Conserved Protein Domain Family
NrdA

?
COG0209: NrdA 
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]
Ribonucleotide reductase alpha subunit is part of the Pathway/BioSystem: Pyrimidine salvage
Statistics
?
PSSM-Id: 439979
Aligned: 617 rows
Threshold Bit Score: 465.044
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
WP_086886798   18 TE------GETLEE-----------RMTANAyHNILPARYLRK------------------------------------- 43  
WP_010898958   19 IAhfe-qvHPITSDmh--------mTRKGVS-RLVMLDRYTFKdtekktlregdfvvltvkddpkfpargygfilelnwd 88  
WP_012874007   12 IHt----iEDLEREvqalidsgratKLEGYR-EKIFLDRYARK------------------------------------- 49  
WP_013176133    1 -------------------------mLSADG-QKLFEARYAIR------------------------------------- 17  
WP_013494757    1 ------------------------mELTGIR-RTVFLDRYARK------------------------------------- 18  
WP_014426173    1 -----------------------mwyDNEVS-MGIMERKYLHEg------------------------------------ 20  
WP_016339111   14 IRehfpylKEIEDSyq--------mVFDGVS-RMVVLDRYAQKdntlktlkkndlvltvikddgwfptrgignivevdri 84  
WP_066396069   20 IAqfp-qvHPVTSTmk--------tTHKGVS-RLVMLDRYSFKdtekktlkpgdfvvltvkedpkfparglgfiqsvnwd 89  
WP_062470624   20 IEqfd-avFPITEDmh--------iTYSGVA-RLVMLDRYSFKdtkkdslkvgdfvlltikedpkypargtgtiqsldwe 89  
WP_119883294   21 IKqft-qvHPITSEmt--------lTHKGVS-RLVMIDRYSFKdtekktlkagdfvvltvkedpkfparglgyivsinel 90  
WP_086886798   44 ----------------D-------Adge----------liE-EQEDLFERVGRNIALAEavyeaekrdlevtvtpdqlkp 89  
WP_010898958   89 enrakvlvdeefhgvlDdpe--eaStgiitrsldviekplEiFYEQIAKRNATGLAAVEttee----------------- 149 
WP_012874007   50 ----------------D-------Pngt----------plEhYPEEMWLRVAKAIAAVEpnpe----------------- 79  
WP_013176133   18 ----------------D-------Ekgt----------vaE-TFDQAVGRLARTVATAEke------------------- 44  
WP_013494757   19 ----------------G-------Pdgk----------pvEsSPEEMWDRVARAIAEVEepg------------------ 47  
WP_014426173   21 ----------------------------------------E-KPEQFIGRVASIFSD-E--------------------- 37  
WP_016339111   85 ngtcgikieeeyvhsiDkdllinnSnniirknlhmvekplEiFYEQIAWRVANALSNQEqn------------------- 145 
WP_066396069   90 dknavvlvedefkavlEkpe--eaEsglitrsldvmdkplEvYYEQIALRNATGLASVEttee----------------- 150 
WP_062470624   90 kgtatiqvsdeyllsiDafs--dsEdgivkrdiitldkplElFYEQIAMRNAHGLAQVEispe----------------- 150 
WP_119883294   91 ekkaevlieedyrsaiDdpr--elEsgivyrsldviekplEvYYEQIALRNATGLSAVEktee----------------- 151 
WP_086886798   90 dhprrdelaeevfgegvttddseesempradgeavdaevplteenvnkfayetvvpelpaevrehveDVADTFIEGMESL 169 
WP_010898958  150 ----------------------------------------------------------------krqQSFERFYEELVNM 165 
WP_012874007   80 ----------------------------------------------------------------aqrQWTLRFYDILQGF 95  
WP_013176133   45 -----------------------------------------------------------------psQWEERFARIIGEL 59  
WP_013494757   48 ----------------------------------------------------------------qreVWERRFRQALEGF 63  
WP_014426173   38 --------------------------------------------------------------------LKPKAKKVLENA 49  
WP_016339111  146 -----------------------------------------------------------------hqSHLESFYNELKDL 160 
WP_066396069  151 ----------------------------------------------------------------rrqESFQKFYKELSEM 166 
WP_062470624  151 ----------------------------------------------------------------kraDAFLEFYEEQKNK 166 
WP_119883294  152 ----------------------------------------------------------------lqkEWQQKFYEQLVDL 167 
WP_086886798  170 SFMPNSPTLMNAGDEL--Q--QLSACFVMS-PDDDLSDIHETAKKAAEVFQSGGGVGYGFWQLRPFGDSVGSTGGIASGP 244 
WP_010898958  166 NFVPAGRVLYGAGAKT--Dv-TYFNCYVMPfVKDSREGISEHRKQVMEIMSRGGGVGTNGSTLRPRNTLARGVNGKSSGS 242 
WP_012874007   96 RFVPGGRILSGAGSGA--Ev-TYYNCFVIPsPEDSVEGIFRNITTAAHIMRRSGGVGVNLSSLRPRGAYIKTVNGTSSGP 172 
WP_013176133   60 FFVPSTPIWANVGKPD--RpwQPAACFVLP-LEDSLESVFETLKDTALVFKSGGGVGYNFSAIRPRGFPVRSSQGQAFGV 136 
WP_013494757   64 KFVPGGRILAGAGTGN--Kv-TYYNCYVIPsPEDSRKGIMDNVSLMVEIMSRGGGVGVNLSTLRPRGTYVRGVNGTASGP 140 
WP_014426173   50 DFLPAGRTLFGAGYKGkrKv-SMSNCYVLPtPKDNIESIFDTAKKIARISSYGGGCGLAIDNLRPKGAPVNNSAMTSTGA 128 
WP_016339111  161 NIVPAGRVLYGAGSNS--Dv-TFFNCFVMPfIKDSREGISIHRKEVMEIMSHGGGVGTNGSTLRPRGTVAKTVGGRSSGA 237 
WP_066396069  167 NFVPAGRVLYGAGAET--Dv-TYFNCYVMPyVKDSREGISDHRKQVMEIMSRGGGVGTNGSTLRPKNALARGVNGKSSGS 243 
WP_062470624  167 NFIPAGRVLYGAGSGT--Dv-TYFNCYVMPmVPDSRGGISDHRKKVMEIMSRGGGVGSNGSTLRPRHALARGVNGRSSGS 243 
WP_119883294  168 KFIPAGRVIYGAGAGT--Dv-TYFNCYVMPfVPDSREGISDHRKQVMEIMSRGGGVGTNGSTLRPRNTLAKGVNGKSSGS 244 
WP_086886798  245 ITFMRTYDQLCETI-AQGGTRRGAQMGIMRVSHPDVIEFIHAKNKdvslahtlrlndpddytyttfae------------ 311 
WP_010898958  243 VSWLDDIAKLTHLV-EQGGSRRGAQMIMLADWHPDVLEFIISKMQnprilryllentdddqirklvkdklkftplsqlee 321 
WP_012874007  173 CSWAILYSDMTGKViIQGGSRRGALMIMLDDDHPDIEEFVEYKRKn---------------------------------- 218 
WP_013176133  137 VELLRLYDHAAGII-VQGGVRRGACMGILNADHPEILEFIRAKL------------------------------------ 179 
WP_013494757  141 VSWAEVYSTATGSV-IQGGSRRGALMLMLDDDHPDIEEFITVKRD----------------------------------- 184 
WP_014426173  129 VSFLNIFDVTGGTI-GQNG-RRAALMVGLRCDHPDIEEFLRIKQDg---------------------------------- 172 
WP_016339111  238 VSWLNDLSTLTHLV-EQGGSRRGAQMIMMADWHPDIVEFIISKMQnpkilrwlkengndklirdeasrkikfspltsldr 316 
WP_066396069  244 VSWLDDIAKLTHLV-EQGGSRRGAQMIMLADWHPDIIDFIISKMQnprilrylientndekikqvaqdklkftpltpaqk 322 
WP_062470624  244 VSWLDDIAKLTHLV-EQGGSRRGAQMIMLTDWHPDIAEFIISKMQnprilryiienfedeqirtlahnklkftpftakei 322 
WP_119883294  245 VSWLDDIAKLTHLV-EQGGSRRGAQMIMLADWHPDIAEFIISKMQnprilrylieqtkdetirklakeklkfkpltsqee 323 
WP_086886798  312 -----------------aleearelideegrvpkhlrnavEGHLSNFNISVGVTDEFMEAVLNNEEYTFTNPR------- 367 
WP_010898958  322 amyqgivnyksipgmggfdakvikeaeeklriggtytvnnPDFLTGANISVCLTKEFMEAVDNDDWYALRFPDvenytee 401 
WP_012874007  219 ----------------------------------------PGHIDHANLSVAVSDAFMEAVKKDLPWDLKWQGkvw---- 254 
WP_013176133  180 ----------------------------------------AGGLANFNLSVGVGDAFMEAVRENGTWRLVF--------- 210 
WP_013494757  185 ----------------------------------------LTKITNANLSVCISDAFMEAVQQDLPWDLKWNGkvy---- 220 
WP_014426173  173 -----------------------------------------SKLSSMNISIKFTNEFMEAVEKNQPFQLVYDSp------ 205 
WP_016339111  317 t----lyeyavnkeadindsavvrearikldeggtwevnnPAFLSGANISVTITHKFMQAVENNEDWELQFPDldnytke 392 
WP_066396069  323 amyegilrykdipgtggfdsdvlrdaetmlrdggtysvhnSEFLTGANISVTITKEFMEAVENDSEYLLRFPSveaytpd 402 
WP_062470624  323 nmytgivnyknspgfggfdesvireaemklrdggtytvndPDFLTGANISVCITDDFMDAVKADAEYDLRFPDvenyske 402 
WP_119883294  324 amyqgilnyqnipgqggfneqimkdaaaklrdggtytvhnSEFLTGANISVTLTKEFMEAVEKDQEFDLRFPAvesyske 403 
WP_086886798  368 -------------------T-EephiateetkemyerydlgehvevgeplsIPAELIWERIVEGAHENGEPGVIYLERVN 427 
WP_010898958  402 emdiynrewsnvgdvreweErGfpvk---------------------tyrmIRAKELWNLINICATYSAEPGIFFIDNAN 460 
WP_012874007  255 -------------------------------------------------ktIRARDLWRKIAESAWAYAEPGLVFIDRYN 285 
WP_013176133  211 -------------------N-Gqai------------------------aeLPAAEVWEAIVEASHACGEPGLVFLDALQ 246 
WP_013494757  221 -------------------------------------------------ktVRARDLWELICESAWASGEPGVVFMERVN 251 
WP_014426173  206 ------------------eT-Ghie------------------------ktIDARSFFHEFCETQWDWGDPGAIFIDRVR 242 
WP_016339111  393 ekvfydenwskigdinewkAlGykvk---------------------tyykMKARDLWDLINFCANYSAEPGIFFIDTAN 451 
WP_066396069  403 emeaynnewhevgdvrvweEkGygir---------------------vykrIQARELWNLINICATYSAEPGIFFIDNAN 461 
WP_062470624  403 emayydaewgnvgdvrdweKaGhavr---------------------vyrtIKARELWKLINVCATYAAEPGIFFIDNAN 461 
WP_119883294  404 emqtynahwhevgdvreweRqGhevr---------------------vyrtIQARELWNLINICATYSAEPGIFFIDNAN 462 
WP_086886798  428 KEHSFD-TDkhpeH----TILATNPCGEQPLEEFEACNLGHINLSTLADFdapdwrvwseehaeeydsheeavaafleEA 502 
WP_010898958  461 DMTNAKaYG----Q----KVVATNPCGEQPLAPYSVCNLAAINLAEMANKq--------------------------eKT 506 
WP_012874007  286 KRSNTW-YF----E----NIRCVNPCGEQGLPPWGVCNLGALNLLAFVKHid------------------------geTY 332 
WP_013176133  247 RSNPIR-G-----T----VIAATNPCGEVPLLAGESCILGSINLAPMVDAa---------------------------GN 289 
WP_013494757  252 KRSNTW-YC----E----PINCVNPCGEQPLGPWGVCNLGAINLAAFVHe----------------------------GE 294 
WP_014426173  243 NFNLLS-------GyleyKIDVSNPCAEFFGNGGNSCNLGSINVYNAIKDkft-----------------------dhAT 292 
WP_016339111  452 DMTNAKaYD----M----KVVATNPCGEQPLAPYSVCNLAAINLANFVDKt--------------------------tKE 497 
WP_066396069  462 DMTNATaYG----Q----KVVATNPCGEQPLAPYSVCNLAAVNLGNMADKe--------------------------nKT 507 
WP_062470624  462 NMTNAQaYG----Q----KVVATNPCGEQPLAPYSVCNLAAVNLAEMVNKd--------------------------lQM 507 
WP_119883294  463 DMTNAKaYG----Q----QVVATNPCGEQPLAPYSVCNLAAVNLARFANKe--------------------------tKT 508 
WP_086886798  503 IDFEEFDERIEYGTRFLENVVT--MSDFPVEEIERKVR-DMRKIGLGIMGLAQLYIQLGIRYGSEEGNEVARQLMTHINH 579 
WP_010898958  507 VDFKKLKQTVEVGVRMQDNVID--ATPYFLEENTKQAK-GERRVGLGVMGLHDLLIYTETVYGSEEGNKLVDQIFETIAT 583 
WP_012874007  333 FDFEDLANTARVAIRFLDNVID--ATVYPFPENEEAQKhGARRTGLGTMGLADVLIKLGVKYGSPEAEPLVERIYRTIRD 410 
WP_013176133  290 LKEVQLAETVGIAVRFLDNLID--VGQYPLTFIAQTTR-ATRRIGVGFTGLADALIKSGLAYDSEEGRAWADRAAAIIKA 366 
WP_013494757  295 LDLEGLKDTVAVAVRFLDNVID--ATEYFFPENEKAQRyGVRRIGLGTMGLADMLIKLRIRYGSEKAFEVCDQVYRLIRD 372 
WP_014426173  293 IDKTHLRMITDTAVRMLDEILDygYDMQPLDLNRETIA-DWRSIGLGVFGLADAFVAMGIRYGSEESRAVASDIMDIIME 371 
WP_016339111  498 ILYDKLSQTVRTCVRMQDNVID--ATPYFLEANQKQAL-GERRVGLGVMGLHDLLIYHGVRYGSVEGNQIVDKIFELMAT 574 
WP_066396069  508 VDFEKLKQTVEVGVRMQDNVID--ATPYFLEPNRVQAL-GERRVGLGVMGLHDLLIYCETVYGSEEGNKLVDQIFETIAV 584 
WP_062470624  508 VDFSKLEKTVCMGVHMQDNVID--STPYFLEENRIQAL-GERRVGLGIMGLADMLIYCGVRYGSEEGNQLIDQVFKTIAV 584 
WP_119883294  509 VDFESLKETVRVGVRMQDNVID--ATPYFLEENRVQAL-GERRVGLGVMGLADLLIYCEKEYGSEEGNKLVDELFETIAA 585 
WP_086886798  580 EAKATSHELALERGSFADWDD----------SKYAapteyrewfehqtgedaddwddgFPIRNHNVTTIAPTGTTSMVGN 649 
WP_010898958  584 TAYRTSIELAKEKGSFPFLVGqtdeetkqlrQRFIgtgymkkmp-----edirqgvleYGIRNSHLLTVAPTGSTGTMVG 658 
WP_012874007  411 AAYDASADLAAEKGPFPKFDR----------DKYMqgefirelp-----eeiqakirrQGIRNAVLLTQAPTGTTSSLAG 475 
WP_013176133  367 AAEEASRELAREKGAFPWWGR----------SVYYp---------------------dDPRRNAALLSVAPTGSVTLIAA 415 
WP_013494757  373 EAYRTSALLAKEKGAFPWFDK----------EKYLqgwfiqrlp-----edirqliaqHGIRNGFLLTQAPTGTTSLLAG 437 
WP_014426173  372 QALLTSASLAAKKGAFRKFDL----------EKTMaspvikayp------eahdlikkYGLRNGTLLSIAPTGTISLFAG 435 
WP_016339111  575 EAYRASIELAKEKGSFPFLVSp---------ERFIntgymkkmp-----edirqdilkYGIRNSHLLTIAPTGSTGTMVG 640 
WP_066396069  585 TAYRTSIELAKEKGSFPFLEGeteettnelrRRFTetgymkklp-----edvredileFGIRNSHLLTVAPTGSTGTMVG 659 
WP_062470624  585 TAYEESIELAKERGSFPFLVGetgretqqlrEKFVnsgfmrgmp-----ehvrqgvlkYGIRNSHLLTVAPTGSTGTMAG 659 
WP_119883294  586 TAYETSSQLAVERGSFPFLIGendaetkqlrEAFTktgfmqkmp-----tsiresilaNGIRNSHLLTVAPTGSTGTMVG 660 
WP_086886798  650 -TTG-GCEPIYNVAYYKNVTDdvqgDEMLVEFDDYFLRVLEAN-DIdvDAVKEEAQEQmatnqfAGVEGLSTVPDSIGEL 726 
WP_010898958  659 -VST-GLEPYFSFSYFRSGRL----GKFIEVKAEIVQEYLRAHpEA----------------------DENHLPEW---- 706 
WP_012874007  476 -VNS-GIEPVFAFVTKRRDRL----GEH-LLYHPLAQEWMDAHpG-------------------------KPLPDY---- 519 
WP_013176133  416 -CEGyGIEPIFAVAYTKSTSA----AGKIEVFSPLFLQECERH-GIp-ETVRSEVARR------GSCQGVDGIPADMARV 482 
WP_013494757  438 -VSS-GIEPVFAFSFKRTDRT----GTH-IVYHELYKEWLEKHpD-------------------------EPVPDY---- 481 
WP_014426173  436 gFTG-GIEPMYKIAYQRTSHSmedsGKTFTVYARGVADLLKFH----------------------GLEGI--SPEEAKKK 490 
WP_016339111  641 -VST-GLEPYFGFKFYRSGRL----GKNIEVNAKIVDEWLKYNpGY----------------------SATSLPDI---- 688 
WP_066396069  660 -VST-GLEPYFSFSYFRSGRL----GKFIEVKADIVKEYLDNNpGA----------------------NENELPEW---- 707 
WP_062470624  660 -VST-GLEPYFSFSYFRSGRL----GKFIEVKAEIVQEYLERHpDA----------------------DPDNLPDF---- 707 
WP_119883294  661 -VST-GLEPYFSFTYYRSGRL----GKFMEVKADIVQEYLEKNpSA----------------------EESSLPEW---- 708 
WP_086886798  727 F---VITADLSAKDHAAVQCACQEGVDSAISKTVNAPNDSTLEDAKEVFEWVYENGGKGVTYYRDGTRSKQVLTTRAD 801 
WP_010898958  707 F---ISTMELAPEAHADVQCIIQRWVDSSLSKTVNAPRGYTVEQVQAVYERLYRGGAKGGTVYVDGSRDAQVLSLKAE 781 
WP_012874007  520 F---VSSADLTPEEHIRIQAVVQKYTDSSISKTVNGPEDNTVEDVERLYMLAYDTGCKGITYYRQGSRDAvleavdtk 594 
WP_013176133  483 F---KGAREIAPEDHLLMQAAVQKHVDNAVSKTVNLPREATPADVDHTFRLAWELGLKGVTVFREGAKPAPVTVGAGE 557 
WP_013494757  482 F---VSADQLTPEEHVRMQAIIQQYVDASISKTVNAPREHTVDQVRTLYRLAYELGCKGITYYRDGSREgvlhklddg 556 
WP_014426173  491 FpflIESHEVPPMERVAFQGILQDYVDNAISSTVNLPNSATVEEIEEIYMAAWKQGLKGITVFRDGCKRGNILGVSDK 568 
WP_016339111  689 F---VAAMDLAPEDHADTQCIIQRWVDSSISKTVNAPRGYSVKDVEKIYTRLYKGGAKGGTVYVDGSRDAQVLSLTTD 763 
WP_066396069  708 F---VAAMELAPEAHADTQCVIQRWVDSSISKTVNAPKGYTVDQVQKVYERLYKGGAKGGTVYVDGSRDSQVLTLKAE 782 
WP_062470624  708 F---TTAMTLSPEEHVDVQTTIQRWVDSSISKTVNAPKGYTVDQVQKIYERLYDGGAKGGTVYVDGSRDSQVLTLKAE 782 
WP_119883294  709 F---VTAMELKPEAHADVQCIIQRWIDSSISKTVNAPRGYSVEQVEGVYERLYKGGAKGGTVYVDGSRDAQVLTLKAE 783 
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap