Conserved Protein Domain Family
SPRY_RNF123
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cd12882: SPRY_RNF123 
SPRY domain at N-terminus of ring finger protein 123
This SPRY domain is found at the N-terminus of RING finger protein 123 domain (also known as E3 ubiquitin-protein ligase RNF123). The ring finger domain motif is present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. RNF123 displays E3 ubiquitin ligase activity toward the cyclin-dependent kinase inhibitor p27 (Kip1).
Links
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Statistics
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PSSM-Id: 293940
Aligned: 11 rows
Threshold Bit Score: 249.166
Created: 15-May-2012
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q5XPI4    123 TIRSTTCVYkGKWLYEVLISSQG-LMQIGWCTISCrFNQEEGVGDTHNSYAYDGnRVRKWNVTTTNYGKaWAAGDIVSCL 201  human
EGD82586   84 SIRSDVAVCaGKWMFEVVIVTTPeTIQLGWCSPACrFTASDGVGDSRDSYAYDGmRRRKWNVGSRKYGEhWVQGDVIGCC 163  Salpingoeca sp. A...
EEC05808   56 TIRGTCCVFkGKWQYELMLGSKG-VMQVGWVTSNCkFSQEKGVGDTQDSYAYDGnRVRKWNVSTYKYGEpWLAGDVIGCC 134  black-legged tick
EDQ77598   27 SVRANACVWkGRWMYEATLGTAG-IQQLGWATISCpFTNEEGVGDAADSYAYDGrRVRKWSKCHASYGQpWVVGDVIGCC 105  Physcomitrella pa...
EAT41084   66 TVKANCCVYsGRWMYEVQLRSKG-VMQIGWCSAHCkFTQDTGVGDTRYSYGLDGsKQRIWHVYTQKYGPfWRSGDVFGVC 144  yellow fever mosq...
Q9SIZ7    137 SARANACIWkGKWMYEVALETSG-IQQLGWATLACpFTDQKGVGDADDSYAFDGrRVSKWNKEAEPYGQsWVAGDVIGCC 215  thale cress
ACO64198  192 SFRANACVFgGRWQYEVTIRTAG-IMQIGWATVRCpFTQEHGVGDAQDSYAFDGhRVRKWNVACQPYGQpWVPGDVITCC 270  Micromonas sp. RC...
EFJ08108   27 SARANACVWrGKWMYEVTLGTAG-IQQLGWATISCpFTDSEGVGDASDSYAYDGrRVKKWSGKSQTYGEpWVVGDVIGCC 105  Selaginella moell...
EEB12423   90 SILCNVCVYqGKWQFEVQLGTKG-VMQIGWATRGCrFSQETGVGDTFDSYAYDGnRIRKWNSYTQKYGQpWLSGDIIGCC 168  human body louse
Q9VFC4    122 TVRANCCVYgGRWMYEIHLHTKG-VMQIGWASNSCqFNENSGVGDTKSSYGYDGsKQQIWHISTKKYGDkWQIGDVIGVT 200  fruit fly
EDP00636    1 SVRANACVYtGKWQYEVTVCTAG-IMQIGWATINTrFTSEEGVGDCPDSYAFDGkRVKKWSVECIPYGEsWAAGDVIGCC 79   Chlamydomonas rei...

Q5XPI4    202 IDLDd-----GTLSFCLNGVSLGTAFENLSrgl-gmAYFPAISLSFkESVAFNFG 250  human
EGD82586  164 IDLDq-----GTISYYRNGRDLGVAFDKVRvgh-rlAYCAGVSVAHgGMVFVNVG 212  Salpingoeca sp. ATCC50818
EEC05808  135 LDLDe-----GTVHFYRNGRSLGVAFDRVRagp-glVYFPAVSLAFgENLVANFG 183  black-legged tick
EDQ77598  106 LDLNk-----KQIIFYRNGICLGVAYDNIRglepreGYYPAISLSLgERCELNFG 155  Physcomitrella patens subsp. patens
EAT41084  145 VDMDe-----GRIEYYRNGAALGEAFKDIErgp-glALYPAVSLAFnDSLTANFG 193  yellow fever mosquito
Q9SIZ7    216 IDLNc-----DEIYFYRNGVSLGAAFTGIRklgpgfGYYPAISLSQgERCELNFG 265  thale cress
ACO64198  271 IDLNsdedggGTVSYLRNGASMGVAFRNVRrsqpglAYFPAVSLSVnEAMDLNFG 325  Micromonas sp. RCC299
EFJ08108  106 IDLEq-----GQIFFYRNGTSLGMAYDCVRrmevkqGYYPAISLSHgERCELNFG 155  Selaginella moellendorffii
EEB12423  169 GDFDk-----GTLEFFRNGVSMGEAFDNVHlgp-grAYFPAVSLGFgEHLTANFG 217  human body louse
Q9VFC4    201 IDVDk-----EVIEYYRNGRSMGVAFNKLEkgp-giSFFAAISLGYtQGIEANFG 249  fruit fly
EDP00636   80 LDLHr-----GEATFYRNGRSMGVAFARVRslqphlAYFPAVSLSHaERAELNFG 129  Chlamydomonas reinhardtii
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