRQILHRHKDTDKLVALMELY 213 green anole
EDM08696     215 QEEDEVYQELVTMATTFFQYLLQPFRDMREVATSCKLGILKSLEEDELGPKRVAALQKEASEWTRRAEEAVVSIQDITVN 294
XP_413835    197 EEEDEAYQDLVTMATQFYQYLLQPFRDMRELATLCKLEILKSLQYDNLGPKRVAALQKDAEEWTKRAESAVCSIQDITVK 276
XP_014344877 337 QEEDAAYCALVEATTELYQYLLQPFRDMRELAMLRRQQIKISMENDYLGPRRIESLKKEDADWQRKAHIAVLSIQNLTVK 416
XP_022532395 302 SVQDEAYGDLVEATTELYHYLLQPFRDMRELAMLRRQQIKISLETEYLGPRRVDALRREDEDWQRKAHTAVLSIQDLTVK 381
Q6NVC9       256 SEQDEAYGELVEATTELYHYLLQPFRDMRELAMLRRQQIKISLETERLGPRRVESLRREDEDWQRKAHTAVLSIQDLTVK 335 zebrafish
EKC42626     225 KSEDKAVFKLNIALASLYNYLLQPFLDVRELAYSRVMEAKEQLENPDVGARVKREYGEMFTEWQAHYEEALDNIQKYYIE 304
XP_015795311 198 KLEDEAISELCVAISEKYNFQLQPFLQLREMAHNHIKQAKSRIIDPDLGNRVKVQSQKELEEYNDQFLSANGALQHLYQE 277
XP_015198438 212 EEEDEAYKELVTVATQLYQYLLQPFRDMRELAMLCKMEIMKSLEFEDLGPKRIEALEKEAEEWRKRAQDAVSSIQDITVN 291
XP_005989684 205 EEEDEAYQELVKVATQFYQYLLQPFRDIRELAMLYKLEIQKSLEFDELGPKRVEALQKELGDWAARADEAVCSIQDITVN 284
XP_001365503 226 EEEDEAYQELVTVATKFYQYLLQPFRDMRELATLYKLEISKSIDFDELGPKRIEALQKEAKKWTKRAEEAVTSIQDITVN 305
2_pfamImport 146 QEEDEAYQELVLMATTFYQYLLQPFRDMREVATSRKLSILKSLDEDDLGPKRVVALQKEAKEWTRRAEEATVSIQDITVN 225
XP_001927350 224 QEEDEAYQELVTVATMFFQYLLQPFRDMRELATSCKLAILKSLDEDDLGPKRIAALQKEAQEWTRRAEEAVVSIQDITVN 303
XP_003228536 214 QEEDEAYLELVTVATEFYQYLLQPFRDMRELATLYRREILKSLQANKLGPKRVEALRKEAEEWANQAEEAVNSIQDITVS 293 green anole
EDM08696     295 YFKETVTALTGMQKQMEQDQRRFGQAAWA-TAMP-RLENLKLMLARETLQLMRAKELCLKHRQAEIQR-KVEDLPDQGKN 371
XP_413835    277 YFKETVKALSAMHKQMEQDQERFGKATWA-SALP-RLENLKYMLAKETLQHLRARELCLKQKRAAIQK-NMENLNEQEEN 353
XP_014344877 417 YFEITTKAQKAAYDRMRADQKKFGKATWA-AAVE-RMEKLQYAVSKETLQLMRAKEICLEQRKHALRD-EMQSLEGGTEA 493
XP_022532395 382 YFETTARAQKVMYERMRADQRKFGKAAWG-AAVE-RMEKLQYAVSKETLQLMRAKEICLEQRKHGLRE-EMQGLQGGEDA 458
Q6NVC9       336 YFETTARAQKVMYERMRADQRKFGKAAWG-AAVE-RMERLQYAVSKETLQLMRAKEICLEQRKHGLRE-EMQGLQGGEDA 412 zebrafish
EKC42626     305 YYTRTSKIYEGMLKRMREDQTKFGKTAFQlIGAE-RFFRIKEDHSLECLQLLNNEKKLYVQERDKVKE-EIACVEDKPGA 382
XP_015795311 278 YYRKVVELISSQITRMKEDQQRFGKLNFNlEGGPvRMLKLQILHNQEVLKLMNTVKATKEYHRDQLKK-YFKSLDAGEKS 356
XP_015198438 292 YFVETSKALAGMLKQMEEDRQRFGPAAWA-SASP-RLEKLKFMQAKEMLQHMRAKEMCLNRKKEDIRK-SVESLADQRDS 368
XP_005989684 285 YFKETVKALSVMQKQMEQDKRGYGQAAWA-SATP-RLEQLKLMLAKETLQLMRAKEMCLNRKKIEIQN-TMESLAERGES 361
XP_001365503 306 YFKETVNALVVMQKQMEQDEKRFGQATWA-LAAP-RLEKLKYMLARESLQHKRAKELCLNQKRVEIRK-KVEGLSEVEKN 382
2_pfamImport 226 YFKETVKALAGMQKQMEQDEKRFGQAAWA-AATP-RLEKLKLMLARESLQFMRAKELCLNHKRAEIRRkKMEDLLGKEKN 303
XP_001927350 304 YFEETVEALAGMQKQMAQDEKRFGQAAWA-TATP-RLEKLKLMLARETLQLMRAKELCLNHRRAEIQG-KMEDLPEQERK 380
XP_003228536 294 YFKETVTALAAMQKQIEQDQKRFGQAAWA-SASP-RLENLKYLLAKETLQYMRAKELCLKHKRADIQK-QMESLNEQEND 370 green anole
EDM08696     372 VGVVDELEIQYYETQLELYDVKLEILRNEETILVTRLDSVKRLIAEKQAEVVYYDPCESPEELK 435
XP_413835    354 VTVAEELEIYYYETQLELYNVQLDVLKHEEMLLIVQLDTLRRQIKEKQDEVVYYDTCENPEELK 417
XP_014344877 494 MAQLDQLESDYYDLQLQLYEVKFEILKCEELLLTAQLESIKRQMTEKQDEVVYYDTYESMEAML 557
XP_022532395 459 MARLDQLEALYYELQLQLYEIQFEILKYEELLLTAQLQSLRRQMTERQDEVVYYDTYESPDAMQ 522
Q6NVC9       413 MARLDQLEALYYELQLQLYEIQFEILKNEELLLTAQLQSLRRQMSERQEEVVYYDTFESPDAMK 476 zebrafish
EKC42626     383 LTELDRLEGVVFNWQIKVQQQQMAILDEEERLIRTQMEAITNQIKADEDVPIFYDAVEDIEELS 446
XP_015795311 357 T-----FEQELKRAELDIINTRLEILMEEEKLLKKRLDLLENS--EDIDDDIFHDAVEEAQNAN 413
XP_015198438 369 VESVDELEMQYYEAQLELYDVKFEILKNEELLLLAQIDTVRRQIKELKEEVVYYDTCENEEELH 432
XP_005989684 362 LETVDQLEMQYYEAQLELYDVQLEILKNEDLLLTAQLDTMRRQIKEKNEEVIYYDACEDPGELR 425
XP_001365503 383 IDVVDELEIQYYDVQLELYEVQLEILKFEEMLLIIELDTIRRLIKEKQDEVVYYDTCENPEELK 446
2_pfamImport 304 IDVVDELEIQYYEVQLELYEAKLEMLKYEEILLITQLDSIKRLIKEKQDEVVYYDTCESLEELK 367
XP_001927350 381 KNVVDALEIQYYEVQLELYEVKFEILKYEEILLVTQLDSTKRLIKDKQDEVVYYDSCESPEELK 444
XP_003228536 371 VAQVEELEIEYYETQLELYEVQFEILKNEELLLTAQLETLRRRMKEIQDEVIYYDTCETPDELE 434 green anole
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