3S1I,3UBC,3UBV,3WFW


Conserved Protein Domain Family
HGbI-like
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cd12131: HGbI-like 
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Hell's gate globin I (HGbI) from Methylacidophilum infernorum and related proteins
HGbI is a single-domain heme-containing protein isolated from Methylacidiphilum infernorum, an aerobic acidophilic and thermophilic methanotroph. M. infernorum grows optimally at pH 2.0 and 60C and its home is New Zealand's Hell's Gate geothermal park. The physiological role of HGbI has yet to be determined. It has an extremely strong resistance to auto-oxidation, and has fast oxygen-binding/slow release characteristics. Its CO on-rate is comparable to the O2 on-rate, and it is able to bind acetate with high affinity in the ferric state. The coordination of the heme iron changes in the ferrous form from pentacoordinate at low pH to predominantly hexacoordinate at high pH; in the ferric form, it is predominantly hexacoordinate at all pH.
Links
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Statistics
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PSSM-Id: 381269
Aligned: 57 rows
Threshold Bit Score: 162.72
Created: 13-Oct-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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heme bindinghomodimer
Conserved site includes 18 residues -Click on image for an interactive view with Cn3D
Feature 1:heme binding site [chemical binding site]
Evidence:
  • Structure:3UBC: Methylacidiphilum infernorum V4 Hell's Gate Globin I binds O2/heme; contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                         ###      #  ##  #                    #  ##  
3S1I_A      6 EKELIKESWKRIePNKNEIGLLFYANLFKEePTVSVLFQn-PISSQSRKLMQVLGILVQGIDNLEglIPTLQDLGRRHKQ 84   Methylokorus infe...
3UBC_A      5 EKELIKESWKRIePNKNEIGLLFYANLFKEePTVSVLFQn-PISSQSRKLMQVLGILVQGIDNLEglIPTLQDLGRRHKQ 83   Methylacidiphilum...
EDL59846    4 NVTALRESFELVaPRADQLAERFYEKLFEDyPDLLRYFThtDFSEQRGKLIQALVLVLKSLESPPalTKVLHQLGKEHGE 83   Planctomyces mari...
EDX84647    2 DVALLEKSFEQIsPRAIEFSASFYQNLFHHhPELKPLFAetSQTIQEKKLIFSLAAIIENLRNPDilQPALKSLGARHAE 81   Synechococcus sp....
CBK42076    4 HIELLESSFKLVaPQGDALVTRFYERLFEKyPAVKPLFKnaSISEQKKKLLASLVLVIQNLRHPEklTPVLQDMGARHVG 83   Candidatus Nitros...
ADY59857    4 DIPQLRDSFGLIaPRADQFAKSFYDRLFADhPELRSLFAgtSMEDQRQKLIQSLLVTMRSLDQPEklQPFLQDLGERHRE 83   Planctomyces bras...
EGL54747   51 PIELVEESFTFIaAKGELLVADFYSELFASqPQLQRLFSgvSQQGQQKKLLAAIVLLVQNLRHPAllDSYLTELGKRHVS 130  Methylophaga amin...
AFI85161   21 DITLVEHNFAALmSFSDALAERFYQRLFAEyPAIMPLFKsvTIEGQHKKLLASMVLLIQHLRDTEmiEDYLQGLGVRHQQ 100  Methylophaga sp. ...
ELS01246    4 QIGLLEQSFNCIrPYGKLFVSSFHENLFQTnPEIKSLFMgvESQIQKNRIWDTLVLIMENIRHPNllNNTLQGLGARLFT 83   Xenococcus sp. PC...
ELS02073    4 QVELLEQSFKYIkPYGTEFISEFYENLFEShPEIQFLLAkiDPETSQHQLWHDLVFVIENLRQPPilENTFQGFGARLFT 83   Xenococcus sp. PC...

Feature 1     # #   ##  #                           #  #   #  
3S1I_A     85 YgVVDSHYPLVGDCLLKSIQEYLgqgFTEEAKAAWTKVYGIAAQVMTA 132  Methylokorus infernorum V4
3UBC_A     84 YgVVDSHYPLVGDCLLKSIQEYLgqgFTEEAKAAWTKVYGIAAQVMTA 131  Methylacidiphilum infernorum V4
EDL59846   84 MgIQDDDYPPVTDTLLRVLAEFAedqWSEELEETWRQALKAVSTTMIE 131  Planctomyces maris DSM 8797
EDX84647   82 VgTIKSHYPLVGQALIETFAEYLaadWTEQLATAWVEAYDVIASTMIE 129  Synechococcus sp. PCC 7335
CBK42076   84 YgAKPAYYDAVGENLLAVLGEFAgeaWTPEVKQAWTDAYAAIKTIMLE 131  Candidatus Nitrospira defluvii
ADY59857   84 YnVMPRHYDLVGGALLETLGEYLeesWTPDLAAQWKLAYQTIAQIMVT 131  Planctomyces brasiliensis DSM 5305
EGL54747  131 YgVKEADYQAVKNCLLTVLEKYAvsaWSQAVASAWNETLDSVIKKMTT 178  Methylophaga aminisulfidivorans MP
AFI85161  101 YgVKQSHYEMFIENWLSVVAEFSeqeWDDTLQQAWRNVLEYVAELMQT 148  Methylophaga sp. JAM1
ELS01246   84 HgLLPKHYPLVKKAFLATFKQFLgneWNSELEQAWKNAYTYFHDLMQE 131  Xenococcus sp. PCC 7305
ELS02073   84 YgILPEHYPMAKNSLFNTFEQFLgdgWTAEFAEAWNIAYINFRKLMLD 131  Xenococcus sp. PCC 7305

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