Conserved Protein Domain Family
7tmA_RNL3R1
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cd15926: 7tmA_RNL3R1 
relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G protein-coupled receptors
The G protein-coupled receptor RNL3R1 is also known as GPCR135, relaxin family peptide receptor 3 (RXFP3), and somatostatin- and angiotensin-like peptide receptor (SALPR). RNL3/relaxin-3, a member of the insulin superfamily, is an endogenous neuropeptide ligand for RNL3R1. RNL3R1 is predominantly expressed in brain regions and implicated in stress, anxiety, and feeding, and metabolism. RNL3R1 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation, and also activates Erk1/2 signaling pathway.
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Statistics
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PSSM-Id: 320592
Aligned: 5 rows
Threshold Bit Score: 511.748
Created: 9-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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Feature 1:putative peptide ligand binding pocket [polypeptide binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                #  ##            ###### 
Q9NSD7        82 ILISVVYWVVCALGLAGNLLVLYLMKSMQGwrkssINLFVTNLALTDFQFVLTLPFWAVENaldfkWPFGkamCKIVSMV 161 human
NP_001122260  57 IIISIIYSVVCALGLIGNILVLYLMKSKQAwkkssINLFVTSLAVTDFQFVLTLPFWAVENamdftWLFGkamCKIVSYV 136 zebrafish
XP_005999422  53 IIISCVYSVVCALGLVGNLLVLYLMKTKQGwkkssINLFVTSLAVTDLQFVLTLPFWAVENaldftWLFGkamCKIVSYV 132 coelacanth
EMC86171      11 IVISLVYSVVCAMGLVGNLLVLYLMKSKQGwrkssINLFVTSLAVTDFQFVLTLPFWAVENaldfnWLFGkamCKIVSYV 90  domestic pigeon
XP_002941625  68 IIISIVYSVVCALGLVGNVLVLYLMKTKQGwkkssINLFVTSLAITDFQFVLTLPFWAVENaldfsWLFGkamCKIVSYV 147 western clawed ...

Feature 1        ##  #                                                           # #####         
Q9NSD7       162 TSMNMYASVFFLTAMSVTRYHSVASALKSHRTRghgrgdccgrslgdscCFSAKALCVWIWALAALASLPSAIFsttvkv 241 human
NP_001122260 137 TATNMYASVFFLTAMSVARYCSVASALKSKRRRl---------------RFSAQWMTVIIWIAAVGAALPNAIFsttatv 201 zebrafish
XP_005999422 133 TAMNMYASVFFLTAMSVARYWSVASALRAKRRPi---------------GCSAKWMSSLIWVSAMLASLPNAIFsttstv 197 coelacanth
EMC86171      91 TAMNMYASVFFLTAMSVARYRSVASALKNQRRGdpl-----------ggCCSAKWLCALIWLLAILASLPHAIFsttatv 159 domestic pigeon
XP_002941625 148 TAMNMYASVFFLTAMSVARYYSVASALKVKRRPa---------------GCSAKWVSVLIWVSAIVASLPNAIFsttatv 212 western clawed ...

Feature 1                              #  ### ### ##                                             
Q9NSD7       242 mgeELCLVRFPdkllgrdrQFWLGLYHSQKVLLGFVLPLGIIILCYLLLVrfiadrraagtkggaavaggrptgasaRRL 321 human
NP_001122260 202 sneELCLVKFPdrs--gdaQFWLGLYHAQKVLLGFLIPFGIISICYLLLLrfitnkn--------------intssaKRR 265 zebrafish
XP_005999422 198 sneELCLVKFPdnr---naQFWLGLYHTQKVMLGFLIPLVIISVCYLLLLryitnkn--------------vtisntKRR 260 coelacanth
EMC86171     160 fddVLCLVKFPegrg-snaQFWLGLYHIQKVLLGFVVPLAVISLCYLLLVrfisdkhvg----------stcsgpstKRR 228 domestic pigeon
XP_002941625 213 sseVLCLVKFPvnn--gnaQFWLGLYHAQKVLLGFLIPLFVITICYLLLVrfitdrn--------------isssstKRR 276 western clawed ...

Feature 1                         #  ## ##  #                 ## ###  #  ##                     
Q9NSD7       322 SKVTKSVTIVVLSFFLCWLPNQALTTWSILikfnavpfsqeyflcQVYAFPVSVCLAHSNSCLNPVLYCLVRrEFRKAL 400 human
NP_001122260 266 SKVTRSVTIVVLSFFLCWLPNQALTAWGILiklnvvhfsyeyyttQVYIFPVTVCLAHSNSCLNPILYCLMRrEFRKAL 344 zebrafish
XP_005999422 261 SKVTKSVTIVVLSFFLCWLPNQAITAWGIMiklnvlhfsyeyyttQAYIFPITVCLAHSNSCLNPILYCLMRrEFRKAL 339 coelacanth
EMC86171     229 SKVTKSVSIVVLSFFLCWLPNQALTTWGILiklnvvhfsteyflsQVYLFPISVCLAHSNSCLNPILYCLMRrEFRKAL 307 domestic pigeon
XP_002941625 277 SKVTKSVTIVVLSFFLCWLPNQALTTWGILiklnivqfsyeyfttQAYIFPITVCLAHSNSCLNPILYCLMRrEFRKAL 355 western clawed frog

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