Conserved Protein Domain Family
Furin-like_2

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pfam15913: Furin-like_2 
Furin-like repeat, cysteine-rich
The furin-like cysteine rich region has been found in a variety of proteins from eukaryotes that are involved in the mechanism of signal transduction by receptor tyrosine kinases, which involves receptor aggregation.
Statistics
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PSSM-Id: 464939
Aligned: 11 rows
Threshold Bit Score: 158.748
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002198269  40 CaR-GCDLCSEFNGCLRCSPKLFILLERNDIRQIGICLPSCPLGYFGLRNTDMNKCIKCKIEN-CESCFSRNFCTKCKEG 117
XP_008117010  36 C-T-GCIMCSEDNGCISCQQKLFLIIWRDGMRQYGACVHACPPGYFGVRGQEVNRCIKCRSPN-CESCFSKDFCIKCKQQ 112
Q2I0M5        35 C-T-GCIICSEENGCSTCQQRLFLFIRREGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCGA-T-CESCFSQDFCIRCKRQ 110 human
EHA97268      35 L-S-FQLSCGSERGCMACQQRLFLLIRREGIRQYGKCVHDCPLGFFGIRGQEVNRCKKCGA-T-CDSCFSQDFCIRCKRR 110
XP_425713    186 C-T-GCVLCSEENGCITCHHRLFLLIWRDGIRQYGVCVHTCPPGYFGVRGLEVNRCTKCRSPS-CESCFSKDFCMKCKEK 262
XP_014348294  36 C-S-SCVRCSGDNGCSTCQKKLFLLIWREGIRQYGACVHSCPPGYFGVRGQEVNRCTKCKTSY-CETCFSKDFCMRCKEG 112
NP_001274481  33 C-R-SCVLCSRENGCLRCSERLFLFLRRDGILHHGSCLHSCPAGHFGLRGKELNRCMKCKA-PeCERCFNKDFCTKCKIG 109
Q5UE89        42 Q-G-GCATCSDYNGCLTCKPQLFFALVRNGMKQIGVCRPSCPNGYFGIRSPEINKCTKCKA-D-CETCFNKNFCTKCKSG 117 tropical clawed...
XP_007656158  33 C-QgGCATCSDYNGCLSCKPRLFFVLERIGMKQIGVCLSSCPSGYFGTRYPDINKCTKCKA-E-CETCFTRTFCTKCKNG 109
Q6DHR0        41 C-SnGCEHCSEYNGCLKCRPRLFILLERNDIRQIGICLAACPVGYYGIRNRDMNKCTQCKIEN-CEACFSRNFCTKCKEG 118 zebrafish
XP_008118101  86 CdK-GCDLCSEFNGCLRCCPRLFILLERNDIRQTGICLQSCPSGYFGLRNPDMNKCIKCKIEN-CEECFSRNFCTKCKEG 163
XP_002198269 118 LYLHKGRCYVTCPEGYAAANGTMEC 142
XP_008117010 113 FYLHKGKCLSTCPLDTIAQPSTQEC 137
Q2I0M5       111 FYLYKGKCLPTCPPGTLAHQNTREC 135 human
EHA97268     111 FFLHKGKCLPTCPPGTLTHQSTREC 135
XP_425713    263 FYLHKGQCFRQCPPSTAAQPGTREC 287
XP_014348294 113 FYLFKGKCLISCPEGTAPDQQQREC 137
NP_001274481 110 FLLFKGKCFKSCPEGTFAQ-ST-DC 132
Q5UE89       118 FYKHNGKCLDTCPEGFEN-NHNMEC 141 tropical clawed frog
XP_007656158 110 YYIHMGKCLDSCPEGLETNNHTMEC 134
Q6DHR0       119 LYSHRGRCFSSCPEGFTV-NGTMEC 142 zebrafish
XP_008118101 164 FHLHKGRCY-NCTKDFSAANSTVEC 187
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