4EXA


Conserved Protein Domain Family
AKR_PA4992-like

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cd19095: AKR_PA4992-like 
Click on image for an interactive view with Cn3D
Pseudomona aeruginosa PA4992 and similar proteins
Pseudomona aeruginosa PA4992 is the prototype of this family. It is a putative aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Statistics
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PSSM-Id: 381321
Aligned: 79 rows
Threshold Bit Score: 160.093
Created: 13-Mar-2018
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
active sitecatalytic
Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:4EXA; Pseudomonas aeruginosa aldo-keto reductase PA4992 in complex with cofactor NADP; contacts at 4A.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1            ##                                                                       
4EXA_A     43 SPLGLGTVKFGRDqgvkypsgftipdDREAADLLALARDLgiNLIDTAPAYGr--SEERLGPLLRg-----qREHWVIVS 115 Pseudomonas aerugi...
OLF74130    8 SRLGFGVTGPHAGlg---------agRGATTRLIHQAIDLgvTLFDTGPAYGrgeAERRLGAALKtv----pRAKVFVAT 74  Maricaulis sp. W15
GAK91051   14 SKLGLGIGGILGMka---------fnEDQANKVLHEAYNKgiNFFDTGSAYSfgnAEVRLGNLIKdv----nRDKLVIAT 80  Nonlabens ulvanivo...
ACT58297   26 PILGFGVSGVLASpl---------vsQAQVNNLTRTARRLgiTVFDTAPFYGdgvAEQRLKIALEksndtehLPPPFIIT 96  Hirschia baltica
KCZ99193   11 PAFGFGVSGPLATpl---------mpDHACDALIHQMLEGggAIFDTGPSYGgglGEIRLGRALAr------RADAFVMT 75  Hyphomonas polymorpha
KPP81704   11 SALGFGVSGPHGTpl---------irRADTVRLVHGAFDAgvRVFDTAPAYGageAEGRLGLALRgi----aRDAVFVTT 77  Oceanicaulis sp. H...
PHR60858   10 GRLGFGISGPHGSam---------vsTRSTRKLIEQAILGgiRTFDTGPSYGrgeAERRLGLVLRev----dRQNLFITT 76  Robiginitomaculum sp.
OYW43083   50 RRLGFGVSGPHGSpl---------irPEATVQMIQHAYALgvRVFDTGPSYGageAERRLGEALArl----pPYDPIVST 116 Rhodobacterales ba...
GAM97955   14 SALGFGVSGPLGSpl---------vsAKEVAGLVRAAIDGgvSLFDTAPFYGa--ADARLGAALTgi----dRANVQIIS 78  alpha proteobacter...
PIW30361    9 SRLGFGVSGPHKCda---------vdRPKTIRLIHEAIDYgiSVFDTAPKYGdgeAESRLGEALKsv----dRENVFIVT 75  Rhodobacterales ba...
Feature 1                                                                                     
4EXA_A    116 KVGEEFVdgqsv-fdfsaAHTRRSVERSLKRLetDRIELVLVHSDgndldilenseVYPTLAALKREGLIGAYGLSGKT- 193 Pseudomonas aerugi...
OLF74130   75 KAGVHAGghrd----lsaGAVEMSLRDSLKRLqrDHVDLLLLHGPapde---ltdkLIRRLQAFRDRGMIRHIGVCGRGg 147 Maricaulis sp. W15
GAK91051   81 KGGTVHVkgntykkdysrKQLTESLETSLRKLnlDYIDLFQLHSPqvkh---ltddVFETLELFKSQGKIRNIGVSCDGk 157 Nonlabens ulvanivo...
ACT58297   97 KAGTHRVgrkmw-kdfsiKGLRAQLSDSKSRL--PHIDAFFLHGPsend---ltpqLLAELQKLKQDGLFKYLGIAGRGh 170 Hirschia baltica
KCZ99193   76 KAGLLSSglkkrsrdfssAGLRASIEGSLQRLgrPAIDLLWLHGParse---itaeVIGLLMELRTSGLVHHFGIAGRTe 152 Hyphomonas polymorpha
KPP81704   78 KAGLSSAglkrrlrdfspRAIERSVRASLERLdlEGVDGLILHGPspse---ltpeLFTRLSGLKASGAFRLLGIAGRGq 154 Oceanicaulis sp. H...
PHR60858   77 KAGQTEFgtsd----wspAAIRDSLGRSLDRLriPAVDGFFLHGPapen---lsdeMFSVLDDLRGQGVFSYLGIAGRGp 149 Robiginitomaculum sp.
OYW43083  117 KVGMLSSglrrrhrdftpEAVRRSVHGSLKRLrrARIDWLFLHGPspae---ltdeLLKTLVDLKFKGDIVSLGICGRGk 193 Rhodobacterales ba...
GAM97955   79 KGGTRRAgrtvl-kdfseRALRADLETSLRALrsTYLDVFLLHGPsqaq---ftpeTARTLARLKAEKLVRATGVCTRGa 154 alpha proteobacter...
PIW30361   76 KAGIVDEtdrr---dftpEGIRTSMQESLKRLgvDYVDALLLQGAange---ltdeLQTGLQELKTNGLVRYVGASGRGe 149 Rhodobacterales ba...
Feature 1                                                  # #                                
4EXA_A    194 -VEGGLRALREgDCAMVTYNLNera-erPVIEYAAAHa-kGILVKKALASGhaclg------------------------ 246 Pseudomonas aerugi...
OLF74130  148 eLDRAIELGVF-DALMAPVNARlteaerQRLEQARAAg-lSVIGIETMAGAaqapsvpgsrgdlwyla-----------q 214 Maricaulis sp. W15
GAK91051  158 vLDHVLNLDFF-DTVMLTYNILeqe-adNQIKKAAQKn-iGVLIKSPMAHGlysndifkirglsdvwyllrvlknyrpql 234 Nonlabens ulvanivo...
ACT58297  171 eLDKAISSNSF-DLIMAPIHRNlpfqdlERLEKAQIQn-lGVIGIEALAPAaqgirlslnpsdmwys------------- 235 Hirschia baltica
KCZ99193  153 dALTALEDPIF-EAVMLPLNRIpgnpgpELAQRARAGg-rAVFAIEILGGLrphgkmtrgqlwrtak------------- 217 Hyphomonas polymorpha
KPP81704  155 eLDAAIATGRF-EIVMAPVHPFag---eQALARLRSArscGIAVMGIEAAGsgpaplswprsladly------------- 217 Oceanicaulis sp. H...
PHR60858  150 eLDVAIASDQF-DLIMMPMGPGamstngPRADLARQVg-lKIIGIEMISHSrkpwrisarpadwwh-------------- 213 Robiginitomaculum sp.
OYW43083  194 eLDAALASGHF-THFMAPVHAGlsshekERIYRLRSAg--ELIGIETLAAAnprfpvpvsagatwrl------------- 257 Rhodobacterales ba...
GAM97955  155 dSAWFVGKDEI-DVIQAPIEDL------SIIEAHGVGf-iAIEIMRNSANDvrlprrlsdlwyl---------------- 210 alpha proteobacter...
PIW30361  150 eLDKPTRTDLF-DIIMAPNYAGmpeeqtVRLQTARDSg-kGIFAIESKNGArpalrlplgkadrwyfkrq-------mkr 220 Rhodobacterales ba...
Feature 1                      #                  ####   #  ##   
4EXA_A    247 ------------agqdPVRASFELVFDqpgVAAAIVGTIN-PLHLAHNVAM 284 Pseudomonas aeruginosa PAO1
OLF74130  215 rvkqrlqrnpvapttgSPADSLRWALSqpyANSVMCLTTK-PTHLAANAAL 264 Maricaulis sp. W15
GAK91051  235 fkgykyryinsypdwkGAEIALKFVIEnqfVNAAMIGTTK-THHLNSNINV 284 Nonlabens ulvanivorans
ACT58297  236 -aravlhgkgfqkqqmTAHECLNWVKHs-gLADIILSTTSrIEHLHSNAAS 284 Hirschia baltica
KCZ99193  218 -rlamrgpapkhvtasTPDEALNWAYDeagADILLMTTTS-STHLAANINT 266 Hyphomonas polymorpha
KPP81704  218 klaqsirsgsgsgprlAMPGALVDPVQgglADCVLVTTTR-ENHLLANIQA 267 Oceanicaulis sp. HL-87
PHR60858  214 -mvrqvirqdhvssgqDPLTALRQALRtspTDMVLSSTTR-HKHVQQWLDC 262 Robiginitomaculum sp.
OYW43083  258 arslvgwanprpptpmTVEEALNWALDeggAHRIISTTSR-LDHLESNVAA 307 Rhodobacterales bacterium 12-64-8
GAM97955  211 ---argvlrrragvtaDPKRALSDALShphISAALFTTTR-LPHLERNIGS 257 alpha proteobacterium U9-1i
PIW30361  221 fqdrlseagapsgsrlPAIEAFRWSLDsplTDCLLVQTTR-SRHLRQLAQM 270 Rhodobacterales bacterium CG15_BIG_FIL_POST_REV...

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