1J8F,1Q14,1MA3,1ICI,1S5P


Conserved Protein Domain Family
SIR2
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cd00296: SIR2 
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SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, producing nicotinamide and the novel metabolite O-acetyl-ADP-ribose. Sir2 proteins, also known as sirtuins, are found in all eukaryotes and many archaea and prokaryotes and have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. The most-studied function, gene silencing, involves the inactivation of chromosome domains containing key regulatory genes by packaging them into a specialized chromatin structure that is inaccessible to DNA-binding proteins. The oligomerization state of Sir2 appears to be organism-dependent, sometimes occurring as a monomer and sometimes as a multimer. Also included in this superfamily is a group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines.
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Statistics
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PSSM-Id: 238184
Aligned: 121 rows
Threshold Bit Score: 60.0498
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1J8F_C        44 RRVICLVGAGISTs--AGIPDFRSPstGLYdnlekyhlpype-------------------aifeisyfkkhPEPFFALa 102  human
NP_832692     30 GKLVLFVGAGVSMkgkSNLPNFDDLvdEIAktlyvekr---------------------------eitephdYYLGKIAk 82   Bacillus cereu...
NP_738072      2 KHSTILLGAGASVt--SGLPDWDTFasRLLstskavsdgdmv------------------kmllarqdplivVEAAKVAa 61   Corynebacteriu...
ZP_00200395   20 GRLVIFAGAGVSKgspSNFPDFEGLadEVMsrsaqi-------------------------------ltrgkAEPVDHFf 68   Moorella therm...
NP_052709     23 GNLIIFVGAGISMl--LGLPSWKGYaqEILedaiekgvidsel-----------------yeklkeedpkkiLTICKMLf 83   anthrax bacterium
NP_762610     22 GRVVFFCGAGVSRa-kAGFADFFGLasSVTselgvetsspalkliea---------akeitastgvegvvsaDRIFGLLe 91   Vibrio vulnifi...
CAE15078      21 GHVVFFCGAGISLa-kAKLPNFFQLaqKVIdllgttndsqarqlydflnkglkdkegnevalpsyastlistDRIFSLLe 99   Photorhabdus l...
NP_900729     32 QKVTIFAGAGISTe--SRIVLKNTFydDVAlelykinphlrvkelt-----------fpnlmqalksqpngrIKLLEMIt 98   Chromobacteriu...
P55383        21 GNVVFLCGAGVSA---PQLPNFRDLvlNVYnrlgeertpa----------------------edhafqasryEEVLGALs 75   Rhizobium sp. ...
NP_721543     23 QKLVIFVGAGVSIs--QGYPNWDNYieHLIkywqgqilae----------------------sdekklgrehHLIFDLIs 78   Streptococcus ...

1J8F_C       103 kely------------------------pgqfkPTICHYFMRLLKdkgl-------llrCYTQNIDTLERIAGLeq---- 147  human
NP_832692     83 tkdvhqvar---------------dlvhiekskPNPLHYAIPRLFpldt-------dirIVTTNFDQHFTTAIKeinrdi 140  Bacillus cereu...
NP_738072     62 gkswdyqlqma----------lyqgldsldslsPSPLHLAVVAHFlene------qstsLVTLNFDNLLEIALEreahek 125  Corynebacteriu...
ZP_00200395   69 grlkkkgvhvhr---------ivreiltrpdakPTKLHKELLSLFrnpq-------evrVVTTNFDRHFSTAASklfgdn 132  Moorella therm...
NP_052709     84 dekeiipksa------------neifkfekneeYKAIYEKLYSMNa------------iYITTNYDECLDVLTTpqsdne 139  anthrax bacterium
NP_762610     92 refltrdiyks-----------vakaltpegevDLSAHQTMLKLAttnd------givrLVTTNFDRLFDLCKPdintfm 154  Vibrio vulnifi...
CAE15078     100 qefetnliekt-----------vaqvlkpsdtvDTSAHKLLLDLAttse------grvqLITTNFDRLFNDCSLteipcf 162  Photorhabdus l...
NP_900729     99 krfslik------------------sfpelrkmATRFHRELGTFFpi----------knIITTNWDTFFEEECKatpfvf 150  Chromobacteriu...
P55383        76 rrlvrsedvid----------aaaaelqvpanpDTAHHDVILRLSrdqv------grpiIVTTNFDTLFERSLMvshsaa 139  Rhizobium sp. ...
NP_721543     79 ksdisnkrkvdlvnyelknvfgedfekrrldfeRGYFKNLLPYSLvnpvleslasldaiFITSNYDYEIENHAKrlkntv 158  Streptococcus ...

1J8F_C       148 -------------------------------------edLVEAHGTFYTSHCvsascrheyplswmkekifsevtpkced 190  human
NP_832692    141 nvyya-----------------------palptgrafkgLAYIHGNVEQEKEal-------------------------- 171  Bacillus cereu...
NP_738072    126 atsvt------------------------rasadvsgnvVHHLHGVITPQDVds-------------------------- 155  Corynebacteriu...
ZP_00200395  133 kipvyw---------------------apalplghrfngIVYLHGCVDQEAEef-------------------------- 165  Moorella therm...
NP_052709    140 kvsnsmdlseenklteqssetkvfidhtelleaelkngnVIHIHGSVKKEESm--------------------------- 192  anthrax bacterium
NP_762610    155 pprlp------------------------dlnhpidfngTVYLHGKVNEDGTgaas------------------------ 186  Vibrio vulnifi...
CAE15078     163 lppnl-----------------------pdlsknelidgLVYLHGRSNSDYIgaeg------------------------ 195  Photorhabdus l...
NP_900729    151 dqdi--------------------------afweaakrrVLKIHGSETNFGSi--------------------------- 177  Chromobacteriu...
P55383       140 fatqesaa-----------------gqdipapgsarftgVVHTHGRLTDDELnlsq------------------------ 178  Rhizobium sp. ...
NP_721543    159 vtindlne------------------fqhnkkgklqfgdVLHIHGTPDCDIEyf-------------------------- 194  Streptococcus ...

1J8F_C       191 cqslvkPDIVFFGESLPar-------fFSCMQSDFlkvDLLLVMGTSLQVQPFASLISkap-----------lsTPRLLI 252  human
NP_832692    172 -----iLTDGDFGRAYLteg-----waRRFLVDLFs-nYTVLFVGYSHNDPVMKYLATglp----------pstRRFAFV 230  Bacillus cereu...
NP_738072    156 ----vvLTLTDFANLIEctn----swqIDYLTAAVa-kGALIIAGTSYRDPDLRQWLHralre------kpdhhSAFVLL 220  Corynebacteriu...
ZP_00200395  166 -----iLTDSDFGRAYLteg-----waTSFLKSLFg-kYAVLFVGYSHNDQIMEYLGRslp----------pesLRFALV 224  Moorella therm...
NP_052709    193 -----lVTVQDYLERYGtiskqshpevSVFLDQVFnsnYVVLFMGYGLEEFEILEYMLsktkn------pshtiSHYMLF 261  anthrax bacterium
NP_762610    187 --ngfvLSSSEFGDAYLang-----waTSFVKGILe-kYVVVFVGYSADDPPIQYLLEalnks-------sshlNDIYAF 251  Vibrio vulnifi...
CAE15078     196 --ngfvLSGSEFGRAYLsdg-----waTNFIREIFs-kYTVVFIGYSANDPPMQYLLEglnkn-------likaKNVYAF 260  Photorhabdus l...
NP_900729    178 -----iADADDYKKCTKnlsk---giiGSKLKDILa-tQTIIFIGYSLSDYDFNSIYTfvrkqm-----rglhkQAYIVT 243  Chromobacteriu...
P55383       179 --telvLTSAQYGEAYLrag-----waARFLFDLMr-cRTLVLVGYTANDAPVRYILNvlegdr----erftdlRRVYAL 246  Rhizobium sp. ...
NP_721543    195 -----vSSSADYSKTYLkgr----nnfNKLVNWFKktkPTVLFIGASLEEDEILSLLHegsqnyalmksentgnSKVDEH 265  Streptococcus ...

1J8F_C       253 NKEKAgqsdpflgmimgl-gggmdfdskkayrDVAWLGE 290  human
NP_832692    231 AQGENtyh---------------------wehLGIRPIV 248  Bacillus cereus ATCC 14579
NP_738072    221 AREAFgvsksgfe------------liqdalsSQWKAIG 247  Corynebacterium efficiens YS-314
ZP_00200395  225 PEDIGeeerekw-------------klrgiepIFYPHTK 250  Moorella thermoacetica ATCC 39073
NP_052709    262 SENEEnpqmtnl-------------ykkyysnFGVELIP 287  anthrax bacterium
NP_762610    252 QSGDEsyass------------------kwhhKGVKAIA 272  Vibrio vulnificus CMCP6
CAE15078     261 QSGTIeeark------------------lwehKGVQAIA 281  Photorhabdus luminescens subsp. laumondii TTO1
NP_900729    244 PFENEiekfrkiglipiitdgtyfikklkqhpKIASHFI 282  Chromobacterium violaceum ATCC 12472
P55383       247 SSSNGdpqaaaapwqal---avepllfdpeggNPYGPLW 282  Rhizobium sp. NGR234
NP_721543    266 YKKIVegffn-----------------senhtQIIWYGD 287  Streptococcus mutans UA159
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