Conserved Protein Domain Family
COG3975

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COG3975: COG3975 
Predicted metalloprotease, contains C-terminal PDZ domain [General function prediction only]
Statistics
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PSSM-Id: 443174
Aligned: 219 rows
Threshold Bit Score: 438.101
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_130537374    1 MSNTNhtsqsp------------------------------------dtpnsfD-LHYQIECFDAHAHLFRVKLDIQP-T 42  
WP_011685177    1 MRLSAlftlpllc---------------------------------vslygqnA-VKVKVDATDAARRLFHVQMTMPA-- 44  
WP_012633427    1 Mlgaavavgl------------------------------------aalgaaaapIDLEVDLRDAPSGVIHARLVIPA-- 42  
WP_013581592    1 MKVGiaavsafvm-------------------------------gaglawgqgApITLSVDLRDAPKKILHATETIPV-- 47  
WP_088874943    1 MKTlgsaavalllvagsasaqpga--------gpqpvtsapfvpapqdrpfngA-IRLEVDATDTVHRVFTVHETIPV-Q 70  
WP_046905162    1 MKTLRafapllaaallattaqpafsavp--nskpvavpvvisvpdaqdvpypgT-IGLNIDASDTDRNVYRITQTFPVeE 77  
WP_010233056    1 MKHPalsaallpfllatpalaqgdirpagntapeqaqlddatplpadtpwpggT-IALDIDATDTARGVYRVTQTIPVtA 79  
WP_069708509    1 MKNLlkgatlltslllstsvfaqdanr----stpmapplppempaakdvpyagT-IGLNIDASDISRGVYRVTQTIPVaP 75  
WP_083712612    1 MRTSRtsvmtdrpsgdglrrgsrlwa-------tawvvilsgmftasaqpqptT-IGVEVDLRDLPRRLVHSTIQIPC-- 70  
WP_081471768   26 gepfaflaagaqlhrragimsasartgeavmprsalavlalvaftlfpppaaaeeIRLHVDASEVARKVIHVREVIPA-- 103 
WP_130537374   43 TGE-KQTLSLPAWIPGSYLIRDFAKHIVEINArDSSG----NLIELIPNGLSAWDFQ---SQ--LPISVEYIVYA----W 108 
WP_011685177   45 KAG-AMTLLYPEWIPGEHGPTGPIANLVGLKI-QGAG----KTIPWKRDSVKMFAFHldvPAgvSSLDVVFDFISp---p 115 
WP_012633427   43 RPG-PLTLVAPKWLPGDHRPSNAVAELASLAV-TAGG----RPLAWARDPVDPYAFHlqvPRgaERVEVALDQLAppagQ 116 
WP_013581592   48 QPG-AMTLAYPKWIPGEHMPSGPIDDQAGFLI-TGNG----QPIRWERDPIDMFAYHltvPAgvTSLTVKMDFLAt---p 118 
WP_088874943   71 QAG-RMVLLYPEYETGSHAATASIAALAGLTL-HAGG----QPLAWRRDPLNPYAFEvevPAgvTAVEADFQFLSp---t 141 
WP_046905162   78 GAS-SLILQLPAWLPGNHASRGPINLLGDLHF-TANG----RELSWTRDPVEVHAFHidlPEgtTAVTARFVHTSp---i 148 
WP_010233056   80 DMR-ELRLLFPEWLPGNHAARGPINLVSGIRF-TAGG----KVLEWKRNPLDVYELIvdlPEgtEAVTAQFVHTSp---i 150 
WP_069708509   76 GAR-DLILLQAGWLPGNHSETGPYGLLADIHF-YADGpngtREIAWVRDTVAVNAFHlalPEgtKTVTAKFVHTSp---l 150 
WP_083712612   71 KPGrELAIWHPKWIPGTHEPCGSIENTGGLRIqSPDG----ATIPWRRDELDLYRIVfkaPAdvSSVRVTLDTICnqaaI 146 
WP_081471768  104 QSE-SLTLHYPKWIPGRHRPVGQIANVTEFRA-AASG----KALTWKRDDADPFTVAvavPDgaKEIEVTFDLLLa---a 174 
WP_130537374  109 DLS---VRKAHFDQT-HAFFNGTSVFLALEEQ-------RDTPVKVTMITNdfthdaQWKVATGMPAL----KvneqgFG 173 
WP_011685177  116 ESEg-fSSGASATSE-LAVLSWNQLLLYPEGAr-----sDDYQYQATLKVPd-----GWRYGTALPIQ----Res-gnQI 178 
WP_012633427  117 GSS---AAGSSFTSQ-LGILGWGTVVLVPAGVp-----aADQPVRARVTLPr-----GWKASTALPVA----Are-gdAM 177 
WP_013581592  119 NGGs-fTAGGSTSAN-LAVLSWNTLVVYPYSGptm--kaSDVMIAPSVTLPe-----GWHYGTALEPTgggnSap-gdQV 188 
WP_088874943  142 GPR---QGPMRMTPG-MVTIAWQTLLLYPAGWf-----tRDIPVAASLRLPt-----GMTPATTLAPT----Sga-ggML 202 
WP_046905162  149 QSN---EGRITMTRE-MLNLQWEKMSLYPAGHy-----vRQIQVKPTVKFPe-----GWEVFTALDGQ----Ses-gnVV 209 
WP_010233056  151 TGS---EGRITMTQE-MLNLQWEKMSFYPAGHy-----vRRIAVKPTVKVPa-----GWQVFTALDGK----Tre-ndTV 211 
WP_069708509  151 QTS---EGRITMTQE-MLNLQWEKMSLYPAGYy-----tRGIPYKPTVTFPr-----GWQVFTALDGF----Qrt-gdTV 211 
WP_083712612  147 EA----SGHLTFGNKlVGVVNWSTCVLYPEGPt-----aAETTVELSARLPe-----TWKYATALKTE----Ava-dgLI 207 
WP_081471768  175 GAEggaQFMTVASPK-LLMLNWNDVLMYPKLDapraaplEELTFTPAVTLPa-----GWVCGTALPAK----Gts-ggVT 243 
WP_130537374  174 DYWASNYRDLVEYPFELGN-YHEIQFTACG-IPHKMVFTGRlnA-NTDF-ERIRSDVQKICETEIEFFGldapqNPPMSE 249 
WP_011685177  179 EFQPASLTTMVDSPVSTGAhYRTFDLGTEQgIPHYLHVAADs-DrALEVsNEVVGQLKQLVKETGALFG-----ARHYRG 252 
WP_012633427  178 RFAPASLELLVDSPVLSGRhLMELPVHAPGaPPHLLVVAAEs-EdALAVpAELRADVERLVAEAGALFG-----GYPFAG 251 
WP_013581592  189 GFKTVSLEQLIDSPVLTGRfFKEIPLAPEVtPKHYLDIVADg-PeDLAInQAHIDDFSKLVRETGALYQ-----SRHFTA 262 
WP_088874943  203 SFATETLEDLVDSPVYAGRhVREVPLSQDKaAPVTLALLAEk-AeDLETtPTQIAGLARMVSQTHRLLG-----SAHYRR 276 
WP_046905162  210 TWDRVDYETLVDSPIFAGKyARSWDMG----HDIKLDVVADe-PeLLEIaPENLDTFRKLADEALALFG-----SKHFDH 279 
WP_010233056  212 TWQTVDYETLVDSPIFAGKyAERWEVG----ENVWLDAVADk-PkYLDLaPENLTRFERLIDEADALFG-----ARHFDH 281 
WP_069708509  212 TWNTIDFERLVDSPIFAGIhSQRWDLG----QNVFMDVVADe-PdLLAIkPENLQTYRNLVKEATTTFG-----SKHFDH 281 
WP_083712612  208 RFAPVSLVDLIDSPLIAGEhLRTIKLETGPyPPASFHLATDa-PaSLELnPNVIAQYSRLVREAGALFG-----SYHHDD 281 
WP_081471768  244 TFGSVPLGTLVDSPLLAGEhVREVPLD-GAnGKHRVFIACDs-AaGLDApEATLAAWKRLPGEAEKLFGp----AKPYTN 317 
WP_130537374  250 YLFQVMLTTSD-Y-GGLEHRNSTALICARDDLayigmeSNTDGYIQ-FLELCSHEYFHTWNVKRIQPKAYQD----SKLD 322 
WP_011685177  253 YHFLYTLSDHVaH-FGLEHHESSDDRTGERTL------IEPDMLRV-SGYLLPHEFVHSWNGKYRRPAGLISggqdGGYD 324 
WP_012633427  252 YRFLVTLSDEIvF-SGLEHHQCADMRMPERAL------ADPIARRT-RAGLLSHEYVHAWNGKSRRPQGMAA----ADFQ 319 
WP_013581592  263 YHFLVTLSDETlH-FGLEHHQSSDDRIPPDTF------TNDHTFVE-AGDLLPHEFTHSWNGKYRRPAGLAT----PNYQ 330 
WP_088874943  277 YALIVALNDQLpGpGGFEHMESSENAVPPDFF------QAADGYAV-YQDLFAHEFVHSWNGRYRQPAGLWA----PTYN 345 
WP_046905162  280 YNWLLALTDRMgG-IGLEHQRSSENQYEPRNF------VDWDTMAH-DRNVISHELVHSWNGKYRRPAKLWT----PDYR 347 
WP_010233056  282 YDILLALTDRMgG-IGLEHQRSAENQYEPTAL------IDWDEMDW-DHNVVSHELVHSWNGKYRRPDDLWT----PDYR 349 
WP_069708509  282 YDFLLALTDRMgG-IGLEHHRSSENQQEPKSW------TDWAGMDW-DRNVIAHEFVHSWNGKFRRGADAWT----PDYQ 349 
WP_083712612  282 FQFLVTCSDDLgY-LGLEHLASSLNGVGARDL------LDDHLRVGwVANLIPHEYVHSWCGKYRRPAGMCT----PNFH 350 
WP_081471768  318 YTFLLGLSNHIpR-AGIEHHQSSDNRLAELAL------VKAGERKA-SATLFPHEFVHSWNGKYRRPADMLK----RDYQ 385 
WP_130537374  323 RPVISEQLWWFEGVTSYYDALFLLKSQIISEVDYLNLLGKQLTRI-YMMPGRHKQSVAESSHYTWSKFYQQ-DEDAPNSI 400 
WP_011685177  325 VPMQGDLLWVYEGLTNYLGEVLAPRSGLWSPEDYRESLANTAAEL-DNKFGRTWRPLEDTATAAQILYEAGgDYGNLRRS 403 
WP_012633427  320 APPDARLLWVYEGLTHYLGWVLAARSGLGGARLp-DSIAVAAQGM-ASTTGRAWRSLEDTAAAAQVGYSARsEGAYARRS 397 
WP_013581592  331 VPMVGDGLWVYEGLTEYLGDVLAARCGIWTPEQFRDRLAEIAAKY-DNRPGRTWRDLQDTARMAQVLYTVGgPYDNWRLG 409 
WP_088874943  346 QPVDGSLLWVYEGQTEFWGRVLAARAGLRTAAQTLDALAIDAAVA-QSRVGRAWKSLQDSANDPSIAIGRPmVWRDWQRR 424 
WP_046905162  348 QPMQDNLLWMYEGQTQFWGWILAGRSGLQPKDIVLGALANSAGYY-SEQPGRSWRSVEDTTHDPIINARRPlPFSSLSRS 426 
WP_010233056  350 TPMQDSLLWLYEGQTQLWGWVLAARSGLQTRQTFLDAFATYAANYsEGQPGRAYRSVADTTNDPIINSRAPlPYSSLARS 429 
WP_069708509  350 QPMQNTMLWVYEGQTQFWGYVLAARSGVQSRDMVMAMFATAAGKYaEGTPGRSWRSVEDTVNAPQLMRRRPlPYTSLTRS 429 
WP_083712612  351 SPMATRLLWVYEGLTQYLGDVLMVRCGLVKPEDYKRTLTGSIGDL-VLQSGRRWRSLEDTAVASSILRARSpNWNELRRS 429 
WP_081471768  386 QPQQTRLLWVYEGLTNYLGWLLAVRSGLYTPDEGRDYLAMTAARM-SNVKARGWRPLDDTAAAASTLFDATgAWRSARRS 464 
WP_130537374  401 ISYYTKGSLIALALDLTLRQQTENRCSLDTVVRYLWnefG--SknngVG----IGLEEKQIEEICSSLCiengGQCLKSF 474 
WP_011685177  404 VDYYPEGSLIWLEVDTIIRQNSKGTKSLDDFCRLFH---GggA----SGapalKSYGFDDVVAALNAVQ----PYDWAGF 472 
WP_012633427  398 VDFYWEGALVWLEVDARIRRESRGARSLDDFVRAFL---Gg-R----SGgptvSAYRLDEVIAALGKVA----PLDWAGL 465 
WP_013581592  410 TDFYEEGELVWLDVDTTIRSKTNGRKTLNDFVAAFH---GlgG----NTgpkvVPYTFEDVVAGLNAVV----PMDWAGF 478 
WP_088874943  425 EDYYGEGVLLWLDADSLIRERTGGKRGLDDVARALF---Gg-P----AGdrviRTYGFDDVCAALNSVL----PFDWAAF 492 
WP_046905162  427 EDYYSEGMLVWLEADQIIREGTDGKKGLDDFAKAFF---Gm-N----DSdwgqLTYEFDDIVSTLNAIH----PYDWAGF 494 
WP_010233056  430 EDYYVEGALVWIEADQIIRQGTKGRKGLDDFAKAFF---Gv-N----DGdwgqLTYDFDEIVATLNGVY----PYDWADF 497 
WP_069708509  430 EDYYVEGALTWLEADQIIRKGTGGAKGLDDFARAFF---Gv-R----DGdwgeVTYDFDEVVKVLNGVY----AYDWAGF 497 
WP_083712612  430 QDYYSEGALLWMEIDALIRQKTDGKKSLDDFCKAFL---Gg-P----TKpekvAPYELPEIAARLNEIA----PNDWKTF 497 
WP_081471768  465 VDFYDEGTLLWLEADVLIRTRTKGAKTLDDFCKAFF---Gt-G----TGapavERYALDDVLKALNEVA----PYDWKGH 532 
WP_130537374  475 FDQVLYGKDDFDLKSLFKPFGYDFILRPAKNpsdtggnieagvlqklvesTPSSIGARL-QDlPaGGieITHVWNQQAAY 553 
WP_011685177  473 LNQRIKSTDAHAPLGGITRAGWKLTYDGVRSdfwkaye-----dkikgldLSYSIGIQVkSD-D-GT--IADVRYGGPAQ 543 
WP_012633427  466 LDARVARPRPEAPTAGIEAAGWRLATSDTPTslqvaqe-----rvlgsfnLEASIGLYL-SE-D--R--VVDVVPGSPAA 534 
WP_013581592  479 LNERLHMLQAAAPLGGITNGGYKLVYKDKMSawsea---------sggvdFWYSLGLHV-SG-K-GQ--IRDVLVGGLGD 544 
WP_088874943  493 LRRRLDAHDDTGLLDGLTRGGYRLVFTDTPTdyfrqte-----tdgggidLSYSIGLVV-DA-K-GQ--ARAVAWNGPAF 562 
WP_046905162  495 LDMKMRQPGQPAPVTGIEKAGYRLVWKDEPNpyeagri-----rggnyvnLAYSLGMSL-TS-D-GT--VTSTIWDGPSF 564 
WP_010233056  498 LTTRLLEPNQPAPLHGIEMGGYQLVWKDEPNsydkgrm-----gngkylnLFYSLGVNL-GT-D-GT--VTGTLWDGPAF 567 
WP_069708509  498 LRTRLYDTNQPAPLNGVQMAGYKLVWKDKPNayekgia-----eerktldLTYSLGVTL-NK-D-GD--VTATLWDGPAY 567 
WP_083712612  498 LEDRVTRPLDALPVDFVARLGYRLQFGAGPSapdhgr-------rrvglsARHSLGLTF-GD-D-GR--VVDVAPGMIAD 565 
WP_081471768  533 FARRVEAVAEAPPLDGITSGGWALAYSDKPTdlfttme-----glakgvnLSDSVGFSV-SA-D-GL--VGDTVPNSPAA 602 
WP_130537374  554 LSGLTKGDQIIAINGIKVRnKSSFEQLLARHQEG-QTWECHYFRRDELYQTQLTPR---KAPLdrvtIQqTESDsRpSNN 629 
WP_011685177  544 QAGIAPAVKLIAVNGRQFN-PTLLRETVAKTATDsKPIELLVKNGEFYQTFRVAYRggeKYPH----LVrDAAV-P-DLL 616 
WP_012633427  535 RAGIPPGARLVAVNGRKHT-RQRLEDALRATERG-GPLELLVEAGDRFRTHAIAWRgglRYPV----LVrEAGV-P-DLL 606 
WP_013581592  545 KAGFGPGMTIVAVNGRAFS-TPVLRAAIVDAKESqAPTEFIVENTGFYKVIKMDYHqgeKFPV----FErVSGV-P-DRL 617 
WP_088874943  563 RAGLTVGSRLTAVNGQPFS-SDRLIEAVRQAAT--RPVELRFDSDGADHTAAVDYHgtlRYPR----LErVTGT-P-DRL 633 
WP_046905162  565 NAGIVDGAKIVAVNGTQFS-KDAIMDAVSMAETNdDPIELLVKRGDRYLTIPIHYHeglRYPW----LEpAAEG-E-QPL 637 
WP_010233056  568 DAGIVNGNTIVAVNGIAYS-GDTIEEAITAAKDTdQPIELLVKRGDTYRTVAIDYHgglRYPW----LEpVGKG-E-QPL 640 
WP_069708509  568 NAGIVNATKIVAVGGRAYS-SDVMKDAITAAKTAkAPISLLIKRGERYQTVAIDYHgglRHPW----LEsTTPG-KvNGF 641 
WP_083712612  566 RSGLSKGTKVVGINGRTFS-AEALHDALTASVSD-KKVDFLIVEGDRLRPLTLAYAdglRHPE----LVrDPSQ-P-DLL 637 
WP_081471768  603 KAGLAPGMKLIAVNGRRFS-PDGLKAAVGATKAG-GKLELLAESGDFFKTHALDYKdglRYPR----LDrTAGK-P-DVL 674 
WP_130537374  630 LKWLKE 635 
WP_011685177  617 TEIIKS 622 
WP_012633427  607 ATIAAP 612 
WP_013581592  618 DEILKP 623 
WP_088874943  634 TALLRP 639 
WP_046905162  638 DRLLEA 643 
WP_010233056  641 DRFLEP 646 
WP_069708509  642 DKLLTA 647 
WP_083712612  638 AAILKP 643 
WP_081471768  675 GELMGS 680 
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