3I4Z,3O24


Conserved Protein Domain Family
Trp_DMAT

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pfam11991: Trp_DMAT 
Tryptophan dimethylallyltransferase
This family of proteins represents tryptophan dimethylallyltransferase (EC:2.5.1.34), which catalyzes the first step of ergot alkaloid biosynthesis. Ergot alkaloids, which are produced by endophyte fungi, can enhance plant host fitness, but also cause livestock toxicosis to host plants. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 390 to 465 amino acids in length.
Statistics
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PSSM-Id: 463422
Aligned: 102 rows
Threshold Bit Score: 173.635
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3I4Z_A        33 KLWWHSTAPMFAKMLETAN-YTTPCQYQYLITYKECVIpSLG---CYP--TnsaprwlSIL--TRYGTPFELSLNCSN-- 102 Aspergillus fum...
M2Y2F4        12 KFWANHLLPQFRRYIAEIGaYTSKQQDEHVKFFDS-LLpHLGprlPHPhtK-------AVL--TVANMPLGFSVNLSDar 81  Dothistroma sep...
EFQ90212      89 NVWANYLVPRFHKYLAETGsYTVEQQEAHALCLSAAVV-ALGprhPHPhvK-------SVM--TPNGCPIELSLNLSEdr 158
Q0C8K4        18 EFWSEHIRSVIGPLMKATGsYSGTAQEANLRFLDNYIApALG---PHPtvAhp----tYVApcTIVGTLFNPSISLSAkg 90  Aspergillus ter...
EFY87044      14 RYWMRHSVPPLLALLRAAGsYSDADQGKHIQFLCDYVLpNFG---PRPteAsp---srSRF--TQSGFPMDLSLNLNAg- 84 
EFY87045      21 KYWSDNFIPPLKSLLQATEsYSRSEQEAQLRILKEDVLpNLG---PRPskAvg----pSHL--TQSGSPLQLSLNASSs- 90 
XP_003715802  13 QYWWQFVEPSLSSMLEYAGqYTPEEQDSHLEWYATQVTpIFG---IQPseEtp---dpNPF--THDSSPCHISINWCSkg 84 
XP_003347762  58 NYWWTACAPSLTSILRHSNsYTPTQQSLHLTWFRNNVIpNLG---PRPssSyr---lrSPL--NYEGSPYRPTWNFCSap 129
ESA42114      57 HYWWTACAPSLTSILRHSHsYTPSQQSLHISWFRNNVIpNLG---PRPssSyr---lrSPL--NYEGSPYRATWNFCSap 128
OBR03216      27 DFWSSYLVPRFHAYLSEAGsYTPEQQAAHLSCVRAAAV-ALGpkhPHPhvK-------SAL--TKNGSPIELSFNLSEdr 96 
3I4Z_A       103 -----------SIVRYTFEPINQHTG-T-DKDPFNTHAI----WESLQHLLPLe---KSIDLE----WFRHFKHDLtl-- 156 Aspergillus fum...
M2Y2F4        82 ----------kPIARMEIEPLDDTSG-S-AEDLFAANCIpacfTTLVKGMt------TRVDTR----WAHQLRQAFt--- 136 Dothistroma sep...
EFQ90212     159 ----------pPTARFYLEPLGSRTG-T-DEDPFGELWT----PSSFACLAAQv---PSADAR----WYQHLSQAFrl-- 213
Q0C8K4        91 ----------kPTVRFDYDLPLPLDRaS-SDDPWGEGKA----RTLFRRLAAa----LGADTQ----WLEYFMARLfl-- 145 Aspergillus ter...
EFY87044      85 ----------kPKVRYCWEFLGPNGP-E-DNDMYAIGAL----RKCLESLATe----LGFSTQ----WADALLDALap-- 138
EFY87045      91 -----------NCVRYCWEMLGASGG-H-GRDPLAIQAA----QDIVASVSAk----FGFSTK----WSSALLSAFav-- 143
XP_003715802  85 ----------kPTVR---------SGmTrPHDVFNSQAF-------VDELQPAmetsDQPDRA----IFDGLAKSLfl-- 132
XP_003347762 130 pgssssspkvkGTLRFSFEPIPATGT-S-EEDPTNQEGY----RRLFPLLAGEchgvGGVETKadltWYNEVKEHMylln 203
ESA42114     129 agsp-ssssvaGTLRFSFDPIPATGS-I-KKDPTNQEEY----KRLFPLLAREchgkGETKVV----FQSKIVSRGsq-- 195
OBR03216      97 ----------lPTARFYIEPLGPETG-T-ENDPFGESWA----ARGFSCLASQm---TSMDTS----WYEHLGQAFrl-- 151
3I4Z_A       157 --------------nSEESAFLahndrlv------------ggtirtqNKLALDLKdgrfALKTYIY----PALKAVVTG 206 Aspergillus fum...
M2Y2F4       137 --------------pTSEESAIakprlrp------------giervslAYFGITFDgd--nrAMKYCtshwPKFLGTATA 188 Dothistroma sep...
EFQ90212     214 -------------qgEDEVSKAksqsrp--------------gvwlptMFMGIDFVaanrLLKCSFC----PILKLLAMG 262
Q0C8K4       146 --------------sPAETEALrskipa--------------dlvipsAMVGVAFDdaqpRLKAWVP----TMRRAILEG 193 Aspergillus ter...
EFY87044     139 --------------tPEEATTTqqnirqwqasllppgvepkpgarlpfAALAFGLDgprtDTKFYIS----PQIKELGSA 200
EFY87045     144 --------------kPDEAQHIidmlpqwlqsfvpegveaaplkripfALTAFDLKgsniSMKLYVN----PKAKEIITG 205
XP_003715802 133 -------------kdPQEIAKVkavvpph------------lhtripnIGIAWDLVgakrKLKLYHN----PQAKKLATS 183
XP_003347762 204 qeravlkerlvpgqlPPEHAAI-----------------------------AIACSrekrVLKPYFF----AGPTSLVTG 250
ESA42114     196 --------------lPPEHAAI-----------------------------AIGCVgekrVLKPYFF----AGPKSMVTG 228
OBR03216     152 -------------kgQVEVDTAnsqsrp--------------gmwlpkVFLGVDFKgadrMLKCGFC----PLLKLSAMG 200
3I4Z_A       207 K------TIHELVFGSVRRLavreprilpP-LNMLEEYIRSRgsk------------------------stAS------P 249 Aspergillus fum...
M2Y2F4       189 Esnd-atSADAFLFSAIRRLkpggealapS-LDAIQHYFQNEr-----------------------------HaklpspI 237 Dothistroma sep...
EFQ90212     263 AdwnhlaDHNQFVLDAVRQLpgfganagaA-LDLLAQYLVEAsesgasvhntsv-----vnsgleegesgpKAktpkpfF 336
Q0C8K4       194 R------SSNEIAVEVLRGLsplgseitpA-IDMVEAWIA-Asph-------------------------------dprL 234 Aspergillus ter...
EFY87044     201 K------SMNETIWNVARHLepp---isqNaIRAVSEFLLERpgp--------------------------------pcM 239
EFY87045     206 T------PAADEVWKVLRNLtpa---fkpEaIDMLEKFFTGLpep--------------------------------spI 244
XP_003715802 184 R------TGNDIIVSSIRALandgynyneA-MDVLERYVTELnpe-------------------------------kleL 225
XP_003347762 251 F------SPHQVLFSALRAIrtrreelkpA-IKLVESYVSSRast--------------------------------mtP 291
ESA42114     229 L------SPHQVLFSALRAIrtkaeelkpA-IDLVEDYVASRkav--------------------------------mmP 269
OBR03216     201 AkwdrlaDHNKFVLDVVRGLpgcganmsaA-LGMLERYLVQDrehsagaqgqgdgvddgrkdassmcqacaKAnrpkpfF 279
3I4Z_A       250 RLVSCDLTSP-------A----KSRIKIYLLEQMVS-LEAMEDLWTLGGRRrdaSTLEGLSLVRELW-DLIQLSPglksy 316 Aspergillus fum...
M2Y2F4       238 LFVGLDCIDP-------S----RARIKMYGRTHSTA-FSNVRNIMTLGGRAltaETTEFLARLRSIWhLLLNDPKakdde 305 Dothistroma sep...
EFQ90212     337 NLVSVDCSDL-------Sn--gKGRVKLYARITSTS-FASIRDAVTLGGRLtdeVTVEGLRHLESIWhLLLNDPAienda 406
Q0C8K4       235 MLVGMDCGEP-------R----DSRLKIYLVTTKNS-WATVQDVMTLGGRLddePTRKQLALLRKIWpYLINEPDntria 302 Aspergillus ter...
EFY87044     240 DMLCVDLVKEqn----lH----RARFKIYVHTTSNS-FNTVRQCISLGGRRqdeATLKGLEVLRTIWhLLLQEKEevtdd 310
EFY87045     245 ELVGIDCVDDgh----lS----DARVKLYIHTRSNS-FKTVRKYVSLGGKLndeETNKYLEKLQPIWhLLLQQPEgpvdd 315
XP_003715802 226 IIIGMDAAEPt-----lP----TTRIKPYGIVAEANsWETVKNIYTLGGQVlnqERKQGLDILRSIW-DLMRCHRgqrla 295
XP_003347762 292 SCFGIDAVSPfpssdqqGgaaaAARVKLYTLVPSNA-FSVMRDAMTMGGRLaspESLRGVALLKWIYhLLRGDRSrvsea 370
ESA42114     270 NCIGIDAVSPd----------qGARVKLYTLIPSNA-FCVMRDAITLGGRLtspEAMRGVGILRGIYhLLRGDRSpinda 338
OBR03216     280 NLVSVDCADP-------Sn--gKGRVKLYTRTSCNA-FACIRDAVTLGGRLtdeDTLEGLRRLRSVWhLLLNDPVsqhdd 349
3I4Z_A       317 papylp--lgvipderlpLMA-NFTLh-qNDP--VpePQVYFTTF--GMNDMAVADALTTFFERRG--WS 376 Aspergillus fumigatus
M2Y2F4       306 dydrp---pldpnslrtgLLV-SFEVsalVSTp---dIKVYVPFWqyHETDVQAINNLEQIFSLLG--WD 366 Dothistroma septosporum N...
EFQ90212     407 dyarp----pdskssfpgIDV-NWEV---SNQlpVphAKVYIPVHifHANDVEVHRNLSQVFRKLG--WN 466
Q0C8K4       303 denwck-permprvgffgLMY-SLEIk-pGRP--TpeVKLYVPLFqyAESWAIAENNMETVLKLLD--ID 365 Aspergillus terreus NIH2624
EFY87044     311 nekpv---ndpaelvmklFF--CIEFt-pGED--LpdVKLHVPIFnyLKSDRETIENLEKVFLKCGqeWA 372
EFY87045     316 dfekpi--ndssmlcqklYF--SFELq-pGRD--FpnVKTYLPTWnyVRTDEETIRNYQEIFQICGhpWG 378
XP_003715802 296 ddyhm---pkndssstrgVLTpSFEVk-pGQS--LpdVKVYVSQWqfAKTDREIAECTVEIFKRLG--WQ 357
XP_003347762 371 tyhvskpcryetrknsywMGFtSYEMq-pGRE--DpdVKVYLPLMqfFETEEAVVAALETVWRVLG--WG 435
ESA42114     339 tenmskpcryesksnsywKGFtSYEMr-pGRE--EpeVKVYVPLMqiFETEQAVIEGLEEVWRGFG--WG 403
OBR03216     350 eysrt----vaveshrqgIDI-NWEI---SDQlpApqAKVYVPVSmfHENDLGANRNLSEAFRKLN--WL 409
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