Q18198 63 QKVDNFDANNNAMYNQRYWYNPTFTQNK--NIVFLMI---QGEAPATDTWISNPnyQYLQWAKEFGADVFQLEHRCFGQS 137 Caenorhabditis elegans O02252 624 QRQDHFDNQNADFFQQKFFKNAQWAKQG--GPNFLMI---GGEGPESARWVLNEniTYLTWAKKYGATVYLLEHRFYGDS 698 Caenorhabditis elegans Q9GRV9 552 QRQDHFDNLNVDFFQQKFYKNSQWARPG--GPNFLMI---GGQEAEGESWVLNEklPWLISAQKYGATVYLLEHRFYGDS 626 Caenorhabditis elegans P90893 61 QKLDHFDPYNTKTWNQKYFYNPVFSRNN--SIIFLMI---GGEGPENGKWAANPnvQYLQWAKEFGADVFDLEHRFFGDS 135 Caenorhabditis elegans O02252 91 QSLDHFIGNASGTFSQRYFYTQQYTLHQ--RTAFLYVsadGVEEAAVISDERNP---IVKTAKQFGATIFSLEHRYYGQS 165 Caenorhabditis elegans P34528 65 QTLDHFDSSVGKTFQQRYYHNNQWYKAG--GPAFLML---GGEGPESSYWVSYPglEITNLAAKQGAWVFDIEHRFYGET 139 Caenorhabditis elegans Q9VDX5 121 QKLDNFDDSNNATWQDRIYINNKYFVDG--SPIFIYL---GGEWAIDPSGITSG--LWKDIAKQHNGSLLYTEHRFFGQS 193 fruit fly Q8SXS7 52 QKLDHFDPEETRTWQMRYMLNDALYQSG--APLFIYL---GGEWEISSGRITGG--HLYDMAKEHNALLAYTEHRYYGQS 124 fruit fly P34676 48 APIDPFAFTNDLEFDLRYFLNIDHYETG--GPILFYT---GNEGSLEAFAENTG--FMWDLAPELKAAVVFVEHRFYGKS 120 Caenorhabditis elegans Q9QXE5 63 QPLDPFNASDRRTFLQRYWVNDQHRTGQd-VPVFLHI---GGEGSLGPGSVMAG--HPAALAPAWGALVISLEHRFYGLS 136 house mouse Q9NQE7 64 QLLDPFNVSDRRSFLQRYWVNDQHWVGQd-GPIFLHL---GGEGSLGPGSVMRG--HPAALAPAWGALVISLEHRFYGLS 137 human Q9VS02 61 QRLDHFKSSDKRTWQQRYFVNADFYRNDssAPVFLMI---GGEGEASAKWMREG--AWVHYAEHFGALCLQLEHRFYGKS 135 fruit fly
Q18198 138 RpYPDTSMpgi---kvCTMTQALADIHNFIQQMNr--RFNFQNPKWITFGGSYPGTLSALFRQQYPADTVGAVASSAPLD 212 Caenorhabditis elegans O02252 699 V-VGDNTNfk-----lLNSLQMLYDLAEFIKAVN---IRTGTSNPWITFGGSYSGAMSAWMREVFPDLVVGAVASSGPVY 769 Caenorhabditis elegans Q9GRV9 627 L-VGNNTNln-----lLSSLQVLYDSAEFIKAIN---YKTQSSTPWITFGRSFP--LSAWTRAIFPDLVTGAVSSSGAIL 695 Caenorhabditis elegans P90893 136 WpIPDMQTssl---ryLTTQQALADLAFFIEFMNq-qY-GFKNPRWVTFGGSYPGSLAAWFRQKYPQLTVGSVASSAPVN 210 Caenorhabditis elegans O02252 166 RpNFDKFDaqn--lrhLNSLQAILDIISFIKSVNv-qFNMDPDVRWVLWGAGYGGILAAEARKWDPVTISGVIASSSPLT 242 Caenorhabditis elegans P34528 140 HpTSDMSVpnl---kyLSSAQAIEDAAAFIKAMTa-kFPQLANAKWVTFGGSYSGALAAWTRAKHPELVYAAVGSSGPVQ 215 Caenorhabditis elegans Q9VDX5 194 IpITPLSTenl--akyQSVEQALADVINVIATLKq-eDKYKDSK-VVVSGCSYSATMATWIRKLYPEIIRGSWASSAPLL 269 fruit fly Q8SXS7 125 KpLPDLSNeni---kyLNVNQSLADLAYFINTIKq-nHEGLSDSKVIIVGGSYSATMVTWFKKLYPDLVAGGWASSAPLL 200 fruit fly P34676 121 QpFKNESYtdirhlgyLSSQQALADFALSVQFFKnekIKGAQKSAVIAFGGSYGGMLSAWFRIKYPHIVDGAIAASAPVF 200 Caenorhabditis elegans Q9QXE5 137 MpAGGLDLall---ryLSSRHALADVASARQALSg-lLNVSSSSPWICFGGSYAGSLATWARLKFPHLVFAAVASSAPLS 212 house mouse Q9NQE7 138 IpAGGLEMaql---rfLSSRLALADVVSARLALSr-lFNISSSSPWICFGGSYAGSLAAWARLKFPHLIFASVASSAPVR 213 human Q9VS02 136 HpTADLSTenl---hyLSSEQALEDLASFVTAMKv-kFNLGDGQKWIAFGGSYPGSLAAWAREKYPELIYGSISSSGPLL 211 fruit fly
Q18198 213 WTLDFF---EYAMVVEDVLKKTSV----D-CWRNVNQAFLNMQQLSLTKAGIQQLntYFNLVPAFVDGQY--TQ-HDIDN 281 Caenorhabditis elegans O02252 770 AKTDFY---EYLMVVENSVRRYNS----K-CADNIQSGFDAIRTLFLTKEGRQNL--SSIFQLQPPFSDSv-TD-TDQHY 837 Caenorhabditis elegans Q9GRV9 696 AKTDFF---EYLMVMETSIRKYDN----S-CADRIKSGFDEIRGLFLTSEGRQDL--SKIFQLLPGFSENv-TE-TDQHF 763 Caenorhabditis elegans P90893 211 LKLDFY---EYAMVVEDDLRITDP----K-CAQATKDAFVQMQKLALTAEGRNSLnnHFNLQPPFDANT---TK-LDINN 278 Caenorhabditis elegans O02252 243 HLYDFW---QFNDQVATTFSQVGG----GlCYNKVRQGFADIRQAMRTPEGRRNV--SSLFQLNPRLDQTp-LNyNDVQI 312 Caenorhabditis elegans P34528 216 AEVDFK---EYLEVVQNSITRNST----E-CAASVTQGFNLVASLLQTSDGRKQL--KTAFHLCQDIQMD---D-KSLKY 281 Caenorhabditis elegans Q9VDX5 270 AKVNFK---DYMKVVGESYATLGG----QyCYDLIDNATSYYENLFEIGNGTQAV---KELNLCSNFNVN--SE-QDRWQ 336 fruit fly Q8SXS7 201 AKVNFV---EYKEITGQSIEQMGG----SaCYKRIENGIAEMETMIATKR-GAEV--KALLKLCEPFDVY--SD-LDVWT 267 fruit fly P34676 201 WFTDSNipeDVYDFIVTRAFLDAG----C-NRKAIEKGWIALDELAKSDSGRQYLnvLYKLDPKSKLENK--DD-IGFLK 272 Caenorhabditis elegans Q9QXE5 213 AVVDFS---AYNQVVARSLTQVAIggslE-CLAAASTAFTEVERLLRAGPAAQAVl-REELGACGSLDLT--ED-QAELL 284 house mouse Q9NQE7 214 AVLDFS---EYNDVVSRSLMSTAIggslE-CRAAVSVAFAEVERRLRSGGAAQAAl-RTELSACGPLGRA-----ENQAE 283 human Q9VS02 212 AEVDFK---EYFEVVKASLAAYKP----E-CVDAVTRSFAQVEILLKHMIGQRSL--DEKFKTCTPIKDSieND-LDMAN 280 fruit fly
Q18198 282 FFANVYSFFQGVVQYT--YDGRNNATlNGLNAQQLCNKMN------DA------TVP--DVITRVNNTINWINQMNGdpv 345 Caenorhabditis elegans O02252 838 FFSNVYGNFQGAVQYS--GDNTGPYA-NGYGIPDMCKIMS------ND------SNTplNNIVAFNQFMIIFYNGGQyt- 901 Caenorhabditis elegans Q9GRV9 764 FFSNLYSNFQLAVQFS--GDNSGPWA-DGYGIPEMCRFMT------GA------GTPl-DNIVAFNAYMTSFNNGGGtyt 827 Caenorhabditis elegans P90893 279 FFGNIFNTYQGMTQYT--YDGQSNSThSDKTVRKMCDIMT------NA------TET--DVVMRVENLFLWFNQMEPa-- 340 Caenorhabditis elegans O02252 313 FYLLIIAPFQQIVQFN--NDFN-------ISISDMCTTID------KS------TWT--NM----EVVRQAYVYLSTtit 365 Caenorhabditis elegans P34528 282 FWETVYSPYMEVVQYS--GDAAGSFAtQLTISHAICRYHI------NT------KST--PL----QKLKQVNDYFNQv-- 339 Caenorhabditis elegans Q9VDX5 337 IFSTIANIFAGIAQYQ--KPEK-------YDIPTYCSILR------EF------SDD--DS---VALSKFINWKINEh-- 388 fruit fly Q8SXS7 268 LFSEISDIFAGVVQ-----------ThNAGQIEGVCEKIM-------A------GSN--DLIGVAGYLLDVFEESGGk-- 319 fruit fly P34676 273 QYIRESMEAMAMVNYP--YPTSFLSSlPAWPVKEACKSAS------QP------GKT--QE----ESAEQLYKIVN---- 328 Caenorhabditis elegans Q9QXE5 285 ------GALQALVGGTvqYDGQAGAPlS---VRQLCGLLL------GKwgnrsrSTP--YLGLRRAVQIVL-RSMGQk-- 344 house mouse Q9NQE7 284 LLGALQALVGGVVQY----DGQTGAPlS---VRQLCGLLLggggnrSH------STP--YCGLRRAVQIVL-HSLGQk-- 345 human Q9VS02 281 FFENLAGNFAGVVQY-----NKDNSPhATITIDDICDVML------NT------TAG--PP---VTRLGLVNDMLLK--- 335 fruit fly
Q18198 346 gPFQNSYSDMMTVLANA---SYDDNSavpgdiAA-NRGWMWLCCNELGALQTTDQ----GRNIFQQTVPLGYFI-DMCTD 416 Caenorhabditis elegans O02252 902 gMDNNYQNMITYLKTAQ---HYGPDS------AA-GLLWTWQTCSEFGYFQSADS----GNGIFGSPTPVNMYV-QMCMD 966 Caenorhabditis elegans Q9GRV9 828 gMGNNYTAMIY-NLKNS---KDYGEGv-----DP-TLLWTWQTCTEYGGFQSADS----GSGLFGSPVPVSFLI-QMCMD 892 Caenorhabditis elegans P90893 341 -SANLTVMPNSYWDVISqvgSGDLNVlgp-dgAA-ARGWMWLCCNEIGFLQTTNQ----GNNVFGTGVPLNLFI-DMCTD 412 Caenorhabditis elegans O02252 366 gS--VQPMVTSYQTIVN---DLGNQSass-pyLD-QRMWQYQTCTEFGWFYTTNNn---ENGLFGAVVPGSLFL-NQCFD 434 Caenorhabditis elegans P34528 340 -SGYFGCNDIDYNGFIS---FMKDETfg--eaQS-DRAWVWQTCTEFGYYQSTSSatagPWFGGVSNLPAQYYI-DECTA 411 Caenorhabditis elegans Q9VDX5 389 -SGACLSTTFK--GAVG---YYEWSKen---yQDsDLPWIFQTCSEFGWFQSSGS----RSQPFGSTFPATLYE-DTCEG 454 fruit fly Q8SXS7 320 -CYDLSYDAITALLLDT---NYNGNIm---------RQWIFQTCNEYGWYQTSGS----SAQPFGTKFPVTYYT-TMCAD 381 fruit fly P34676 329 -LYYNYTGDKSTHCANA---AKCDSAyg--slGD-PLGWPFQTCTEMVMPLCGSGyp-nDFFWKDCPFTSEKYA-EFCMQ 399 Caenorhabditis elegans Q9QXE5 345 -CLSFSRAETVAQLSNT---EPQVSG------VG-DRQWLYQTCTEFGFYVTCEG-----LQCPFSQLPALPFQlELCEQ 408 house mouse Q9NQE7 346 -CLSFSRAETVAQLRST---EPQLSG------VG-DRQWLYQTCTEFGFYVTCEn----PRCPFSQLPALPSQL-DLCEQ 409 human Q9VS02 336 -ESNTTCLDYKYDKMVA---DMKNVSwdsetaKG-MRQWTYQTCHEFGFYQTSDn----PADTFGDRFGVDFFI-RQCMD 405 fruit fly
Q18198 417 MFGADIGIKYVRDNNKQTLYK--YKGADNYQATNVVLPNGAFDPWHVLGt-YNNDTANHMTPLLIQGAAHCSDMYPTYPG 493 Caenorhabditis elegans O02252 967 VFNNQYQRTSIDYSIANTNYK--YGERFHYRGTNVVLPNGNVDPWHALG--LYYPTDSSVVSYLIDGTAHCADMYPARDA 1042 Caenorhabditis elegans Q9GRV9 893 LFGNTYDRSKIDSLIDFTNYK--YGGRDNFKGSNVVFINGNIDPYHVLG--LFNSPDSSVVSYLIDGSSHCADMFPARDS 968 Caenorhabditis elegans P90893 413 MFGDSMKMSQIMGGNKKSQNY--YGGADFYNATNVVLPNGSLDPWHALGt-YGTIKSQSLLPYLINGTAHCGDMYPSYDG 489 Caenorhabditis elegans O02252 435 IF-PDANLTATSIRDLVIEYNnyYGSAFDYSGTNAVFTNGLLDPWTILG--KKSTGDFSVVPYIIPGASFASDMFPGDTN 511 Caenorhabditis elegans P34528 412 IYGAAYNSQEVQTSVDYTNQY--YGGRDNLNTDRILLPNGDIDPWHALG--KLTSSNSNIVPVVINGTAHCADMYGASSL 487 Caenorhabditis elegans Q9VDX5 455 VFGAKYDSAGIHANIRATNDD--FGG-LNVNATNIYFVQGALDGWSKVG--AGVAQGATIIPY----ASHCPDTGSISAS 525 fruit fly Q8SXS7 382 LYGSEYSNEFISNQVSITNQF--FGG-LFPNVENVYLTHGQLDPWRAMG--IQDETQATIIP----EHAHCKDFNSISSS 452 fruit fly P34676 400 TFSSIHYN-KTLLRPLAGGLA--FGATSLPSASNIVFSNGYLDPWSGGGydHSDKVQGSVISVILKQGAHHYDLRGAHPQ 476 Caenorhabditis elegans Q9QXE5 409 VFGLSPAS--VAQAVAQTNSY--YGG-QSPGATQVLFVNGDTDPWHVLS--VTQDLGLSEPALLIPSASHCFDMAPMRPS 481 house mouse Q9NQE7 410 VFGLSALS--VAQAVAQTNSY--YGG-QTPGANKVLFVNGDTDPWHVLS--VTQALGSSESTLLIRTGSHCLDMAPERPS 482 human Q9VS02 406 VFSKNMNAKFLKLVVSATNDN--YGA-LKPKTTNVLYVHGSIDPWHALG--LVKSTNAALPTIYIEGTAHCANMYEPVKT 480 fruit fly
Q18198 494 EPTDLAKNRAII 505 Caenorhabditis elegans O02252 1043 DVPGLKVVRDLV 1054 Caenorhabditis elegans Q9GRV9 969 DVPGLKVARDLV 980 Caenorhabditis elegans P90893 490 EPGSLLAARAFV 501 Caenorhabditis elegans O02252 512 NSFIIHAH-ALM 522 Caenorhabditis elegans P34528 488 DSMYLTNARQRI 499 Caenorhabditis elegans Q9VDX5 526 DSAELVASKKKL 537 fruit fly Q8SXS7 453 DTAEMRASKERI 464 fruit fly P34676 477 DTEEVKKVRAME 488 Caenorhabditis elegans Q9QXE5 482 DSPSLRLGRQKI 493 house mouse Q9NQE7 483 DSPSLRLGRQNI 494 human Q9VS02 481 DPPQLVAARNKI 492 fruit fly