Conserved Protein Domain Family
PAXNEB

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pfam05625: PAXNEB 
PAXNEB protein
PAXNEB or PAX6 neighbour is found in several eukaryotic organizms. PAXNED is an RNA polymerase II Elongator protein subunit. It is part of the HAP subcomplex of Elongator, which is a six-subunit component of the RNA polymerase II holoenzyme. The HAP subcomplex is required for Elongator structural integrity and histone acetyltransferase activity. This protein family has a P-loop-like motif and adopts a RecA-ATPase-like fold, lacking the conserved sequence signature of ATPases.
Statistics
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PSSM-Id: 461696
Aligned: 67 rows
Threshold Bit Score: 242.504
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002006649   9 VQKPIR-GTRTSPHTGQVITSSGNPSLDLILGGGLPIGSICLIEEDRFMTHAKVLAKYFLAEGLLSKQELFLGSLdd-lP 86 
XP_002438727  24 SSSGAA-GVRIGP-NGAAFVSSGIPDLDRILGGGFLLGSVVMIMEDADAPHHLLLLRCFMSQGVVHKQPLLFSGAmk-eP 100
EFH61096      20 SSPQIP-GLKSGP-NGTAFISTGIRDLDRILGGGYPLGSLVMVMEDPEAPHHMDLLRTFMSQGLVNNQPLLYASPsk-dP 96 
XP_006593446  18 VTSQNH-GLKHGP-NGTMFISSGIPDLDKILGGGFSLGSLVMVMEDPEAPHHMLLLRNFMSQGLVQKQPLLYASAsr-dP 94 
XP_010646438  19 PAPQAP-GLKSGP-NGTIFLSSGIPDLDKILGGGFPLGSLVMVMEDTEAPHHMLLLRNFMSQGLVHNQPLLYASPsk-dP 95 
XP_015166714  19 ATTQIP-GVKLGP-NGTSFLSSGIPDLDQILGGGFTLGSLVMVMEDAEAPHHMLLLRNFMSQGLIHKQTLLYASPer-dP 95 
XP_002316217  19 SAPQLP-GIKCGP-NGTFFVSSGIPDLDKILGGGFPLGSLVMIMEDAEAPHHMLLLRNFMSQGLVQNQPLLYASPak-dP 95 
XP_004993576  13 ARKPPP-ATKPSLANGQLLTSTGMDAIDHLLGGGVAVGSVFLIEAQAKSPYADVVLKYFLSQGICHNHHVTLMSAdt-dP 90 
1_pfamImport   1 GGIVIP-GTHPSLHNGLLLVSSGIPSLDVVLGGGLPVGSIMMIEEDSGRRFSKIIMKYFLAEGVMSTHSLFVASYde-kP 78 
Q54XS0        42 AAKKLPnGCKISIKNSNLLTSTGLTDLDDIIGGGIPIGSILMIEEDINSSYYMFLLKYFLAEGVLQQQGVFFSSLigidP 121 Dictyostelium d...
XP_002006649  87 EEMLRRLPKPLTd-------eEVEQEQRLEQEQQAdk-----ngLRIAFRYND-----LPLVNS--EQATA-----KIGH 142
XP_002438727 101 RLFLGTLPAPVSs-------sKEDGRHRAMGAAASsdgrandegLRIAWQYKKy----FGDD----SRAEHkdnkqEFSN 165
EFH61096      97 RGFLGTLPHPASs-------kEDKSTAPDPDqg---------esLRIAWQYRKy-------------LESQknsidDYSN 147
XP_006593446  95 KSFLGTLPSPASp-------kGDNKSSDLShe----------kdLRIAWQYKKy----FGEPQL--NLNTNnggqhDYCN 151
XP_010646438  96 RAFLGTLPSPVLs-------kDDRSHNRDPEQLqe-------kgLRIAWQYKKy----FGEHRP--NFDSHrdtkhEYCN 155
XP_015166714  96 RGFLGTLPSPMAs-------kEEKSHERPAEqd---------anLRIAWQYKKy----FGEQ----NSEGQrggkaEYCN 151
XP_002316217  96 RGFLGTLPCPSSs-------kDDKSRNHDTEqe---------kgLRIAWQYKKy----FSENQK--NIDDHkdsnqEFCN 153
XP_004993576  91 SKFLKSCPRSVDtlnipesasVEKpe----------------kdMKIAWRYKN-----LPKVSSvvGTASRttfstKFCH 149
1_pfamImport  79 QEIVEHLPKPVCk-------dTVSASkt--------------ddMKIAFRYRD-----LSTASN--SLDAPp----KYGH 126
Q54XS0       122 FEILNKLPARITkeeeieadkNDTTNNINTNINTNnnnkqptdeLKIAWRYQQyvsneLSKQQQ--QQSAStimnqTFCH 199 Dictyostelium d...
XP_002006649 143 HFNLMEHMDAMMLS-YAHATIWNdkktnqedyedfdvandseqpragggeslpdpsesmlysyaqvvgskadpdqegeqS 221
XP_002438727 166 DFDLRKPLERHLLN-----------------------------------------------------------------G 180
EFH61096     148 DFDMRKPLERQFLS-----------------------------------------------------------------G 162
XP_006593446 152 DFDLRKPLDRHFFS-----------------------------------------------------------------G 166
XP_010646438 156 DFDLRKPLERYFLT-----------------------------------------------------------------A 170
XP_015166714 152 DFDLRKPLERHFYS-----------------------------------------------------------------G 166
XP_002316217 154 DFDLRKPLEKHFYS-----------------------------------------------------------------G 168
XP_004993576 150 TFNLSQQVEEKDLS-----------------------------------------------------------------N 164
1_pfamImport 127 FYDISQTMDEKDLE-NCEIETLNln----------------------------------------------------etS 153
Q54XS0       200 SYDFTRKMNVQSMNpELIHTLSHda----------------------------------------------------qsQ 227 Dictyostelium d...
XP_002006649 222 PppdaaptqaaaaaaetdeatpmeqsdgqktapninnnnnnnmdnstannttsttgttttttptaspptgKPQFFYNArY 301
XP_002438727 181 Qni------------------------------------------------------------------eCVSIQDADtL 194
EFH61096     163 Rpi------------------------------------------------------------------dCVSLLDSSdL 176
XP_006593446 167 Nnv------------------------------------------------------------------dCVSIKDSPnL 180
XP_010646438 171 Qni------------------------------------------------------------------cCLSIQDPPnL 184
XP_015166714 167 Qrv------------------------------------------------------------------dCISLRDSPnL 180
XP_002316217 169 Qrv------------------------------------------------------------------dCVSIKDSPnL 182
XP_004993576 165 Dti------------------------------------------------------------------hTADLRISKsG 178
1_pfamImport 154 D---------------------------------------------------------------------TDFPLLNTsL 164
Q54XS0       228 A----------------------------------------------------------------------EG---TSpY 234 Dictyostelium d...
XP_002006649 302 DRLLNYIQLLLNDsifEPGANmqe----knLCRVCLTSLGSPLWy--------------------dDHFAEDLLKFLTIL 357
XP_002438727 195 SSLQDCCSAFLSKlprKDGGSl-------tAGRIAIQSLCAPQCr--------------------yFEKDWDMVSFIRSL 247
EFH61096     177 SVAQDHCSTFLSKfsrSSSNIa-------sIGRIAIQSFSSPLCe--------------------ySDKESDMLSFIRLL 229
XP_006593446 181 TALQDCCAGFLAKfsrNEGSIs-------sAGRIAIQSFCSPQCk--------------------ySNEEWHMLSFIRSL 233
XP_010646438 185 AAFRDCCAKFLAQfsrNNSSIs-------cAGRVAIQSFCAPQCe--------------------ySNMEWDMLSFIRSL 237
XP_015166714 181 APLLERCSTFSAQiakSDDNIt-------cAGRIAIQSLCSPQCd--------------------fSDKDWEMLSFIRSL 233
XP_002316217 183 ATLHDRCATFLAQfprNDGSFs-------cMGRIAIQSLCAPQCe--------------------lSKMDWDMLSFIRSL 235
XP_004993576 179 NTFADAMQLILEAvepFRMVPqpgplvsaaVHRIGVHRLGSSAWdlgatdkdddggggynddqysvEERVQAACAFLHQL 258
1_pfamImport 165 QTILTKLKKMVSNskfTAPKIldpt-trlnVLRVTIPNLGSPVWcd------------------nsNTSVSAITRFLHAL 225
Q54XS0       235 RNLFLEIQNLVYKynkEAAMNpdq----trVLRLCIQSFSSPLW----------------------SNDEEGVIEFLHAL 288 Dictyostelium d...
XP_002006649 358 RGSVRSCTAVCFITMPMHLIAkYDSSLVPKIRQLVDYAIELESFAGSERETHpa---fkEYSGLLHLHKMSAINTLAVHM 434
XP_002438727 248 KAMVRSSNSVAVITFPSTVL---SNSFCKRWQHLADTLLSIKAIPDEDKDLAklltgyqDMVGFLHVHKVAQTNSQVPVI 324
EFH61096     230 KSMLMVSNAVAIVTFPPSLL---SPSSSKRLQHMADTLLSIKAIPDGDKELEklltgykDINGFLNIHKVARINTQVPVI 306
XP_006593446 234 KGMARSSNAVIVVTFPPSLL---PPSCSKRLQHMADTLLSVKAIPDEDKELAklltgyqDMIGLLNVHKVARLNTQVPVI 310
XP_010646438 238 KGMIRDSNAVAVITFPPSLL---SPSSSKRWQHIADTLLSVKAIPDEDKELAnlltgyqDMVGLLNVHKVANVNTQVPVI 314
XP_015166714 234 KGMVRSSGAVAVISFPPSLV---SPAFLKRWQHLADTLISVKAIPDEDKELAklltgyqDMLGLLSVHKVARINTQVPAI 310
XP_002316217 236 KSMLRSANAVAIITFPSSLL---SPSFCKRWQHMADVLLSVKAIPDEDKELGklltgyqDMVGFLNVHKIARINTQVPMI 312
XP_004993576 259 RGIARRSCAVVFVTVPSSLLS-SSPHHRHRIHLLADAVVRMEGFAGTSNEHHpa---lkEYHGFFKVLRMPQLNSLVAAT 334
1_pfamImport 226 RSLARNCLMTCLITVPTHLY---TPQQVTHIRHMVDCSIHLESFTG--EKTNpv---fiQFHGLLKIQKLPCLNSLVPYI 297
Q54XS0       289 KGLLRSSVATCVISVPTYIY---SGAFVKKIAHLCDTVVSINSFSGLGGETPeq---faEYLGLFNIRKIARLNTLSLSF 362 Dictyostelium d...
XP_002006649 435 -PETTDLAFKLRRKK-FVIEKLHLPPDLQESSeqtaksadvlpipncG--------VNSNVSMDF 489
XP_002438727 325 lE-ASTLSLKLRKRRlLVLERLNQAPVDGstg-------------psSaas--sscSSQGSQLDF 373
EFH61096     307 lE-AKTFSMSLKKRRfLALECLNQAPVDGssg-------------tsYgts--gscSSKSGALDF 355
XP_006593446 311 lE-ATTFSIKLQKRRfLVLECLNQAPVDGssg-------------ssYgtsggcsgSTKAGPLDF 361
XP_010646438 315 lE-ATTFSIKLQKRRyLVLECLNQAPVDGssg-------------ssYastgscsgSTKTGTLDF 365
XP_015166714 311 lE-ATTFSMKLRKRRaLVLECLNQAPVDGssg-------------ssYgtsgscsgSSKTGNLDF 361
XP_002316217 313 lE-ATTFSIKLHKRRfLVLECLNQAPIDGssg-------------tsYgtsggcsgSSRSGALDF 363
XP_004993576 335 -PDTADLVFKLKKKQ-FVIEKFHLPPELSDMPsrpqeda-----------pvtpssSSSSSSSSS 386
1_pfamImport 298 -PESLDLGFELKKTK-FLIKCLHLPPDMSETAlddrkt---qksspcDg-------TTLHKKLDF 350
Q54XS0       363 hPDMLTFVFKMKRRK-MCIETIHLPPESSrag-------------dsKpdnndsnkNKSDQNNIV 413 Dictyostelium discoideum
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