Conserved Protein Domain Family
HPIP
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pfam15226: HPIP 
HCF-1 beta-propeller-interacting protein family
HPIP is a small cellular polypeptide that binds to the beta-propeller domain of HCF-1. HPIP regulates HCF-1 activity by modulating its subcellular localization. HCF-1 is a cellular protein required by VP16 to activate the herpes simplex virus- immediate-early genes. VP16 is a component of the viral tegument and, after release into the cell, binds to HCF-1 and translocates to the nucleus to form a complex with the POU domain protein Oct-1 and a VP16-responsive DNA sequence. HPIP-mediated export may provide the pool of cytoplasmic HCF-1 required for import of virion-derived VP16 into the nucleus.
Links
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Statistics
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PSSM-Id: 373659
Aligned: 7 rows
Threshold Bit Score: 143.204
Created: 22-Aug-2024
Updated: 4-Dec-2024
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_013970147   2 ILQQPLERGPPGRAQrdpRAASGTPRAQDVSSPLRGAVPMSTKRRLEEE------QEPLRKQFLSEENMATHFSRLSLHN 75 
1_pfamImport   1 ILQQPLERASPGLAL---RATSGVTRGLDTSSPVRGAVPMSTKQRLEEQiflslpREALRKQFLTEENMATHFSRLSLHN 77 
3_pfamImport   1 ILQQPLERGPQGRGVcrmRRGGAYRQSLGISSPLRGAVPMSTKRRLEEE------QEPLRKQFLSEENMATHFSQLSLHN 74 
2_pfamImport   1 ILPQPLERGPRGRTQrdpSAASGATWSLDASSPLQ-AVPMSTKRRLEV-------QETLHKQFLSEENMATHFSQLRLHN 72 
XP_003790863   2 ILLQPSERGPQGRTQrrsQATLGVTRGPDASSPLRGAVLMSTKRRLEEE------QEPLHKQFLSEENMATHFSRLSLHN 75 
XP_016878873   2 ILQQPLQRGPQGGAQrlpRAALGVTWGLDARLP-----PVSVSQPASLPsl---pREPLRKQFLSEENMATHFSQLSLHN 73 
XP_002722813   2 ILQKSLERGPLSRALrdpRAVSGTSRGLDA-------------------------REPVRKHSPSEESMATHFSRLSLHN 56 

XP_013970147  76 DHPYCSPPMVFPPSLPPLRSPCSELLLWRYPGNLIPEALRLLRLGDSPTPHYPATQTGE 134
1_pfamImport  78 DHPYCSPPMPFLPALPPLRSPCSELFLWRYPGSLIPEALRLLRLGDTPTPHFAATPAGD 136
3_pfamImport  75 DHPYCSPPRAFPPALPPLRSPCSELLLWRYPGNLIPEALRLLRLGDPPPPPPPSSPA-- 131
2_pfamImport  73 HHPYCSPLRALPPVLPPLRSPCSELHLWCYSGNLIPEALRLLRLGDTP-PPYSVTTAGD 130
XP_003790863  76 DHPYCTPAVAFPPALPPLRSPCSELLLWRYPGSLIPEALRLLRLGDTPMPHYSAAPAGD 134
XP_016878873  74 DHPYCSPPMTFSPALPPLRSPCSELLLWRYPGSLIPEALRLLRLGDTPSPPYPATPAGD 132
XP_002722813  57 DHPYCSPPGVSP---PPSR-PSSEVLLWRYPGSLIPEALRLLRLGDPPTPSHPATPAGD 111
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