Conserved Protein Domain Family
STELLO

?
pfam03385: STELLO 
STELLO glycosyltransferases
This domain family is found in Metazoa and in Virdiplantae. Two of the family members are characterized in Arabidopsis thaliana, named STELLO1 (STL1) and STELLO2 (STL2) respectively. They are Golgi-localized proteins that can interact with CesAs (cellulose synthase A) and control cellulose quantity. In the absence of STELLO function, the spatial distribution within the Golgi, secretion and activity of the CSCs are impaired indicating a central role of the STELLO proteins in CSC assembly. Point mutations in the predicted catalytic domains of the STELLO proteins indicate that they are glycosyltransferases facing the Golgi lumen. STL homologs are present throughout the plant kingdom, but STL proteins are distinct from distantly related proteins in nematodes, fungi and molluscs.
Statistics
?
PSSM-Id: 427273
Aligned: 13 rows
Threshold Bit Score: 760.032
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Q965Z8        289 RTTDIWRSFVSQKILHLSGLTVSFVPTNAVQFRNAHDYLKDFKDEKQVYEDSGKMIEYLHDWKCAPENssDLERCVKQLA 368  Caenorhabditi...
P91204        300 RTTDIWRSFISQKILHLSGLTVSFVPTNAVHFRNAHNYLKDFKDEQQVYEDSGRIIEFLHNWNCKTGS--SIQSCIVQLA 377  Caenorhabditi...
Q9TXX9        286 RTTDIWRSFISQKILHLSGLTVSFVPTNAVQFRNAHNYLKDFKDEKQVYEDSGRMIDYLHNWKCSPENskQIENCIKQLV 365  Caenorhabditi...
O45587        297 RTTDIWRSFISQKILHLSGLTVSFVSTNAVQFRNAHDYLKDFKNEKQVYEDSGKMIEFLHNWNCTRNNstVLENCINQLL 376  Caenorhabditi...
O17744        301 RTTDIWRSFISQKILHLSGLTVSFVPTNAIQFRNAHDYLKDFRDEKRVYEDSGKMIDFFHNWKCDSK---TLEDCIHKLL 377  Caenorhabditi...
O45585        297 RTTDIWRSFISQKILHLSGLTVSFVPANAVQFRNAHDYLKDFKDEKQVYEDSGKMIEFLHNWNCTLNNstVLEDCIDRLL 376  Caenorhabditi...
EGT42494      219 RTTDIWRSFISQKILHLSGLTVSFVPTNAVQFRNAHDYLKDFKDEKQVYEDSGKMIKFLHEWKCSNAIsnNLENCIYELM 298 
EGT42571       77 RTTDIWRSFISQKILHLSGLTVSFVPTNAVQFRNAHDYLKDFKDEKQVYEDSGKMIEFLHNWKCLNG---TLEECIYKLL 153 
EGT58634      155 RTTDIWRSFISQKILHLSGLTVSFVPTNAVQFRNAHDYLKDFKDEKQVYEDSGRMIEFLHGWKCQK----KIEDCMVLLA 230 
XP_003097903   77 RTTDIWRSFISQKILHLSGLTVSFVPTNAIQFRNAHDYLKDFKDEKQVYEDSGKIIDFLNGWNCLKVI--NLEDCINELL 154 
XP_003098581  334 RTTDIWRSFISQKILHLSGLTVSFVPTNAIQFRNAHDYLKDFKDEKQVYEDSGKMIEFLSNWKCLNGN--SLEGCINDLL 411 
CAP26715      260 RTTDIWRSFISQKILHLSGLTVSFVPTNAVQFRNAHDYLKDFKDEKSVYEDSGRFLEFLHSWNCKNGP--VLENCMNQLA 337 
NP_504731      77 RTTDIWRSFISQKILHLSGLTVSFVPTNAVQFRNAHNYLKDLKDEKQVYEDSGRMIEFLHNWKCSTRN--SSQNCIIEMT 154  Caenorhabditi...
Q965Z8        369 NDLVEVKLWGKEDAMLTEMFLNDLKRVGFEFPRILDGNYEDPYTPSKNETSRDVNCRRMQLDFELKETKKTDlDENVQRA 448  Caenorhabditi...
P91204        378 NDLVEVKLLGEEDESLMEMFLNDLTALGFEFPSLIGDNYVDPYAPSANESSREVNCRRMYLEFKLVDPNTNV-SEISRTS 456  Caenorhabditi...
Q9TXX9        366 NDLVKVKLWGEQDAVLTELFLADLKDMRFEFPSLVGDNFKEPYFPSTNEISRDVNCRRMQLSFELKDPRKTEkDENVQRA 445  Caenorhabditi...
O45587        377 VDLAKEKLWGSEDARLMGMYLEDLKSMGFKFPKLVGNSTQD-YSASRDETTRDVNCRRMHLEFDLLKPRE---DQSIRRA 452  Caenorhabditi...
O17744        378 YDLVTADFWLRDDAEMMEMYLDDLKNLGFQFSKLLDYANSPNYSPSQDETTRNVNCRRMHLEFDLLKSKKEE-DFSIRKA 456  Caenorhabditi...
O45585        377 YDLVKVGFWLEDDAKMMEMYLDDLKNMGFEFPKLIDNT---DYSPSTNETTRDVNCRRMHLEFDLLKPRE---NQSIKRA 450  Caenorhabditi...
EGT42494      299 NELVVENLWGKKDSELMKMFLNDLKSVGFEFPVMVGESYRDPYSPSTNETSRDVNCRRMNLEFELIDPKEHH-RKNKKRA 377 
EGT42571      154 TDLVAENLWGEEDLKLMRMFLSDLKTLGFIFPKIIKNRYIDPYSPSTNETTRDVNCRRINLEFDLVDPREYE-Q------ 226 
EGT58634      231 KDLVTEELWSEEDSELLEMFITDLKLMGFEFPELVTENYQDPYSPSTNESSRDVNCRRMNLEFELVDPREYD-EQNLKKA 309 
XP_003097903  155 EDLVENNLWGEDDSKLMKLFLNDLKSMGFKYPDLIGEKYEDPYIASDNETDRNVNCRRMNLEFELIDPKKYD-QENIRKA 233 
XP_003098581  412 KDLVTNNLWGKEDFKLMSFFLNDLKYMGFEFPELIGENYQDPYTASNNEEDRNVNCRRMNLEFDLVDPREYQ-RQNIIKA 490 
CAP26715      338 EDLVENNFWRNEDAKLMMMFLSDLKLLGFEFPEILKGEYVEPYLASANETERNVNCRRMNLEFELVDPRNYE-QQNLQKA 416 
NP_504731     155 NDLVKKKLLGKEDAKLMEMFLNDLTEMGFKFPILIENDFLDPYAPSTNETSRDVNCRRMHLEFELVDPNKKV-SEVTQKS 233  Caenorhabditi...
Q965Z8        449 TRKINYFGDIVYWCNETDYSNLTNQFPSPEQLSRKHENSYVLKKNLNTVLIVVNNYPWKYGMGLFQRLYEPYFASTIFCG 528  Caenorhabditi...
P91204        457 QEKLNYFGDIIKWCNETRKSSVSINFPSPKQLASLHEKSYVLKKHMDSVLIVVNNYPWKYGMGLIQRLYQPYFATVIFCG 536  Caenorhabditi...
Q9TXX9        446 AQKINYFGDIAQWCNETGYSNLTGIFSSPEQLAREHDNSYVFKKDLNSVLIVVNNYPWKYGMGLLQRLYQPYFATTIFCG 525  Caenorhabditi...
O45587        453 EQKLNYFGNIVDWCNETGYSDISINFPSPKQLAKQNNESYVFQKDLNSVLLAVNNYPWDYGMGLIQRLYQPYFATIIFCG 532  Caenorhabditi...
O17744        457 EQKLKYFGDIVNWCKETGYSDLPNTFPIATQLAKEHDDTYVFQKDLNSVLIAVNNYPWQYGMGLIQRLYQPYFATIIFCG 536  Caenorhabditi...
O45585        451 EQKLNYFGDIVDWCNETGYSNLSNQFPSATQLAKQHGDTYVFQKDQNSVLIAVNNYPWQYGMGLIQRLYQPYFATIIFCG 530  Caenorhabditi...
EGT42494      378 VQKLNYFGNLVEWCNETGYSGLAKHLPSSEQLEREHSESYVLEKDLKSVLIVVNNFPWKYGIGLIQRLYQPYFATVIFCG 457 
EGT42571      227 -QKLNYFGHLVKWCNESGYP--TKSFPSPEQLEEQHADTYVLQKDLNSVLILVNNYPWKYGMGLLQRLYQPYFAAVIFCG 303 
EGT58634      310 VQKLNYFGDLVDWCNETGHSNLSQSFPSPEQLKNEHDNSVVLQKYSNSVLILVNNYPWQYGMGLLQRLYQPYFATVIFCG 389 
XP_003097903  234 EQKINYFGDLVDWCNETGYSNLSKSFPSAKQLSEKHEESYVLQQDKNSVLIAVNNFPWKYGVGLIQRLYQPYFAAVIFCG 313 
XP_003098581  491 EQKLNYFGDLVEWCNEAGYHNLSKQFPSANQLAKKHDESYVLQNDKDSVLIVVNNYPWKYGHGIIQRLYQPYFASVVFCG 570 
CAP26715      417 GQKLQYIGDLVDWCKETGYSDLLKTFPSAQQLSRQHEKSDTLQKHSKSVLVVVNNYPWNYGHGIIQRLYQPYFAAVVFCG 496 
NP_504731     234 IQKLDYFGEIINWCGETGESIVSTKLSSPKQVHDQHRTSYVLQKHMNSVLIVVNNYPWKYGMGLIQRLYQPYFAMVIFCG 313  Caenorhabditi...
Q965Z8        529 SWYPENFTNVDNFTSTIFPINYVHVNPAEIHKGYFAYHCVTLVKEMRLSNVEGYFMMADDAIFNIWQRIDYSRVFHLNGI 608  Caenorhabditi...
P91204        537 SWYPAEFSDDTNFTPTLFPINYIHMNPAEIEKGYFAYHCVTLAKELGLHDVEGYFLVADDTVFNIWQRIDFSRVHHLTGV 616  Caenorhabditi...
Q9TXX9        526 SWYPENFTEIDNFTTTLYPINYVHLNEAEIHQGYFGYHCLTVVKEMGLSNVEGYFLMADDAIFNIWQRIDYSRVFHLHGS 605  Caenorhabditi...
O45587        533 SWYPENFQNLDKTTSIMHPINYIHMNPAEMSKGAFAYHCVTLVKELRLNNVQGYFLMSDDAVFNIWQRIDYARVHHIHGS 612  Caenorhabditi...
O17744        537 SWYPEKIETVDNMTSVLHPINYIHMNPSEISYGAYAYHCVTLVKEMRLNNVQGYFMMSDDAVFNIWQRVDYSRVHHLTGS 616  Caenorhabditi...
O45585        531 SWYPENYLNLDNTTSVMHPVNYIHMNPAEMSKGVFAYHCVTLVKELHLSNVQGYFLMSDDTVFNIWQRIDYSRVHHLHGS 610  Caenorhabditi...
EGT42494      458 SWYPDQIMDHDNFTSIIHPVNYVHINPAEIHNGYFSYHCMTLVKEMGLQNVEGYFFVADDTVFNMWQRIDYSRVSHFTGV 537 
EGT42571      304 PWYPEQFQN-DNYTSLVHPVNYIHFNPAENHRGYFCYHCMTLVKEMGLQNVEGYFFVADDTVFNMWQRIDYSRVSHFT-- 380 
EGT58634      390 SWYPENIIDQDNYTSTLHPINYIHLNPEENHRGYFSYHCLTLVKEMGLSNVEGYFFVADDTVFNIWQQIDYSRVAHFT-- 467 
XP_003097903  314 SWYSDEVVDVDNYTSTLNPINYIHMNPAEIHKGYFAYHCVTLVKEMRLNNVNGYFLMADDTIFNIWQRIDYSRVHHLMGP 393 
XP_003098581  571 PWYPDVIIEQDNFTSTINPINYIHINPVELRRGYYGYHCVSLVKEMRFNNVRGYFVMSDDAIFNLWQRIDYSRVHHLVGV 650 
CAP26715      497 SWYPDQVKDHDNYTSTIQPFNFIHMNPTEMRKGYSAYHCLTLAKEMGLANVQGYFLMADDAIFNIWQEIDFSTVHHSTGV 576 
NP_504731     314 PWYPAQFSDDTNFTSTISPINYIHMNPAEIEKGFYAYHCATLVQELGIQNVAGYFLMGDDTVFNIWQRIDFSRIHHLTGV 393  Caenorhabditi...
Q965Z8        609 YNISNV-WWSG-DYGKKAAINILKTIKITNNTKFQDAWNKFDKGLQNYAFFNLTDNAETQMLNPIGKSISDF 678  Caenorhabditis elegans
P91204        617 TCEDSPiWWSIaDVGMDAAKRVVGYINNSTAPEIAETWTKFETGLKKNGYVKNNLTVMDEMTSGLGRSVSDF 688  Caenorhabditis elegans
Q9TXX9        606 YNTEN--EWHFrDHGGQRVVTILKAIKSTTDKKLLAAWDRFDKGLQKYGYYNETDNAEEQMKSPIGKSISDF 675  Caenorhabditis elegans
O45587        613 NNLYNS-WYNHtQYGAKAAKRVLEIVKTTNDTEIKTTWQKFDDGLRKYDYHNLTEGAEAQMLNHLGKSVSDF 683  Caenorhabditis elegans
O17744        617 LNIYNT-YFTG-IYGEPAAKKILATVKDSTDLKVLETWKKFDDGLKKYAYNNITDGAEAVLLSTYGKSYSDF 686  Caenorhabditis elegans
O45585        611 TNFYNS--WSPtEYGIQAAKKIIETVKASTDPKVLTTWKKFDNGLKQFAYHNITDGGEAQLSSTHGKSISDF 680  Caenorhabditis elegans
EGT42494      538 RYETDKmWWGT-DLGFPAVKRISEDVKNSTDKNVLEAWKRFEDGLRKYGYINSSQTAEDELFAKRGKSISDF 608 
EGT42571      381 --------------GLPAAKNIVKKVKNSTDVKVKKAWKHFEDGLRKYGYINSSQTAEDELLAKRGKSISDF 438 
EGT58634      468 --------------GLPAARNIATEIKNTTGVEVQNAWVQFEEGLRKHGYINGSQTAEDELLARRGKSISDF 525 
XP_003097903  394 VADYGYnWWNL-EYGLRAAKNMVLTIKNNTDSKIEKAWKQFTEELKTYGYMKENHTAFDEIASGKGKSVSDF 464 
XP_003098581  651 NHANDPlWWFVdDYGIVAARKIVESIKTNTDPKVSETWKRFSDGLKANGYVRKGWSVNQEMTSGSGRSQSDF 722 
CAP26715      577 VLDESDlFWDL-DVGIFASRNVVKTFETSKSPGIQNAWKQFQNGLEING---NKKLAKQEMTSGKGRTYSDF 644 
NP_504731     394 SFEKSSeWWQYpDIGMGAAKNVVRFVNISRDPKIAETWKRLDTGLMKSGYLTNNVTVNDEMTSGHGRSFSDF 465  Caenorhabditis elegans
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap