3F1R


Conserved Protein Domain Family
beta-trefoil_FGF20
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cd23327: beta-trefoil_FGF20 
FGF domain, beta-trefoil fold, found in fibroblast growth factor 20 (FGF20) and similar proteins
FGF20 acts as a neurotrophic factor that regulates central nervous development and function. It interacts with fibroblast growth factor receptors, FGFR2 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. FGF20 contains a FGF domain with beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.
Links
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Statistics
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PSSM-Id: 467013
Aligned: 6 rows
Threshold Bit Score: 340.786
Created: 6-Apr-2021
Updated: 27-Apr-2023
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
homodimer
Conserved site includes 19 residues -Click on image for an interactive view with Cn3D
Feature 1:homodimer interface [polypeptide binding site]
Evidence:
  • Structure:3F1R; Homo sapiens FGF20 forms a homodimer, contacts at 4A
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         #   # ### #  #     #              #                                            
3F1R_A        56 QLAHLHGILRRRQLYCRTGFHLQILPdGSVQGTRQDHSlFGILEFISVAvGLVSIRGVdSGLYLGMNdKGELYGSEKLTs 135 human
Q9NP95        56 QLAHLHGILRRRQLYCRTGFHLQILPdGSVQGTRQDHSlFGILEFISVAvGLVSIRGVdSGLYLGMNdKGELYGSEKLTs 135 human
NP_001083766  53 DLSHLQGILRRRQLYCRTGFHLQILPdGNVQGTRQDHSrFGILEFISVAiGLVSIRGVdTGLYLGMNdKGELFGSEKLTs 132 African clawed ...
XP_006000150  53 DLAHLQGILRRRQLYCRTGFHLEILPgGTVQGTRKDHSrFGILEFISVAvGLVSIRGVdTGLYLGMNdKGELYGSEKLTa 132 coelacanth
XP_007890980  52 DLVHLQGILRRRQLYCRTGFHLEILPdGTVQGTRKDHSpFGILEFISVAvGLVSIRGVdSGLYLGMNdKGDLYGSEKLIa 131 elephant shark
NP_001034261  53 DLTHLKGILRRRQLYCRTGFHLEILPdGSVQGTRKDHSrFGILEFISLAvGLISIRGVdSGLYLGMNdKGELYGSEKLTa 132 zebrafish

Feature 1                   #                                            #######        ##
3F1R_A       136 ECIFREQFEENWYNTYSSNIYKHgDTGRRYFVALNKDGTPRDGARSKRHQKFTHFLPRPVDPErVPELYKDLL 208 human
Q9NP95       136 ECIFREQFEENWYNTYSSNIYKHgDTGRRYFVALNKDGTPRDGARSKRHQKFTHFLPRPVDPErVPELYKDLL 208 human
NP_001083766 133 ECIFREQFEENWYNTYSSNLYKHgDSGRRYFVALNKDGTPRDGTRAKRHQKFTHFLPRPVDPEkVPELYKDLM 205 African clawed frog
XP_006000150 133 ECIFKEQFEENWYNTYSSNLYKHgDTGRRYFVALNKDGTPRDGTRSKRHQKFTHFLPRPVDPDrVPELYKDVL 205 coelacanth
XP_007890980 132 ECIFREQFEENWYNTYSSNLYKHnDTGRRYFVALNKDGSPRDGTRSKRHQKFTHFLPRPVDPEkVPELYRDIL 204 elephant shark
NP_001034261 133 ECVFREQFEENWYNTYSSNLYKHgERGARYFVALNKDGTPRDGTKSRRHQKFTHFLPRPVDPEkVPELYKEVL 205 zebrafish

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