Conserved Protein Domain Family
TFCD_C

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pfam12612: TFCD_C 
Tubulin folding cofactor D C terminal
This domain family is found in eukaryotes, and is typically between 182 and 199 amino acids in length. The family is found in association with pfam02985. There is a single completely conserved residue R that may be functionally important. Tubulin folding cofactor D does not co-polymerize with microtubules either in vivo or in vitro, but instead modulates microtubule dynamics by sequestering beta-tubulin from GTP-bound alphabeta-heterodimers in microtubules.
Statistics
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PSSM-Id: 463643
Aligned: 99 rows
Threshold Bit Score: 69.9591
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EGC31893     1085 TEFISKLIQLSGEKLDKIRDVVCKIIHQI----LWMEPTi-----------kTIIPHREEL-LKIFvkvPDD-----HFN 1143
EFC42721      876 TSLMCSLLKQAVEKIDRVRDNACRSIVRI----LANEHS-------------KNIPLREEIsQIIH---SSDdg--sLVD 933 
Q10197        821 WCCISYIIRQTFDKIDSLRGLAYQALEQI----RVH----------------YLIRRCEAL-TNII---N-R-------I 868  Schizosacchar...
EPY50656      826 ISVLSFMVRQAFEKIDNLRLLALHCLEDS----KEH----------------PILKHDEGL-RNII---DSSlkyetKL- 880 
XP_008184182  869 KQIMCALVRQGVDRIDKIRGLSCMVITNL----LHRKKNi-----------vPNIAHRNEL-ERLF---KKKd----SFN 925 
XP_012739890  892 GSLYSRTLRLSAEKLDKVRGEAQTALAIL----IQDSIQh------------SAFTSANHVsRTYF---RHLl----DLQ 948 
XP_007807717  951 RQLFPCILRLAAEKLDRVRPEAQAVVALM----MKERYAh------------PSWYRKCNK-KKAD---NKSas--dSES 1008
EHA54560     1032 LTLFPKILRLSAEKLDKVRAEAQTALALA----LNQDWAlklr-----rstySSRPYHSFL-LSL----PTTts--eRL- 1094
XP_009650360  947 SKLYLNVLRLAAEKLDRVRTEAQAVLSLT----LTPSYAvwf--------nkLTFSSRTYL-LALL---T---------L 1001
XP_003111416  878 IKCARHMVQQSAERIGRTREVKTGAFRHTtyisLFQCACealkklteceitgRRLPYIDLL-MKIYv-dPK--------E 947 
EGC31893     1144 WF----RTEE---SLPL-ICLI--LQF-----------DI---YLYPLLFGLFS-SLGGNSKYLIDDSINSINNYFnny- 1197
EFC42721      934 WS----SAEK---SFPI-FVKL--LPL-----------EI---YRYSLLSGLVV-SMGGMSSHVFKHSTTALIDYL---- 984 
Q10197        869 RN----NPNMdgeVLNElNISL--LEI-----------PN---LRLQAFYGITVfTADGFGSDLAVKCFEFYLSYVyql- 927  Schizosacchar...
EPY50656      881 ------VEED---KIESpAIRF--LNY-----------TA---FREDAFKGIVTfTGNGFGGGKITSYYKNYQRYVyqlk 935 
XP_008184182  926 WF----TESD---SFSV-MVNF--LSM-----------PE---YKYPVLVGLLV-CIGGVSESLVKEACHNFTKHMks-- 978 
XP_012739890  949 LP----SSAS---WLSNtHLHL--H-------------QR---WTDHLFDGYVS-AADSGAEGLIRASRAALNDFC---- 998 
XP_007807717 1009 FRsltfSSRA---YFET-LLKL--ILSdslspalepseADrsgWMAELMSGLVT-SADAGNDDLVIASRAALTDFC---- 1077
EHA54560     1095 ------HPSVs--ATPV-LRDA---DA-----------SR---WMEELMTGYVT-SADAGHEDLVIASRGALAAYC---- 1143
XP_009650360 1002 YA----QDEY---IHPL-IMELarADP-----------GA---WMAELLAGYVT-SADTGNEDLVIAARAALTEYCs--- 1055
XP_003111416  948 FI----SDRT---VFQ--LKAI--LDIg----------DE---YYENLILGIVV-SAGGLAEGTQKFSKQLLLEHQrdi- 1001
EGC31893     1198 ---kneE-KENKII---KFLQTVLEIS------QNVPERMVQPTFKSITNLLLTHHFDFIITTKdksI--LERILFICYE 1262
EFC42721      985 ------KtSDDMSE---KILTVMLEIGv----qYALDDRVIVPLLKSYALLIGHGVFERFQPPQ---YdyTEKLIVATTK 1048
Q10197        928 ---edsFkKSNSRYgkrDLLQLYIDILs----sEDEIARFYFPIMKSFTSLLAYGCFTDFQNVK---G--MSKAIFIVQR 995  Schizosacchar...
EPY50656      936 dfknesCsDCGLSKq--DIFELYIKFFs----sKTEDSRLYYQIASSFTSLSLCGVFEKFISSKs-----VVRVAFLAQK 1004
XP_008184182  979 -------vPDDEFE---NLCTDIIAVWggkvaeVDADERIHQCILMSIERLATAGAFKDQFERNeseF--AANILTLVKK 1046
XP_012739890  999 ------FaAPANRE---LVCNTLVGSVkr--lhDAGDERVLLPMMSVVAFLFDAGILEGGHKG-------LRGLFLATQR 1060
XP_007807717 1078 ------EtSQRHVD---MVCNALALNLr----aHYADDRIAVPTLEIIAFLFRVGIFHCSRGVD------FRTLCLYTQK 1138
EHA54560     1144 ------ArSQDDLD---RACGALARNLarlsrqQPQPDRVVVPTLNVAAFLFHVGVFSRCSVVD------YKALCLAVQR 1208
XP_009650360 1056 -------mAPANRD---DVCTALVRNLs----sRQGQDRVLVPTLEIVAFLYRAGLFAGCRGVD------PKRLCLLVQK 1115
XP_003111416 1002 ------ceDKPRFD---HFLATCAALFq----rGKKVARIGNSFMQVLPQLFGNLGIYELCPETsh---sLVEMVEIMKA 1065
EGC31893     1263 RIKAsHDDIYL 1273
EFC42721     1049 EIVGtCKNVQK 1059
Q10197        996 RALT-CKSPGG 1005 Schizosaccharomyces pombe 972h-
EPY50656     1005 RALK-CTSTTG 1014
XP_008184182 1047 EAVSsKGGSTK 1057
XP_012739890 1061 AHFK-SGNVRK 1070
XP_007807717 1139 AGYK-TGNVRK 1148
EHA54560     1209 CGYK-TGNVRK 1218
XP_009650360 1116 AGYK-TGSIRK 1125
XP_003111416 1066 ITVK-SSLMSR 1075
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