Conserved Protein Domain Family
Peptidase_S28

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pfam05577: Peptidase_S28 
Serine carboxypeptidase S28
These serine proteases include several eukaryotic enzymes such as lysosomal Pro-X carboxypeptidase, dipeptidyl-peptidase II, and thymus-specific serine peptidase.
Statistics
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PSSM-Id: 310284
Aligned: 12 rows
Threshold Bit Score: 517.316
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q18198   63 QKVDNFDANNNAMYNQRYWYNPTFTQNK--NIVFLMI---QGEAPATDTWISNPnyQYLQWAKEFGADVFQLEHRCFGQS 137  Caenorhabditis elegans
O02252  624 QRQDHFDNQNADFFQQKFFKNAQWAKQG--GPNFLMI---GGEGPESARWVLNEniTYLTWAKKYGATVYLLEHRFYGDS 698  Caenorhabditis elegans
Q9GRV9  552 QRQDHFDNLNVDFFQQKFYKNSQWARPG--GPNFLMI---GGQEAEGESWVLNEklPWLISAQKYGATVYLLEHRFYGDS 626  Caenorhabditis elegans
P90893   61 QKLDHFDPYNTKTWNQKYFYNPVFSRNN--SIIFLMI---GGEGPENGKWAANPnvQYLQWAKEFGADVFDLEHRFFGDS 135  Caenorhabditis elegans
O02252   91 QSLDHFIGNASGTFSQRYFYTQQYTLHQ--RTAFLYVsadGVEEAAVISDERNP---IVKTAKQFGATIFSLEHRYYGQS 165  Caenorhabditis elegans
P34528   65 QTLDHFDSSVGKTFQQRYYHNNQWYKAG--GPAFLML---GGEGPESSYWVSYPglEITNLAAKQGAWVFDIEHRFYGET 139  Caenorhabditis elegans
Q9VDX5  121 QKLDNFDDSNNATWQDRIYINNKYFVDG--SPIFIYL---GGEWAIDPSGITSG--LWKDIAKQHNGSLLYTEHRFFGQS 193  fruit fly
Q8SXS7   52 QKLDHFDPEETRTWQMRYMLNDALYQSG--APLFIYL---GGEWEISSGRITGG--HLYDMAKEHNALLAYTEHRYYGQS 124  fruit fly
P34676   48 APIDPFAFTNDLEFDLRYFLNIDHYETG--GPILFYT---GNEGSLEAFAENTG--FMWDLAPELKAAVVFVEHRFYGKS 120  Caenorhabditis elegans
Q9QXE5   63 QPLDPFNASDRRTFLQRYWVNDQHRTGQd-VPVFLHI---GGEGSLGPGSVMAG--HPAALAPAWGALVISLEHRFYGLS 136  house mouse
Q9NQE7   64 QLLDPFNVSDRRSFLQRYWVNDQHWVGQd-GPIFLHL---GGEGSLGPGSVMRG--HPAALAPAWGALVISLEHRFYGLS 137  human
Q9VS02   61 QRLDHFKSSDKRTWQQRYFVNADFYRNDssAPVFLMI---GGEGEASAKWMREG--AWVHYAEHFGALCLQLEHRFYGKS 135  fruit fly
Q18198  138 RpYPDTSMpgi---kvCTMTQALADIHNFIQQMNr--RFNFQNPKWITFGGSYPGTLSALFRQQYPADTVGAVASSAPLD 212  Caenorhabditis elegans
O02252  699 V-VGDNTNfk-----lLNSLQMLYDLAEFIKAVN---IRTGTSNPWITFGGSYSGAMSAWMREVFPDLVVGAVASSGPVY 769  Caenorhabditis elegans
Q9GRV9  627 L-VGNNTNln-----lLSSLQVLYDSAEFIKAIN---YKTQSSTPWITFGRSFP--LSAWTRAIFPDLVTGAVSSSGAIL 695  Caenorhabditis elegans
P90893  136 WpIPDMQTssl---ryLTTQQALADLAFFIEFMNq-qY-GFKNPRWVTFGGSYPGSLAAWFRQKYPQLTVGSVASSAPVN 210  Caenorhabditis elegans
O02252  166 RpNFDKFDaqn--lrhLNSLQAILDIISFIKSVNv-qFNMDPDVRWVLWGAGYGGILAAEARKWDPVTISGVIASSSPLT 242  Caenorhabditis elegans
P34528  140 HpTSDMSVpnl---kyLSSAQAIEDAAAFIKAMTa-kFPQLANAKWVTFGGSYSGALAAWTRAKHPELVYAAVGSSGPVQ 215  Caenorhabditis elegans
Q9VDX5  194 IpITPLSTenl--akyQSVEQALADVINVIATLKq-eDKYKDSK-VVVSGCSYSATMATWIRKLYPEIIRGSWASSAPLL 269  fruit fly
Q8SXS7  125 KpLPDLSNeni---kyLNVNQSLADLAYFINTIKq-nHEGLSDSKVIIVGGSYSATMVTWFKKLYPDLVAGGWASSAPLL 200  fruit fly
P34676  121 QpFKNESYtdirhlgyLSSQQALADFALSVQFFKnekIKGAQKSAVIAFGGSYGGMLSAWFRIKYPHIVDGAIAASAPVF 200  Caenorhabditis elegans
Q9QXE5  137 MpAGGLDLall---ryLSSRHALADVASARQALSg-lLNVSSSSPWICFGGSYAGSLATWARLKFPHLVFAAVASSAPLS 212  house mouse
Q9NQE7  138 IpAGGLEMaql---rfLSSRLALADVVSARLALSr-lFNISSSSPWICFGGSYAGSLAAWARLKFPHLIFASVASSAPVR 213  human
Q9VS02  136 HpTADLSTenl---hyLSSEQALEDLASFVTAMKv-kFNLGDGQKWIAFGGSYPGSLAAWAREKYPELIYGSISSSGPLL 211  fruit fly
Q18198  213 WTLDFF---EYAMVVEDVLKKTSV----D-CWRNVNQAFLNMQQLSLTKAGIQQLntYFNLVPAFVDGQY--TQ-HDIDN 281  Caenorhabditis elegans
O02252  770 AKTDFY---EYLMVVENSVRRYNS----K-CADNIQSGFDAIRTLFLTKEGRQNL--SSIFQLQPPFSDSv-TD-TDQHY 837  Caenorhabditis elegans
Q9GRV9  696 AKTDFF---EYLMVMETSIRKYDN----S-CADRIKSGFDEIRGLFLTSEGRQDL--SKIFQLLPGFSENv-TE-TDQHF 763  Caenorhabditis elegans
P90893  211 LKLDFY---EYAMVVEDDLRITDP----K-CAQATKDAFVQMQKLALTAEGRNSLnnHFNLQPPFDANT---TK-LDINN 278  Caenorhabditis elegans
O02252  243 HLYDFW---QFNDQVATTFSQVGG----GlCYNKVRQGFADIRQAMRTPEGRRNV--SSLFQLNPRLDQTp-LNyNDVQI 312  Caenorhabditis elegans
P34528  216 AEVDFK---EYLEVVQNSITRNST----E-CAASVTQGFNLVASLLQTSDGRKQL--KTAFHLCQDIQMD---D-KSLKY 281  Caenorhabditis elegans
Q9VDX5  270 AKVNFK---DYMKVVGESYATLGG----QyCYDLIDNATSYYENLFEIGNGTQAV---KELNLCSNFNVN--SE-QDRWQ 336  fruit fly
Q8SXS7  201 AKVNFV---EYKEITGQSIEQMGG----SaCYKRIENGIAEMETMIATKR-GAEV--KALLKLCEPFDVY--SD-LDVWT 267  fruit fly
P34676  201 WFTDSNipeDVYDFIVTRAFLDAG----C-NRKAIEKGWIALDELAKSDSGRQYLnvLYKLDPKSKLENK--DD-IGFLK 272  Caenorhabditis elegans
Q9QXE5  213 AVVDFS---AYNQVVARSLTQVAIggslE-CLAAASTAFTEVERLLRAGPAAQAVl-REELGACGSLDLT--ED-QAELL 284  house mouse
Q9NQE7  214 AVLDFS---EYNDVVSRSLMSTAIggslE-CRAAVSVAFAEVERRLRSGGAAQAAl-RTELSACGPLGRA-----ENQAE 283  human
Q9VS02  212 AEVDFK---EYFEVVKASLAAYKP----E-CVDAVTRSFAQVEILLKHMIGQRSL--DEKFKTCTPIKDSieND-LDMAN 280  fruit fly
Q18198  282 FFANVYSFFQGVVQYT--YDGRNNATlNGLNAQQLCNKMN------DA------TVP--DVITRVNNTINWINQMNGdpv 345  Caenorhabditis elegans
O02252  838 FFSNVYGNFQGAVQYS--GDNTGPYA-NGYGIPDMCKIMS------ND------SNTplNNIVAFNQFMIIFYNGGQyt- 901  Caenorhabditis elegans
Q9GRV9  764 FFSNLYSNFQLAVQFS--GDNSGPWA-DGYGIPEMCRFMT------GA------GTPl-DNIVAFNAYMTSFNNGGGtyt 827  Caenorhabditis elegans
P90893  279 FFGNIFNTYQGMTQYT--YDGQSNSThSDKTVRKMCDIMT------NA------TET--DVVMRVENLFLWFNQMEPa-- 340  Caenorhabditis elegans
O02252  313 FYLLIIAPFQQIVQFN--NDFN-------ISISDMCTTID------KS------TWT--NM----EVVRQAYVYLSTtit 365  Caenorhabditis elegans
P34528  282 FWETVYSPYMEVVQYS--GDAAGSFAtQLTISHAICRYHI------NT------KST--PL----QKLKQVNDYFNQv-- 339  Caenorhabditis elegans
Q9VDX5  337 IFSTIANIFAGIAQYQ--KPEK-------YDIPTYCSILR------EF------SDD--DS---VALSKFINWKINEh-- 388  fruit fly
Q8SXS7  268 LFSEISDIFAGVVQ-----------ThNAGQIEGVCEKIM-------A------GSN--DLIGVAGYLLDVFEESGGk-- 319  fruit fly
P34676  273 QYIRESMEAMAMVNYP--YPTSFLSSlPAWPVKEACKSAS------QP------GKT--QE----ESAEQLYKIVN---- 328  Caenorhabditis elegans
Q9QXE5  285 ------GALQALVGGTvqYDGQAGAPlS---VRQLCGLLL------GKwgnrsrSTP--YLGLRRAVQIVL-RSMGQk-- 344  house mouse
Q9NQE7  284 LLGALQALVGGVVQY----DGQTGAPlS---VRQLCGLLLggggnrSH------STP--YCGLRRAVQIVL-HSLGQk-- 345  human
Q9VS02  281 FFENLAGNFAGVVQY-----NKDNSPhATITIDDICDVML------NT------TAG--PP---VTRLGLVNDMLLK--- 335  fruit fly
Q18198  346 gPFQNSYSDMMTVLANA---SYDDNSavpgdiAA-NRGWMWLCCNELGALQTTDQ----GRNIFQQTVPLGYFI-DMCTD 416  Caenorhabditis elegans
O02252  902 gMDNNYQNMITYLKTAQ---HYGPDS------AA-GLLWTWQTCSEFGYFQSADS----GNGIFGSPTPVNMYV-QMCMD 966  Caenorhabditis elegans
Q9GRV9  828 gMGNNYTAMIY-NLKNS---KDYGEGv-----DP-TLLWTWQTCTEYGGFQSADS----GSGLFGSPVPVSFLI-QMCMD 892  Caenorhabditis elegans
P90893  341 -SANLTVMPNSYWDVISqvgSGDLNVlgp-dgAA-ARGWMWLCCNEIGFLQTTNQ----GNNVFGTGVPLNLFI-DMCTD 412  Caenorhabditis elegans
O02252  366 gS--VQPMVTSYQTIVN---DLGNQSass-pyLD-QRMWQYQTCTEFGWFYTTNNn---ENGLFGAVVPGSLFL-NQCFD 434  Caenorhabditis elegans
P34528  340 -SGYFGCNDIDYNGFIS---FMKDETfg--eaQS-DRAWVWQTCTEFGYYQSTSSatagPWFGGVSNLPAQYYI-DECTA 411  Caenorhabditis elegans
Q9VDX5  389 -SGACLSTTFK--GAVG---YYEWSKen---yQDsDLPWIFQTCSEFGWFQSSGS----RSQPFGSTFPATLYE-DTCEG 454  fruit fly
Q8SXS7  320 -CYDLSYDAITALLLDT---NYNGNIm---------RQWIFQTCNEYGWYQTSGS----SAQPFGTKFPVTYYT-TMCAD 381  fruit fly
P34676  329 -LYYNYTGDKSTHCANA---AKCDSAyg--slGD-PLGWPFQTCTEMVMPLCGSGyp-nDFFWKDCPFTSEKYA-EFCMQ 399  Caenorhabditis elegans
Q9QXE5  345 -CLSFSRAETVAQLSNT---EPQVSG------VG-DRQWLYQTCTEFGFYVTCEG-----LQCPFSQLPALPFQlELCEQ 408  house mouse
Q9NQE7  346 -CLSFSRAETVAQLRST---EPQLSG------VG-DRQWLYQTCTEFGFYVTCEn----PRCPFSQLPALPSQL-DLCEQ 409  human
Q9VS02  336 -ESNTTCLDYKYDKMVA---DMKNVSwdsetaKG-MRQWTYQTCHEFGFYQTSDn----PADTFGDRFGVDFFI-RQCMD 405  fruit fly
Q18198  417 MFGADIGIKYVRDNNKQTLYK--YKGADNYQATNVVLPNGAFDPWHVLGt-YNNDTANHMTPLLIQGAAHCSDMYPTYPG 493  Caenorhabditis elegans
O02252  967 VFNNQYQRTSIDYSIANTNYK--YGERFHYRGTNVVLPNGNVDPWHALG--LYYPTDSSVVSYLIDGTAHCADMYPARDA 1042 Caenorhabditis elegans
Q9GRV9  893 LFGNTYDRSKIDSLIDFTNYK--YGGRDNFKGSNVVFINGNIDPYHVLG--LFNSPDSSVVSYLIDGSSHCADMFPARDS 968  Caenorhabditis elegans
P90893  413 MFGDSMKMSQIMGGNKKSQNY--YGGADFYNATNVVLPNGSLDPWHALGt-YGTIKSQSLLPYLINGTAHCGDMYPSYDG 489  Caenorhabditis elegans
O02252  435 IF-PDANLTATSIRDLVIEYNnyYGSAFDYSGTNAVFTNGLLDPWTILG--KKSTGDFSVVPYIIPGASFASDMFPGDTN 511  Caenorhabditis elegans
P34528  412 IYGAAYNSQEVQTSVDYTNQY--YGGRDNLNTDRILLPNGDIDPWHALG--KLTSSNSNIVPVVINGTAHCADMYGASSL 487  Caenorhabditis elegans
Q9VDX5  455 VFGAKYDSAGIHANIRATNDD--FGG-LNVNATNIYFVQGALDGWSKVG--AGVAQGATIIPY----ASHCPDTGSISAS 525  fruit fly
Q8SXS7  382 LYGSEYSNEFISNQVSITNQF--FGG-LFPNVENVYLTHGQLDPWRAMG--IQDETQATIIP----EHAHCKDFNSISSS 452  fruit fly
P34676  400 TFSSIHYN-KTLLRPLAGGLA--FGATSLPSASNIVFSNGYLDPWSGGGydHSDKVQGSVISVILKQGAHHYDLRGAHPQ 476  Caenorhabditis elegans
Q9QXE5  409 VFGLSPAS--VAQAVAQTNSY--YGG-QSPGATQVLFVNGDTDPWHVLS--VTQDLGLSEPALLIPSASHCFDMAPMRPS 481  house mouse
Q9NQE7  410 VFGLSALS--VAQAVAQTNSY--YGG-QTPGANKVLFVNGDTDPWHVLS--VTQALGSSESTLLIRTGSHCLDMAPERPS 482  human
Q9VS02  406 VFSKNMNAKFLKLVVSATNDN--YGA-LKPKTTNVLYVHGSIDPWHALG--LVKSTNAALPTIYIEGTAHCANMYEPVKT 480  fruit fly
Q18198  494 EPTDLAKNRAII 505  Caenorhabditis elegans
O02252 1043 DVPGLKVVRDLV 1054 Caenorhabditis elegans
Q9GRV9  969 DVPGLKVARDLV 980  Caenorhabditis elegans
P90893  490 EPGSLLAARAFV 501  Caenorhabditis elegans
O02252  512 NSFIIHAH-ALM 522  Caenorhabditis elegans
P34528  488 DSMYLTNARQRI 499  Caenorhabditis elegans
Q9VDX5  526 DSAELVASKKKL 537  fruit fly
Q8SXS7  453 DTAEMRASKERI 464  fruit fly
P34676  477 DTEEVKKVRAME 488  Caenorhabditis elegans
Q9QXE5  482 DSPSLRLGRQKI 493  house mouse
Q9NQE7  483 DSPSLRLGRQNI 494  human
Q9VS02  481 DPPQLVAARNKI 492  fruit fly
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