Conserved Protein Domain Family
AceK

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COG4579: AceK 
Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]
Statistics
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PSSM-Id: 443636
Aligned: 106 rows
Threshold Bit Score: 607.55
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_067753621   1 MSkngdllr------------------iepvppaAAGPGEVAAQILAGFDRHYALFRYSAQRAKSLFESGEWQGMQQLSR 62 
WP_012633180   1 Mld-----------------------------erGALARGAAEAIRAGYEAYQAERARITARARGRFEARDWAGAQRDAR 51 
WP_014401606   1 MDpqilpg---------------------llvaaDARPAAAAALVLDAFEDYNARFSDITRRARRHFERRDWRQSAADMQ 59 
WP_014434421   1 MQreniltisdklss-------dksslpsaepfrRNLAHQAASAIHSAFEDYHRAFKAITHRAQERFERREWTKWQSDSI 73 
WP_052744024   1 MTvafqassspasfipveevardalsalpeattrEAQASHIANAILAVFDNYYVRSRHIPYLAKEAFETRNWPETTNLSR 80 
WP_049725442   1 MTprp--------------------------gqlNESVESAVSLIVTGFEDYNASFGDIARRGRRRFEAGDRQGMRRDVV 54 
WP_066918552   1 MSsiiessslp---------------lppgnsprDLLVEQCASALARAFADYNTEYRAITRRAPHRFEERDWRGSQRDAV 65 
WP_067649953   1 MQarp---------------------------dpTSVPARAAALILDAFLDYNARFSDITRRAKRWFERRSWRQAQIDLV 53 
WP_106893309   1 MNadnl-------------------------qqvPWQSRTGATLIVDGFKRYNREFRRITQRAEQHFVNRDFAAQSRDLN 55 
WP_095042655   1 MNqrl---------------------------sgSRLANVGAKTISTAYATLHAQHQAITERARHRFDTQDWAGLQADTA 53 
WP_067753621  63 ERIEYYDMRVRECAAKVGQTLRraparhdetrtatheaplrMDGAEAAYWQAVKQAYAAQLIGHRQPECAETFFNSVSCR 142
WP_012633180  52 ERLDLRDGVVHRTVGEVRAELG-------------------GAVQDREVWRRAKEAFEAAAGSRPDFEVAGSFFNSVTRR 112
WP_014401606  60 ARIRLYDECIRETQGRLDSLLD-------------------DGLRSRALWAGMRLEYAARLQDKLDAELYKTWFSTLSRR 120
WP_014434421  74 ERLELREQIIQRLVSGLRTMLG-------------------EQVNSRYVWIAIKDAYARQINQRKDVELAETFYNSVTRR 134
WP_052744024  81 ERLDIYGRNLDALIPLLKQSWP-------------------QFADERGFWVEVEAQYLTQIRERYEADLAFAFLRSTRRL 141
WP_049725442  55 ERMALYDQGIDELIGRLDVLLA-------------------SRLFSRSVWKHLRAAYERRIRDRLDQELYKTWFNTISRR 115
WP_066918552  66 ERIELYEKCVNRAVAQMRNRLG-------------------EDVNERAVWSSIKRRFTMLIETLPDREFDKTFFNSVTRR 126
WP_067649953  54 WRLDLYEECLAETLGRLELLLD-------------------DRVRSRPLWRQIRDAFDHQVAPLLDRELSKTFFNSLSRR 114
WP_106893309  56 ARIELYDASVADISTTLIEILG-------------------EAASRRDIWEGIKAAYAELIQSELDQELYKTFYNTLTRR 116
WP_095042655  54 ERLGLYRRIVDLVEAAVRDLLG-------------------DRVEDKIIWASMKAVYSGLIADRDDWELAETFFNSATRR 114
WP_067753621 143 VLHRDYFHNDFLFVRPHAATDYLDSALPAYRVYYPASEGLRRSLVRMLADFGLAAPFADLPRDAGRLARAALSALQEqLp 222
WP_012633180 113 VFTTVGVDPAIEFLAADAPPPRe---DPPQHRTFPREATTEALLARVLRATPISASFEDLARDARLAALELDAHVRGlP- 188
WP_014401606 121 NFHTRGVDELVEYVALEREAVDAATPLPPLHS-YVVHGDIARTFHVLLDDFRPACGYADIARAVDLLATAFRQRLLDh-- 197
WP_014434421 135 ILTTIGVDPALEFVWFGATTLPTGg-TPIVRV-YTQVGSLEAMIKAILCDYQFAAPYEDLEGDARRVARAMEHALRYyW- 211
WP_052744024 142 MRQGEWAPVSYFAGRQKEIVPHDNGPTAI-RTFTCIWPVKNETVIDLLQVPGFNAPFRDIVDDARLIAMRINETLEAaTn 220
WP_049725442 116 LFKTRGVDPKIEFMAPDIDPTDRI-THPVSRHVYAVSGRPAATFERILRDHPFSIDYGDVRGDARKLAEHMASELKAr-- 192
WP_066918552 127 TFGTVGVDAAVEFVALDFDPIAAI-TAQIQTSVYVNRGSLELLFEDVLTEYRFRTPYVDFERSIQIITNEVRAQLERdAt 205
WP_067649953 115 FFHTTGVAADIEFVALDSDPTAHV-VRAVERTPYPLGTEPAHAVERVFADFPFACGYADAAADAAAVLDALAAQLDAl-- 191
WP_106893309 117 FFKTRGVAPAIEFVALDIEPTDRI-THPVARLVYHPNGDWQRGFEKLLADTPFARHFTDLEACANRLAEALAQRVQHw-- 193
WP_095042655 115 IFTTVGVDHHMEFVATDFETPPTRPRAPVYRV-YNRAATTVDLIAAILRDFSFATPYRHADQDAGLIAGRITAQLEKlG- 192
WP_067753621 223 rgvgpRLAADCQVHVLGTLFFRNKGAYVVGRLINHGK-LHPFSIALLRDPAgRIQPDALLFTEDDLSRLFSFTRAYFLVD 301
WP_012633180 189 -----DRQPIEAVELARPVFYRGKGAYLVGRIRRGRH-LTPLVLALAHGER-GVALDAILFTEEDVSIVFGFTRSYFHVE 261
WP_014401606 198 ------LGAVIQLDMLTAVFYRDRRAYLVGRHVSLQG-SAPLVLVLAQSPQ-GVVVDALLTEMADISALFDYSHSYFHAD 269
WP_014434421 212 -----DTPDFDVIEMVKSVFYRNKAAYLVGRIRKRNR-VIPIILPLLHEDR-GIYVDAALFSEEEASVVFSFTRAYFHVD 284
WP_052744024 221 s---dISGASITIEMIDGGFFRNRGAYLVGRIKQPSGpDIPLALALLNEKD-GIYVDAVLFEADRLHYVFSSALANFHVT 296
WP_049725442 193 -----GEDGLSSIELLETVFYREGRAYLVGRAFARDA-FLPCVIALKAEQG-EVRVDALLCRRIQVSILFGFTFSYFLAD 265
WP_066918552 206 a--sqPPLQVTQIEFIRTVFFQMTRAYVVGRISGPGW-MRPFVLALKNSDS-GIVIDAVMMDEDTVSILFSFTRSYFHAD 281
WP_067649953 192 -----DCGAATAIELLPTPFFRERRAYLVGRAFGERA-GTPLVIALVSTAE-GIRADAVLTDAARISMLFGFTRSYFLAD 264
WP_106893309 194 -----PNGAARAIELLQTRFYRERRCYLMGRLFGDDR-FGPIVIALTNSDA-GIEADALIVDREDFSQLVGFTRSYFLAD 266
WP_095042655 193 -----ALQTIDRVEMIRAPFFRGMGAYLVGRLFSGSH-RIPLALALLHSPE-GIVVDAVLLDENSVSILFSFAHSYFHVE 265
WP_067753621 302 METPSITVRFLSTLLPRKPQAELYTMIGLQKQGKTLFYRDFLEHLAH-SHDR------FDIAPGIRGMVMCVFTLPSYPY 374
WP_012633180 262 LERPRAMVAFLSTLLPLKRRSELYTGLGYHKHGKAELYREVTLHLAD-GEDR------FVPARGDRGLVMCVFTLPGLDV 334
WP_014401606 270 IAPVGSVVAFMHVLLPRKPLEELYTVLGRAKQGKTERYRRLFQHFRQhPGDR------LVHAEGKRGMVMLVLTPIRLPV 343
WP_014434421 285 AEIPGDLVGFLKSILPLKPIAELYIAIGYHKHGKTERYRALYRHLNN-SNDK------FEIARGTKGMVMTVFTLPSYDM 357
WP_052744024 297 AEAYHQLAHFLHSVMPKRPLGLHYSTIGFNHVGKVAVMRELQAEHNT-ATEQ------LDFALGFRGTVAIGFSTPSSRY 369
WP_049725442 266 LPTVGDAVVFLRTLLPDKPLDELYTVLGRAKQGKTERYRAFYRHIEQaPKEQ------MQAAEGTPGMVMMVFTLPSYPL 339
WP_066918552 282 LTHVGQAVVFLKSILPLKAVSELYTVLGRAKQGKTERYRELFRHLQQ-SEDQ------FIHAPGERGLVMICFTLPSYDV 354
WP_067649953 265 LPTIADTIVYLHGLMPHKPIEELYTVLGRAKQGKTERYRHLFRHLAAhPAER------LVRADGERGMVMAVFTPRDYPL 338
WP_106893309 267 FETVGDAIVFLQTLAPRKPVDEWYAMLGRLKQAKTERYRHFVRHFDQ-ARDDtgapelFRHADGERGMVMAVFTLHSYPL 345
WP_095042655 266 VDRVYDLVHFLKSMLPRKRTGELYISLGYHKHGKTELYRDLLDHLAS-TTDK------FEIARGQRGMVMLVFTMPGYDM 338
WP_067753621 375 VFKLIRDRSA-KRHMD----PATVRRKYQMVKLHDRAGRMADTWEYSQVALPRARFAPGLLEELRGTAPSLIEADGDSIV 449
WP_012633180 335 IFKVIRDRFApPKQTT----RREVMDRYRHVFRHDRAGRLVDAQEYEHLAFPAGRFAPALLDELRTECGDGVRVADGEVA 410
WP_014401606 344 VIKLIRDRFVwPKDMK----RRDVEEKYRLVMLHDRVGRLVDAQEFRQLRLARACFPDELLTELMAECGSSVSEEGDDIV 419
WP_014434421 358 VFKVIKDQFAyPKTTT----RQQVMERYRMVFQHDRVGRMVDAQEFEGLTFSRDRFSPELLKELQESAAKTVTITDDEVI 433
WP_052744024 370 VLKVIRDQPAeGYKWDtfpgVDAILQKYRAVHETDRAGSMLDNIIYDNVRLDREWFTPQLLQEFANAAPDSVKILHRYVL 449
WP_049725442 340 VFKLLRDRFDpAKKVH----RKDVFERYHLVYRHDRVGRLLDAQEFKDLRFDASRFPEPLRQELVEGCSKVVNEEEGSLV 415
WP_066918552 355 VFKIIRDRFAyPKNVL----REEVLQKYELVFKHDRAGRLVDAQEFKRLKFPVARFSAAVLEELNNEAANTVHFEGDELV 430
WP_067649953 339 VFKVIRDRFAyPKDIG----RRQVEEKYRLVFRYDRIGRLVDAQEFRHLRFPLDQFDPPMLDELLRECAETVTTDGDDLV 414
WP_106893309 346 VFKLIRDQFApPKNVT----REEVAAKYQLVFKHDRAGRLIDAQEFRFLRFPLARFHQPLLDELVQGCAQSVYVDGDDLV 421
WP_095042655 339 VFKVIKDHFNyPKDST----RKEVMGKYDLVYRHDRAGRLVDAQAFEYLEFGRDLFSDELLAILAADCGQSVCITEESVV 414
WP_067753621 450 LRHVYIERRMTPLNLYLQQAPGALRDAAVRDYGQAIRDIAAAGLFPGDMLYKNFGVTRLGRVVFYDYDEIQRMTEINFRA 529
WP_012633180 411 IRHLYAERRVTPLNLFVREADEWTARQAVLDFGCALRDLAATDTFPGDLLLKNFGVTRHGRVIFYDYDELTRVTDCNFRD 490
WP_014401606 420 ISHCYIQRRLRPLDLYLREVEPEAARRAVLDYGQAIKDLAGSRLFPGDMLLKNFGVSRAGRAIFYDYDEVCALDDCHFRA 499
WP_014434421 434 IKHLYTERRLYPLDLYIKEMSFERARAAVIDYGQAIIDLATANIFPGDLFIKNFGVTRHGRVVFYDYDELCLLTDCNFRK 513
WP_052744024 450 FRHLIVQMKLTPVPEFLKKASPTEAKAAIRELGTCIANNAAANIFNKDLDARNYGVSRIGRVYLFDYDAVEPLTGIKVRT 529
WP_049725442 416 IRHCWVERRVRPLNLYLKEVDDAQAEAAVLDMGQALKDLARSNIFAGDLLPKNFGVTRSGRVVFYDYDELMLLTDCRFRR 495
WP_066918552 431 IGHMYIERRMTPLNLYLRDASPRDAELAVLDYGQCIRDLAVTNIFAGDLLLKNFGVTRHGRVIFYDYDELCAVSDCRFRE 510
WP_067649953 415 VAHCYVERRLRPLNLYAREAEPAAALQAVLDYGQAIKDLARSNIFPGDLLLKNFGITRGGRAIFYDYDELCLVESCRFRA 494
WP_106893309 422 IMHCYVERKLRPLNLFVKEAPTELVHKAVVDYGQAIKDLAISNIFPGDLLLKNFGVTRHSRAIFYDYDEICLVTECRFRR 501
WP_095042655 415 IAHAYFQRRVIPLDIYVREARDHAAHLAVCDYGQAIKDMASCNIFPGDMLLKNFGVTRHGRVVFYDYDELCLLEECNFRR 494
WP_067753621 530 IPPAPDDEAEM---------SSEPWYPVGENDVFPEEFGQFL-LGQPRVRTVFMAHHAALLDPAWWQACRDRVARGGVAD 599
WP_012633180 491 LPAAGGGDDGWgggpdagydGGDPPFYVGPADVFPEELLPFL-GLTGRLREVFLRAHGELLTGRWWRGIQARLRAGEIVD 569
WP_014401606 500 LPPARPGEEML---------PLEDRVYAAPGDVFPEMFIHFM-GVGAELRRLLGEAHPELFDPAWWQGLQARLRSGEYVD 569
WP_014434421 514 LPASRDYDDEI---------ADQPWFPVAPNDIFPEEFRKFL-WFPAPLRKVMEEHHGQLFTVEFWQELQRRVRSGEVID 583
WP_052744024 530 NLDRIEGEEDI-----------PDWFFEKGTIFLPEEMLVGLrVDDPDLRRAFREINGELMTTAYWEGMQRALNAGLVPK 598
WP_049725442 496 IPEARDFTDIY---------SSQPWYSIEDNDVFPEEFRRFM-GLKRDHMALLERVHGELFDADWWAEVQSRIRSGQALD 565
WP_066918552 511 VPQARHEEDEM---------RAEAWFHVNENDVFPETFINFL-GFDERLKTVFLEVHGEVMTAQWWREIQQRLQEGDVLE 580
WP_067649953 495 LPDARDEDETR---------PLEDWLTVRENDVFPEQFPRFL-GIPAELRAALIATHGEIFDPRWWQAVQAGLAAGDYAD 564
WP_106893309 502 MPEPSDHDEEM---------HHGAWYHVDDFDVFPEQFPRFL-GLTDAQREALIAAHGDIFTVPFWLDLQNRFRKGLPPE 571
WP_095042655 495 LPPRDRYEEEL---------AAEPWFHVNPNDIFPEEFPNFL-GLSGALRAAFEDCHADLYTADYWREQQAALRAGRHAH 564
WP_067753621 600 VFPYDTHRRLPGPS 613
WP_012633180 570 IFPYREEQRLRHAR 583
WP_014401606 570 VPPYPRRARLL--- 580
WP_014434421 584 FFPYAPEKRFKRRM 597
WP_052744024 599 VRAYPTHMRLRASR 612
WP_049725442 566 VPPYNEGALLSCSG 579
WP_066918552 581 VLPYHRHRVHVFGS 594
WP_067649953 565 VPPYPPSARLAALP 578
WP_106893309 572 MTPYPERLRLRSGA 585
WP_095042655 565 IFPYQSEQRLYQDI 578
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