3EF0


Conserved Protein Domain Family
FCP1_euk
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TIGR02250: FCP1_euk 
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FCP1-like phosphatase, phosphatase domain
This model represents the phosphatase domain of the humanRNA polymerase II subunit A C-terminal domain phosphatase (FCP1) and closely related phosphatases from eukaryotes including plants, fungi, and slime mold. This domain is a member of the haloacid dehalogenase (HAD) superfamily by virtue of a conserved set of three catalytic motifs and a conserved fold as predicted by PSIPRED. The third motif in this family is distinctive (hhhhDDppphW). This domain is classified as a "Class III" HAD, since there is no large "cap" domain found between motifs 1 and 2 or motifs 2 and 3. This domain is related to domains found in the human NLI interacting factor-like phosphatases, and together both are detected by the pfam03031.
Links
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Statistics
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PSSM-Id: 131304
Aligned: 18 rows
Threshold Bit Score: 212.139
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3EF0_A     13 LRQEKRLSLIVDLDQTIIHATVDPTVGEWMS----DPGNVNYDV---LRDVRSFNLqegpsgY--------TSCYYIKFR 77   fission yeast
AAS86390  165 LLRERKLVLILDLDHTLINSTKLFDLSAAENe--lGIQSAAKEV---VPDRSLFTL------E--------TMQMLTKLR 225  Japanese rice
BAD19278  101 LLRARKLILVVDLDHTLINSTRFAHLSDDEKa--nGFTERTGDD----RSRGLFRM------G--------LFRMITKLR 160  Japanese rice
AAM94371  922 MFASQKLSLVLDIDHTLLNSAKFNEVESRHEeilrKKEEQDREKp--YRHLFRFLH------Mg----------MWTKLR 983  thale cress
BAB10744   83 CFNDKKLHLVLDLDHTLLHTVMISNLTKEETy---LIEEEDS-----REDLRRLNG------Gys-------sEFLIKLR 141  thale cress
BAB02162   71 VYGRKKLHLVLDLDHTLIHSMKTSNLSKAEKy---LIKEEKSGS---RKDLRKYNN------------------RLVKFR 126  thale cress
BAB09563   81 WLEDKKLHLVLDLDQTLIHTIKTSLLYESEKy---IIEEVES-----RKDIKRFNT------Gfp-------eESLIKLR 139  thale cress
AAM81360  155 LLGAKKLTLIVDLDQTVIHTTCERTIAEWQA----DPENPNHGA---VKDVEGFQL------AddnvsnvaANWYYVKKR 221  blackleg of rapes...
CAD25621   55 LEMQMKLILVLDLDQTVLHTTYGTSSLEG---------------------TVKFVI------Dr--------CRYCVKLR 99   Encephalitozoon c...
BAB08870  742 LQRQRKLYLVLDLDHTLLNTTILRDLKPEEEy--lKSHTHSLQDgcnVSGGSLFLL------E--------FMQMMTKLR 805  thale cress

3EF0_A     78 PGLAQFLQKISELYELHIYTMGTKAYAKEVAKIIDPTGKLFQDRVLSRDDSG------SLAQKS--LRRLFPc----DTS 145  fission yeast
AAS86390  226 PFVRRFLKEASDMFEMYIYTMGDKAYAIEIAKLLDPDNVYFGSKVISNSDCT------QRHQKG--LDVVLG-----DES 292  Japanese rice
BAD19278  161 PFVHEFLREASAMFEMHVYTLGNRNYATAVAKLLDPDGAYFGERIISSGESS------QPDRKS--LGDVFGwapemERA 232  Japanese rice
AAM94371  984 PGIWNFLEKASKLYELHLYTMGNKLYVTEMAKLLDPKGVLFNGRVISKGDDGdpldgdERVPKSkdLEGVMG-----MES 1058 thale cress
BAB10744  142 PFVHEFLKEANKMFSMYVYTMGDRDYAMNVLNLIDPEKVYFGDRVITRNE--------SPYIKT---LDLVLa----DEC 206  thale cress
BAB02162  127 PFVEEFLKEANKLFTMTAYTKGGSTYGQAVVRMIDPNKIYFGDRIITRKE--------SPDLKT---LDLVLa----DER 191  thale cress
BAB09563  140 PFVHQFLKECNEMFSMYVYTKGGYDYARLVLEMIDPDKFYFGNRVITRRE--------SPGFKT---LDLVLa----DER 204  thale cress
AAM81360  222 PGLEDFFKRMSKLYEMHVYTMATRAYAQAVCKIIDPDRRYFGDRILSRDENY------TDKTKS--LSRLFq-----NTT 288  blackleg of rapes...
CAD25621  100 PNLDYMLRRISKLYEIHVYTMGTRAYAERIVEIIDPSGKYFDDRIITRDENQ------GVLVKR--LSRLFPh----DHR 167  Encephalitozoon c...
BAB08870  806 PFVHSFLKEASEMFVMYIYTMGDRNYARQMAKLLDPKGEYFGDRVISRDDGT------VRHEKS--LDVVLG-----QES 872  thale cress

3EF0_A    146 MVVVIDDRGDVWDWNP-NLIKVVPYEFF 172  fission yeast
AAS86390  293 VAVILDDTEYVWQKHKeNLILMERYHYF 320  Japanese rice
BAD19278  233 AVVILDDTAEVWKGYRdNLIEMERYLYF 260  Japanese rice
AAM94371 1059 SVVIIDDSVRVWPQHKmNLIAVERYLYF 1086 thale cress
BAB10744  207 GVVIVDDTPHVWPDHKrNLLEITKYNYF 234  thale cress
BAB02162  192 GIVIVDNTPNVWPHHKrNLLEITSYFYF 219  thale cress
BAB09563  205 GIVIVDDTSSVWPHDKkNLLQIARYKYF 232  thale cress
AAM81360  289 MVVIIDDRADVWQYSP-HLVRVPVFNFF 315  blackleg of rapeseed fungus
CAD25621  168 NIVILDDRPDVWDYCE-NLVLIRPFWYF 194  Encephalitozoon cuniculi GB-M1
BAB08870  873 AVLILDDTENAWPKHKdNLIVIERYHFF 900  thale cress
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