3LOT,3FA5,2Y7G,3E02


Conserved Protein Domain Family
BKACE

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pfam05853: BKACE 
beta-keto acid cleavage enzyme
BKACE, beta-keto acid cleavage enzyme plays, a role in lysine degradation. In certain instances it catalyzes the conversion of 3-keto-5-aminohexanoate and acetyl-CoA into acetoacetate and 3-aminobutyryl-CoA. The family is found to have at least 14 slightly different potential new enzymatic activities, all of which can therefore be designated as beta-keto acid cleavage enzymes.
Statistics
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PSSM-Id: 461759
Aligned: 213 rows
Threshold Bit Score: 143.007
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3LOT_A              8 VIVTCAITGAIHTPSXSPYLPVTPDQIVEEAVKAAEAGAGXVHIHARDp-KDGRPTTDVEVFRYICREIKK-QSDVVINV 85  Archaeoglo...
WP_020462214        6 LIIEVRIN-EGTTRDISPHVPYSPEEIASQAVECWQQGASLVHYHARDp-ETGAQSADVDLYADVVRRIKQ-ESDLITFP 82  Frankia sp...
Q28MR0              4 IIIEARVN-ELATRIGNPHVPFLPAEVIADAKACHDAGASIFHFHGRN--EDGTPSHDPNFYLETNAGIRA-QSDILIHP 79  Jannaschia...
jgi:Cyan7822_4323   7 LIIECRCN-EITPRGDNPALPHSPKEIIREAIRAWEAGASIFHWHGRDp-DTGKPRNDVELYLEVIQGIRE-HTDLLIHP 83 
jgi:Psed_2557      10 LFIEVRCN-ESTMRGANPHLPYSTEEIVREAVRAHDAGAAIIHWHGRDp-DTGGPDNSVETYRAASEGIRG-ATDLITKP 86 
jgi:Psed_3787      23 VIVELALNGP-TPRSVNRHVPRSPAEITAVALEGIELGASIVHNHNDDpmFTADGVHAVEPYVRAWTPILDrYPDVLLYP 101
EGP06373            4 VWIEAALNGP-WTRAKQPGIPVAVEAIVADGIACAEAGAAIIHAHAYDv-TTGRQRDDWEIYARIIEGIRA-TVDVIVYP 80 
jgi:Dshi_0339       4 ICLEVALNGP-WSRSLQPGMPITTDELIAQGIACARAGAAVVHVHVYDp-DTGRQREDYDAYAKVIEGIRA-VEDVIVYP 80 
QianUST:TMO_2162    9 VWIEAALNGP-WGRDRQPGIPVTEAEIIADGIAAARAGAGIIHVHAYDp-ETGRQNDDGATYARIIEGIRA-TTDALVYP 85 
WP_015930015        3 VWIEAALNGP-WTRARQPRMPLAVDEIVADGIACARAGAAIIHVHAYDp-ATGRQIDDPDTYAAIIEGIRG-VEDVIVYP 79  Methylobac...
3LOT_A             86 TTGgggtlgiPV-EE------RAK-VVPA-----LKPEIATFNXGSXNFAIhpllkkykefkydwepeylextrDIVFRN 152 Archaeoglo...
WP_020462214       83 TLGa---------SMlptaeeRVGhIVEMakdpaTRPDCVPVDMLTTNLDRydsqrr------------afisnDRVYLN 141 Frankia sp...
Q28MR0             80 TLG--------YvANdtdakgRFAaIEQMmqsaeTAPDFAPMDTGSVNVDWwnpdeg------------kydttELIYKN 139 Jannaschia...
jgi:Cyan7822_4323  84 TLG--------YiTQhrv-edRVKhILAVnddplLRVDMVPVDFGSLNVDFwnpqtk------------eftttDQVYIN 142
jgi:Psed_2557      87 TLG--------YiSQtgv-edRVKhLRALaddpwLRFDAAAVDFGSLNIDTwdgqr--------------ftpgDGVYVN 143
jgi:Psed_3787     102 TMG--------AaARgipverRWA-HVEElarrrM--GMTLVDPGSVNLGLtsdgvl------------dpvaaAEPYAN 158
EGP06373           81 TIP-------SPgLGqeqntnRFG-HTLElakrgLI-EWAVIDPGSVHISRfdd-----------------lahGGVYAN 134
jgi:Dshi_0339      81 TLPls---gsRDaATamtpeaRFA-VVEAlardgLL-EWAVVDPGCAILSSlseir--------------agreGFVYHN 141
QianUST:TMO_2162   86 TIPla---gaALtGQaagpaaRFA-HIDFlasrgLI-EMAVIDPGTVCFIDrrdgp--------------aalaSFVYTN 146
WP_015930015       80 TIPfv---qsADaFRpgavemRFA-AIESlgrrgLL-EWAVVDPGSINLATfdeaa--------------raepGSVYLN 140 Methylobac...
3LOT_A            153 TFKDLEALSRIFKENDTKPELECYDIGQIYNTAFXFHEGYLE-------PPLRLQFIHg----iLGGIGTAVEDVL---- 217 Archaeoglo...
WP_020462214      142 TTKMLTHVCETVSAVGVQPVSMIWNIAGVRLTEAFLEMGLYK-------EPLFCELTLfadpfvSYGHPATIRGLHalld 214 Frankia sp...
Q28MR0            140 STGTLMYFADRIRHYNLTPYLVSWNVSFTRQIEQFLKMGVLD-------APAYICFCMtde-iiFAGHPGTEAGLDahta 211 Jannaschia...
jgi:Cyan7822_4323 143 TRANLMAVLEVFKKHNLHVSSVCWDVGQMRTARCFQEMGLLP-------RETLWELVFtge-vmPAGAAATIPGLQafva 214
jgi:Psed_2557     144 SRNDIEAVLRILDDIDTYLTTVVWDIGQIRTAKCFREMGLAQ-------APTFWELVFtgd-srPSGAGTNLLALQamva 215
jgi:Psed_3787     159 PHADTDHMITRTAALGAAPSISIFEPGYLRTVLTWHRTGRLP-------AGAIVKLYFgg--rlEFGLPPTPTALEayle 229
EGP06373          135 PHEDIMEGMRIARAHNVHPSYAVYEPGFT-------RLGAALaaiappsPTPIYRFMFsd--efAWGFPPREKYLDihld 205
jgi:Dshi_0339     142 SEAEVRHGLDLARTYGFHPSYAIYEPGFA-------RLGAALaaqvpgvPRPIYRFMFse--gfTFGYPPRGYALDsyla 212
QianUST:TMO_2162  147 TEAEIRHGLALAATHRLVPSYAIYEPGFT-------RAGALLagqtpglATPLYRFMFsd--afAWGFPPRRYGLEahla 217
WP_015930015      141 PGEHVLRGLTLAAQHGFVPSYAVYEPGFL-------RLGAALaravpgcPPPLYRFMFsd--rfTFGFPPAAYALDayle 211 Methylobac...
3LOT_A            218 FXKQTADRligrenyT-WSLVGAGRFQXP--LGTLAVIXGGDVRVGLEDSLYIERGKLAKSNAEQVEKXVRIVKELGKRP 294 Archaeoglo...
WP_020462214      215 FFPAQANWp--------WFLSVIGGNAFP--ALAGAIESGGHVAIGVADHSYQ--ELGVPTNAELVARVVEMARSMGREV 282 Frankia sp...
Q28MR0            212 FLPPEFETv--------WTVVNYKGDLFQ--LTEKIIRTGGHISIGLGDYAY-MDGSRHMTNAEVIAKVADQARRLGREP 280 Jannaschia...
jgi:Cyan7822_4323 215 EVPADNQ----------WLALCWNGDVMR--VAAWAITMGGHVGIGLGDYSYT--RFGKPHNGELVEKVAKMAHTLGREV 280
jgi:Psed_2557     216 ELPPG----------EpWQLMCYGGDVLP--LAAAAIVLGGHVAIGLGDHDYA--RFGTPHNGELVAKVVALAETIGRPV 281
jgi:Psed_3787     230 LLAPSGLP---------WSVAVLGGDVVGcgLAELAVRRGGHVRVGLEDHA----GPGEPSNADLLRALGELLADMGRVP 296
EGP06373          206 LLAETTPG-------ApWMIAGLGVDITS--LIPHTVARGGHVRVGLEDALWG----DPRTNEALVKDAVKRVRAAGGEP 272
jgi:Dshi_0339     213 LMAELDPG-------ApCMIAGLQVDILP--LIGAAVPAGVHVRVGLEDAPFG----TELSNIGWTEAAAQAIAQAGGTL 279
QianUST:TMO_2162  218 LLGEAAPA-------ApWMIAGLCVDLED--LLPHAVAAGGHVRTGLEDAPFG----TETGNAGLVARMVQMVEAAGGLP 284
WP_015930015      212 LLERTTAG-------SpWMVAGLGVDVRP--LVPHAVARGGHVRVGLEDAPFG----TEIGNPALVEEMVQLVEAAGGRP 278 Methylobac...
3LOT_A            295 ATPDEVREILGL 306 Archaeoglobus fulgidus
WP_020462214      283 ATPAEAREMLGL 294 Frankia sp. EAN1pec
Q28MR0            281 ASVAETREILNM 292 Jannaschia sp. CCS1
jgi:Cyan7822_4323 281 ATPAQAREILKM 292
jgi:Psed_2557     282 ATPAQARELLGM 293
jgi:Psed_3787     297 ASIAETRAILGv 308
EGP06373          273 ATTAEVRRELke 284
jgi:Dshi_0339     280 ARAAEIRRKiag 291
QianUST:TMO_2162  285 ATPAEIRAGLGL 296
WP_015930015      279 ATAAEIRRAcpa 290 Methylobacterium nodulans
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