Conserved Protein Domain Family
SLC6sbd_B0AT3
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cd11517: SLC6sbd_B0AT3 
glycine transporter, B0AT3; solute-binding domain
B0AT3 (also called Xtrp2, XT2) transports glycine. Human B0AT3 is encoded by the SLC6A18 gene. B0AT3 is expressed in the kidney. Mutations in the SLC6A18 gene may contribute to the autosomal recessive disorder iminoglycinuria and its related disorder hyperglycinuria. SLC6A18 or its neighboring genes are associated with increased susceptibility to myocardial infarction. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.
Links
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Statistics
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PSSM-Id: 212086
Aligned: 7 rows
Threshold Bit Score: 1028.22
Created: 8-Jul-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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  next features
Feature 1: putative glycosylation site [posttranslational modification site], 1 residue position
Conserved feature residue pattern:NClick to see conserved feature residue pattern help
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
Q96N87        17 ERPKWDNKAQYLLSCTGFAVGLGNIWRFPYLCQTYGGGAFLIPYVIALVFEGIPIFHVELAIGQRLRKGSVGVWTAISPY 96  human
XP_517609     17 ERPKWDNKAQYLLSCIGFAVGLGNIWRFPYLCQTYGGGAFLIPYVIALVFEGIPIFHVELAIGQRLRKGSVGVWTAISPY 96  chimpanzee
XP_002815433  17 ERPKWDNKAQYLLSCIGFAVGLGNIWRFPYLCQTYGGGAFLIPYVIALVFEGIPIFHVELAIGQRLRKGSVGVWTAISPY 96  Sumatran orangutan
Q62687        16 ERPKWDNKLQYLLSCIGFAVGLGNIWRFPYLCHTHGGGAFLIPYFIALVFEGIPLFYIELAIGQRLRRGSIGVWKTISPY 95  Norway rat
NP_001108369  12 ERPKWDNKVQYLLTCVGFAVGLGNIWRFPYLCQIYGGGAFLIPYLIALVFEGLPLLYLELAIGQSLRKGSIGVWHSISPL 91  zebrafish
XP_003640835  12 GRPKWDNKFQYILSCIGFAVGLGNVWRFPYLCQIHGGGTFLIPYFIALIFEGIPLLHLELALGQCLRKGSINAWHTISPY 91  chicken
XP_002187681  16 GRPKWDNKFQYILSCIGFAVGLGNVWRFPYLCQIHGGGAFLIPYFIALLFEGIPLLHLELALGQCLRKGSIGAWNTISPY 95  Taeniopygia gut...

Feature 1                                                       #                                
Q96N87        97 LSGVGLGCVTLSFLISLYYNTIVAWVLWYLLNSFQHPLPWSSCPPDLNRTGFVEECQGSSAVSYFWYRQTLNITADINdS 176 human
XP_517609     97 LSGVGLGCVTLSFLISLYYNTIVAWVLWYLLNSFQHPLPWSSCPPDLNRTGFVEECQGSSAVSYFWYRQTLNITADINdS 176 chimpanzee
XP_002815433  97 LSGVGLGCVTLSFLISLYYNTIVAWVLWYLLNSFQHPLPWSSCPPDLNRTGFVEECQGSSAVSYFWYRQTLNITADINdS 176 Sumatran orangutan
Q62687        96 LGGVGLGCFSVSFLVSLYYNTILLWVLWFFLNSFQHPLPWSTCPLDLNRTGFVQECQSSGTVSYFWYRQTLNITSDISnT 175 Norway rat
NP_001108369  92 LGGVGVASMVVSFLVGLFYNTILAWVLWYFFHSFEDPLPWSQCPINDNLEGYVEECVSSTPVNYYWYRQTLNISPDIEqS 171 zebrafish
XP_003640835  92 LGGVGVASLMVSILVSLYYNTILTWVMWYFINSFQEPLPWSICPLNENRTGLNEECYESTAVNYFWYRKTLNITPDVTdS 171 chicken
XP_002187681  96 LGGVGVGSWMVSILVSLYYNTVLTWVMWYFINSFQEPLPWSVCPLNENRTGFNEECYESTAVNYFWYRKTLNITPDIAeS 175 Taeniopygia gut...

Feature 1                                                                                        
Q96N87       177 GSIQWWLLICLAASWAVVYMCVIRGIETTGKVIYFTALFPYLVLTIFLIRGLTLPGATKGLIYLFTPNMHILQNPRVWLD 256 human
XP_517609    177 GSIQWWLLICLAASWAVVYMCVIRGIETTGKVIYFTALFPYLVLTIFLIRGLTLPGATKGLIYLFTPNMHILQNPRVWLD 256 chimpanzee
XP_002815433 177 GSIQWWLLICLAASWAVVYMCVIRGIETTGKVIYFTALFPYLVLTIFLIRGLTLPGATKGLIYLFTPNMHILQNPRVWLD 256 Sumatran orangutan
Q62687       176 GTIQWKLFLCLVACWTTVYLCVIRGIESTGKVIYFTALFPYLVLTIFLIRGLTLPGATEGLTYLFTPNMKILQNSRVWLD 255 Norway rat
NP_001108369 172 GSLQWTLVLCLATAWSIVYICFIRGIETIGKAVYVTATFPYLVLTIFLVRALTLPGATDGLQYLFTPDWTLLTNPQVWLD 251 zebrafish
XP_003640835 172 GTLQWWLILCLAACWAIVYLCTIRGIETTGKAIYVTAIFPYLVLTIFLIHGLSLPGATEGLVYLFTPNLNILQNPRVWLD 251 chicken
XP_002187681 176 GTFQWWLILCLAACWAIVYLCTIRGIETTGKAIYVTAIFPYLVLTIFLIQGLTLPGATEGLIYLFTPNLNTLKNPRVWLD 255 Taeniopygia gut...

Feature 1                                                                                        
Q96N87       257 AATQIFFSLSLAFGGHIAFASYNSPRNDCQKDAVVIALVNRMTSLYASIAVFSVLGFKATNDYEHCLDRNILSLINDFDF 336 human
XP_517609    257 AATQIFFSLSLAFGGHIAFASYNSPRNDCQKDAVVIALVNSMTSLYASIAVFSVLGFKATNDYEHCLDRNILSLINEFDF 336 chimpanzee
XP_002815433 257 AATQIFFSLSLAFGGHIAFASYNSPRNDCQKDAVAIALVNSMTSLYASIAVFSVLGFKATNDYEHCLDRNILSLINEFDF 336 Sumatran orangutan
Q62687       256 AATQIFFSLSLAFGGHIAFASYNQPRNNCEKDAVTIALVNSMTSLYASITIFSIMGFKASNDYGRCLDRNILSLINEFDF 335 Norway rat
NP_001108369 252 AATQIFFSLSLAFGGLIAFSSYNPKKNDCERDALFVGIINSATSLYASIPIFAILGFKATSNFNSCVNSNILDLTNAFDI 331 zebrafish
XP_003640835 252 AATQIFFSLSLAFGGLIAFSSYNPSKNDCEKDAVTVAIVNSITSLYASIPVFSVLGFKALTGYWDCLDRNIISVINEYDL 331 chicken
XP_002187681 256 AATQIFFSLSLAFGGLIAFASYNPTKNDCEKDAVTVAIVNSMTSLYASIPVFSVLGFKATTAYWDCLDRNIISIINEFDL 335 Taeniopygia gut...

Feature 1                                                                                        
Q96N87       337 PEQSISRDDYPAVLmhLNATWPKRVAqLPLKACLLEDFLDKSASGPGLAFVVFTETDLHMPGAPVWAMLFFGMLFTLGLS 416 human
XP_517609    337 PEQSISRDDYPAVLmhLNATWPKRVAqLPLKACLLEDFLDKSASGPGLAFIVFTETVLHMPGAPVWAVLFFGMLFTLGLS 416 chimpanzee
XP_002815433 337 PEQSISRDDYPAVLmhLNATWPKRVAqLPLKACLLEDFLDKSASGPGLAFVVFTEAVLHMPGAPVWAVLFFGMLFTLGLS 416 Sumatran orangutan
Q62687       336 PELSISRDEYPSVLmyLNATQPERVArLPLKTCHLEDFLDKSASGPGLAFIVFTEAVLHMPGASVWSVLFFGMLFTLGLS 415 Norway rat
NP_001108369 332 GDRNITIENYDSWLrdLNASDPDRVSsLNLKHCVLKNFLDQSASGTGLAFIVFTEAVIEMPGSQVWAVLFFVMLFSLGLS 411 zebrafish
XP_003640835 332 PEQSITRQNYTDWItfLNSSKPEKLAgLKLKSCDLQEFLDQSVSGSGLAFIVFTQAIILMPGSQAWAILFFVMLFSLGLS 411 chicken
XP_002187681 336 PEESIMRQNYTSWIsfLNSSYPEKIGgLNLKSCDLQEFLDQSVSGTGLAFIVFTQAIILMPGSQAWAILFFIMLFSLGLS 415 Taeniopygia gut...

Feature 1                                                                                        
Q96N87       417 TMFGTVEAVITPLLDVgVLPRWVPKEALTGLVCLVCFLSATCFTLQSGNYWLEIFDNFAASPNLLMLAFLEVVGVVYVYG 496 human
XP_517609    417 TMFGTVEAVITHLLDVgVLPRWVPKEALTGLVCLVCFLSATCFTLQSGNYWLEIFDNFAASLNLLMLAFLEVVGVVYVYG 496 chimpanzee
XP_002815433 417 TMFGTVEAVITPLLDVgVLPRWVPKEALTGLVCLVCFLSATCFTLQSGNYWLEIFDNFAASLNLLMLAFLEVVGVVYVYG 496 Sumatran orangutan
Q62687       416 SMFGNMEGVITPLFDMgILPKGVPKETMTGVVCFICFLSAICFTLQSGSYWLEIFDSFAASLNLIIFAFMEVVGVIHVYG 495 Norway rat
NP_001108369 412 SMFGNLEGVLTPLLDLhMVPRWMPKEIFTGLICVVNFLVALIFTLGSGNYWLEIFNSYVGSVPLLVIAFFEIIAVVCFYG 491 zebrafish
XP_003640835 412 SMFGNIEGVFTPLLEVkVISKSIPKELLSGIICLASFLFALCFTLGSGSYWIDIFDSYAGSLPLLVIAFFEVIGVAYVYK 491 chicken
XP_002187681 416 SMFGNIEGVFTPLLELqIIPKSAPKELLSGIICLISFLIALCFTLRSGSYWIDIFDRYAGSVPLLVIAFFEVIGVVYIYK 495 Taeniopygia gut...

Feature 1                                                                                        
Q96N87       497 MKRFcDDIAWMTGRRPSPYWRLTWRVVSPLLL-TIFVAYIILLFWKPLRYKAWNPKYELFPSRQEKLYPGWARAACVLLS 575 human
XP_517609    497 MKRFcDDIAWMTGRRPSPYWRLTWRVVSPLLLlTIFVAYIILLFWKPLSYKAWNPKYELFPSRQEKLYPGWVRAACVLLS 576 chimpanzee
XP_002815433 497 MKRFcDDIAWMTGRRPSPYWRLTWRVVSPLLLlTIFVAYIILLFWKPLSYKAWNPKYELFPSRQEKLYPGWVRAACVLLS 576 Sumatran orangutan
Q62687       496 IKRFcDDIEWMTGRRPSLYWQVTWRVVSPMLLfGIFLSYIVLLAQSSPSYKAWNPQYEHFPSREEKLYPGWVQVTCVLLS 575 Norway rat
NP_001108369 492 IKRFsDDIEQMTGRRPNLFWRCCWMGISPVMLlVVLVAYVVVQVQKHPTYPAWNPQYENFPETEEKPYSTWVFSICVLLS 571 zebrafish
XP_003640835 492 IKRFsKDMKWMTGRKLNLYWQITWKFISPLLLlIVFVAFVTLQIQKKPTYAAWNPKYEHFPVKEQKVYPPWVQAICVLLA 571 chicken
XP_002187681 496 IKRFsEDVEWMTGRKLNLFWQITWRFISPLLLlIVFMAFVTLQMQKPPSYTAWNPKYEGFPMKEEKVYPPWVQAICVLLA 575 Taeniopygia gut...

Feature 1                        
Q96N87       576 LLPVLWVPVAALAQLL 591 human
XP_517609    577 LLPVLWVPVAALAQLL 592 chimpanzee
XP_002815433 577 LLPVLWVPVAALAQLL 592 Sumatran orangutan
Q62687       576 FLPSLWVPGIALAQLL 591 Norway rat
NP_001108369 572 SVPVISIPIVALYRLI 587 zebrafish
XP_003640835 572 ALPCIFIPLVALIHLI 587 chicken
XP_002187681 576 ALPCVCVPLVALFHLI 591 Taeniopygia guttata

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