3EBB


Conserved Protein Domain Family
PUL

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pfam08324: PUL 
PUL domain
The PUL (PLAP, Ufd3p and Lub1p) domain is a novel alpha-helical Ub-associated domain. It directly binds to Cdc48, a chaperone-like AAA ATPase that collects ubiquitylated substrates.
Statistics
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PSSM-Id: 462428
Aligned: 175 rows
Threshold Bit Score: 60.0391
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3EBB_A        45 PKKEAVTFDQ-ANPTQILGKLKEL------NGTaPEEKKLTE----------DDLILLEKILSLIcnsssekp---tvqq 104
1_pfamImport   2 PVAGYNTFET-TKISKLMSTLRQFndkmkeTGE---ATALID----------SQLIALEQIVHTVqdtafyhsstfaale 67 
EEY64581     497 PVPGYNTFET-TKITKLMATLRQFndkmkeSQA---PEALID----------SQLIALDQIAHTVqdtaffhsstfaaae 562
XP_002504496 545 PMRTPVAFET-AKYDGILRKLSEFgaeegaAGDvAAACNGGDppgas--------------------------------s 591
XP_003059881 485 PTTTCLLFDTsLNLDGILKKIAEF----------AAELATAA----------QRVEGLRECAAAAasktpps-----tta 539
EGT34984     597 GLS--------GKGEKAVAKLKELne-------kQDAFQLST----------DQINCLEELFHLAttsny---------s 642
2_pfamImport   2 GLT--------GKGEKAVAKLREFne-------kQDAFQLNP----------DQLNCLEELFLLPassny---------s 47 
XP_001961840 531 PISSYRTFDT-CDASKVLEKLKEFnnkistSDGkVGEELLLAvikfteptpeLDLTSLEALIVLL--------------- 594
Q9VPY2       531 PVSNYRIFDT-CDAKKVLEKMIEFngklslPDGrVGEEVLLAvikladqspeLDLTSLEALAILL--------------- 594 fruit fly
Q7Q8I1       516 PHRHYILLEN-ADLSKVLVKLKELnsk-----leDQSLRMSD----------DTLNDIVRYAGEVmtcgeqn-----sac 574 Anopheles gambi...
3EBB_A       105 lqilWKAI----NCPEDIVFPALDILRLSIKHpsvnenfcnekegaqfsshlinllNPKGK------------PAN---- 164
1_pfamImport  68 mtalGDVLd---KWPAKFAFPTLDLLRLVVVHpqgpsalgev-----gldtlvtkvLSLGLqtapkegddaipVAT---- 135
EEY64581     563 ittlRSVLd---KWPAKYAFPTLDLLRLVLVHpqgpaalgea-----glatlvtqvLTLGLqpgptdgddaipMSS---- 630
XP_002504496 592 iaalAAYLe---SWPVDKLFPLLDLCRMAALRgdaagvsre-------vasamaaaCARSVae---------aPRLpa-- 650
XP_003059881 540 aaalLDASa---AWPKEKLFPLLDVARMLVLVpgacdaat---------sgafaaaACRALesgg-----dgaPAPpg-- 600
EGT34984     643 sdvaQSAFdtalQWPVEHLAPVLDFFRVALTHeslnsyfctgerg-----------------qdlvmkiiailvsDpadm 705
2_pfamImport  48 sdlaQSALetalQWPVEHMTPVLDFFRIALMHeslnsyfctnerg-----------------velvgrliailvsDpndl 110
XP_001961840 595 ------------KWPAGMLFPVLDILRLAVRNeaifsvlnnth---nflsiviphlAGSAAn------------------ 641
Q9VPY2       595 ------------KWPASMQFPVLDILRLAVRNeaifsvlnnsh---nflatvipqlSGSAPn------------------ 641 fruit fly
Q7Q8I1       575 ltalKFLYt---TWPTEKLFPIMDITRLIVREpracqelfeda---sfmgtflqhtNHLPAn------------------ 630 Anopheles gambi...
3EBB_A       165 --QLLALRTFCNCFVGQAGQKLXXSQRESLXSHAIELKSGs----NK-NIHIALATLALNYSVCFhkdH-NI--EGKAQC 234
1_pfamImport 136 --RMLSLRVLANMFLHDAPRKAMLAHKTEVLGKLPSFQAf----hHK-LVALSLSTVLLNFARVQ---AaSPgsLTADDQ 205
EEY64581     631 --RMLSLRVLANMFLHDAARKAILAHKTVVLSKLPSFQAf----hHK-LVALSLSTVLLNFARAQ---VaNPgaLTPDDQ 700
XP_002504496 651 -nLLTAGRLFCNAFRHEVARDAFVlRASEILDGLAAAASp----dAKtPARLALATAVLNVSTRVh----VSdaSLAECA 721
XP_003059881 601 -nVLTAGRLFANAFKHGETRDAFLpFGQALLDGLAPAAAa----dAKpPARLALATAILNLASFA-----SDipAAADLA 670
EGT34984     706 vlKVMVCRCIGNAFAHPAGRSLFA---SYELSTLAPLVIRqllneKQ-ILQMSAATALANWSLAL---------LKQSET 772
2_pfamImport 111 glKVLVCRCIGNAFSHQAGRNLFA---STELSTLAPLVVRqvvheKP-VLQISATTTLANWSLAL---------LKESER 177
XP_001961840 642 --QLMVIRCLANSLGHTTGRLHIEKQLPEIIDLVAGIKAGs------aNLQIAVATFYLNVTISQ-----ILgvAKGEVC 708
Q9VPY2       642 --QLMVVRCLANIMSHAAGRQNVMSRLAEIIDLVGAIKTGs------aNLQIAVATFYLNLTISQ-----TLdvAKSEVC 708 fruit fly
Q7Q8I1       631 --QLMSARCFTNMLAHQPGRNVVVEHIRAIVDRFAVLRGSac----spNLQIALASFYLNLTMTQ-----LDklSSVDFC 699 Anopheles gambi...
3EBB_A       235 LSLISTILEVV---------------QDLEATFRLLVALGTLIs-------dDSnAVQLAKSLGVDSQIKKYSS------ 286
1_pfamImport 206 VVVVSLAADLLngay-------tvqeLGDDTILRSLVAIGTLAls---------gDAKAKEAAGVHVAIFTAAKa----s 265
EEY64581     701 IVVVSLSADLLngsy-------tvqeLGDDTILRSLVTIGTLAlt---------gDAKAKEAAGVHIAIFSAAKa----s 760
XP_002504496 722 PRAVSVGAELLlsc----------paEEDDARFRTLVALAQIAadg---gaeCKsLAKDLGLGDVAEALRVSGG------ 782
XP_003059881 671 PACVAVGSQLLyas----------paADVDARFRALVALGTAAtta---gaeAKkLAIDLGVLDVATALAAAES------ 731
EGT34984     773 VEQLGPKEDLLralitgieavdsfgfVSEEALSRLLQTIVTIMw-------gDSsVIRLAKNRNMAAIAARLKD------ 839
2_pfamImport 178 VEQLGPKEDLLrailsgl--ensnttLCEEAVIRLLQAIVTVMw-------gDAsVIRLAKNRNVTSIAARLKD------ 242
XP_001961840 709 HVVTSGVVELLkw------------aKDLEACYRSMQAIGNLTt-------tPCgQETIAQVISVDYVMDKLREltntpq 769
Q9VPY2       709 HVVTSGIVELLkw------------aKDLEACYRSMQAIGNLTt-------tSCgQETIAQVVSVDYVMDKLREltitpq 769 fruit fly
Q7Q8I1       700 KVLAGTIGELLcw------------lTDNEATYRGYQALGNLLsmpgpgmgaIAdTLKGNSALTDKILFNISSE------ 761 Anopheles gambi...
3EBB_A       287 VSEPaKVSECCR 298
1_pfamImport 266 EATSpAVQECLA 277
EEY64581     761 EATSqVVQDCLA 772
XP_002504496 783 ---SeRVRDAAG 791
XP_003059881 732 ---AgKVKDAAA 740
EGT34984     840 ATQNeTTKSMAR 851
2_pfamImport 243 IITDeTGKSIAR 254
XP_001961840 770 GENFsKVnsvgq 781
Q9VPY2       770 DKNFsKVNSVGQ 781 fruit fly
Q7Q8I1       762 LPNFgKLNECAS 773 Anopheles gambiae str. PEST
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